标题
Therapeutic targets in cancer cell metabolism and autophagy
作者
关键词
-
出版物
NATURE BIOTECHNOLOGY
Volume 30, Issue 7, Pages 671-678
出版商
Springer Nature
发表日期
2012-07-10
DOI
10.1038/nbt.2285
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Silibinin – A Promising New Treatment for Cancer
- (2012) Catherine Wing Ying Cheung et al. Anti-Cancer Agents in Medicinal Chemistry
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
- (2012) Mariia O. Yuneva et al. Cell Metabolism
- Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
- (2012) Anne Le et al. Cell Metabolism
- Diphenylarsinic Acid Promotes Degradation of Glutaminase C by Mitochondrial Lon Protease
- (2012) Kayoko Kita et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
- (2012) J. Ye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism
- (2012) A. Cassago et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy as a therapeutic target in cancer
- (2011) Ning Chen et al. CANCER BIOLOGY & THERAPY
- Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo
- (2011) Joon-Ho Sheen et al. CANCER CELL
- Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: A beneficial strategy to combat non-small cell lung cancer
- (2011) Yaara Gorzalczany et al. CANCER LETTERS
- Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis
- (2011) F. Vegran et al. CANCER RESEARCH
- Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
- (2011) H. Wei et al. GENES & DEVELOPMENT
- Pancreatic cancers require autophagy for tumor growth
- (2011) S. Yang et al. GENES & DEVELOPMENT
- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
- (2011) J. Y. Guo et al. GENES & DEVELOPMENT
- Autophagy-deficient mice develop multiple liver tumors
- (2011) A. Takamura et al. GENES & DEVELOPMENT
- Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation
- (2011) Min-Jung Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells
- (2011) Carlotta Granchi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
- (2011) Richard Possemato et al. NATURE
- Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
- (2011) Jason W Locasale et al. NATURE GENETICS
- Autophagy as a target for anticancer therapy
- (2011) Filip Janku et al. Nature Reviews Clinical Oncology
- Targeting cancer metabolism: a therapeutic window opens
- (2011) Matthew G. Vander Heiden NATURE REVIEWS DRUG DISCOVERY
- Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
- (2011) Q. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability
- (2011) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ammonia-induced autophagy is independent of ULK1/ULK2 kinases
- (2011) H. Cheong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review
- (2011) Paolo E. Porporato et al. Frontiers in Pharmacology
- Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism
- (2010) Anne S. Tibbetts et al. Annual Review of Nutrition
- Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase
- (2010) Jian-kang Jiang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
- (2010) Jian-Bin Wang et al. CANCER CELL
- Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1
- (2010) G. Qing et al. CANCER RESEARCH
- The Combination of a Histone Deacetylase Inhibitor with the Bcl-2 Homology Domain-3 Mimetic GX15-070 Has Synergistic Antileukemia Activity by Activating Both Apoptosis and Autophagy
- (2010) Y. Wei et al. CLINICAL CANCER RESEARCH
- Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins
- (2010) Tianzuo Zhan et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- (2010) A. Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
- (2010) Rebecca Lock et al. MOLECULAR BIOLOGY OF THE CELL
- Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
- (2010) Nathalie Carayol et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
- (2010) W. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
- (2010) A. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
- (2010) F. Weinberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
- (2010) M. G. Vander Heiden et al. SCIENCE
- Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma
- (2010) Q.-W. Fan et al. Science Signaling
- Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy
- (2010) C. H. Eng et al. Science Signaling
- Metabolic Modulation of Glioblastoma with Dichloroacetate
- (2010) E. D. Michelakis et al. Science Translational Medicine
- Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells
- (2009) Rayhana Rahim et al. ANTI-CANCER DRUGS
- Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells
- (2009) Keng-Fu Hsu et al. Autophagy
- Identification of small molecule inhibitors of pyruvate kinase M2
- (2009) Matthew G. Vander Heiden et al. BIOCHEMICAL PHARMACOLOGY
- The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy
- (2009) L. Ellis et al. BLOOD
- Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
- (2009) R. Crazzolara et al. BLOOD
- Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling
- (2009) C. Yang et al. CANCER RESEARCH
- Autophagy Suppresses Tumorigenesis through Elimination of p62
- (2009) Robin Mathew et al. CELL
- Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase
- (2009) Matthew B. Boxer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma
- (2009) V. Milano et al. MOLECULAR CANCER THERAPEUTICS
- Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy
- (2009) W.-X. Ding et al. MOLECULAR CANCER THERAPEUTICS
- BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing
- (2009) A. P. Martin et al. MOLECULAR PHARMACOLOGY
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
- (2009) Ping Gao et al. NATURE
- Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells
- (2009) K Zhu et al. ONCOGENE
- Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells
- (2008) Satoshi Fujii et al. CANCER SCIENCE
- Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma
- (2008) Victor Y. Yazbeck et al. EXPERIMENTAL HEMATOLOGY
- Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
- (2008) Michael Degtyarev et al. JOURNAL OF CELL BIOLOGY
- Pyruvate kinase M2 is a phosphotyrosine-binding protein
- (2008) Heather R. Christofk et al. NATURE
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Autophagic cell death: the story of a misnomer
- (2008) Guido Kroemer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy
- (2008) Saroj P. Mathupala et al. SEMINARS IN CANCER BIOLOGY
- Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
- (2007) Kirsteen H. Maclean et al. JOURNAL OF CLINICAL INVESTIGATION
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