Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock

An Inactivating Caspase-11 Passenger Mutation Muddles Sepsis Research

(2013) Tom Vanden Berghe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Update on biologicals for treatment of juvenile idiopathic arthritis

(2013) Gerd Horneff   EXPERT OPINION ON BIOLOGICAL THERAPY

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1

(2012) Niall S. Kenneth et al.   BIOCHEMICAL JOURNAL

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

(2011) Lien Dejager et al.   TRENDS IN MICROBIOLOGY

Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1α, IL-1β or IL-1 receptor type I

(2010) LEO A.B. JOOSTEN et al.   APMIS

Inflammasomes as microbial sensors

(2010) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients

(2010) Andreas Hillenbrand et al.   BMC Surgery

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival

(2009) M. Lamkanfi et al.   BLOOD

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

The P2X7 receptor–pannexin connection to dye uptake and IL-1β release

(2009) Pablo Pelegrin et al.   Purinergic Signalling

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS