Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans*

(2015) Anne J. van der Meer et al.   CRITICAL CARE MEDICINE

Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α

(2015) Irina N. Shalova et al.   IMMUNITY

IFN-γ Priming of Macrophages Represses a Part of the Inflammatory Program and Attenuates Neutrophil Recruitment

(2015) Marten A. Hoeksema et al.   JOURNAL OF IMMUNOLOGY

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

(2015) Xiaodi Su et al.   NATURE IMMUNOLOGY

Electronic Implementation of a Novel Surveillance Paradigm for Ventilator-associated Events. Feasibility and Validation

(2014) Peter M. C. Klein Klouwenberg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

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The interplay between central metabolism and innate immune responses

(2014) Shih-Chin Cheng et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Epigenetic coordination of acute systemic inflammation: potential therapeutic targets

(2014) Vidula Vachharajani et al.   Expert Review of Clinical Immunology

Cellular Metabolism and Macrophage Functional Polarization

(2014) Linnan Zhu et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

PPAR- /IL-10 Axis Inhibits MyD88 Expression and Ameliorates Murine Polymicrobial Sepsis

(2014) A. E. Ferreira et al.   JOURNAL OF IMMUNOLOGY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

(2014) Austin Pantel et al.   PLOS BIOLOGY

NLRP3 and ASC Differentially Affect the Lung Transcriptome during Pneumococcal Pneumonia

(2013) Miriam H. van Lieshout et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Peroxisome Proliferator–Activated Receptor-γ Activation Prevents Sepsis-Related Cardiac Dysfunction and Mortality In Mice

(2013) Konstantinos Drosatos et al.   Circulation-Heart Failure

Interobserver Agreement of Centers for Disease Control and Prevention Criteria for Classifying Infections in Critically Ill Patients*

(2013) Peter M. C. Klein Klouwenberg et al.   CRITICAL CARE MEDICINE

Synergistic Activation of Inflammatory Cytokine Genes by Interferon-γ-Induced Chromatin Remodeling and Toll-like Receptor Signaling

(2013) Yu Qiao et al.   IMMUNITY

MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes

(2013) Laura Brudecki et al.   IMMUNOLOGY AND CELL BIOLOGY

Metabolic roles of AMPK and metformin in cancer cells

(2013) Yeon Kyung Choi et al.   MOLECULES AND CELLS

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of Tumor Necrosis Factor-α in the Human Systemic Endotoxin-Induced Transcriptome

(2013) Brendon P. Scicluna et al.   PLoS One

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

(2013) Sanne P. Smeekens et al.   Nature Communications

Reversal of Immunoparalysis in HumansIn Vivo

(2012) Jenneke Leentjens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Updates of mTOR Inhibitors

(2012) Hongyu Zhou et al.   Anti-Cancer Agents in Medicinal Chemistry

Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells

(2012) Martina J Schmitt et al.   Cell Communication and Signaling

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARγ contributes to PKM2 and HK2 expression in fatty liver

(2012) Ganna Panasyuk et al.   Nature Communications

Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription

(2011) Ping Li et al.   NUCLEIC ACIDS RESEARCH

Macrophages, Meta-Inflammation, and Immuno-Metabolism

(2011) Haim Shapiro et al.   TheScientificWorldJOURNAL

IFN-γ and TNF-α Synergistically Induce microRNA-155 Which Regulates TAB2/IP-10 Expression in Human Mesangial Cells

(2010) Tadaatsu Imaizumi et al.   AMERICAN JOURNAL OF NEPHROLOGY

Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis

(2010) Jane E. Carré et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Independent filtering increases detection power for high-throughput experiments

(2010) R. Bourgon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome

(2009) Anna J. Dare et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic Assessment of Gradual Development of Moderate Experimental Colitis in IL-10 Deficient Mice

(2009) Francois-Pierre J. Martin et al.   JOURNAL OF PROTEOME RESEARCH

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Redox imbalance provokes deactivation of macrophages in sepsis

(2009) Ting Chen et al.   Proteomics Clinical Applications

Cellular energetic metabolism in sepsis: The need for a systems approach

(2008) Jane E. Carré et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

arrayQualityMetrics—a bioconductor package for quality assessment of microarray data

(2008) Audrey Kauffmann et al.   BIOINFORMATICS

Cellular Dysfunction in Sepsis

(2008) Mervyn Singer   CLINICS IN CHEST MEDICINE