The ageing epigenome and its rejuvenation

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

NAD + supplementation rejuvenates aged gut adult stem cells

(2019) Masaki Igarashi et al.   AGING CELL

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction

(2019) Si Wang et al.   Protein & Cell

Roles and regulation of histone methylation in animal development

(2019) Ashwini Jambhekar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The diverse roles of DNA methylation in mammalian development and disease

(2019) Maxim V. C. Greenberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

(2019) Irene Hernando-Herraez et al.   Nature Communications

Revisiting the genomic hypomethylation hypothesis of aging

(2018) Archana Unnikrishnan et al.   Annals of the New York Academy of Sciences

Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging

(2018) Peggie Cheung et al.   CELL

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

(2018) Mark P. Mattson et al.   Cell Metabolism

Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging

(2018) Leanne M. Redman et al.   Cell Metabolism

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys

(2018) Timothy W. Rhoads et al.   Cell Metabolism

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with aging in humans

(2018) Lawrence C. Johnson et al.   CLINICAL SCIENCE

Epigenetic effects of metformin: From molecular mechanisms to clinical implications

(2018) Stephanie Claire Bridgeman et al.   DIABETES OBESITY & METABOLISM

Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE‐1 repression

(2018) François‐Xavier Blaudin de Thé et al.   EMBO JOURNAL

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

Impaired DNA demethylation of C/EBP sites causes premature aging

(2018) Andrea Schäfer et al.   GENES & DEVELOPMENT

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Interventions to promote cardiometabolic health and slow cardiovascular ageing

(2018) Luigi Fontana   Nature Reviews Cardiology

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

(2018) Steve Horvath et al.   NATURE REVIEWS GENETICS

Cellular and epigenetic drivers of stem cell ageing

(2018) Maria Ermolaeva et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance

(2018) Steven Bradburn et al.   NEUROBIOLOGY OF AGING

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice

(2018) Kan Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

(2018) Ludovic S. Mure et al.   SCIENCE

Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency

(2018) Bruno Bernardes de Jesus et al.   Nature Communications

Aspirin Recapitulates Features of Caloric Restriction

(2018) Federico Pietrocola et al.   Cell Reports

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

(2018) Ray Kreienkamp et al.   Cell Reports

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

(2018) Geraldine Gontier et al.   Cell Reports

Tau Activates Transposable Elements in Alzheimer’s Disease

(2018) Caiwei Guo et al.   Cell Reports

Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice

(2018) Ting Cao et al.   Frontiers in Aging Neuroscience

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

(2018) Zeming Wu et al.   Protein & Cell

Epigenetic Modifications in Cardiovascular Aging and Diseases

(2018) Weiqi Zhang et al.   CIRCULATION RESEARCH

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

(2018) Weiqi Zhang et al.   NATURE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

(2018) Di Wu et al.   NATURE

Targeting senescence

(2018) Manuel Serrano et al.   NATURE MEDICINE

Rejuvenating senolytics

(2018) Kim Baumann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPα-p300 Axis

(2018) Phuong Nguyen et al.   Cell Reports

Chemical screen identifies a geroprotective role of quercetin in premature aging

(2018) Lingling Geng et al.   Protein & Cell

DNA methylation associated with healthy aging of elderly twins

(2018) Sangkyu Kim et al.   GeroScience

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

(2018) Marion Claudia Salzer et al.   CELL

Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock

(2018) Chanachai Sae-Lee et al.   MOLECULAR NUTRITION & FOOD RESEARCH

De novo NAD+ synthesis enhances mitochondrial function and improves health

(2018) Elena Katsyuba et al.   NATURE

Turning back time with emerging rejuvenation strategies

(2018) Salah Mahmoudi et al.   NATURE CELL BIOLOGY

Linking cellular stress responses to systemic homeostasis

(2018) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

(2017) Nian Liu et al.   NATURE

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

(2017) Michalis Agathocleous et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

(2017) Shuo Han et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

(2017) Nard Kubben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ten principles of heterochromatin formation and function

(2017) Robin C. Allshire et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The brain, sirtuins, and ageing

(2017) Akiko Satoh et al.   NATURE REVIEWS NEUROSCIENCE

Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans

(2017) Saya Kishimoto et al.   Nature Communications

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Caloric restriction delays age-related methylation drift

(2017) Shinji Maegawa et al.   Nature Communications

Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage

(2017) Hong Wang et al.   Cell Reports

Impact of Dietary Interventions on Noncoding RNA Networks and mRNAs Encoding Chromatin-Related Factors

(2017) Christopher D. Green et al.   Cell Reports

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells

(2017) Pedro Sousa-Victor et al.   Cell Reports

Epigenetic Regulation of Cellular Senescence and Aging

(2017) Corinne Sidler et al.   Frontiers in Genetics

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

(2016) Masaki Igarashi et al.   CELL

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Bursts of Reprogramming: A Path to Extend Lifespan?

(2016) Salah Mahmoudi et al.   CELL

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Chromosome organisation during ageing and senescence

(2016) Tamir Chandra et al.   CURRENT OPINION IN CELL BIOLOGY

The Aging Epigenome

(2016) Lauren N. Booth et al.   MOLECULAR CELL

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Out with the old

(2016) Jesús Gil et al.   NATURE

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

(2016) Caroline Heintz et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Epigenetic control of adult stem cell function

(2016) Alexandra Avgustinova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The molecular basis of metabolic cycles and their relationship to circadian rhythms

(2016) Jane Mellor   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span inDrosophila

(2016) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice

(2016) Henrik Ahlenius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone availability as a strategy to control gene expression

(2016) Félix Prado et al.   RNA Biology

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

The Metabolic Impact on Histone Acetylation and Transcription in Ageing

(2016) Shahaf Peleg et al.   TRENDS IN BIOCHEMICAL SCIENCES

iPSCs: On the Road to Reprogramming Aging

(2016) Clara Soria-Valles et al.   TRENDS IN MOLECULAR MEDICINE

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

(2016) Karl Bacos et al.   Nature Communications

The molecular basis of metabolic cycles and their relationship to circadian rhythms

(2016) Jane Mellor   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability

(2016) Salvatore Fusco et al.   Cell Reports

Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

(2016) Ying Li et al.   Protein & Cell

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

(2016) Marco De Cecco et al.   Aging-US

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

Aged iPSCs display an uncommon mitochondrial appearance and fail to undergo in vitro neurogenesis

(2016) Andrea Masotti et al.   Aging-US

Blockade of senescence-associated microRNA-195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells.

(2015) Hideyuki Kondo et al.   AGING CELL

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Reprogramming aging through DOT1L inhibition

(2015) Clara Soria-Valles et al.   CELL CYCLE

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

The metabolic regulation of aging

(2015) Toren Finkel   NATURE MEDICINE

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Progeria accelerates adult stem cell aging

(2015) R. Brunauer et al.   SCIENCE

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

(2014) Anita Öst et al.   CELL

Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model

(2014) Indranil Sinha et al.   CELL AND TISSUE RESEARCH

Inactivation of Yeast Isw2 Chromatin Remodeling Enzyme Mimics Longevity Effect of Calorie Restriction via Induction of Genotoxic Stress Response

(2014) Weiwei Dang et al.   Cell Metabolism

Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of thePgc-1αGene and Age-Dependent Metabolic Dysfunction in the Offspring

(2014) Rhianna C. Laker et al.   DIABETES

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Stem cell aging: mechanisms, regulators and therapeutic opportunities

(2014) Juhyun Oh et al.   NATURE MEDICINE

Sleeping dogs of the genome

(2014) Vera Gorbunova et al.   SCIENCE

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

Sirtuins and the circadian clock: Bridging chromatin and metabolism

(2014) S. Masri et al.   Science Signaling

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

DNA Methylation in Mammals

(2014) E. Li et al.   Cold Spring Harbor Perspectives in Biology

Systemic regulation of mammalian ageing and longevity by brain sirtuins

(2014) Akiko Satoh et al.   Nature Communications

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

(2014) Sandra Weimer et al.   Nature Communications

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

Concealing cellular defects in pluripotent stem cells

(2013) Weiqi Zhang et al.   TRENDS IN CELL BIOLOGY

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

Regulation of transcription and chromatin structure by pRB: Here, there and everywhere

(2012) Srikanth Talluri et al.   CELL CYCLE

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

(2012) Massimiliano Cerletti et al.   Cell Stem Cell

Rejuvenation of senescent cells—The road to postponing human aging and age-related disease?

(2012) Ewa Sikora   EXPERIMENTAL GERONTOLOGY

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs

(2012) Jiekai Chen et al.   NATURE GENETICS

Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling

(2011) Richard P. Koche et al.   Cell Stem Cell

Age-related loss of CpG methylation in the tumour necrosis factor promoter

(2011) Isobel R. Gowers et al.   CYTOKINE

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Epigenetic Predictor of Age

(2011) Sven Bocklandt et al.   PLoS One

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets

(2011) I. Sandovici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrotransposition is associated with genome instability during chronological aging

(2011) P. H. Maxwell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

Substantial Histone Reduction Modulates Genomewide Nucleosomal Occupancy and Global Transcriptional Output

(2011) Barbara Celona et al.   PLOS BIOLOGY

Metabolic Networks of Longevity

(2010) Riekelt H. Houtkooper et al.   CELL

Elevated Histone Expression Promotes Life Span Extension

(2010) Jason Feser et al.   MOLECULAR CELL

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise

(2010) G. Valdez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression

(2009) Yuanyuan Li et al.   FASEB JOURNAL

Senescence impairs successful reprogramming to pluripotent stem cells

(2009) A. Banito et al.   GENES & DEVELOPMENT

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

(2009) Nidhi Bhutani et al.   NATURE

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

DNA methylation profiles in monozygotic and dizygotic twins

(2009) Zachary A Kaminsky et al.   NATURE GENETICS

Valproic acid extends Caenorhabditis elegans lifespan

(2008) Kimberley Evason et al.   AGING CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

Decline in genomic DNA methylation through aging in a cohort of elderly subjects

(2008) Valentina Bollati et al.   MECHANISMS OF AGEING AND DEVELOPMENT