Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner

(2017) Jens Frey Halling et al.   EXPERIMENTAL GERONTOLOGY

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

(2017) Min Wei et al.   Science Translational Medicine

Autophagy-Dependent Beneficial Effects of Exercise

(2017) Jens Frey Halling et al.   Cold Spring Harbor Perspectives in Medicine

Effects of aerobic training on markers of autophagy in the elderly

(2016) Yubisay Mejías-Peña et al.   AGE

The regulation of autophagy during exercise in skeletal muscle

(2016) Anna Vainshtein et al.   JOURNAL OF APPLIED PHYSIOLOGY

Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition

(2016) Jeong-sun Ju et al.   Journal of Physiological Sciences

Exercise: the lifelong supplement for healthy ageing and slowing down the onset of frailty

(2016) Jose Viña et al.   JOURNAL OF PHYSIOLOGY-LONDON

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle

(2016) Ling Yang et al.   Cell Reports

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults

(2016) Steven C. Moore et al.   JAMA Internal Medicine

Comparison of High-Protein, Intermittent Fasting Low-Calorie Diet and Heart Healthy Diet for Vascular Health of the Obese

(2016) Li Zuo et al.   Frontiers in Physiology

Acute Endurance Exercise Induces Nuclear p53 Abundance in Human Skeletal Muscle

(2016) Bill Tachtsis et al.   Frontiers in Physiology

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

(2016) J. Julie Wu et al.   Aging-US

Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

(2015) Anna Ulbricht et al.   Autophagy

Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice

(2015) Lina Ma et al.   BRAIN RESEARCH BULLETIN

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation

(2015) Céline Schwalm et al.   FASEB JOURNAL

Physical exercise increases autophagic signaling through ULK1 in human skeletal muscle

(2015) Andreas Buch Møller et al.   JOURNAL OF APPLIED PHYSIOLOGY

Autophagy as a Potential Target for Sarcopenia

(2015) Jingjing Fan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Dose of Jogging and Long-Term Mortality

(2015) Peter Schnohr et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Radical Oxygen Species, Exercise and Aging: An Update

(2015) Mohamed Amine Bouzid et al.   SPORTS MEDICINE

Leisure Time Physical Activity and Mortality

(2015) Hannah Arem et al.   JAMA Internal Medicine

Regulation of autophagy by amino acids and MTOR-dependent signal transduction

(2014) Alfred J. Meijer et al.   AMINO ACIDS

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits

(2014) Fengying Yang et al.   BEHAVIOURAL BRAIN RESEARCH

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

Autophagy and the immune function in aging

(2014) Ana Maria Cuervo et al.   CURRENT OPINION IN IMMUNOLOGY

Autophagy in aging and in neurodegenerative disorders

(2014) Yogendra Rajawat et al.   Hormones-International Journal of Endocrinology and Metabolism

Systematic review and meta-analysis of reduction in all-cause mortality from walking and cycling and shape of dose response relationship

(2014) Paul Kelly et al.   International Journal of Behavioral Nutrition and Physical Activity

mTOR and the health benefits of exercise

(2014) Kurt Watson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagic Cellular Responses to Physical Exercise in Skeletal Muscle

(2014) Bjorn T. Tam et al.   SPORTS MEDICINE

Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings

(2014) Adrienne R. Barnosky et al.   Translational Research

Protein and amino acid restriction, aging and disease: from yeast to humans

(2014) Hamed Mirzaei et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

(2013) Evi M. Mercken et al.   AGING CELL

Role of autophagy in the progression from obesity to diabetes and in the control of energy balance

(2013) Wenying Quan et al.   ARCHIVES OF PHARMACAL RESEARCH

Growth or longevity: the TOR’s decision on lifespan regulation

(2013) Yuehua Wei et al.   BIOGERONTOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Mortality of French participants in the Tour de France (1947-2012)

(2013) E. Marijon et al.   EUROPEAN HEART JOURNAL

Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats

(2013) Li Luo et al.   EXPERIMENTAL GERONTOLOGY

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance

(2013) Vitor A. Lira et al.   FASEB JOURNAL

Acute environmental hypoxia induces LC3 lipidation in a genotype-dependent manner

(2013) Evi Masschelein et al.   FASEB JOURNAL

Regulatory Coordination between Two Major Intracellular Homeostatic Systems

(2013) Karol Dokladny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuins' modulation of autophagy

