The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Bacteria to alleviate metabolic syndrome

(2019) Fernando F. Anhê et al.   NATURE MEDICINE

The gut microbiome and elevated cardiovascular risk in obesity and autoimmunity

(2018) Lora J. Kasselman et al.   ATHEROSCLEROSIS

Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial

(2018) Bouke N. Salden et al.   CLINICAL NUTRITION

Distal versus proximal intestinal short-chain fatty acid release in man

(2018) Evelien PJG Neis et al.   GUT

The cell biology of systemic insulin function

(2018) Victoria L. Tokarz et al.   JOURNAL OF CELL BIOLOGY

Short-chain fatty acids suppress food intake by activating vagal afferent neurons

(2018) Chayon Goswami et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Microbiota in obesity: interactions with enteroendocrine, immune and central nervous systems

(2018) R. J. Mulders et al.   Obesity Reviews

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Postbiotics: An evolving term within the functional foods field

(2018) J.E. Aguilar-Toalá et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model

(2018) Johan W. E. Jocken et al.   Frontiers in Endocrinology

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

(2018) Jotham Suez et al.   CELL

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

(2018) Monica Bodogai et al.   Science Translational Medicine

Varieties, production, composition and health benefits of vinegars: A review

(2017) Chin Wai Ho et al.   FOOD CHEMISTRY

Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals

(2017) Emanuel E. Canfora et al.   GASTROENTEROLOGY

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

(2017) Leandra Abarca-Gómez et al.   LANCET

Gut Microbiota Interacts with Markers of Adipose Tissue Browning, Insulin Action and Plasma Acetate in Morbid Obesity

(2017) José María Moreno-Navarrete et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials

(2017) H. Borgeraas et al.   Obesity Reviews

Delayed utilization of some fast-fermenting soluble dietary fibers by human gut microbiota when presented in a mixture

(2017) Yunus E. Tuncil et al.   Journal of Functional Foods

Impact of Glycosidic Bond Configuration on Short Chain Fatty Acid Production from Model Fermentable Carbohydrates by the Human Gut Microbiota

(2017) Hannah Harris et al.   Nutrients

In vitro colonisation of the distal colon by Akkermansia muciniphila is largely mucin and pH dependent

(2017) F. Van Herreweghen et al.   Beneficial Microbes

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

(2017) Lucy Brooks et al.   Molecular Metabolism

The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages

(2017) Akira Nakajima et al.   PLoS One

A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation

(2017) Ryo Aoki et al.   Scientific Reports

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

(2017) Emanuel E. Canfora et al.   Scientific Reports

Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice

(2017) Boon Kee Beh et al.   Scientific Reports

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

(2016) Dorien Reijnders et al.   Cell Metabolism

Colonic acetate in obesity: location matters!

(2016) L. B. Bindels et al.   CLINICAL SCIENCE

Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

(2016) C. M. van der Beek et al.   CLINICAL SCIENCE

Short-Chain Fatty Acid Acetate Stimulates Adipogenesis and Mitochondrial Biogenesis via GPR43 in Brown Adipocytes

(2016) Jiamiao Hu et al.   ENDOCRINOLOGY

Selection of potential probiotic bifidobacteria and prebiotics for elderly by using in vitro faecal batch cultures

(2016) L. Valdés et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans

(2016) S Rahat-Rozenbloom et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice

(2016) Satoko Hanatani et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Role of Gut Microbiota and Short Chain Fatty Acids in Modulating Energy Harvest and Fat Partitioning in Youth

(2016) Martina Goffredo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vinegar as a functional ingredient to improve postprandial glycemic control-human intervention findings and molecular mechanisms

(2016) Joseph Lim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Importance of propionate for the repression of hepatic lipogenesis and improvement of insulin sensitivity in high-fat diet-induced obesity

(2016) Karolin Weitkunat et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Microbial signals to the brain control weight

(2016) Mirko Trajkovski et al.   NATURE

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

Activation of AMP-Activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells

(2016) Hitomi Maruta et al.   PLoS One

Obesity Statistics

(2016) Kristy Breuhl Smith et al.   PRIMARY CARE

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

(2016) Xue Gao et al.   Nature Communications

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes

(2016) Emilia Heimann et al.   Adipocyte

Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota

(2016) Yuanyuan Lu et al.   Scientific Reports

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

GPR43 Potentiates β-Cell Function in Obesity

(2015) Joanne C. McNelis et al.   DIABETES

The role of acetic acid on glucose uptake and blood flow rates in the skeletal muscle in humans with impaired glucose tolerance

(2015) P Mitrou et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Effects of wheat bran extract rich in arabinoxylan oligosaccharides and resistant starch on overnight glucose tolerance and markers of gut fermentation in healthy young adults

(2015) Elin V. Johansson Boll et al.   EUROPEAN JOURNAL OF NUTRITION

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

Composition and function of the undernourished neonatal mouse intestinal microbiome

(2015) Geoffrey A. Preidis et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion

(2015) Medha Priyadarshini et al.   MOLECULAR ENDOCRINOLOGY

Contrasting effects of fresh and fermented kimchi consumption on gut microbiota composition and gene expression related to metabolic syndrome in obese Korean women

(2015) Kyungsun Han et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

(2015) Cong Tang et al.   NATURE MEDICINE

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

The gut microbiome, diet and links to cardiometabolic and chronic disorders

(2015) Judith Aron-Wisnewsky et al.   Nature Reviews Nephrology

Obesity and the gastrointestinal microbiota: a review of associations and mechanisms

(2015) C. Graham et al.   NUTRITION REVIEWS

Targeting fatty acid metabolism to improve glucose metabolism

(2015) R. Stinkens et al.   Obesity Reviews

Increased gut microbiota diversity and abundance of Faecalibacterium prausnitzii and Akkermansia after fasting: a pilot study

(2015) Marlene Remely et al.   WIENER KLINISCHE WOCHENSCHRIFT

Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation

(2015) Mayu Kasubuchi et al.   Nutrients

Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study

(2014) Tannaz Eslamparast et al.   BRITISH JOURNAL OF NUTRITION

Functional Properties of Vinegar

(2014) Nilgün H. Budak et al.   JOURNAL OF FOOD SCIENCE

A Perspective on the Complexity of Dietary Fiber Structures and Their Potential Effect on the Gut Microbiota

(2014) Bruce R. Hamaker et al.   JOURNAL OF MOLECULAR BIOLOGY

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

(2014) Jin Young Huh et al.   MOLECULES AND CELLS

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

The Impact of Diet and Lifestyle on Gut Microbiota and Human Health

(2014) Michael Conlon et al.   Nutrients

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Sodium acetate decreases phosphorylation of hormone sensitive lipase in isoproterenol-stimulated 3T3-L1 mature adipocytes

(2014) Nicola Aberdein et al.   Adipocyte

Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study

(2013) Camilla Pedersen et al.   APPETITE

The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty

(2013) Astrid Plamboeck et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

(2013) Laura Wrzosek et al.   BMC BIOLOGY

The immune cells in adipose tissue

(2013) A. W. Ferrante   DIABETES OBESITY & METABOLISM

GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

(2013) Mark K. Nøhr et al.   ENDOCRINOLOGY

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Increased brain uptake and oxidation of acetate in heavy drinkers

(2013) Lihong Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

(2013) Anne Vrieze et al.   JOURNAL OF HEPATOLOGY

A Mixture of trans-Galactooligosaccharides Reduces Markers of Metabolic Syndrome and Modulates the Fecal Microbiota and Immune Function of Overweight Adults

(2013) Jelena Vulevic et al.   JOURNAL OF NUTRITION

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome

(2013) Fabíola Málaga Barreto et al.   NUTRITION

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Nutrient control of hunger by extrinsic gastrointestinal neurons

(2013) Gilles Mithieux   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Environmental factors influencing the efficacy of probiotic bacteria

(2012) Maria L Marco et al.   CURRENT OPINION IN BIOTECHNOLOGY

GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependence

(2012) A. R. Meloni et al.   DIABETES OBESITY & METABOLISM

Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans

(2012) J Fernandes et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Bacteria, Colonic Fermentation, and Gastrointestinal Health

