Article
Medicine, Research & Experimental
Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan, Qun Wang
Summary: This study analyzed the metabolic characteristics of glycolysis and oxidative phosphorylation in 9668 patients across 33 tumor types, identifying four metabolic subtypes. Patients with high glycolysis and low oxidative phosphorylation were consistently associated with worse prognosis. Common dysregulated molecular features were found between different metabolic subgroups, with their mutual interfering relationships investigated.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Allergy
Alexandra Goretzki, Yen-Ju Lin, Stefan Schulke
Summary: This review highlights the metabolic changes in immune cells during allergic responses, with a focus on key cell types involved in allergy. Different immune cell types exhibit distinct metabolic phenotypes upon activation, indicating the relevance of immune metabolism in allergic diseases. Further understanding of immune cell metabolism could potentially lead to new treatment targets/strategies for allergic diseases.
Review
Immunology
Yen-Ju Lin, Alexandra Goretzki, Stefan Schuelke
Summary: Allergic disorders have been on the rise in recent decades, prompting the emergence of a new research field called immune metabolism. It has been found that metabolic changes in T and B cells may play a role in the development and maintenance of allergies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biology
Toshiyuki Murai, Satoru Matsuda
Summary: Alzheimer's disease is characterized by the formation of plaques and tangles in the brain, leading to neuronal cell death. Patients with Alzheimer's disease show a preference for glycolysis instead of normal mitochondrial function, and certain dietary patterns may help prevent the disease. Effective therapies for Alzheimer's disease are still lacking, and researchers are working towards finding novel treatments and understanding the underlying mechanisms of neurodegeneration.
Article
Biochemistry & Molecular Biology
Fereshteh Moradi, Christopher Moffatt, Jeffrey A. Stuart
Summary: The study shows that different cell culture media composition and oxygen levels can significantly affect mitochondrial abundance, network structure, and cellular energy metabolism in cancer cells. Cells cultured in DMEM generally exhibit higher glycolytic activity and lower oxygen consumption rates.
Article
Multidisciplinary Sciences
Ying Zhang, Wenhuan Li, Yuan Bian, Yan Li, Lei Cong
Summary: Liver cancer, a common and deadly malignancy, is closely associated with changes in liver metabolism and mitochondrial dysfunction. While defects in mitochondrial respiration are not generally responsible for aerobic glycolysis or selected during tumor evolution, dysfunction of mitochondrial oxidative phosphorylation (OXPHOS) may promote the proliferation, metastasis, and invasion of primary hepatic carcinoma. This review explores the roles of aerobic glycolysis and OXPHOS in the occurrence and development of hepatocellular carcinoma (HCC), highlighting the cooperative nature of mitochondrial OXPHOS and cytoplasmic glycolysis in maintaining energy balance in HCC cells. The findings suggest that targeting mitochondrial metabolism could be a potential therapy for HCC.
Review
Oncology
Kasey R. Cargill, William L. Hasken, Carl M. Gay, Lauren A. Byers
Summary: Metabolic reprogramming is a key feature of cancer initiation, progression, and relapse, with unique shifts in metabolism playing an important role in targeting cancer treatment. Research on lung cancer metabolism has been relatively limited, but recent evidence suggests that lung cancers have their own unique metabolic preferences.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alpna Tyagi, Subbiah Pugazhenthi
Summary: SIRT3 is a mitochondrial deacetylase that regulates the functions of mitochondrial proteins. Its downregulation in neurodegenerative diseases is starting to be understood. SIRT3 plays a crucial role in brain energy metabolism and metabolic coupling. It is involved in the health benefits of lifestyle modifications and its deficiency is associated with metabolic syndrome. SIRT3 downregulation leads to mitochondrial dysfunction and inflammation, potentially contributing to Alzheimer's disease pathogenesis. This review discusses the roles of SIRT3 in brain physiology and pathology, as well as potential therapeutic agents for dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Endocrinology & Metabolism
Russel J. Reiter, Ramaswamy Sharma, Qiang Ma
Summary: The circadian melatonin rhythm plays an essential role in reducing the development of diseases such as solid tumors by controlling the metabolism of cancer cells, switching them from aerobic glycolysis to mitochondrial oxidative phosphorylation.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Neurosciences
Robert Zorec, Nina Vardjan
Summary: Ageing is a major factor in the development of cognitive decline and dementia. The cholinergic hypothesis has long been considered the main cause of cognitive decline, but recent evidence suggests that an impaired noradrenergic system may also play a role in Alzheimer's disease. The review focuses on the role of astrocytes in neurodegeneration and cognitive decline, as well as the noradrenergic control of astroglial function.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Gastroenterology & Hepatology
Yu-De Chu, Chun-Wei Chen, Ming-Wei Lai, Siew-Na Lim, Wey-Ran Lin
Summary: This review summarizes the metabolic reprogramming and bioenergetic alterations in gastrointestinal (GI) cancers, highlighting the interplay between different metabolic pathways and their oncogenetic links. It emphasizes the potential of targeting bioenergetic regulators for anti-cancer therapy, provides details on various anti-cancer drugs and strategies, and discusses the challenges faced by targeted therapies due to the diverse metabolic patterns. Further research is needed to understand specific mechanisms of inhibiting bioenergetic enzymes and address side effects, as well as leverage omics technologies for targeted bioenergetic therapies.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cell Biology
Irene H. Flones, Charalampos Tzoulis
Summary: Parkinson's disease is a common neurodegenerative disorder with unclear etiology. This review summarizes the evidence for mitochondrial respiratory chain dysfunction in Parkinson's disease and proposes directions for future research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Arvinder Kapur, Pooja Mehta, Aaron D. Simmons, Spencer S. Ericksen, Geeta Mehta, Sean P. Palecek, Mildred Felder, Zach Stenerson, Amruta Nayak, Jose Maria Ayuso Dominguez, Manish Patankar, Lisa M. Barroilhet
Summary: The Warburg effect, characterized by high glucose uptake and lactate release, is a hallmark of most cancers. Atovaquone, a mitochondrial complex III inhibitor, has been found to slow ovarian cancer growth and inhibit the proliferation of cancer stem cells both in vitro and in vivo. The drug is able to inhibit oxygen consumption and ATP production, and it alters several metabolic pathways. These findings provide mechanistic insights and preclinical data to support further investigation of atovaquone as a potential therapy for gynecologic cancers.
Article
Chemistry, Medicinal
Cheng Hu, Haiyue Xu, Zehao Li, Dandan Liu, Siqi Zhang, Fang Fang, Liguo Wang
Summary: The current treatments for prostate cancer are inadequate, and new therapies targeting metabolic alterations in tumor cells are urgently needed. In this study, juglone was found to inhibit energy metabolism in prostate cancer cells, leading to decreased cell proliferation and induction of apoptosis. The inhibition of hexokinase, phosphofructokinase, and pyruvate kinase activities by juglone contributed to its suppressive effects on oxidative phosphorylation and glycolysis in prostate cancer cells.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
M. Martins Pinto, P. Paumard, C. Bouchez, S. Ransac, S. Duvezin-Caubet, J. P. Mazata, M. Rigouleta, A. Devina
Summary: Cancer cells exhibit altered energy metabolism, with decreased respiration and increased glycolysis compared to normal cells. This phenomenon, known as the Warburg effect, suggests that cancer cells mainly rely on fermentative metabolism for ATP generation. The mechanisms and implications of this metabolic shift are still a topic of debate. Understanding how cancer cells regulate their energy metabolism pathways and how this metabolism affects cell proliferation is crucial for unraveling the mechanisms of cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2023)
Article
Biochemistry & Molecular Biology
Derek L. Clouthier, Cameron N. Harris, Richard A. Harris, Claire E. Martin, Mira C. Puri, Nina Jones
MOLECULAR AND CELLULAR BIOLOGY
(2015)
Article
Neurosciences
Richard A. Harris, Lauren Tindale, Asad Lone, Olivia Singh, Shannon L. Macauley, Molly Stanley, David M. Holtzman, Robert Bartha, Robert C. Cumming
JOURNAL OF NEUROSCIENCE
(2016)
Article
Oncology
Robert Arseneault, Andrew Chien, Jordan T. Newington, Tim Rappon, Richard Harris, Robert C. Cumming
Review
Food Science & Technology
Richard A. Harris, Fabrizio Anniballi, John W. Austin
Article
Cell Biology
Ujval Anilkumar, Mireille Khacho, Alexanne Cuillerier, Richard Harris, David A. Patten, Maria Bilen, Mohamed Ariff Iqbal, Ding Yuan Guo, Louis-Eric Trudeau, David S. Park, Mary-Ellen Harper, Yan Burelle, Ruth S. Slack
CELL DEATH & DISEASE
(2020)
Article
Food Science & Technology
Yanwen Shao, Hosahalli S. Ramaswamy, Jeff Bussey, Richard Harris, John W. Austin
Summary: The study found that high-pressure high-temperature treatment can effectively kill Clostridium botulinum spores, with destruction rates increasing with higher pressures and temperatures. Thermal inactivation was identified as the main mode of spore destruction at temperatures exceeding 120 degrees Celsius.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Cell Biology
Yubing Liu, Maria Bilen, Marie-Michelle McNicoll, Richard A. Harris, Bensun C. Fong, Mohamed Ariff Iqbal, Smitha Paul, Janice Mayne, Krystal Walker, Jing Wang, Daniel Figeys, Ruth S. Slack
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to dementia. The hippocampus, one of the main sites for neurogenesis, exhibits significant neuronal loss in AD. Using the 3xTg mouse model, researchers discovered that neurogenic deficits are present during postnatal stages, even before the onset of neuropathology or behavioral deficits. Specifically, the 3xTg mice had fewer neural stem/progenitor cells, reduced proliferation, and decreased numbers of newborn neurons. The findings suggest that impairments in neurogenesis occur early in AD, opening up possibilities for early diagnosis and intervention.
CELL DEATH & DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Richard A. Harris, Madeleine Blondin-Brosseau, Christine Levesque, Pat E. Rasmussen, Suzanne Beauchemin, John W. Austin
Summary: Analyzing vacuum cleaner dust samples from Canadian households revealed no positive results for Clostridium botulinum spores. The most common anaerobic bacteria identified were of the genus Clostridium, with the most common species being Clostridium perfringens. Dust samples containing different types of C. botulinum spores successfully produced positive reactions during testing.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Microbiology
Richard Harris, Forest Dussault, Annika Flint, John W. Austin, Kelly Weedmark
Summary: This report details the complete genome of Clostridium botulinum CJ0611A1, a strain isolated from carrot juice in Canada and linked to a 2006 international foodborne botulism outbreak. The strain encodes a full-length bont/A1 gene and a truncated bont/B gene.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
