Article
Multidisciplinary Sciences
Lin Zhu, Ting Gao, Yi Huang, Jing Jin, Di Wang, Leike Zhang, Yanwen Jin, Ping Li, Yong Hu, Yan Wu, Hainan Liu, Qincai Dong, Guangfei Wang, Tong Zheng, Caiwei Song, Yu Bai, Xun Zhang, Yaoning Liu, Weihong Yang, Ke Xu, Gang Zou, Lei Zhao, Ruiyuan Cao, Wu Zhong, Xianzhu Xia, Gengfu Xiao, Xuan Liu, Cheng Cao
Summary: The Ebola virus VP35 protein uses the host PKA-CREB1 signaling pathway for viral replication and pathogenesis, and upregulates the transcription of coagulation-related genes, potentially leading to hemorrhage.
NATURE COMMUNICATIONS
(2022)
Article
Psychiatry
Xiaorong Wang, Guofu Zhang, Weihong Lu, Yi Zhang, Weixing Fan, Wei Tang, Chen Zhang
Summary: This study identified a novel BD risk SNP rs10932201 in Han Chinese, which may be a risk factor for cognitive dysfunction in patients with BD. The G allele of rs10932201 was associated with a higher frequency in BD patients compared to control subjects, and carriers of this allele had significantly lower levels of CREB1 expression in intralobular white matter.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Shi Yao, Hao Wu, Tong-Tong Liu, Jia-Hao Wang, Jing-Miao Ding, Jing Guo, Yu Rong, Xin Ke, Ruo-Han Hao, Shan-Shan Dong, Tie-Lin Yang, Yan Guo
Summary: The research focuses on identifying genes associated with bipolar disorder through a new transcriptome-wide association study method. This method, called ETWAS, takes into account genetic variants and epigenetic features to uncover novel candidate genes overlooked by previous studies. Several genes were identified as potentially linked to BD, shedding light on the complex genetic factors contributing to the disorder.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Multidisciplinary Sciences
Karina Patasova, Annechien E. G. Haarman, Anthony M. Musolf, Omar A. Mahroo, Jugnoo S. Rahi, Mario Falchi, Virginie J. M. Verhoeven, Joan E. Bailey-Wilson, Caroline C. W. Klaver, Priya Duggal, Alison Klein, Jeremy A. Guggenheim, Chris J. Hammond, Pirro G. Hysi
Summary: This study demonstrates the importance of rare variants in the genetic risk of refractive errors, with strong associations found between the genes SIX6 and CRX and SPHE. These genes are related to eye, retina, optic disc development, photoreceptor specification, and expression in the retina.
Article
Clinical Neurology
Vinay Srinivas Bharadhwaj, Sarah Mubeen, Astghik Sargsyan, Geena Mariya Jose, Stefan Geissler, Martin Hofmann-Apitius, Daniel Domingo-Fernandez, Alpha Tom Kodamullil
Summary: Schizophrenia and bipolar disorder share similar neurobiological mechanisms and comorbidities such as type 2 diabetes mellitus (T2DM). By analyzing multiple gene expression datasets, this study identifies shared patterns and pathways related to the immune and nervous systems. These findings suggest potential mechanisms mediating the link between schizophrenia, bipolar disorder, and T2DM.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Jin-Xiu Li, Xue-Zhen Huang, Wei-ping Fu, Xiao-hua Zhang, David H. Mauki, Jing Zhang, Chang Sun, Lu-Ming Dai, Li Zhong, Li Yu, Ya-ping Zhang
Summary: This study conducted comprehensive bioinformatics analyses and experimental verifications to explore the regulatory mechanism of rs10516526 and GSTCD in COPD. The results showed that low expression of GSTCD was associated with COPD, and the transcription factors C-Jun and CREB1 were found to be essential for the regulation of GSTCD by specific genetic signals. Moreover, certain mutated forms of these signals showed a stronger binding ability to the transcription factors, potentially leading to allele-specific regulation and reduced susceptibility to COPD.
Article
Multidisciplinary Sciences
Eloi Gine-Serven, Maria Martinez-Ramirez, Ester Boix-Quintana, Eva Davi-Loscos, Nicolau Guanyabens, Virginia Casado, Desiree Muriana, Cristina Torres-Rivas, M. J. Cuesta, Javier Labad
Summary: This study found that thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis, including fewer prodromal symptoms, shorter duration of untreated psychosis, and sudden onset of psychosis. Additionally, thyroid hormone levels were also associated with affective psychosis diagnoses at the 12-month follow-up.
Article
Psychiatry
Camila Nascimento, Helena Kyunghee Kim, Paula Villela Nunes, Renata Elaine Paraiso Leite, De Oliveira Katia Cristina, Andre Barbosa, Fernanda Bernardi Bertonha, Carlos Alberto Moreira-Filho, Wilson Jacob-Filho, Ricardo Nitrini, Carlos A. Pasqualucci, Lea Tenenholz Grinberg, Claudia Kimie Suemoto, Helena Paula Brentani, Beny Lafer
Summary: In this study, gene expression changes in the hippocampus of older patients with bipolar disorder were examined, and several genes of interest were identified. These findings provide potential targets for future research to understand the pathophysiology of bipolar disorder in later life.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Behavioral Sciences
Joanne S. Carpenter, Jacob J. Crouse, Elizabeth M. Scott, Sharon L. Naismith, Chloe Wilson, Jan Scott, Kathleen R. Merikangas, Ian B. Hickie
Summary: Major mood syndromes are common and disabling mental disorders, with a lack of clear delineation of underlying pathophysiological mechanisms hindering prevention and treatment. Dysfunction of the 24-h circadian system is a potential mechanism linked to mood syndromes. 'Circadian depression' is proposed as a new clinical phenotype with disrupted 24-h sleep-wake cycles, reduced motor activity, low subjective energy, and weight gain as key characteristics. Early onset, bipolarity features, poor response to traditional antidepressants, and concurrent cardiometabolic and inflammatory issues are part of the illness course associated with this phenotype. Identifying and targeting circadian disturbances in mood syndromes may offer valuable clinical insights for effective treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Xiaoyan Li, Xi Su, Jiewei Liu, Huijuan Li, Ming Li, Wenqiang Li, Xiong-Jian Luo
Summary: The study identified 53 significant risk genes for depression through a transcriptome-wide association study, with 7 of them showing associations in two independent brain expression datasets. Pathway enrichment analysis revealed biologically pathways relevant to depression. Further mechanistic study and functional characterization of the risk genes may facilitate the diagnostics and therapeutics for depression.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Florian Krull, Ibrahim Akkouh, Timothy Hughes, Francesco Bettella, Lavinia Athanasiu, Olav B. Smeland, Kevin S. O'Connell, Hans-Richard Brattbakk, Vidar M. Steen, Nils Eiel Steen, Srdjan Djurovic, Ole A. Andreassen
Summary: The study found significant associations between lithium serum concentrations and the expression levels of 52 genes, including 32 up-regulated genes and 20 downregulated genes. The down-regulated gene set was enriched for processes related to the translational machinery. Two adverse effects, tremor and xerostomia, were significantly associated with three or more lithium-associated genes, while the largest effect was seen between CAMK1D expression and nausea/vomiting. These results suggest potential transcriptional mechanisms that may predict lithium adverse effects and have implications for clinical practice.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Monica Aas, Ole A. Andreassen, Johannes Gjerstad, Linn Rodevand, Gabriela Hjell, Ingrid Torp Johansen, Synve Hoffart Lunding, Monica B. E. G. Ormerod, Trine V. Lagerverg, Nils Eiel Steen, Srdjan Djurovic, Ibrahim Akkouh
Summary: Exposure to early life trauma increases the risk of psychopathology, and ANK3 mRNA levels have been found to moderate the association between childhood trauma and affective traits in mental disorders.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Hildur Soley Sveinsdottir, Christian Christensen, Haraldur Porsteinsson, Perrine Lavalou, Matthew O. Parker, Alena Shkumatava, William H. J. Norton, Emile Andriambeloson, Stephanie Wagner, Karl Aegir Karlsson
Summary: This study established a genetic model of ADHD in zebrafish and identified five potential non-stimulant therapeutic options. These findings provide a new tool for understanding the neural circuits and etiology of ADHD, and also discover novel treatment options.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elizabeth M. Humphries, Kwangmi Ahn, Rachel L. Kember, Fabiana L. Lopes, Evelina Mocci, Juan M. Peralta, John Blangero, David C. Glahn, Fernando S. Goes, Peter P. Zandi, Peter Kochunov, Cristopher Van Hout, Alan R. Shuldiner, Toni I. Pollin, Braxton D. Mitchell, Maja Bucan, L. Elliot Hong, Francis J. McMahon, Seth A. Ament
Summary: By conducting a genome-wide association study of mood disorders in a founder population, the Old Order Amish, four significant risk loci were identified, all of which were associated with more than a 2-fold relative risk. Further assessments revealed effects of these risk variants on sub-clinical depressive symptoms and information processing speed. Network analysis suggested that these risk loci may harbor novel risk-associated genes, which interact with known neuropsychiatry-associated genes through gene interaction networks. Annotation of the variants at these risk loci revealed enrichment of non-synonymous variants in two genes encoding neurodevelopmental transcription factors, CUX1 and CNOT1. These findings provide valuable insights into the genetic architecture of mood disorders and serve as a foundation for mechanistic and clinical studies.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Trang T. T. Truong, Chiara C. Bortolasci, Srisaiyini Kidnapillai, Briana Spolding, Bruna Panizzutti, Zoe S. J. Liu, Brad Watmuff, Jee Hyun Kim, Olivia M. Dean, Mark Richardson, Michael Berk, Ken Walder
Summary: This study evaluated the transcriptional changes induced by four commonly prescribed psychotropic drugs for bipolar disorder (BD) and identified potential genes and biological pathways associated with therapeutic efficacy and BD pathophysiology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Developmental
Helene Vulser, Herve S. Lemaitre, Stella Guldner, Pauline Bezivin-Frere, Martin Loffler, Anna S. Sarvasmaa, Jessica Massicotte-Marquez, Eric Artiges, Marie-Laure Paillere Martinot, Irina Filippi, Ruben Miranda, Argyris Stringaris, Betteke Maria van Noort, Jani Penttila, Yvonne Grimmer, Andreas Becker, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Juliane H. Frohner, Hugh Garavan, Antoine Grigis, Penny A. Gowland, Andreas Heinz, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Philip A. Spechler, Henrik Walter, Robert Whelan, Gunter Schumann, Herta Flor, Jean-Luc Martinot, Frauke Nees
Summary: Adolescence is a critical period for circadian rhythm, with a shift toward eveningness. Eveningness in adolescence predicts later onset of depressive symptoms. This study investigates the structural variations associated with chronotype in early adolescence and its contribution to the development of depressive symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Alice Chavanne, Marie Laure Paillere Martinot, Jani Penttilae, Yvonne Grimmer, Patricia Conrod, Argyris Stringaris, Betteke van Noort, Corinna Isensee, Andreas Becker, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah S. Hohmann, Sabina Millenet, Juliane Froehner, Michael Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jean-Luc Martinot, Eric Artiges
Summary: Recent studies have found MRI correlates of prospective anxiety symptoms in youth, but their predictive value is still uncertain. This study used machine-learning algorithms to predict clinical anxiety using MRI data and psychometric scores. The results showed that psychometric features were the main predictors for overall anxiety disorders, while MRI regional volumes were more valuable for predicting GAD. In conclusion, future clinical anxiety in non-anxious 14-year-old adolescents can be individually predicted using psychometric features, and including neuroanatomical data improves the prediction of GAD.
MOLECULAR PSYCHIATRY
(2023)
Article
Genetics & Heredity
Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond Walters, Karen Therrien, Trine Tollerup Nielsen, Leila Farajzadeh, Georgios Voloudakis, Jaroslav Bendl, Biau Zeng, Wen Zhang, Jakob Grove, Thomas D. Als, Jinjie Duan, F. Kyle Satterstrom, Jonas Bybjerg-Grauholm, Marie Baekved-Hansen, Olafur O. Gudmundsson, Sigurdur H. Magnusson, Gisli Baldursson, Katrin Davidsdottir, Gyda S. Haraldsdottir, Esben Agerbo, Gabriel E. Hoffman, Soren Dalsgaard, Joanna Martin, Marta Ribases, Dorret Boomsma, Maria Soler Artigas, Nina Roth Mota, Daniel Howrigan, Sarah E. Medland, Tetyana Zayats, Veera M. Rajagopal, Merete Nordentoft, Ole Mors, David M. Hougaard, Preben Bo Mortensen, Mark J. Daly, Stephen Faraone, Hreinn Stefansson, Panos Roussos, Barbara Franke, Thomas Werge, Benjamin M. Neale, Kari Stefansson, Anders D. Borglum
Summary: This study conducted a meta-analysis of genome-wide association studies on ADHD and identified 27 significant genetic loci associated with ADHD. They also found that these loci were enriched with genes involved in early brain development. Moreover, they discovered an increased load of rare protein-truncating variants in ADHD, implicating SORCS3 as a potential gene involved in ADHD.
Article
Computer Science, Interdisciplinary Applications
Harshvardhan Gazula, Kelly Rootes-Murdy, Bharath Holla, Sunitha Basodi, Zuo Zhang, Eric Verner, Ross Kelly, Pratima Murthy, Amit Chakrabarti, Debasish Basu, Subodh Bhagyalakshmi Nanjayya, Rajkumar Lenin Singh, Roshan Lourembam Singh, Kartik Kalyanram, Kamakshi Kartik, Kumaran Kalyanaraman, Krishnaveni Ghattu, Rebecca Kuriyan, Sunita Simon Kurpad, Gareth J. Barker, Rose Dawn Bharath, Sylvane Desrivieres, Meera Purushottam, Dimitri Papadopoulos Orfanos, Eesha Sharma, Matthew Hickman, Mireille Toledano, Nilakshi Vaidya, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rudiger Bruhl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Tomas Paus, Luise Poustka, Juliane H. Frohner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne Winterer, Robert Whelan, Jessica A. Turner, Anand D. Sarwate, Sergey M. Plis, Vivek Benegal, Gunter Schumann, Vince D. Calhoun
Summary: With the growth of decentralized/federated analysis approaches in neuroimaging, the opportunities to study brain disorders using data from multiple sites has grown multi-fold. One such initiative is the Neuromark, a fully automated spatially constrained independent component analysis (ICA) that is used to link brain network abnormalities among different datasets, studies, and disorders while leveraging subject-specific networks.
Article
Substance Abuse
Rene Freichel, Janine Pfirrmann, Janna Cousjin, Peter de Jong, Ingmar Franken, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah H. Hohmann, Juliane N. Froehner, Michael Smolka, Nilakshi Vaidya, Robert Whelan, Gunter Schumann, Henrik M. Walter, Ilya W. Veer, Reinout Wiers
Summary: This study aims to examine the dynamic associations between distal and proximal risk factors (personality traits, life stressors, and drinking motives) and their relationship with alcohol use in adolescence and early adulthood. The findings suggest that heavy and frequent alcohol use, along with social drinking motives, are key targets for preventing alcohol-related problems during late adolescence. However, there was no evidence found for personality traits and life stressors predisposing towards distinct drinking motives over time.
Review
Medicine, General & Internal
Annika Walinski, Julia Sander, Gabriel Gerlinger, Vera Clemens, Andreas Meyer-Lindenberg, Andreas Heinz
Summary: Climate change has negative and complex effects on human living conditions and health, including mental health. Extreme weather events and chronic stresses due to climate change increase the risk of mental disorders and psychological distress. Further research is needed to understand the mechanisms and effects of climate change on mental health.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Lachlan T. Strike, Narelle K. Hansell, Kai-Hsiang Chuang, Jessica L. Miller, Greig I. de Zubicaray, Paul M. Thompson, Katie L. McMahon, Margaret J. Wright
Summary: The QTAB dataset includes multimodal neuroimaging, cognitive, and mental health data of adolescent twins. It provides a detailed methodology and technical validation for data usage. The project aims to promote health-related research in adolescence.
Article
Neurosciences
Kristina Meyer, Catherine Hindi Attar, Jana Fiebig, Thomas Stamm, Tyler R. Bassett, Michael Bauer, Udo Dannlowski, Thomas Ethofer, Irina Falkenberg, Andreas Jansen, Georg Juckel, Tilo Kircher, Christoph Mulert, Gregor Leicht, Anne Rau, Jonas Rauh, Dirk Ritter, Philipp Ritter, Sarah Trost, Christoph Vogelbacher, Henrik Walter, Sarah Wolter, Martin Hautzinger, Felix Bermpohl
Summary: In this study, an emotion-centered psychotherapeutic intervention (FEST) was found to enhance amygdala activation and connectivity in patients with bipolar disorder (BD), and this increase was associated with a reduction in depressive symptoms.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Biochemical Research Methods
Andreas Glaessner, Gerda Wurpts, Stefanie Roeseler, Amir S. Yazdi, Christine Kraemer, Amol Fatangare, Albert Sickmann, Per Hoffmann, Markus Noethen, Bernhardt Sachs
Summary: The lymphocyte transformation test (LTT) is used to detect drug sensitization in allergic patients. However, the specificity of LTT has not been analyzed in relation to specific drugs in a larger control group. This study investigated the impact of amoxicillin, cefuroxime, and clindamycin on the specificity of LTT with ELISA read-out in control persons.
JOURNAL OF IMMUNOLOGICAL METHODS
(2023)
Article
Biochemistry & Molecular Biology
Azmeraw T. Amare, Anbupalam Thalamuthu, Klaus Oliver Schubert, Janice M. Fullerton, Muktar Ahmed, Simon Hartmann, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Liping Hou, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Roland Hasler, Helene Richard-Lepouriel, Nader Perroud, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Maria Del Zompo, J. Raymond DePaulo, Bruno etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Andreas J. Fallgatter, Sophia Stegmaier, Thomas Ethofer, Silvia Biere, Kristiyana Petrova, Ceylan Schuster, Kristina Adorjan, Monika Budde, Maria Heilbronner, Janos L. Kalman, Mojtaba Oraki Kohshour, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Udo Dannlowski, Detlef Dietrich, Christian Figge, Markus Jaeger, Fabian U. Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Max Schmauss, Andrea Schmitt, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Joerg Zimmermann, Till F. M. Andlauer, Andre Fischer, Felix Bermpohl, Philipp Ritter, Silke Matura, Anna Gryaznova, Irina Falkenberg, Cueneyt Yildiz, Tilo Kircher, Julia Schmidt, Marius Koch, Kathrin Gade, Sarah Trost, Ida S. Haussleiter, Martin Lambert, Anja C. Rohenkohl, Vivien Kraft, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Scott R. Clark, Bernhard T. Baune
Summary: A polygenic score (Li-PGS(+)) for lithium treatment response in bipolar disorder patients was developed in this study. Li-PGS(+) was found to be positively associated with lithium treatment response. Gene-based analysis also identified 36 candidate genes related to lithium's molecular mechanism.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Andrew Zalesky, Ben J. Harrison, Christopher G. Davey, Carles Soriano-Mas, Narcis Cardoner, Jeggan Tiego, Murat Yucel, Leah Braganza, Chao Suo, Michael Berk, Sue Cotton, Mark A. Bellgrove, Andre F. Marquand, Alex Fornito
Summary: Classical case-control research often overlooks the individual heterogeneity of people with mental illness. Our study provides a comprehensive multiscale characterization of gray matter volume differences in individuals diagnosed with six different mental conditions. We found that while the regional deviations in gray matter volume were highly varied, they were embedded within common functional circuits and networks.
NATURE NEUROSCIENCE
(2023)
Article
Behavioral Sciences
M. Ribases, M. Mitjans, C. A. Hartman, M. Soler Artigas, D. Demontis, H. Larsson, J. A. Ramos-Quiroga, J. Kuntsi, S. Faraone, AD. Borglum, A. Reif, B. Franke, B. Cormand
Summary: This review summarizes and interprets the genetic architecture of comorbidities between attention-deficit/hyperactivity disorder (ADHD) and other psychiatric disorders and traits. Quantitative genetic studies indicate the substantial role of genetic factors in the co-occurrence of ADHD with various disorders and traits, and molecular genetic correlations from genome-wide association studies provide smaller effect estimates compared to twin studies. The identification of specific genetic variants and biological pathways underlying comorbidity is still in its early stages. Causal inference analyses using genetic data support causal relationships between ADHD and comorbid disorders, but bidirectional effects suggest complex relationships.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Primary Health Care
Linda Sanftenberg, Antina Beutel, Chris Maria Friemel, Robert Philipp Kosilek, Maggie Schauer, Thomas Elbert, Ulf-Dietrich Reips, Sabine Gehrke-Beck, Tomke Schubert, Konrad Schmidt
Summary: The PICTURE trial in Germany aims to test a brief psychological intervention for post-traumatic stress disorder symptoms following intensive care unit treatment. This study found that a short-term psychological intervention in a primary care setting is feasible and well-received, particularly when there is a long-term trustful relationship between patient and GP team, the intervention is conducted by a medical doctor, the GP team maintains a professional emotional distance, and the intervention is brief.
Meeting Abstract
Biochemistry & Molecular Biology
Axel Schmidt, Eva C. Schulte, Susanne Motameny, Nicolas Casadei, Fabian Brand, Michael Nothnagel, Elaheh Vojgani, German Demidov, Kerstin Becker, Janine Altmueller, Andre Heimbach, Markus M. Noethen, Peter Nuernberg, Stephan Ossowski, Olaf Riess, Kerstin Ludwig
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Lisa Sindermann, Udo Dannlowski, Susanne Meinert, