Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Hot spots in dynamic18FET-PET delineate malignant tumor parts within suspected WHO grade II gliomas

(2011) M. Kunz et al.   NEURO-ONCOLOGY

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of in Vivo Two-dimensional MR Spectroscopy to Compare the Biochemistry of the Human Brain to That of Glioblastoma

(2011) Saadallah Ramadan et al.   RADIOLOGY

The prognostic IDH1 R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

(2010) Fonnet E. Bleeker et al.   ACTA NEUROPATHOLOGICA

R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma

(2010) Susan C. Williams et al.   ACTA NEUROPATHOLOGICA

Spectroscopic imaging with improved gradient modulated constant adiabaticity pulses on high-field clinical scanners

(2010) Ovidiu C. Andronesi et al.   JOURNAL OF MAGNETIC RESONANCE

Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?

(2010) Nanne K Kloosterhof et al.   LANCET ONCOLOGY

Low-power adiabatic sequences for in vivo localized two-dimensional chemical shift correlated MR spectroscopy

(2010) Ovidiu C. Andronesi et al.   MAGNETIC RESONANCE IN MEDICINE

High resolution spectroscopic imaging of GABA at 3 Tesla

(2010) He Zhu et al.   MAGNETIC RESONANCE IN MEDICINE

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

(2010) Olaf Beckonert et al.   Nature Protocols

Cancer-associated IDH mutations: biomarker and therapeutic opportunities

(2010) K E Yen et al.   ONCOGENE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

1H HR-MAS and genomic analysis of human tumor biopsies discriminate between high and low grade astrocytomas

(2009) Valeria Righi et al.   NMR IN BIOMEDICINE

Toward accurate quantification of metabolites, lipids, and macromolecules in HRMAS spectra of human brain tumor biopsies using LCModel

(2008) Kirstie S. Opstad et al.   MAGNETIC RESONANCE IN MEDICINE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Brain morphometry with multiecho MPRAGE

(2008) André J.W. van der Kouwe et al.   NEUROIMAGE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE