Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab

Immune Checkpoint Inhibition in Sepsis

(2019) Richard S. Hotchkiss et al.   CRITICAL CARE MEDICINE

Novel Interventions

(2018) Jean-Louis Vincent et al.   CRITICAL CARE CLINICS

Nivolumab for Relapsed/Refractory Classic Hodgkin Lymphoma After Failure of Autologous Hematopoietic Cell Transplantation: Extended Follow-Up of the Multicohort Single-Arm Phase II CheckMate 205 Trial

(2018) Philippe Armand et al.   JOURNAL OF CLINICAL ONCOLOGY

Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis

(2018) Julie A. Stortz et al.   SHOCK

Association between mRNA expression of CD74 and IL10 and risk of ICU-acquired infections: a multicenter cohort study

(2017) Estelle Peronnet et al.   INTENSIVE CARE MEDICINE

Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit

(2017) Eamon P. Raith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014

(2017) Chanu Rhee et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nivolumab plus interferon-γ in the treatment of intractable mucormycosis

(2017) David Grimaldi et al.   LANCET INFECTIOUS DISEASES

Advances in the understanding and treatment of sepsis-induced immunosuppression

(2017) Fabienne Venet et al.   Nature Reviews Nephrology

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1

(2016) Andriani C. Patera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Up-regulation of Programmed Cell Death 1 Ligand 1 on Neutrophils May Be Involved in Sepsis-induced Immunosuppression

(2015) Jia-Feng Wang et al.   ANESTHESIOLOGY

Persistent lymphopenia is an independent predictor of mortality in critically ill emergency general surgical patients

(2015) P. E. Vulliamy et al.   European Journal of Trauma and Emergency Surgery

Timing and causes of death in septic shock

(2015) Fabrice Daviaud et al.   Annals of Intensive Care

Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts

(2014) Vincent Liu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Persistent Lymphopenia After Diagnosis of Sepsis Predicts Mortality

(2014) Anne M. Drewry et al.   SHOCK

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

Reduction of Immunocompetent T Cells Followed by Prolonged Lymphopenia in Severe Sepsis in the Elderly*

(2013) Shigeaki Inoue et al.   CRITICAL CARE MEDICINE

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samples

(2012) Julie Demaret et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

(2010) P. Brahmamdam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA