Article
Biochemistry & Molecular Biology
Mahmoud A. Alfaqih, Lina Elsalem, Mohamad Nusier, Khawla Mhedat, Yousef Khader, Ebaa Ababneh
Summary: This study found a correlation between obesity and increased risk of bladder cancer. The levels of leptin and its receptor are often deregulated in obese individuals and these changes are associated with the development of bladder cancer. Additionally, certain genetic variants are also associated with bladder cancer.
Article
Biochemistry & Molecular Biology
Laura Braud, Maria Pini, Donald F. Stec, Sylvie Manin, Genevieve Derumeaux, David E. Stec, Roberta Foresti, Roberto Motterlini
Summary: The up-regulation of Sirt1 levels specifically in the visceral adipose tissue of Nrf2(-/-) mice is a key adaptive mechanism that mitigates glucose intolerance induced by nutritional stress.
Article
Oncology
Cody J. Schmidlin, Aryatara Shakya, Matthew Dodson, Eli Chapman, Donna D. Zhang
Summary: NRF2 plays a complex role in cancer by regulating genes involved in cell function and survival, and its activation mode determines its effects in cancer. The discovery of pharmacological modulators targeting NRF2 provides potential breakthroughs in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Health Care Sciences & Services
John J. Milner, Zhao-Feng Chen, James Grayson, Shyang-Yun Pamela Koong Shiao
Summary: Obesity with adiposity is a common disorder in modern society and can influence the epigenetics of colorectal cancer. Research shows that DMRs of different genes can potentially be novel biomarkers for colon cancer in obese patients, aiding in cancer prevention and progression.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Bingchen Pan, Bowen Zheng, Chengzhong Xing, Jingwei Liu
Summary: Non-canonical programmed cell death (PCD) plays an important role in colon cancer, influencing its tumorigenesis, treatment, and prognosis. This review examines the mechanisms, applications, and prospects of different types of non-canonical PCD in colon cancer. Various types of non-canonical PCD, including mitotic catastrophe, ferroptosis, pyroptosis, necroptosis, parthanatos, oxeiptosis, NETosis, PANoptosis, and entosis, are involved in the initiation and development of colon cancer. The review summarizes the association of these non-canonical PCD types with tumorigenesis, progression, prevention, treatments, and prognosis of colon cancer, as well as the potential of drug-resistant colon cancer therapy related to non-canonical PCD and the interaction between different types of non-canonical PCD.
Article
Biology
Jose Manuel Garcia-Martinez, Ana Chocarro-Calvo, Javier Martinez-Useros, Maria Jesus Fernandez-Acenero, M. Carmen Fiuza, Jose Caceres-Rentero, Antonio De la Vieja, Antonio Barbachano, Alberto Munoz, Maria Jesus Larriba, Custodia Garcia Jimenez
Summary: Posttranslational modifications of epigenetic modifiers provide a mechanism for rapid adaptations in cancer cells. The study shows that 1,25(OH)(2)D-3 activates SIRT1 by auto-deacetylation in colon cancer cells, inhibiting cell proliferation.
Article
Oncology
Xiangwei Li, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Lina Jansen
Summary: The results of this case-control study suggest that cumulative lifetime excess weight plays a greater role in the risk of colorectal cancer than estimated by traditional BMI measurements at a single point in time.
Article
Cell Biology
Wei-Lun Hsu, Chieh-Min Wang, Chao-Ling Yao, Ssu-Ching Chen, Chung-Yi Nien, Yang-Ho Sun, Tsung-Yu Tseng, Yueh-Hsia Luo
Summary: The selenocompound SeC selectively attacks Nrf2-addicted colorectal cancer cells by reducing Nrf2 and autophagy pathway protein expression, resulting in cell death.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Francesco Vitali, Katia Tortora, Monica Di Paola, Gianluca Bartolucci, Marta Menicatti, Carlotta De Filippo, Giovanna Caderni
Summary: This study examined the fecal and colon mucosal associated microbiota in a model of colorectal cancer in rats. The results showed that age played a significant role in the distribution of the samples, with young rats without tumors being separated from older rats with tumors. There were significant differences in the microbiota between older rats with tumors and younger rats, as well as between the tumor microbiota and both types of rats, indicating a specific relationship between the gut microbiota profile and colorectal cancer. Additionally, the study found correlations between CRC biomarkers, fecal short chain fatty acids, and both the fecal and mucosal microbiota, suggesting the need for further investigation into these functional mucosal parameters.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Martina Chiriaco, Lorenzo Nesti, Allan Flyvbjerg, Alain Golay, Julie-Anne Nazare, Christian-Heinz Anderwald, Asimina Mitrakou, Roberto Bizzotto, Andrea Mari, Andrea Natali
Summary: The impact of obesity on glucose homeostasis varies greatly among individuals, which may be attributed to different concentrations of adipokines. Subjects with inappropriately elevated leptin levels for their fat mass show whole-body/adipose tissue insulin resistance and hyperinsulinemia, regardless of BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Sergio Montserrat-de la Paz, Antonio Perez-Perez, Teresa Vilarino-Garcia, Carlos Jimenez-Cortegana, Francisco Javier G. Muriana, Maria C. Millan-Linares, Victor Sanchez-Margalet
Summary: Obesity is characterized by the accumulation and dysregulation of adipose tissue, often accompanied by resistance to leptin and elevated leptin levels. Leptin, a hormone produced by adipose tissue, plays a crucial role in energy homeostasis. Dietary components can modulate leptin metabolism, with some reducing inflammation and enhancing leptin sensitivity, while others may exacerbate chronic inflammation and increase the risk of complications. Research into nutritional mechanisms to restore leptin metabolism could lead to new treatment options for obesity-related disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Taylor Marshall, Jing Chen, Alicia M. Viloria-Petit
Summary: Obesity has been identified as a serious health concern in domestic cats, and Feline Mammary Cancer (FMC) is highly prevalent and aggressive. This review investigated the association between adipokines and other obesity-associated molecules and FMC, and identified research gaps for future studies. The findings suggest a positive correlation between leptin, serum amyloid A, and estrogen with FMC, while a negative correlation between leptin and FMC. The roles of adiponectin and prolactin in FMC development require further investigation.
Review
Biochemistry & Molecular Biology
Roberto Buonaiuto, Fabiana Napolitano, Sara Parola, Pietro De Placido, Valeria Forestieri, Giovanna Pecoraro, Alberto Servetto, Luigi Formisano, Pietro Formisano, Mario Giuliano, Grazia Arpino, Sabino De Placido, Carmine De Angelis
Summary: Leptin, a hormone involved in appetite control and energy balance, can contribute to chronic inflammation and cancer development when adipose tissue expands. Leptin activates multiple cancer pathways and affects cancer immune response. High levels of leptin associated with obesity are related to breast cancer risk.
Article
Medicine, General & Internal
Dariusz Boron, Robert Nowakowski, Beniamin Oskar Grabarek, Nikola Zmarzly, Marcin Oplawski
Summary: The study investigated the expression profile of leptin-related genes in endometrial cancer patients, showing an overexpression of leptin and its receptors, particularly correlating with patient body mass index, which may contribute to the progression of cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Xizhu Fang, Yeon-Hwa Lee, Jeong-Hoon Jang, Su-Jung Kim, Seong Hoon Kim, Do-Hee Kim, Hye-Kyung Na, Kyung-Ok Kim, Jeong-Heum Baek, Young-Joon Surh
Summary: This study found that ARD1 stabilizes NRF2 by increasing its acetylation levels, thereby enhancing the oncogenic function of NRF2 in human colon cancer.
Article
Oncology
Young-Il Hahn, Soma Saeidi, Su-Jung Kim, Se-Young Park, Na-Young Song, Jie Zheng, Do-Hee Kim, Han-Byoel Lee, Wonshik Han, Dong-Young Noh, Hye-Kyung Na, Young-Joon Surh
Summary: STAT3 and NF-kappa B are critical transcription factors in inflammation-associated tumorigenesis, working together at multiple levels. Breast carcinomas have a significant dependency on both classical and non-classical NF-kappa B pathways. STAT3 stabilizes and activates IKK alpha, leading to NF-kappa B activation and promoting breast cancer growth and progression.
Article
Surgery
Youngbae Jeon, Kyoung-Won Han, Won-Suk Lee, Jeong-Heum Baek
Summary: This study evaluated the clinical outcomes of surgical treatment for nonagenarian patients with colorectal cancer, showing that surgery can be considered in carefully selected patients due to better overall survival compared to nonsurgical treatment.
Article
Biochemistry & Molecular Biology
Jaekyung Jung, Yeon-Hwa Lee, Xizhu Fang, Su-Jung Kim, Seong Hoon Kim, Do-Hee Kim, Na-Young Song, Hye-Kyung Na, Jeong-Heum Baek, Young-Joon Surh
Summary: IL-1β-induced upregulation of SIRT1 stimulates the production of proinflammatory cytokines via nuclear accumulation of c-Jun, leading to the growth and progression of colon cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Oncology
Jeong-Heum Baek, Youngbae Jeon, Kyoung-Won Han, Dong Hae Jung, Kyung-Ok Kim
Summary: The study evaluated the effect of mistletoe extract on tumor responses in rectal cancer patients undergoing neoadjuvant chemoradiotherapy. Patients treated with mistletoe extract showed better outcomes in terms of tumor responses, indicating potential efficacy in improving oncologic outcomes. Further prospective and randomized studies are needed to confirm and extend these results.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Se-Young Park, Sun Kyoung Lee, Mihwa Lim, Bomi Kim, Byeong-Oh Hwang, Eunae Sandra Cho, Xianglan Zhang, Kyung-Soo Chun, Won-Yoon Chung, Na-Young Song
Summary: Oral squamous cell carcinoma (OSCC) is often diagnosed at an advanced stage with metastasis. Platelets play a crucial role in cancer metastasis. This study found that platelets can upregulate PDPN and integrin beta 1 expression and promote invasiveness in OSCC cells. PDPN may be a potential target for regulating platelet-tumor interaction and metastasis.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Oncology
Yeon-Hwa Lee, Su-Jung Kim, Xizhu Fang, Na-Young Song, Do-Hee Kim, Jinyoung Suh, Hye-Kyung Na, Kyung-Ok Kim, Jeong-Heum Baek, Young-Joon Surh
Summary: SIRT1 and its phosphorylated form at serine 27 are upregulated in colon cancer patients' tissues and cells. The phosphorylated form of SIRT1 regulates the activity of Snail and transcription of interleukin by deacetylation, promoting the proliferation and tumor formation of colon cancer cells.
MOLECULAR ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Na-Young Song, Xin Li, Buyong Ma, Jami Willette-Brown, Feng Zhu, Chengfei Jiang, Ling Su, Jyoti Shetty, Yongmei Zhao, Gongping Shi, Sayantan Banerjee, Xiaolin Wu, Bao Tran, Ruth Nussinov, Michael Karin, Yinling Hu
Summary: The low expression of IKK alpha in lung adenocarcinoma cells is associated with increased monocyte-derived macrophages and regulatory T cells, as well as elevated levels of cytokines that recruit macrophages and induce Tregs. These cytokines stimulate the progression of lung adenocarcinoma by promoting the recruitment of macrophages and generating Tregs through TNF/TNFR2/c-Rel signaling cascade. Depletion of TNFR2, c-Rel, or TNF inhibits Treg generation and lung tumorigenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
So-Yeon Park, Jee-Heun Kim, Jang-Hyun Choi, Choong-Jae Lee, Won-Jae Lee, Sehoon Park, Zee-Yong Park, Jeong-Heum Baek, Jeong-Seok Nam
Summary: This study highlights the important role of lipid rafts (LRs) in colorectal cancer, where an LR-disrupting alkylphospholipid drug can suppress CSC populations and their self-renewal activities. By inhibiting the LR/CHEK1 axis, the drug forces CSCs to enter inappropriate mitosis, leading to catastrophic cell death.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Jaya Bagaria, Kyung-Ok Kim, Eva Bagyinszky, Seong Soo A. An, Jeong-Heum Baek
Summary: This study aimed to investigate genes responsible for locally advanced rectal cancer patients not reacting to radiotherapy, identifying specific genes more commonly mutated in non-complete response patients and potentially serving as genetic biomarkers for early detection of radiation-resistant rectal cancer patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Youngbae Jeon, Kug Hyun Nam, Seok Won Choi, Tae Sik Hwang, Jeong-Heum Baek
Summary: This study compared the oncologic outcomes between surgical T4 and T3 in pathologic stage IIA right colon cancer patients. It found significant differences in the 5-year overall survival rate and 5-year disease-free survival rate between the two groups, with surgical T4 being an independent predictive factor for recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Xizhu Fang, Yeon-Hwa Lee, Jeong-Hoon Jang, Su-Jung Kim, Seong Hoon Kim, Do-Hee Kim, Hye-Kyung Na, Kyung-Ok Kim, Jeong-Heum Baek, Young-Joon Surh
Summary: This study found that ARD1 stabilizes NRF2 by increasing its acetylation levels, thereby enhancing the oncogenic function of NRF2 in human colon cancer.
Article
Oncology
Youngbae Jeon, Sun Jin Sym, Bong Kyu Yoo, Jeong-Heum Baek
Summary: This study evaluated the safety and tolerability of a dietary supplement of G-NLC in patients with colorectal cancer, showing comparable long-term survival outcomes with acceptable toxicity. Further research is needed to establish the efficacy of this treatment regimen.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Spectroscopy
Kyung-Ok Kim, Van-An Duong, Na-Young Han, Jong-Moon Park, Jung Ho Kim, Hookeun Lee, Jeong-Heum Baek
Summary: This study aimed to identify possible biomarkers for predicting the response of rectal cancer patients to neoadjuvant chemoradiotherapy (nCRT). Comparative proteomic analysis was performed on rectal tissue samples before and after nCRT, and several potential biomarkers were identified, including lyso-phosphatidylcholine acyltransferase 2, annexin A13, aldo-ketose reductase family 1 member B1, and cathelicidin antimicrobial peptide.
MASS SPECTROMETRY LETTERS
(2022)
Meeting Abstract
Oncology
Joon-Hyop Lee, Jeong-Heum Baek, Young Jae Kim, Kwang-Gi Kim
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)