Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

Role of Metabolic Reprogramming in Epithelial–Mesenchymal Transition (EMT)

(2019) Hyunkoo Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

(2019) Aaron Goldman et al.   Science Signaling

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

(2019) Btissame El Hassouni et al.   SEMINARS IN CANCER BIOLOGY

The Flick of a Switch: Conferring Survival Advantage to Breast Cancer Stem Cells Through Metabolic Plasticity

(2019) Hayley R. Walsh et al.   Frontiers in Oncology

Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis

(2019) Jianshuang Guo et al.   Frontiers in Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Aspirin inhibits the proliferation of hepatoma cells through controlling GLUT1-mediated glucose metabolism

(2018) Yun-xia Liu et al.   ACTA PHARMACOLOGICA SINICA

LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma

(2018) Xiangchou Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

(2018) Linchong Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Hypoxia and acidosis: immune suppressors and therapeutic targets

(2018) Sultan Damgaci et al.   IMMUNOLOGY

Vitamin C in Cancer: A Metabolomics Perspective

(2018) Seyeon Park et al.   Frontiers in Physiology

Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly

(2018) Niraj Shenoy et al.   CANCER CELL

Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy

(2018) Barbara Wegiel et al.   Frontiers in Oncology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells

(2018) Nuzhat Ahmed et al.   SEMINARS IN CANCER BIOLOGY

Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors

(2018) Mengrou Shan et al.   PLoS Computational Biology

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

(2017) Shunsuke Shibao et al.   NEURO-ONCOLOGY

Mitochondrial elongation-mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress

(2017) J Li et al.   ONCOGENE

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development

(2017) Lindsay Wilde et al.   SEMINARS IN ONCOLOGY

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia

(2017) Monique Cunha de Padua et al.   Oncotarget

Targeting MYC Dependence by Metabolic Inhibitors in Cancer

(2017) Himalee S. Sabnis et al.   Genes

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

(2017) Seema Gupta et al.   Frontiers in Oncology

High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study

(2017) Kishore Polireddy et al.   Scientific Reports

Hallmarks of cancer stem cell metabolism

(2016) Patricia Sancho et al.   BRITISH JOURNAL OF CANCER

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress

(2016) De Huang et al.   CELL RESEARCH

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

(2016) Aaron Boudreau et al.   Nature Chemical Biology

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program

(2016) Esther Aguilar et al.   STEM CELLS

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7

(2016) Sahar Olsadat Sajadian et al.   Clinical Epigenetics

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

(2016) Susana Romero-Garcia et al.   Frontiers in Immunology

Metabolism in embryonic and cancer stemness

(2015) Hyonchol Jang et al.   ARCHIVES OF PHARMACAL RESEARCH

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

(2015) Kensuke Tateishi et al.   CANCER CELL

Novel Therapeutic Targets of Tumor Metabolism

(2015) Rigel J. Kishton et al.   CANCER JOURNAL

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

(2015) Linchong Sun et al.   CELL RESEARCH

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

(2015) Valéry L. Payen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glucose addiction in cancer therapy: advances and drawbacks

(2015) Sara Granja et al.   CURRENT DRUG METABOLISM

PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma

(2015) Chenggang Li et al.   DIGESTIVE DISEASES AND SCIENCES

Metabolic modulation of cancer: a new frontier with great translational potential

(2015) Adam Kinnaird et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Immunosuppressive cells in tumor immune escape and metastasis

(2015) Yang Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metabolic plasticity in CLL: adaptation to the hypoxic niche

(2015) K M Koczula et al.   LEUKEMIA

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Organization of Enzyme Concentration across the Metabolic Network in Cancer Cells

(2015) Neel S. Madhukar et al.   PLoS One

Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance

(2015) Kenta Masui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2

(2015) Timothy H. Witney et al.   Science Translational Medicine

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

(2015) Sriram Venneti et al.   Science Translational Medicine

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

(2015) Wenting Xu et al.   Cell Adhesion & Migration

Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism

(2015) Xiao Dong Xu et al.   Oncology Research and Treatment

Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress

(2015) Megumi Uetaki et al.   Scientific Reports

Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease

(2014) Richard A. Harris et al.   BIOGERONTOLOGY

Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis

(2014) Tania Valencia et al.   CANCER CELL

Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma

(2014) Yao-An Shen et al.   CELL CYCLE

Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin

(2014) S. Dalva-Aydemir et al.   CLINICAL CANCER RESEARCH

Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery

(2014) Meghna Talekar et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition

(2014) A. Hamabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

New modalities of cancer treatment for NSCLC: focus on immunotherapy

(2014) Marianne Davies   Cancer Management and Research

p53-Induced miR-15a/16-1 and AP4 Form a Double-Negative Feedback Loop to Regulate Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer

(2013) Lei Shi et al.   CANCER RESEARCH

Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis

(2013) Li Ma et al.   CELL

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force

(2013) F. Polet et al.   JOURNAL OF INTERNAL MEDICINE

Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients

(2013) Nina Mikirova et al.   Journal of Translational Medicine

Emergence of spatial structure in the tumor microenvironment due to the Warburg effect

(2013) C. Carmona-Fontaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

(2013) F. Wang et al.   SCIENCE

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate

(2013) S. J. Nelson et al.   Science Translational Medicine

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Metabolic reprogramming and metabolic dependency in T cells

(2012) Ruoning Wang et al.   IMMUNOLOGICAL REVIEWS

Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice

(2012) JOHN CHA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells

(2012) Taylor A. Murphy et al.   METABOLIC ENGINEERING

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic targets in cancer cell metabolism and autophagy

(2012) Heesun Cheong et al.   NATURE BIOTECHNOLOGY

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

(2012) Changho Choi et al.   NATURE MEDICINE

Metabolism of [U-13C]glucose in human brain tumorsin vivo

(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

(2012) O. C. Andronesi et al.   Science Translational Medicine

EMT as the ultimate survival mechanism of cancer cells

(2012) Neha Tiwari et al.   SEMINARS IN CANCER BIOLOGY

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tumor-infiltrating B cells

(2012) Michael Linnebacher et al.   OncoImmunology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Anti-neoplastic action of aspirin against a T-cell lymphoma involves an alteration in the tumour microenvironment and regulation of tumour cell survival

(2011) Anjani Kumar et al.   BIOSCIENCE REPORTS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

(2011) Kristina Goetze   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

(2011) D. A. Chan et al.   Science Translational Medicine

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

Basics and principles of radiopharmaceuticals for PET/CT

(2010) W. Wadsak et al.   EUROPEAN JOURNAL OF RADIOLOGY

Imaging and ‘omic’ methods for the molecular diagnosis of cancer

(2010) Sarah E Bohndiek et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

CD20+ B Cells: The Other Tumor-Infiltrating Lymphocytes

(2010) B. H. Nelson   JOURNAL OF IMMUNOLOGY

The Role of Tumor-Infiltrating Immune Cells and Chronic Inflammation at the Tumor Site on Cancer Development, Progression, and Prognosis: Emphasis on Non-small Cell Lung Cancer

(2010) Roy M. Bremnes et al.   Journal of Thoracic Oncology

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Cancer Stem Cell–Directed Therapies: Recent Data From the Laboratory and Clinic

(2008) Christopher Y Park et al.   MOLECULAR THERAPY

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA