NRF2 as a Therapeutic Target in Neurodegenerative Diseases

Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2

(2019) Gahee Bahn et al.   NEUROMOLECULAR MEDICINE

Expression of nuclear factor erythroid 2-related factor 2 following traumatic brain injury in the human brain

(2019) Yuxin He et al.   NEUROREPORT

Chlorogenic acid isomers directly interact with Keap 1-Nrf2 signaling in Caco-2 cells

(2019) Ningjian Liang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dimethyl fumarate, a two-edged drug: Current status and future directions

(2019) Nathaniel Edward Bennett Saidu et al.   MEDICINAL RESEARCH REVIEWS

Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1α Signaling Pathway

(2019) Yao-Chung Chuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt/Nrf2 pathway in vitro and in vivo

(2019) Qiu Liu et al.   CELL STRESS & CHAPERONES

Epigallocatechin Gallate Protects against TNFα- or H2O2- Induced Apoptosis by Modulating Iron Related Proteins in a Cell Culture Model

(2019) Qi Xu et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Alpha lipoic acid inhibits oxidative stress‐induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injury

(2019) Dayong Xia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of Mitochondria in the Mechanism(s) of Action of Metformin

(2019) Guillaume Vial et al.   Frontiers in Endocrinology

Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions

(2019) Liwei Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

Nrf2 Induction Re-establishes a Proper Neuronal Differentiation Program in Friedreich’s Ataxia Neural Stem Cells

(2019) Piergiorgio La Rosa et al.   Frontiers in Cellular Neuroscience

Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats

(2019) Zhe Meng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway

(2019) Sisi Liu et al.   NEUROSCIENCE LETTERS

Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro

(2019) Xiao Chen et al.   Frontiers in Neuroscience

Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice

(2019) Jayesh Mudgal et al.   INFLAMMOPHARMACOLOGY

Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis

(2018) Na-Young Song et al.   BIOCHEMICAL PHARMACOLOGY

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Age-dependent effects of dimethyl fumarate on cognitive and neuropathological features in the streptozotocin-induced rat model of Alzheimer’s disease

(2018) Irena Majkutewicz et al.   BRAIN RESEARCH

Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway

(2018) Yunyi Dai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Markers of oxidative damage to lipids, nucleic acids and proteins and antioxidant enzymes activities in Alzheimer's disease brain: A meta-analysis in human pathological specimens

(2018) Matthew Zabel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway

(2018) Yu-Ling Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial

(2018) Ebrahim Kouchaki et al.   JOURNAL OF NUTRITION

Lycopene mitigates β-amyloid induced inflammatory response and inhibits NF-κB signaling at the choroid plexus in early stages of Alzheimer’s disease rats

(2018) Chong-Bin Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress

(2018) Ming-Chang Chiang et al.   NEUROCHEMISTRY INTERNATIONAL

Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats

(2018) Juan Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Fingolimod vs dimethyl fumarate in multiple sclerosis

(2018) Luca Prosperini et al.   NEUROLOGY

Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling

(2018) Wenwen Dong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models

(2018) Rosella Abeti et al.   Frontiers in Cellular Neuroscience

Dimethyl fumarate induces a persistent change in the composition of the innate and adaptive immune system in multiple sclerosis patients

(2018) G. Montes Diaz et al.   Scientific Reports

Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain

(2018) Zhenhua Shi et al.   MEDICAL SCIENCE MONITOR

Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

(2018) Zexu Wei et al.   Frontiers in Molecular Neuroscience

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

(2018) Ana I. Rojo et al.   Redox Biology

The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis

(2018) Anna Hammer et al.   Annals of Clinical and Translational Neurology

Nrf2 activation attenuates the early suppression of mitochondrial respiration due to the α-synuclein overexpression

(2018) Mu-Hui Fu et al.   Biomedical Journal

Parkinson's disease: Cause factors, measurable indicators, and early diagnosis

(2018) Shreya Bhat et al.   COMPUTERS IN BIOLOGY AND MEDICINE

MiR-155 aggravated septic liver injury by oxidative stress-mediated ER stress and mitochondrial dysfunction via targeting Nrf-2

(2018) Zhao-Bin Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease

(2018) Lynne Shinto et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity

(2018) Nora E. Gray et al.   JOURNAL OF ALZHEIMERS DISEASE

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice

(2018) Nora E. Gray et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Ferulic Acid Rescues LPS-Induced Neurotoxicity via Modulation of the TLR4 Receptor in the Mouse Hippocampus

(2018) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Dimethyl fumarate treatment in multiple sclerosis: Recent advances in clinical and immunological studies

(2018) Gwendoline Montes Diaz et al.   AUTOIMMUNITY REVIEWS

Biogenic nanoselenium particles activate Nrf2-ARE pathway by phosphorylating p38, ERK1/2, and AKT on IPEC-J2 cells

(2018) Xiao Xiao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways

(2018) Jie Fan et al.   Drug Design Development and Therapy

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

(2018) Amjad Khan et al.   Frontiers in Pharmacology

Comparative effectiveness of dimethyl fumarate versus fingolimod and teriflunomide among MS patients switching from first-generation platform therapies in the US

(2018) Daniel Ontaneda et al.   Multiple Sclerosis and Related Disorders

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells

(2017) Kaipeng Huang et al.   EXPERIMENTAL CELL RESEARCH

The role of oxidative stress in Friedreich's ataxia

(2017) Federica Lupoli et al.   FEBS LETTERS

Effects of green tea epigallocatechin-3-gallate on the proteolipid protein and oligodendrocyte transcription factor 1 messenger RNA gene expression in a mouse model of multiple sclerosis

(2017) Mohammadreza Semnani et al.   FOLIA NEUROPATHOLOGICA

Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway

(2017) Beita Zhao et al.   FOOD AND CHEMICAL TOXICOLOGY

Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans

(2017) Genki Hayashi et al.   HUMAN MOLECULAR GENETICS

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

(2017) Caterina Branca et al.   HUMAN MOLECULAR GENETICS

Neurochemical effects of the R form of α-lipoic acid and its neuroprotective mechanism in cellular models of Parkinson’s disease

(2017) Hong Zhao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nrf2-Inducers Counteract Neurodegeneration in Frataxin-Silenced Motor Neurons: Disclosing New Therapeutic Targets for Friedreich’s Ataxia

(2017) Sara Petrillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Asiaticoside Mitigates the Allergic Inflammation by Abrogating the Degranulation of Mast Cells

(2017) Jing Zhi Jiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Meta-Analysis of Parkinson’s Disease and Alzheimer’s Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes

(2017) Qian Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation

(2017) Lixia Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury

(2017) Raghavendar Chandran et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress

(2017) Lisa D. Coles et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Sulforaphane Promotes Mitochondrial Protection in SH-SY5Y Cells Exposed to Hydrogen Peroxide by an Nrf2-Dependent Mechanism

(2017) Marcos Roberto de Oliveira et al.   MOLECULAR NEUROBIOLOGY

Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies

(2017) Sreeja Gopal et al.   Multiple Sclerosis Journal

The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

(2017) Mohsen Taghizadeh et al.   NEUROCHEMISTRY INTERNATIONAL

Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease

(2017) Nikita Katila et al.   NEUROPHARMACOLOGY

Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification

(2017) Nora E. Gray et al.   NEUROSCIENCE LETTERS

Protective effects of resveratrol on mitochondrial function in the hippocampus improves inflammation-induced depressive-like behavior

(2017) Wen-Jin Chen et al.   PHYSIOLOGY & BEHAVIOR

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

(2017) Luisa Quinti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soybean isoflavones ameliorate ischemic cardiomyopathy by activating Nrf2-mediated antioxidant responses

(2017) Yang Li et al.   Food & Function

Mechanism of oxidative stress p38MAPK-SGK1 signaling axis in experimental autoimmune encephalomyelitis (EAE)

(2017) Liang Wang et al.   Oncotarget

Antioxidant and pro-angiogenic effects of corilagin in rat cerebral ischemia via Nrf2 activation

(2017) Yi Ding et al.   Oncotarget

Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies

(2017) Sreeja Gopal et al.   Multiple Sclerosis Journal

Comparative effectiveness of delayed-release dimethyl fumarate versus glatiramer acetate in multiple sclerosis patients: results of a matching-adjusted indirect comparison

(2017) Andrew Chan et al.   Journal of Comparative Effectiveness Research

Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients

(2017) Timur Khaibullin et al.   Frontiers in Immunology

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission

(2017) Gary B. O'Mealey et al.   Redox Biology

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

(2017) Shikha Prasad et al.   Redox Biology

Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?

(2017) Mohammad A. Kaisar et al.   Redox Biology

Dimethyl fumarate alters B-cell memory and cytokine production in MS patients

(2017) Matthew D. Smith et al.   Annals of Clinical and Translational Neurology

Mitochondria and the Link Between Neuroinflammation and Neurodegeneration

(2017) Massimiliano Di Filippo et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of Vitamin D Replacement on Cognition in Multiple Sclerosis Patients

(2017) Hala Darwish et al.   Scientific Reports

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Dimethyl fumarate attenuates intracerebroventricular streptozotocin-induced spatial memory impairment and hippocampal neurodegeneration in rats

(2016) Irena Majkutewicz et al.   BEHAVIOURAL BRAIN RESEARCH

The acetylenic tricyclic bis(cyano enone), TBE-31, targets microtubule dynamics and cell polarity in migrating cells

(2016) Eddie Chan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

Madecassic Acid protects against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ROS-mediated endoplasmic reticulum stress

(2016) Boyu Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease

(2016) Hanaa Hibishy Gaballah et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Dimethylfumarate Impairs Neutrophil Functions

(2016) Susen Müller et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Green tea EGCG, T-cell function, and T-cell-mediated autoimmune encephalomyelitis

(2016) Dayong Wu   JOURNAL OF INVESTIGATIVE MEDICINE

Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury After Intracerebral Hemorrhage in Mice

(2016) Sangeetha Sukumari-Ramesh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R

(2016) Wei Li et al.   MICROVASCULAR RESEARCH

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice

(2016) Kunmu Zheng et al.   MOLECULAR NEUROBIOLOGY

Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons

(2016) Mingyue Qu et al.   NEUROCHEMICAL RESEARCH

Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity

(2016) Kaige Peng et al.   Oxidative Medicine and Cellular Longevity

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

(2016) Ulf Schulze-Topphoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of IDH2 exacerbates H2O2-mediated cell death and hypertrophy

(2016) Hyeong Jun Ku et al.   REDOX REPORT

'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich’s ataxia'

(2016) R Abeti et al.   Cell Death & Disease

Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression

(2016) Fanhua Meng et al.   Oncology Letters

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance

(2016) Robert Saddawi-Konefka et al.   Cell Reports

Huntington’s Disease: Mechanisms of Pathogenesis and Therapeutic Strategies

(2016) Maria Jimenez-Sanchez et al.   Cold Spring Harbor Perspectives in Medicine

Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice

(2016) Yang Yao et al.   Translational Stroke Research

Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis

(2016) Mona Sadeghian et al.   Scientific Reports

Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease

(2015) Yan Gao et al.   ACTA PHARMACOLOGICA SINICA

Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression

(2015) Bao-feng Wang et al.   ACTA PHARMACOLOGICA SINICA

Biological and physiological role of reactive oxygen species - the good, the bad and the ugly

(2015) L. Zuo et al.   Acta Physiologica

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

(2015) E. V. Knatko et al.   Cancer Prevention Research

Dimethyl Fumarate: A Review in Relapsing-Remitting MS

(2015) Emma D. Deeks   DRUGS

Dimethyl fumarate attenuates cerebral edema formation by protecting the blood–brain barrier integrity

(2015) Reiner Kunze et al.   EXPERIMENTAL NEUROLOGY

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model

(2015) Priya Chaudhary et al.   JOURNAL OF NEUROIMMUNOLOGY

Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system

(2015) Yizhi Liu et al.   JOURNAL OF NEUROSURGERY

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

(2015) XIAOFENG LEI et al.   Molecular Medicine Reports

Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways

(2015) Minhee Jang et al.   MOLECULAR NEUROBIOLOGY

Epigallocatechin-3-Gallate Protects HUVECs from PM2.5-Induced Oxidative Stress Injury by Activating Critical Antioxidant Pathways

(2015) Guang-Zhao Yang et al.   MOLECULES

Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients

(2015) Erin E Longbrake et al.   Multiple Sclerosis Journal

Inflammation is genetically implicated in Parkinson’s disease

(2015) N. Dzamko et al.   NEUROSCIENCE

Neuroprotective effect of lycopene against MPTP induced experimental Parkinson’s disease in mice

(2015) Asokan Prema et al.   NEUROSCIENCE LETTERS

The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing thePGC-1α–NRF1/NRF2Pathway and Mitochondrial Respiratory Function in Rats

(2015) Zheng Ping et al.   Oxidative Medicine and Cellular Longevity

Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia

(2015) Rosella Abeti et al.   PHARMACOLOGICAL RESEARCH

Neuroprotective Effect of Lycopene Against PTZ-induced Kindling Seizures in Mice: Possible Behavioural, Biochemical and Mitochondrial Dysfunction

(2015) Manveen Bhardwaj et al.   PHYTOTHERAPY RESEARCH

Resveratrol Preconditioning Protects Against Cerebral Ischemic Injury via Nuclear Erythroid 2–Related Factor 2

(2015) Srinivasan V. Narayanan et al.   STROKE

Sulforaphane, a naturally occurring isothiocyanate, exhibits anti-inflammatory effects by targeting GSK3β/Nrf-2 and NF-κB pathways in T cells

(2015) Rahul Checker et al.   Journal of Functional Foods

Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients

(2015) Erin E Longbrake et al.   Multiple Sclerosis Journal

Mitochondrial Dysfunction in Parkinson's Disease

(2015) Hyo Eun Moon et al.   Experimental Neurobiology

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease

(2014) Maurice W. Dysken et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mitochondrial reactive oxygen species production and elimination

(2014) Alexander Nickel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

(2014) Yanying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

(−)-Epigallocatechin Gallate Protects Against Cerebral Ischemia-Induced Oxidative Stress via Nrf2/ARE Signaling

(2014) Jie Han et al.   NEUROCHEMICAL RESEARCH

Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain

(2014) Haneul Noh et al.   NEUROCHEMISTRY INTERNATIONAL

Does Lipoic Acid Consumption Affect the Cytokine Profile in Multiple Sclerosis Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

(2014) Mohammad Khalili et al.   NEUROIMMUNOMODULATION

Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity

(2014) P. Browne et al.   NEUROLOGY

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics

(2014) Azman Abdullah et al.   Pharmacological Reports

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes

(2013) Mohammed Mahidur Rahman et al.   AGING CELL

Activation of Nrf2-ARE signal pathway protects the brain from damage induced by epileptic seizure

(2013) Wei Wang et al.   BRAIN RESEARCH

Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities

(2013) Ramon Rodrigo et al.   CNS & Neurological Disorders-Drug Targets

Alzheimer’s disease treated patients showed different patterns for oxidative stress and inflammation markers

(2013) Miriana Gubandru et al.   FOOD AND CHEMICAL TOXICOLOGY

A Role for Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1) in the Regulation of Cardiac Mitochondrial Phospholipid Biosynthesis

(2013) Ling Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevalence gradients of Friedreich's Ataxia and R1b haplotype in Europe co-localize, suggesting a common Palaeolithic origin in the Franco-Cantabrian ice age refuge

(2013) Pierre Vankan   JOURNAL OF NEUROCHEMISTRY

Temporal and spatial distribution of Nrf2 in rat brain following stroke: quantification of nuclear to cytoplasmic Nrf2 content using a novel immunohistochemical technique

(2013) Salil Srivastava et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis

(2013) M. Schrag et al.   NEUROBIOLOGY OF DISEASE

NRF2-regulation in brain health and disease: Implication of cerebral inflammation

(2013) Mats Sandberg et al.   NEUROPHARMACOLOGY

Synthesis of a Dicyano Abietane, a Key Intermediate for the Anti-inflammatory Agent TBE-31

(2013) Evans O. Onyango et al.   ORGANIC LETTERS

Genetic Activation of Nrf2 Protects against Fasting-Induced Oxidative Stress in Livers of Mice

(2013) Yu-Kun Jennifer Zhang et al.   PLoS One

Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant Huntingtin

(2013) Youngnam N. Jin et al.   PLoS One

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

(2013) Edward C. Jauch et al.   STROKE

Burden of Friedreich’s Ataxia to the Patients and Healthcare Systems in the United States and Canada

(2013) Barbara Polek et al.   Frontiers in Pharmacology

Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model

(2012) Hyunjin Vincent Kim et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies

(2012) Gang Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxidative stress – assassin behind the ischemic stroke

(2012) Hanumanthappa Pradeep et al.   FOLIA NEUROPATHOLOGICA

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective effect of (–)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury

(2012) Tatsuki Itoh et al.   JOURNAL OF NEURAL TRANSMISSION

Inhibition of NF-κB nuclear translocation via HO-1 activation underlies α-tocopheryl succinate toxicity

(2012) Ilaria Bellezza et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis

(2012) Bruce Morgan et al.   Nature Chemical Biology

Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism

(2012) Atish Prakash et al.   NEUROLOGICAL SCIENCES

Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats

(2012) Rizwana Tabassum et al.   NEUROLOGICAL SCIENCES

Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity

(2012) Tracy P. Williamson et al.   NEUROTOXICOLOGY

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

(2012) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients

(2012) Kuo-Hsuan Chang et al.   PLoS One

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants in Huntington's disease

(2011) Ashu Johri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Curcumin induces stress response and hormetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro

(2011) Dino Demirovic et al.   BIOGERONTOLOGY

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

(2011) Abena S. Agyeman et al.   BREAST CANCER RESEARCH AND TREATMENT

Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain

(2011) Vandita Kakkar et al.   FOOD AND CHEMICAL TOXICOLOGY

Sulforaphane inhibits mitochondrial permeability transition and oxidative stress

(2011) Tiffany Greco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary Supplementation with tBHQ, an Nrf2 Stabilizer Molecule, Confers Neuroprotection Against Apoptosis in Amyloid β-Injected Rat

(2011) Fatemeh Nouhi et al.   NEUROCHEMICAL RESEARCH

Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons

(2011) Mingyue Qu et al.   NEUROSCIENCE LETTERS

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Acetyl-l-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy

(2011) Sawsan A. Zaitone et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice

(2011) Nidhi Bharal Agarwal et al.   PHYTOMEDICINE

Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease

(2011) Gisa Ellrichmann et al.   PLoS One

The Promise of Neuroprotective Agents in Parkinson?s Disease

(2011) Stacey E. Seidl et al.   Frontiers in Neurology

Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice

(2010) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondria and Huntington's Disease Pathogenesis

