Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation

(2016) S Blondel et al.   Cell Death & Disease

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

(2016) Lina Fu et al.   Protein & Cell

Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery

(2015) Alessandra Lo Cicero et al.   AGEING RESEARCH REVIEWS

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

(2015) Rute Martins et al.   AGING CELL

Regulation of the Epigenome by Vitamin C

(2015) Juan I. Young et al.   Annual Review of Nutrition

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis

(2015) Hongtan Wu et al.   Nature Communications

Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span

(2014) Alexandra Dallaire et al.   BMC GENOMICS

Tau promotes neurodegeneration through global chromatin relaxation

(2014) Bess Frost et al.   NATURE NEUROSCIENCE

Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease

(2014) Giorgio Fata et al.   Nutrients

Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

(2014) Hoi-Hung Cheung et al.   Stem Cell Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Therapeutic Translation of iPSCs for Treating Neurological Disease

(2013) Diana X. Yu et al.   Cell Stem Cell

Epigenetics, vitamin supplements and cellular reprogramming

(2013) Martin F Pera   NATURE GENETICS

Vitamin C modulates TET1 function during somatic cell reprogramming

(2013) Jiekai Chen et al.   NATURE GENETICS

Concealing cellular defects in pluripotent stem cells

(2013) Weiqi Zhang et al.   TRENDS IN CELL BIOLOGY

Gating pluripotency via nuclear pores

(2013) Jiping Yang et al.   TRENDS IN MOLECULAR MEDICINE

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

iPSC technology to study human aging and aging-related disorders

(2012) Guang-Hui Liu et al.   CURRENT OPINION IN CELL BIOLOGY

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

(2012) Guang-Hui Liu et al.   NATURE

Vitamin C improves the quality of somatic cell reprogramming

(2012) Miguel A Esteban et al.   NATURE GENETICS

The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner

(2011) Tao Wang et al.   Cell Stem Cell

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin

(2010) Michel Lebel et al.   Annals of the New York Academy of Sciences

Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide

(2010) Adam Labbé et al.   BMC GENOMICS

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

(2010) Miguel Angel Esteban et al.   Cell Stem Cell

Vitamin C requirement in surgical patients

(2010) Ryoji Fukushima et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Aging Is Accompanied by a Progressive Decrease of Expression of the WRN Gene in Human Blood Mononuclear Cells

(2010) J. Polosak et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease

(2009) Krishanu Saha et al.   Cell Stem Cell

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

(−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells

(2008) Hye-Kyung Na et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL