Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

Cancer Stem Cell Metabolism and Potential Therapeutic Targets

(2018) Vusala Snyder et al.   Frontiers in Oncology

Does the sequence of anthracycline and taxane matter? The NeoSAMBA trial.

(2018) Jose Bines et al.   JOURNAL OF CLINICAL ONCOLOGY

Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma

(2018) Shariful Islam et al.   Oncotarget

Erratum: Cancer metabolism: a therapeutic perspective

(2017) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Tumour heterogeneity and resistance to cancer therapies

(2017) Ibiayi Dagogo-Jack et al.   Nature Reviews Clinical Oncology

Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer

(2017) Andrew Dhawan et al.   Scientific Reports

Rationally Designed 2-in-1 Nanoparticles Can Overcome Adaptive Resistance in Cancer

(2016) Aaron Goldman et al.   ACS Nano

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells

(2016) Raju V. Pusapati et al.   CANCER CELL

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

(2016) Boyang Zhao et al.   CELL

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

(2016) Marcelo Boareto et al.   Journal of the Royal Society Interface

T Cells and Cancer: How Metabolism Shapes Immunity

(2016) Barbara Molon et al.   Frontiers in Immunology

A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516

(2016) Kazuya Arai et al.   PLoS One

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

(2015) Hideki Makinoshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

(2015) Aaron Goldman et al.   Nature Communications

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

(2015) Biswanath Majumder et al.   Nature Communications

5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

(2015) Corti Denise et al.   Oncotarget

Inhibition of human GLUT1 and GLUT5 by plant carbohydrate products; insights into transport specificity

(2015) Alayna M. George Thompson et al.   Scientific Reports

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response

(2014) R Lall et al.   CELL DEATH AND DIFFERENTIATION

Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)

(2014) Teresa Valero   CURRENT PHARMACEUTICAL DESIGN

Akt/Ezrin Tyr353/NF-κB pathway regulates EGF-induced EMT and metastasis in tongue squamous cell carcinoma

(2013) Y Wang et al.   BRITISH JOURNAL OF CANCER

ROS Links Glucose Metabolism to Breast Cancer Stem Cell and EMT Phenotype

(2013) Michael S. Schieber et al.   CANCER CELL

Cancer as a metabolic disease: implications for novel therapeutics

(2013) T. N. Seyfried et al.   CARCINOGENESIS

Cancer Cell Phenotypes, in Fifty Shades of Grey

(2013) A. Marusyk et al.   SCIENCE

Non-Darwinian dynamics in therapy-induced cancer drug resistance

(2013) Angela Oliveira Pisco et al.   Nature Communications

Cellular Heterogeneity and Molecular Evolution in Cancer

(2012) Vanessa Almendro et al.   Annual Review of Pathology-Mechanisms of Disease

Mitochondria organelle transplantation: introduction of normal epithelial mitochondria into human cancer cells inhibits proliferation and increases drug sensitivity

(2012) R. L. Elliott et al.   BREAST CANCER RESEARCH AND TREATMENT

Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells

(2012) M. Tamada et al.   CANCER RESEARCH

Bacterial Inactivation of the Anticancer Drug Doxorubicin

(2012) Erin L. Westman et al.   CHEMISTRY & BIOLOGY

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

(2012) Chiara Riganti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer

(2012) Balaji Krishnamachary et al.   PLoS One

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity

(2011) Manuela Polimeni et al.   BIOCHEMICAL JOURNAL

Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia

(2011) Melissa M. Singh et al.   CANCER

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression

(2010) Rodrigo Diaz-Ruiz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of mitochondrial biogenesis

(2010) François R. Jornayvaz et al.   Essays in Biochemistry

Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements

(2010) Shivanni Kummar et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolism and proliferation share common regulatory pathways in cancer cells

(2010) V Fritz et al.   ONCOGENE

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Resistance mechanisms to cancer chemotherapy

(2008) Kelly Marie Redmond   Frontiers in Bioscience-Landmark

Structural Basis for CD44 Recognition by ERM Proteins

(2008) Tomoyuki Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Causes and Consequences of Increased Glucose Metabolism of Cancers

(2008) R. J. Gillies et al.   JOURNAL OF NUCLEAR MEDICINE

The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1

(2008) Jeremy W. Chambers et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Paclitaxel Induces Vascular Endothelial Growth Factor Expression through Reactive Oxygen Species Production

(2008) Hyun Sun Kim et al.   PHARMACOLOGY