Article
Biochemistry & Molecular Biology
Kaitlyn B. Hartnett, Bradley J. Ferguson, Patrick M. Hecht, Luke E. Schuster, Joel I. Shenker, David R. Mehr, Kevin L. Fritsche, Martha A. Belury, Douglas W. Scharre, Adam J. Horwitz, Briana M. Kille, Briann E. Sutton, Paul E. Tatum, C. Michael Greenlief, David Q. Beversdorf
Summary: This pilot study aimed to explore the relationship between stress exposure and dietary omega-3 fatty acid intake in relation to the risk of Alzheimer's disease (AD). The results showed that among individuals with high stress exposure, healthy controls had significantly higher omega-3 fatty acid intake compared to AD patients. No difference was observed among those with low stress exposure. These preliminary findings suggest that omega-3 fatty acids may mitigate AD risk in the setting of greater stress exposure.
Article
Nutrition & Dietetics
Rebecca Power, John M. Nolan, Alfonso Prado-Cabrero, Warren Roche, Robert Coen, Tommy Power, Riona Mulcahy
Summary: The study suggests that omega-3 fatty acids, carotenoids, and vitamin E can improve cognitive performance in older adults. The participants who received supplements showed better working memory performance and increased concentrations of carotenoids and omega-3 fatty acids in their tissues and blood. These nutrients may work together to enhance cognitive function in older individuals.
CLINICAL NUTRITION
(2022)
Article
Medicine, Research & Experimental
Saeid Doaei, Somayeh Gholami, Samira Rastgoo, Maryam Gholamalizadeh, Fatemeh Bourbour, Seyedeh Elaheh Bagheri, Forough Samipoor, Mohammad Esmail Akbari, Mahdi Shadnoush, Fereshteh Ghorat, Seyed Alireza Mosavi Jarrahi, Narjes Ashouri Mirsadeghi, Azadeh Hajipour, Parvin Joola, Alireza Moslem, Mark O. Goodarzi
Summary: This study investigated the effects of n3-PUFA supplementation on critically ill patients with COVID-19. The results suggest that Omega-3 supplementation can improve certain biochemical and inflammatory markers, as well as increase survival rates in critically ill patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Meghan Dempsey, Michelle S. Rockwell, Laurel M. Wentz
Summary: The majority of the population lack adequate omega-3 fatty acids (n-3 FA), leading to global deficiencies and poor omega-3 status. This study aimed to evaluate the effect of n-3 FA interventions on omega3-index (O3i) and estimate sufficient intake to meet recommendations.
FRONTIERS IN NUTRITION
(2023)
Article
Geriatrics & Gerontology
R. De Giuseppe, I. Di Napoli, C. E. Tomasinelli, Alessandra Vincenti, G. Biino, E. Sommella, L. Ferron, P. Campiglia, F. Ferrara, P. M. Casali, H. Cena
Summary: This study aimed to investigate the effects of Camelina oil-enriched crackers on serum omega-3 concentration, inflammatory markers, and serum lipid profile. The results showed that consuming Camelina oil-enriched crackers significantly increased the serum concentration of alpha-linolenic acid, but had no significant effects on inflammatory markers and lipid profile.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Psychiatry
Renata Pauluci, Ana Regina Noto, Daniela Fernandez Curado, Miguel Siqueira-Campos Jr, Andreia Gomes Bezerra, Jose Carlos Fernandes Galduroz
Summary: This study aimed to evaluate if omega-3 supplementation can prevent relapse of alcohol use disorder after hospital discharge. The results showed that the group receiving omega-3 had fewer days of alcohol consumption at 2 and 3 months after discharge. Further research is needed to confirm these findings.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Maria Notarnicola, Valentina De Nunzio, Tamara Lippolis, Valeria Tutino, Anna Maria Cisternino, Palma Aurelia Iacovazzi, Rosa Anna Milella, Marica Gasparro, Roberto Negro, Maurizio Polignano, Maria Gabriella Caruso
Summary: This clinical trial investigated the effects of fresh table grape intake on the serum Omega-3 index. The results showed that grape intake increased oleic acid content, improved the Omega-3 index, increased adiponectin levels, and reduced FGF21 levels, leading to beneficial effects on liver function.
Article
Chemistry, Medicinal
Lena Stiefvatter, Katja Lehnert, Konstantin Frick, Alexander Montoya-Arroyo, Jan Frank, Walter Vetter, Ulrike Schmid-Staiger, Stephan C. Bischoff
Summary: The microalgae Phaeodactylum tricornutum (PT) is a valuable source of nutrients such as proteins, polyunsaturated omega-3 fatty acids (n-3 PUFA), particularly eicosapentaenoic acid (EPA), carotenoids like fucoxanthin (FX), and beta-glucans. Intake of PT leads to an increase in n-3 PUFA and EPA levels, while also decreasing the n-6:n-3 ratio in plasma. The study shows that PT is a safe and effective source of EPA and other nutrients, suggesting its potential as a sustainable food source.
Review
Environmental Sciences
Priyanshi Sikka, Tapan Behl, Sanchay Sharma, Aayush Sehgal, Saurabh Bhatia, Ahmed Al-Harrasi, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Ω-3 fatty acids are recognized for their benefits on physical and mental health, primarily obtained from fish and fish products. Adequate intake of Ω-3 fatty acids can improve brain function and neuronal function, reduce depressive symptoms, and have fewer side effects compared to antidepressants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Jae-Woo Lee, Yonghwan Kim, Taisun Hyun, Seunghye Song, Woojung Yang, Ye-Seul Kim, Hyo-Sun You, Young-Chang Chang, Seung-Ho Shin, Hee-Taik Kang
Summary: The study found that incorporating a low omega-6/omega-3 fatty acid ratio home meal replacement (HMR) can improve cardiometabolic parameters and reduce the prevalence of metabolic syndrome in obese individuals. This randomized crossover trial demonstrated significant reductions in BMI, weight, and MetS prevalence after a 4-week intervention with the HMR.
Article
Nutrition & Dietetics
Mingjin Cheng, Shengqiang Zhang, Chengdong Ning, Qianlun Huo
Summary: This study confirmed the efficacy of omega-3 fatty acid supplementation in improving the nutritional status and suppressing systemic inflammatory response in patients with lung cancer. Compared to the placebo group, the omega-3 group showed significant improvements in weight, albumin, and triglyceride levels, as well as reductions in inflammatory markers.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Ayu Kasamatsu, Hiroshi Tachimoto, Mitsuyoshi Urashima
Summary: This study investigated the associations between maternal dietary habits, infant feeding patterns, and serum levels of DHA and other LCPUFAs in 5-6-month-old infants in Japan. It found that frequent consumption of Blue-back fish and/or White fish by lactating mothers, as well as prioritizing breastfeeding, can effectively increase infants' serum DHA levels.
Article
Cardiac & Cardiovascular Systems
Are Annesonn Kalstad, Peder Langeland Myhre, Kristian Laake, Sjur Hansen Tveit, Erik Berg Schmidt, Paal Smith, Dennis Winston Trygve Nilsen, Arnljot Tveit, Morten Wang Fagerland, Svein Solheim, Ingebjorg Seljeflot, Harald Arnesen
Summary: The addition of 1.8g n-3 PUFA to standard care did not result in a significant reduction in cardiovascular events during a 2-year follow-up in elderly patients with recent AMI.
Article
Cardiac & Cardiovascular Systems
Richard L. Weinberg, Robert D. Brook, Melvyn Rubenfire, Kim A. Eagle
Summary: Omega-3 polyunsaturated fatty acids play a key role in heart-healthy diet, and can be obtained through fatty fish consumption or fish oil supplementation. They not only treat hypertriglyceridemia, but also prevent cardiovascular events, with additional benefits such as reducing inflammation and improving plaque stability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Immunology
Pan-Yen Lin, Chin Cheng, Senthil Kumaran Satyanarayanan, Lu-Ting Chiu, Yu-Chuan Chien, Chih-Pin Chuu, Tsuo-Hung Lan, Kuan-Pin Su
Summary: The study found that n-3 PUFAs supplements did not significantly reduce cognitive, functional, and depressive symptoms outcomes in Alzheimer's disease patients, but showed improvements in spoken language ability and constructional praxis scores. Attention to clinical heterogeneity in dementia is crucial, and CCL4 may be a better indicator for EPA treatment response compared to other inflammatory cytokines.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Lee E. Neilson, Joseph F. Quinn, Nora E. Gray
Summary: NRF2, a transcription factor critical in maintaining cellular redox balance, has been identified as a therapeutic target in various human diseases. PBMCs can serve as a convenient source of biomarkers to monitor NRF2 activation and disease progression in clinical trials, indicating their potential as exploratory markers for targeting NRF2 activation.
Article
Spectroscopy
Elena Ryzhikova, Nicole M. Ralbovsky, Vitali Sikirzhytski, Oleksandr Kazakov, Lenka Halamkova, Joseph Quinn, Earl A. Zimmerman, Igor K. Lednev
Summary: The current diagnostics for Alzheimer's disease relies on clinical assessments, imaging, and neuropsychological tests which are only efficient in the advanced stages of the disease. Early diagnosis of AD is crucial for preventive treatment and disease-modifying drug development. Cerebrospinal fluid (CSF) is the most promising body fluid for AD diagnostic test development due to its reflective changes associated with the disease. The novel method using NIR Raman spectroscopy combined with machine learning analysis shows potential for early AD detection with high sensitivity and specificity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Psychology, Clinical
Brenna A. Cholerton, Kathleen L. Poston, Laurice Yang, Liana S. Rosenthal, Ted M. Dawson, Alexander Pantelyat, Karen L. Edwards, Lu Tian, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Shu-Ching Hu, Thomas J. Montine, Cyrus P. Zabetian
Summary: The study found that patients diagnosed with PD show significant decline in processing speed and semantic verbal fluency, even without evident cognitive impairment or dementia. This suggests that specific cognitive domains may experience subtle decline in PD patients, emphasizing the importance of early awareness of potential cognitive impacts in PD even in the absence of mild cognitive impairment or dementia.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2021)
Article
Medicine, Research & Experimental
Valerie C. Anderson, Ian J. Tagge, Aaron Doud, Xin Li, Charles S. Springer, Joseph F. Quinn, Jeffrey A. Kaye, Katherine Wild, William D. Rooney
Summary: Metabolic deficits at brain-fluid barriers, including reduced water efflux rate constant at the blood-cerebrospinal fluid barrier, are associated with cognitive decline in older adults. Significant associations were observed between water efflux rate constant and cognitive dysfunction, indicating a potential biomarker for cognitive impairment in later life.
Article
Biochemistry & Molecular Biology
Nathan Hwangbo, Xinyu Zhang, Daniel Raftery, Haiwei Gu, Shu-Ching Hu, Thomas J. Montine, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Dongfang Wang, Qiang Fei, Lisa Bettcher, Cyrus P. Zabetian, Elaine R. Peskind, Ge Li, Daniel E. L. Promislow, Marie Y. Davis, Alexander Franks
Summary: Metabolomics has been utilized to analyze human cerebrospinal fluid samples and found strong separation between PD and AD patients and healthy controls in the metabolome. Key metabolites associated with PD and AD classification were identified, along with metabolic pathways linked to these neurodegenerative diseases.
Article
Public, Environmental & Occupational Health
Ana R. Quinones, Siting Chen, Corey L. Nagel, Anda Botoseneanu, Heather G. Allore, Jason T. Newsom, Stephen Thielke, Jeffrey Kaye
Summary: Evaluating the associations between multimorbidity combinations, racial/ethnic background, educational attainment, and sex with age-related cognitive changes is crucial. The study found racial/ethnic differences in cognitive trajectories in later life, with significant interactions with sex and education.
SSM-POPULATION HEALTH
(2022)
Article
Psychology, Clinical
Mira Leese, Nora Mattek, John P. K. Bernstein, Katherine E. Dorociak, Sarah Gothard, Jeffrey Kaye, Adriana M. Hughes
Summary: This study aimed to develop a brief web-based cognitive assessment tool and establish preliminary norms. The results showed that age was the only demographic variable associated with performance on the assessment tool, with older adults having slower completion time. Male participants generally had longer completion time compared to females. Overall, the tool was well-accepted by participants, with more than half willing to complete it on a weekly basis.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Clinical Neurology
Delaram Safarpour, Barbara H. Brumbach, Monica Arena, Joseph Quinn, Sarah Diamond, Jay G. Nutt, RonaldF. Pfeiffer
Summary: This study aimed to investigate whether altered segmental gastrointestinal transit time (GITT) correlates with clinical response and plasma levodopa concentration (PLC) variability in patients with Parkinson's disease. The results showed no significant difference in GITT between typical and erratic responders. Additionally, Small Intestinal Bacterial Overgrowth (SIBO) was positive in half of the erratic responders and negative in most typical responders.
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Jack C. Lennon, Nathan Hantke, Nora Mattek, Chao-Yi Wu, Hiroko Dodge, Rachel Wall, Zachary Beattie, Jeffrey Kaye, Lisa C. Silbert
Summary: A study found that older Veterans and their cohabitants reported significantly higher levels of blue mood and loneliness during the COVID-19 pandemic, as well as a significant decrease in travel away from home. The prevalence of these negative moods was not affected by the rural or urban residence.
CLINICAL GERONTOLOGIST
(2023)
Article
Chemistry, Analytical
Christina L. Reynolds, Aylmer Tan, Jonathan E. Elliott, Carolyn E. Tinsley, Rachel Wall, Jeffrey A. Kaye, Lisa C. Silbert, Miranda M. Lim
Summary: Aging has a significant impact on sleep patterns, and inadequate and/or mistimed light exposure contributes to poor sleep. However, methods for long-term collection of light levels in the home are not well established. This study demonstrates the feasibility and acceptability of remotely deploying light sensors to assess the relationship between light exposure and sleep in older adults.
Article
Geriatrics & Gerontology
Marijn Muurling, Wan-Tai M. Au-Yeung, Zachary Beattie, Chao-Yi Wu, Hiroko Dodge, Nathaniel K. Rodrigues, Sarah Gothard, Lisa C. Silbert, Lisa L. Barnes, Joel S. Steele, Jeffrey Kaye
Summary: This study compares the life space activity patterns of individuals living alone and couples, and assesses the behavior of individuals with mild cognitive impairment (MCI) using in-home sensors. The results indicate that there are differences in in-home behavior between individuals living alone and couples, with the impact of MCI status varying based on household type.
Article
Health Care Sciences & Services
Chao-Yi Wu, Deanne Tibbitts, Zachary Beattie, Hiroko Dodge, Jackilen Shannon, Jeffrey Kaye, Kerri Winters-Stone
Summary: This study found significant differences in health and behavior changes before and after a cancer diagnosis through continuous passive monitoring of older adults. Over the year preceding a cancer diagnosis, there were gradual reductions in step counts and weight, and gradual increases in pain severity, step count variability, hospitalization or emergency room visits, and days away from home overnight. In the year after the cancer diagnosis, there was a gradual increase in the number of pillbox door openings. The results of this study suggest that continuous passive monitoring can provide important information for health management.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychology, Developmental
John P. K. Bernstein, Katherine Dorociak, Nora Mattek, Mira Leese, Chelsea Trapp, Zachary Beattie, Jeffrey Kaye, Adriana Hughes
Summary: Assessing everyday activities at home over a period of months to years can help predict cognitive decline in older adults. This study found that even a relatively brief monitoring period of 3 months can provide valuable diagnostic information related to computer use, sleep, medication use, pain, and independence, which are linked to cognitive function.
AGING NEUROPSYCHOLOGY AND COGNITION
(2022)
Article
Health Care Sciences & Services
Katherine Wild, Nicole Sharma, Nora Mattek, Jason Karlawish, Thomas Riley, Jeffrey Kaye
Summary: The study deployed in-home monitoring technologies to detect changing care needs in older adults and assess the efficacy of computer-based tools in informing care transitions. Despite lower than expected staff engagement with the data dashboard, a portion of residents required higher levels of care due to new or increased care needs.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
