The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration

(2019) David Lee et al.   Cells

Role of Mitochondria in the Mechanism(s) of Action of Metformin

(2019) Guillaume Vial et al.   Frontiers in Endocrinology

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains

(2019) M. Di Rienzo et al.   Science Advances

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

(2019) Slaven Stekovic et al.   Cell Metabolism

Higher spermidine intake is linked to lower mortality: a prospective population-based study

(2018) Stefan Kiechl et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Aspirin—another caloric-restriction mimetic

(2018) Federico Pietrocola et al.   Autophagy

Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging

(2018) Leanne M. Redman et al.   Cell Metabolism

Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

(2018) Yan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity

(2018) Heather N. Carter et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impairment of PPARαand the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging

(2018) Ki Wung Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The impact of aging, calorie restriction and dietary fat on mitochondrial ultrastructure, dynamics and autophagy markers in mouse skeletal muscle

(2018) Elena Gutiérrez-Casado et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy: The Last Defense against Cellular Nutritional Stress

(2018) Long He et al.   Advances in Nutrition

Aspirin Recapitulates Features of Caloric Restriction

(2018) Federico Pietrocola et al.   Cell Reports

Autophagy in Adipose Tissue Physiology and Pathophysiology

(2018) Maroua Ferhat et al.   ANTIOXIDANTS & REDOX SIGNALING

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

(2018) Kurt A. Escobar et al.   AGING CELL

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?

(2018) Frank Madeo et al.   Autophagy

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

(2018) Hideya Shintani et al.   Nutrients

Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk

(2018) Jinjin Cai et al.   Cell Reports

mTORC1 as the main gateway to autophagy

(2017) Yoana Rabanal-Ruiz et al.   Essays in Biochemistry

Autophagy was involved in the protective effect of metformin on hyperglycemia-induced cardiomyocyte apoptosis and Connexin43 downregulation in H9c2 cells

(2017) Guang-Yu Wang et al.   International Journal of Medical Sciences

Calorie restriction promotes cardiolipin biosynthesis and distribution between mitochondrial membranes

(2017) Luis Alberto Luévano-Martínez et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Advance of autophagy in chronic kidney diseases

(2017) Xu Deng et al.   RENAL FAILURE

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential

(2017) Priya Balasubramanian et al.   EBioMedicine

Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue

(2016) Amiya Kumar Ghosh et al.   Aging-US

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Function of Autophagy in Nonalcoholic Fatty Liver Disease

(2016) Mark J. Czaja   DIGESTIVE DISEASES AND SCIENCES

Regulation of Liver Metabolism by Autophagy

(2016) Julio Madrigal-Matute et al.   GASTROENTEROLOGY

Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance

(2016) Peter Bond   Journal of the International Society of Sports Nutrition

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle

(2016) Ling Yang et al.   Cell Reports

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

(2016) Eugenia Morselli et al.   Aging-US

Polyamines in aging and disease

(2016) Nadège Minois et al.   Aging-US

Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1

(2015) Yulia Haim et al.   Autophagy

DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity

(2015) Hedi Soussi et al.   DIABETES

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Beneficial Effects of Caloric Restriction on Chronic Kidney Disease in Rodent Models: A Meta-Analysis and Systematic Review

(2015) Xiao-meng Xu et al.   PLoS One

Regulation of autophagy by amino acids and MTOR-dependent signal transduction

(2014) Alfred J. Meijer et al.   AMINO ACIDS

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Longevity, aging and rapamycin

(2014) Dan Ehninger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

(2014) Christoph Ruckenstuhl et al.   PLoS Genetics

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Defective regulation of adipose tissue autophagy in obesity

(2013) C E Nuñez et al.   INTERNATIONAL JOURNAL OF OBESITY

Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage

(2013) Yi-Chun Ning et al.   MECHANISMS OF AGEING AND DEVELOPMENT

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Skeletal muscle autophagy: a new metabolic regulator

(2013) Brian A. Neel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy

(2013) Jonathan Zirin et al.   PLOS BIOLOGY

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

Effects of aging, antiaging calorie restriction and in vivo stimulation of autophagy on the urinary excretion of 8OHdG in male Sprague–Dawley rats

(2012) Alessio Donati et al.   AGE

Metabolic and Neuropsychiatric Effects of Calorie Restriction and Sirtuins

(2012) Sergiy Libert et al.   Annual Review of Physiology

Emerging role of autophagy in kidney function, diseases and aging

(2012) Tobias B. Huber et al.   Autophagy

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

(2012) Massimiliano Cerletti et al.   Cell Stem Cell

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

(2012) Susmita Kaushik et al.   EMBO REPORTS

Autophagy Activity Is Up-Regulated in Adipose Tissue of Obese Individuals and Modulates Proinflammatory Cytokine Expression

(2012) H. J. Jansen et al.   ENDOCRINOLOGY

Recent advances in calorie restriction research on aging

(2012) K.W. Chung et al.   EXPERIMENTAL GERONTOLOGY

Adverse events associated with mTOR inhibitors

(2012) Nicolas Pallet et al.   Expert Opinion On Drug Safety

Age-related impairments in memory and in CREB and pCREB expression in hippocampus and amygdala following inhibitory avoidance training

(2012) Ken A. Morris et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

(2012) N Minois et al.   Cell Death & Disease

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Renal lipid metabolism and lipotoxicity

(2010) Ion Alexandru Bobulescu   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

(2010) Mirela Matecic et al.   PLoS Genetics

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications

(2009) J. E. Gerich   DIABETIC MEDICINE

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

(2009) Stephanie Eva Wohlgemuth et al.   EXPERIMENTAL GERONTOLOGY

Autophagy regulates adipose mass and differentiation in mice

(2009) Rajat Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE