标题
Validating therapeutic targets through human genetics
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 12, Issue 8, Pages 581-594
出版商
Springer Nature
发表日期
2013-07-19
DOI
10.1038/nrd4051
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines
- (2013) D C Swinney CLINICAL PHARMACOLOGY & THERAPEUTICS
- Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway
- (2013) Gang Li et al. PLoS Genetics
- Five Years of GWAS Discovery
- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Low-Density Lipoprotein Receptor Gene Familial Hypercholesterolemia Variant Database: Update and Pathological Assessment
- (2012) Ebele Usifo et al. ANNALS OF HUMAN GENETICS
- Therapeutic targeting of the complement system in age-related macular degeneration: a review
- (2012) Robyn Troutbeck et al. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite
- (2012) Kenneth J. Katschke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Will Cholesteryl Ester Transfer Protein Inhibition Succeed Primarily by Lowering Low-Density Lipoprotein Cholesterol?
- (2012) Sekar Kathiresan JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial
- (2012) Evan A Stein et al. LANCET
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- (2012) Benjamin F Voight et al. LANCET
- The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
- (2012) LANCET
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- (2012) Luke Jostins et al. NATURE
- Use of genome-wide association studies for drug repositioning
- (2012) Philippe Sanseau et al. NATURE BIOTECHNOLOGY
- High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
- (2012) Steve Eyre et al. NATURE GENETICS
- Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
- (2012) Karol Estrada et al. NATURE GENETICS
- Genetics of gene expression in primary immune cells identifies cell type–specific master regulators and roles of HLA alleles
- (2012) Benjamin P Fairfax et al. NATURE GENETICS
- Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
- (2012) Eli A Stahl et al. NATURE GENETICS
- Chromatin marks identify critical cell types for fine mapping complex trait variants
- (2012) Gosia Trynka et al. NATURE GENETICS
- Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
- (2012) Lam C Tsoi et al. NATURE GENETICS
- Cholesterol-lowering blockbuster candidates speed into Phase III trials
- (2012) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Diagnosing the decline in pharmaceutical R&D efficiency
- (2012) Jack W. Scannell et al. NATURE REVIEWS DRUG DISCOVERY
- Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population
- (2012) Mia Kero et al. NEUROBIOLOGY OF AGING
- Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis
- (2012) Roy Fleischmann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis
- (2012) Ronald F. van Vollenhoven et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol
- (2012) Evan A. Stein et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes
- (2012) D. G. MacArthur et al. SCIENCE
- Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets
- (2011) Xinli Hu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- What makes a good drug target?
- (2011) Isabella Gashaw et al. DRUG DISCOVERY TODAY
- An overview of international literature from cystic fibrosis registries. Part 3. Disease incidence, genotype/phenotype correlation, microbiology, pregnancy, clinical complications, lung transplantation, and miscellanea
- (2011) Donatello Salvatore et al. Journal of Cystic Fibrosis
- A rare penetrant mutation in CFH confers high risk of age-related macular degeneration
- (2011) Soumya Raychaudhuri et al. NATURE GENETICS
- Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
- (2011) Manuel A Rivas et al. NATURE GENETICS
- Phase II failures: 2008–2010
- (2011) John Arrowsmith NATURE REVIEWS DRUG DISCOVERY
- A CFTR Potentiator in Patients with Cystic Fibrosis and theG551DMutation
- (2011) Bonnie W. Ramsey et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cholesteryl ester transfer protein inhibition to reduce cardiovascular risk: where are we now?
- (2011) Philip Barter et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology
- (2011) Elizabeth J. Rossin et al. PLoS Genetics
- Riluzole pharmacokinetics in young patients with spinal muscular atrophy
- (2010) Chadi Abbara et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Progress and Promise of Genome-Wide Association Studies for Human Complex Trait Genetics
- (2010) B. E. Stranger et al. GENETICS
- Spinal muscular atrophy: mechanisms and therapeutic strategies
- (2010) C. L. Lorson et al. HUMAN MOLECULAR GENETICS
- Etiology of Type 1 Diabetes
- (2010) John A. Todd IMMUNITY
- A method and server for predicting damaging missense mutations
- (2010) Ivan A Adzhubei et al. NATURE METHODS
- Competitiveness in follow-on drug R&D: a race or imitation?
- (2010) Joseph A. DiMasi et al. NATURE REVIEWS DRUG DISCOVERY
- Uncovering the roles of rare variants in common disease through whole-genome sequencing
- (2010) Elizabeth T. Cirulli et al. NATURE REVIEWS GENETICS
- Network medicine: a network-based approach to human disease
- (2010) Albert-László Barabási et al. NATURE REVIEWS GENETICS
- New Therapeutic Approaches to Mendelian Disorders
- (2010) Harry C. Dietz NEW ENGLAND JOURNAL OF MEDICINE
- Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS
- (2010) Dan L. Nicolae et al. PLoS Genetics
- Laminopathies and the long strange trip from basic cell biology to therapy
- (2009) Howard J. Worman et al. JOURNAL OF CLINICAL INVESTIGATION
- Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
- (2009) Prateek Kumar et al. Nature Protocols
- A network view of disease and compound screening
- (2009) Eric E. Schadt et al. NATURE REVIEWS DRUG DISCOVERY
- Assessing the translatability of drug projects: what needs to be scored to predict success?
- (2009) Martin Wehling NATURE REVIEWS DRUG DISCOVERY
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- (2009) L. A. Hindorff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
- (2009) S. Nejentsev et al. SCIENCE
- Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions
- (2009) Soumya Raychaudhuri et al. PLoS Genetics
- Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13
- (2008) Ralph Burkhardt et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders
- (2008) M. Estacion et al. JOURNAL OF NEUROSCIENCE
- ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors
- (2008) W. A. Schmalhofer et al. MOLECULAR PHARMACOLOGY
- Common variants at CD40 and other loci confer risk of rheumatoid arthritis
- (2008) Soumya Raychaudhuri et al. NATURE GENETICS
- Common variants at 30 loci contribute to polygenic dyslipidemia
- (2008) Sekar Kathiresan et al. NATURE GENETICS
- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
- (2008) Sekar Kathiresan et al. NATURE GENETICS
- Genome-wide association studies for complex traits: consensus, uncertainty and challenges
- (2008) Mark I. McCarthy et al. NATURE REVIEWS GENETICS
- Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome
- (2008) Benjamin S. Brooke et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of -thalassemia
- (2008) M. Uda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA polymorphisms at the BCL11A, HBS1L-MYB, and -globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
- (2008) G. Lettre et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic Mapping in Human Disease
- (2008) D. Altshuler et al. SCIENCE
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