HMGB1 as a therapeutic target for sepsis: it's all in the timing!

Targeting HMGB1 in the treatment of sepsis

(2014) Haichao Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages

(2011) Wei Li et al.   BIOCHEMICAL PHARMACOLOGY

Long-term Survival of Adult Trauma Patients

(2011) Giana H. Davidson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Computerized clinical decision support improves mortality in intra abdominal surgical sepsis

(2010) Laura Jane Moore et al.   AMERICAN JOURNAL OF SURGERY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE