The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine
出版年份 2019 全文链接
标题
The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine
作者
关键词
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出版物
MOLECULAR PSYCHIATRY
Volume 25, Issue 1, Pages 48-66
出版商
Springer Science and Business Media LLC
发表日期
2019-11-14
DOI
10.1038/s41380-019-0592-0
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
- (2019) Olav B Smeland et al. MOLECULAR PSYCHIATRY
- Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19)
- (2019) Liang Ma et al. MOLECULAR PSYCHIATRY
- Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia
- (2019) Brandon C. McKinney et al. NEUROPSYCHOPHARMACOLOGY
- Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder
- (2019) Huijuan Li et al. NEUROPSYCHOPHARMACOLOGY
- Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
- (2019) David M. Howard et al. NATURE NEUROSCIENCE
- Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
- (2019) Laura M. Huckins et al. NATURE GENETICS
- Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions
- (2019) Summer B. Thyme et al. CELL
- Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders
- (2019) Zhonghua Hu et al. MOLECULAR PSYCHIATRY
- Genome-wide association study identifies 30 loci associated with bipolar disorder
- (2019) Eli A. Stahl et al. NATURE GENETICS
- Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits
- (2019) Eric R. Gamazon et al. NATURE GENETICS
- The association between familial risk and brain abnormalities is disease-specific: an ENIGMA–Relatives study of schizophrenia and bipolar disorder
- (2019) Sonja M.C. de Zwarte et al. BIOLOGICAL PSYCHIATRY
- Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia
- (2019) Leonardo Collado-Torres et al. NEURON
- Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies
- (2019) Amber Berdenis van Berlekom et al. SCHIZOPHRENIA BULLETIN
- Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study
- (2019) Jentien M. Vermeulen et al. BRITISH JOURNAL OF PSYCHIATRY
- Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder
- (2019) Huijuan Li et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Synergistic effects of common schizophrenia risk variants
- (2019) Nadine Schrode et al. NATURE GENETICS
- Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis
- (2018) Marie Stefanie Kejser Starzer et al. AMERICAN JOURNAL OF PSYCHIATRY
- A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability
- (2018) Theron A. Russell et al. BIOLOGICAL PSYCHIATRY
- Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
- (2018) Douglas M. Ruderfer et al. CELL
- Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity
- (2018) Dirk J.A. Smit et al. HUMAN BRAIN MAPPING
- CNTNAP2 stabilizes interneuron dendritic arbors through CASK
- (2018) Ruoqi Gao et al. MOLECULAR PSYCHIATRY
- Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures
- (2018) Emanuele Felice Osimo et al. MOLECULAR PSYCHIATRY
- Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
- (2018) Jeanne E. Savage et al. NATURE GENETICS
- Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights
- (2018) Alexander Gusev et al. NATURE GENETICS
- Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
- (2018) Antonio F. Pardiñas et al. NATURE GENETICS
- Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
- (2018) Andrew E. Jaffe et al. NATURE NEUROSCIENCE
- Dendritic structural plasticity and neuropsychiatric disease
- (2018) Marc P. Forrest et al. NATURE REVIEWS NEUROSCIENCE
- Bipolar disorders
- (2018) Eduard Vieta et al. Nature Reviews Disease Primers
- Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia
- (2018) Janet H.T. Song et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
- (2018) Michael J. Gandal et al. SCIENCE
- Integrative functional genomic analysis of human brain development and neuropsychiatric risks
- (2018) Mingfeng Li et al. SCIENCE
- Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk
- (2018) Prashanth Rajarajan et al. SCIENCE
- Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci
- (2017) John F Fullard et al. HUMAN MOLECULAR GENETICS
- The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders
- (2017) X Xiao et al. MOLECULAR PSYCHIATRY
- The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions
- (2017) H Chang et al. MOLECULAR PSYCHIATRY
- The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders
- (2017) H Chang et al. MOLECULAR PSYCHIATRY
- Hippocampal subfield volumes in mood disorders
- (2017) B Cao et al. MOLECULAR PSYCHIATRY
- Cannabis use and risk of schizophrenia: a Mendelian randomization study
- (2017) J Vaucher et al. MOLECULAR PSYCHIATRY
- GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
- (2017) J W Trampush et al. MOLECULAR PSYCHIATRY
- An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome
- (2017) Bernard Ng et al. NATURE NEUROSCIENCE
- Genetic insights into the neurodevelopmental origins of schizophrenia
- (2017) Rebecca Birnbaum et al. NATURE REVIEWS NEUROSCIENCE
- TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation
- (2017) Smita Yadav et al. NEURON
- Spine Dynamics: Are They All the Same?
- (2017) Kalen P. Berry et al. NEURON
- The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder
- (2017) Xiao Xiao et al. NEUROPSYCHOPHARMACOLOGY
- Structural variants caused byAluinsertions are associated with risks for many human diseases
- (2017) Lindsay M. Payer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel genetic loci associated with hippocampal volume
- (2017) Derrek P. Hibar et al. Nature Communications
- γ-Protocadherins Interact with Neuroligin-1 and Negatively Regulate Dendritic Spine Morphogenesis
- (2017) Michael J. Molumby et al. Cell Reports
- Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition
- (2017) Julia M. Sheffield et al. JAMA Psychiatry
- Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function
- (2017) Olav B. Smeland et al. JAMA Psychiatry
- Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania
- (2017) Puja K. Parekh et al. BIOLOGICAL PSYCHIATRY
- Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance
- (2016) Ming Li et al. BRITISH JOURNAL OF PSYCHIATRY
- Abnormal asymmetries in subcortical brain volume in schizophrenia
- (2016) N Okada et al. MOLECULAR PSYCHIATRY
- Subcortical volumetric abnormalities in bipolar disorder
- (2016) D P Hibar et al. MOLECULAR PSYCHIATRY
- Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia
- (2016) S P Hagenaars et al. MOLECULAR PSYCHIATRY
- Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)
- (2016) G Davies et al. MOLECULAR PSYCHIATRY
- Schizophrenia risk from complex variation of complement component 4
- (2016) Aswin Sekar et al. NATURE
- Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
- (2016) Christian R Marshall et al. NATURE GENETICS
- Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
- (2016) Zhihong Zhu et al. NATURE GENETICS
- Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
- (2016) Ronald S Duman et al. NATURE MEDICINE
- A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus
- (2016) Ming Li et al. NATURE MEDICINE
- Gene expression elucidates functional impact of polygenic risk for schizophrenia
- (2016) Menachem Fromer et al. NATURE NEUROSCIENCE
- Novel genetic loci underlying human intracranial volume identified through genome-wide association
- (2016) Hieab H H Adams et al. NATURE NEUROSCIENCE
- Schizophrenia risk variants in ITIH4 and CALN1 regulate gene expression in the dorsolateral prefrontal cortex
- (2016) Kazutaka Ohi et al. PSYCHIATRIC GENETICS
- Cognition as a target in schizophrenia, bipolar disorder and depression
- (2015) Anabel Martinez-Aran et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
- (2015) T G M van Erp et al. MOLECULAR PSYCHIATRY
- Common genetic variants influence human subcortical brain structures
- (2015) Derrek P. Hibar et al. NATURE
- Sparse whole-genome sequencing identifies two loci for major depressive disorder
- (2015) Na Cai et al. NATURE
- The PsychENCODE project
- (2015) Schahram Akbarian et al. NATURE NEUROSCIENCE
- Commingling analysis of age-of-onset in bipolar I disorder and the morbid risk for major psychoses in first degree relatives of bipolar I probands
- (2014) Maria Grigoroiu-Serbanescu et al. JOURNAL OF AFFECTIVE DISORDERS
- Synaptic dysregulation in a human iPS cell model of mental disorders
- (2014) Zhexing Wen et al. NATURE
- Psychiatric Risk Factor ANK3/Ankyrin-G Nanodomains Regulate the Structure and Function of Glutamatergic Synapses
- (2014) Katharine R. Smith et al. NEURON
- Prefrontal Cortical Dendritic Spine Pathology in Schizophrenia and Bipolar Disorder
- (2014) Glenn T. Konopaske et al. JAMA Psychiatry
- Beyond GWASs: Illuminating the Dark Road from Association to Function
- (2013) Stacey L. Edwards et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Neuropsychological Impairments in Schizophrenia and Psychotic Bipolar Disorder: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Study
- (2013) S. Kristian Hill et al. AMERICAN JOURNAL OF PSYCHIATRY
- ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1
- (2013) Daimei Sasayama et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
- (2013) LANCET
- Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function and bipolar disorder susceptibility
- (2013) M Li et al. MOLECULAR PSYCHIATRY
- Genetic Variants on 3q21 and in the Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: A Genetic Association Study
- (2013) Kenji Kondo et al. PLoS One
- Matrix eQTL: ultra fast eQTL analysis via large matrix operations
- (2012) A. A. Shabalin BIOINFORMATICS
- Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder
- (2012) Evangelos Vassos et al. BIOLOGICAL PSYCHIATRY
- Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
- (2012) Hyo Jung Kang et al. NATURE MEDICINE
- Synaptic Dysfunction in Depression: Potential Therapeutic Targets
- (2012) R. S. Duman et al. SCIENCE
- Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression
- (2011) Gerome Breen et al. NATURE GENETICS
- Dendritic spine pathology in neuropsychiatric disorders
- (2011) Peter Penzes et al. NATURE NEUROSCIENCE
- HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
- (2011) L. D. Ward et al. NUCLEIC ACIDS RESEARCH
- Alu elements: know the SINEs
- (2011) Prescott Deininger GENOME BIOLOGY
- Analysis of Dendritic Spine Morphology in Cultured CNS Neurons
- (2011) Deepak P. Srivastava et al. Jove-Journal of Visualized Experiments
- Neurocognitive Endophenotypes for Bipolar Disorder Identified in Multiplex Multigenerational Families
- (2010) David C. Glahn et al. ARCHIVES OF GENERAL PSYCHIATRY
- LocusZoom: regional visualization of genome-wide association scan results
- (2010) R. J. Pruim et al. BIOINFORMATICS
- Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
- (2010) H. J. Williams et al. HUMAN MOLECULAR GENETICS
- SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
- (2010) S. Michan et al. JOURNAL OF NEUROSCIENCE
- Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1
- (2010) Francis J McMahon et al. NATURE GENETICS
- Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
- (2010) Akiko Hayashi-Takagi et al. NATURE NEUROSCIENCE
- Abnormal neural oscillations and synchrony in schizophrenia
- (2010) Peter J. Uhlhaas et al. NATURE REVIEWS NEUROSCIENCE
- From genotype to EEG endophenotype: a route for post-genomic understanding of complex psychiatric disease?
- (2010) Eco JC de Geus Genome Medicine
- Schizophrenia
- (2009) Jim van Os et al. LANCET
- Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
- (2009) Paul Lichtenstein et al. LANCET
- The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
- (2009) E K Green et al. MOLECULAR PSYCHIATRY
- Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
- (2009) Kevin M Woolfrey et al. NATURE NEUROSCIENCE
- Neurocognitive Dysfunction in Bipolar and Schizophrenia Spectrum Disorders Depends on History of Psychosis Rather Than Diagnostic Group
- (2009) C. Simonsen et al. SCHIZOPHRENIA BULLETIN
- Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images
- (2008) Alfredo Rodriguez et al. PLoS One
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