(2010) Susan E. Browne   Annals of the New York Academy of Sciences

NF-κB and innate immunity in ischemic stroke

(2010) Olivier A. Harari et al.   Annals of the New York Academy of Sciences

Friedreich Ataxia: Molecular Mechanisms, Redox Considerations, and Therapeutic Opportunities

(2010) Renata Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Biomarkers of oxidative damage and inflammation in Alzheimer’s disease

(2010) Douglas Galasko et al.   Biomarkers in Medicine

Covalent Binding of Tea Catechins to Protein Thiols: The Relationship between Stability and Electrophilic Reactivity

(2010) Taiki MORI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

(2010) Malin von Otter et al.   BMC Medical Genetics

Immune-Inflammatory Responses and Oxidative Stress in Alzheimers Disease: Therapeutic Implications

(2010) D. Bona et al.   CURRENT PHARMACEUTICAL DESIGN

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: A multimodal imaging study

(2010) Marios Politis et al.   HUMAN BRAIN MAPPING

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

(2010) J. Kim et al.   HUMAN MOLECULAR GENETICS

Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition

(2010) Tiffany Greco et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

An Exceptionally Potent Inducer of Cytoprotective Enzymes

(2010) Albena T. Dinkova-Kostova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease

(2010) Jian Guo Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Flavanol (−)-Epicatechin Prevents Stroke Damage through the Nrf2/HO1 Pathway

(2010) Zahoor A Shah et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxidative stress and plasma aminopeptidase activity in Huntington’s disease

(2010) Raquel Duran et al.   JOURNAL OF NEURAL TRANSMISSION

Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression

(2010) Ute Boettler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Clinical study on CXCL13, CCL17, CCL20 and IL-17 as immune cell migration navigators in relapsing−remitting multiple sclerosis patients

(2010) Alicja Kalinowska-Łyszczarz et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats

(2010) Nagaraja Haleagrahara et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Mitochondria in Huntington's disease

(2009) Maria Damiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid β formation in NT2N neurons

(2009) Bahareh Eftekharzadeh et al.   BIOCHIMIE

Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease

(2009) Elke Hattingen et al.   BRAIN

Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes

(2009) Alan R. Collins et al.   CIRCULATION RESEARCH

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice

(2009) Weisong Duan et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharide

(2009) Lijia Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Brain mitochondrial dysfunction and oxidative damage in Parkinson’s disease

(2009) Ana Navarro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Green Tea (-)-Epigallocatechin-3-Gallate Inhibits β-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-κB Pathways in Mice

(2009) Jae Woong Lee et al.   JOURNAL OF NUTRITION

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Genome-Wide Microarray Analysis of the Differential Neuroprotective Effects of Antioxidants in Neuroblastoma Cells Overexpressing the Familial Parkinson’s Disease α-Synuclein A53T Mutation

(2009) Lei Ma et al.   NEUROCHEMICAL RESEARCH

Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia

(2009) Vincent Paupe et al.   PLoS One

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis

(2009) Delinda A. Johnson et al.   TOXICOLOGICAL SCIENCES

Sulforaphane suppresses TNF-α-mediated activation of NF-κB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3

(2008) Dong-Oh Moon et al.   CANCER LETTERS

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

(2008) M Alba Sorolla et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia

(2008) K. Li et al.   HUMAN MOLECULAR GENETICS

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

(2008) Maria Björkqvist et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear Factor- B Activation and Postischemic Inflammation Are Suppressed in CD36-Null Mice after Middle Cerebral Artery Occlusion

(2008) A. Kunz et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) Ludwig Kappos et al.   LANCET

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

(2008) Katja Kanninen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice

(2008) George K. Shinomol et al.   NEUROTOXICOLOGY

Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: Novel cytoprotective mechanism against oxidative damage

(2008) Ju Hee Lim et al.   PHARMACOLOGICAL RESEARCH

Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria

(2008) George K. Shinomol et al.   PHYTOMEDICINE