(2013) Fanny Ng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease

(2013) Anna Vainshtein et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Caloric restriction may reverse age-related autonomic decline in humans

(2012) Phyllis K. Stein et al.   AGING CELL

A novel method for autophagy detection in primary cells

(2012) Kanchan Phadwal et al.   Autophagy

Exercise induces autophagy in peripheral tissues and in the brain

(2012) Congcong He et al.   Autophagy

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Autophagy and cardiovascular aging

(2012) Sreejayan Nair et al.   CELL CYCLE

Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running

(2012) Cécile Jamart et al.   JOURNAL OF APPLIED PHYSIOLOGY

Skeletal Muscle Autophagy and Protein Breakdown Following Resistance Exercise are Similar in Younger and Older Adults

(2012) C. S. Fry et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations

(2012) Cynthia M Kroeger et al.   Nutrition & Metabolism

Autophagy: a multifaceted intracellular system for bulk and selective recycling

(2012) Faqiang Li et al.   TRENDS IN PLANT SCIENCE

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles

(2011) Paolo Grumati et al.   Autophagy

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

From growing to secreting: New roles for mTOR in aging cells

(2011) Giovambattista Pani   CELL CYCLE

Cross-Talk between AMPK and mTOR in Regulating Energy Balance

(2011) Jia Xu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise

(2011) Cécile Jamart et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol

(2011) Zhihui Feng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Increased Average Longevity among the “Tour de France” Cyclists

(2011) F. Sanchis-Gomar et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth

(2011) Craig A. Goodman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effect of Aging and Anti-Aging Caloric Restriction on the Endocrine Regulation of Rat Liver Autophagy

(2011) A. Donati et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Autophagy: cellular defense to excessive inflammation

(2011) Eun-Kyeong Jo et al.   MICROBES AND INFECTION

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Transcriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein

(2011) David S. Rowlands et al.   PHYSIOLOGICAL GENOMICS

An Exploratory Analysis of the Effects of a Weight Loss Plus Exercise Program on Cellular Quality Control Mechanisms in Older Overweight Women

(2011) Stephanie E. Wohlgemuth et al.   REJUVENATION RESEARCH

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Long-term effects of calorie restriction on serum sex-hormone concentrations in men

(2010) Roberto Cangemi et al.   AGING CELL

Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β2-adrenergic receptor activation

(2010) Miki Tadaishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging

(2010) Laurent Mouchiroud et al.   BIOFACTORS

Strenuous endurance exercise improves life expectancy: it's in our genes

(2010) J. R. Ruiz et al.   BRITISH JOURNAL OF SPORTS MEDICINE

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

(2010) S. V. de Kreutzenberg et al.   DIABETES

SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model

(2010) Yu Wang et al.   FEBS LETTERS

Autophagy in skeletal muscle

(2010) Marco Sandri   FEBS LETTERS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Can autophagy promote longevity?

(2010) Frank Madeo et al.   NATURE CELL BIOLOGY

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Aging: Central role for autophagy and the lysosomal degradative system

(2009) Yogendra S. Rajawat et al.   AGEING RESEARCH REVIEWS

Autophagy and amino acid homeostasis are required for chronological longevity inSaccharomyces cerevisiae

(2009) Ashley L. Alvers et al.   AGING CELL

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Autophagy genes as tumor suppressors

(2009) Chengyu Liang et al.   CURRENT OPINION IN CELL BIOLOGY

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

(2009) Stephanie Eva Wohlgemuth et al.   EXPERIMENTAL GERONTOLOGY

Human muscle protein synthesis and breakdown during and after exercise

(2009) Vinod Kumar et al.   JOURNAL OF APPLIED PHYSIOLOGY

Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration

(2009) Chun-Chi Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mortality and longevity of elite athletes

(2009) Masaru Teramoto et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

(2008) Francesco Cecconi et al.   DEVELOPMENTAL CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

(2008) Sakiko Honjoh et al.   NATURE

Reduced cytosolic protein synthesis suppresses mitochondrial degeneration

(2008) Xiaowen Wang et al.   NATURE CELL BIOLOGY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy

(2007) Espen E. Spangenburg et al.   JOURNAL OF PHYSIOLOGY-LONDON