(2012) George T. Macfarlane et al.   JOURNAL OF AOAC INTERNATIONAL

Short communication: Effect of supplementation with Lactobacillus casei Shirota on insulin sensitivity, β-cell function, and markers of endothelial function and inflammation in subjects with metabolic syndrome—A pilot study

(2012) N.J. Tripolt et al.   JOURNAL OF DAIRY SCIENCE

Vinegar co-ingestion does not improve oral glucose tolerance in patients with type 2 diabetes

(2012) Jan-Willem van Dijk et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Galacto-Oligosaccharides Have Prebiotic Activity in a Dynamic In Vitro Colon Model Using a 13C-Labeling Technique

(2012) Annet J. H. Maathuis et al.   JOURNAL OF NUTRITION

Profiling of fermentative metabolites in kimchi: Volatile and non-volatile organic acids

(2012) Soon-Mi Shim et al.   Journal of the Korean Society for Applied Biological Chemistry

Short chain fatty acids and their receptors: new metabolic targets

(2012) Brian T. Layden et al.   Translational Research

Negative association of acetate with visceral adipose tissue and insulin levels

(2012) Brian Layden et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Origins of metabolic complications in obesity

(2011) Bettina Mittendorfer   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Trichinella spiralis: The influence of short chain fatty acids on the proliferation of lymphocytes, the goblet cell count and apoptosis in the mouse intestine

(2011) J. Piekarska et al.   EXPERIMENTAL PARASITOLOGY

In Vitro Batch Fecal Fermentation Comparison of Gas and Short-Chain Fatty Acid Production Using “Slowly Fermentable” Dietary Fibers

(2011) Amandeep Kaur et al.   JOURNAL OF FOOD SCIENCE

Relevance of protein fermentation to gut health

(2011) Karen Windey et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Fermented kimchi reduces body weight and improves metabolic parameters in overweight and obese patients

(2011) Eun Kyoung Kim et al.   NUTRITION RESEARCH

Nutrition and L and K-enteroendocrine cells

(2011) Ruth Gutierrez-Aguilar et al.   Current Opinion in Endocrinology Diabetes and Obesity

Bacterial biogeography of the human digestive tract

(2011) Jennifer C. Stearns et al.   Scientific Reports

Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila

(2011) Muriel Derrien et al.   Frontiers in Microbiology

Vinegar reduces postprandial hyperglycaemia in patients with type II diabetes when added to a high, but not to a low, glycaemic index meal

(2010) S Liatis et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

High-resolution nuclear magnetic resonance spectroscopic study of metabolites in the cerebrospinal fluid of patients with cervical myelopathy and lumbar radiculopathy

(2010) Hideki Nagashima et al.   EUROPEAN SPINE JOURNAL

PPARγ in adipocyte differentiation and metabolism - Novel insights from genome-wide studies

(2010) Rasmus Siersbaek et al.   FEBS LETTERS

Bioavailability of Acetate from Two Vinegar Supplements: Capsule and Drink

(2010) Shino SUGIYAMA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults

(2009) Jill A Parnell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Expression of short-chain fatty acid receptor GPR41 in the human colon

(2009) Hideaki Tazoe et al.   BIOMEDICAL RESEARCH-TOKYO

Vinegar Intake Reduces Body Weight, Body Fat Mass, and Serum Triglyceride Levels in Obese Japanese Subjects

(2009) Tomoo KONDO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Effects of Acetate on Lipid Metabolism in Muscles and Adipose Tissues of Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

(2009) Hiromi YAMASHITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-α

(2009) Kristin R. Freeland et al.   BRITISH JOURNAL OF NUTRITION

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Acetic Acid Upregulates the Expression of Genes for Fatty Acid Oxidation Enzymes in Liver To Suppress Body Fat Accumulation

(2009) Tomoo Kondo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents

(2008) June Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acetogenesis and the Wood–Ljungdahl pathway of CO2 fixation

(2008) Stephen W. Ragsdale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Brain Regulation of Appetite and Satiety

(2008) Rexford S. Ahima et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Fructooligosaccharides exhibit more rapid fermentation than long-chain inulin in an in vitro fermentation system

(2008) Maria L. Stewart et al.   NUTRITION RESEARCH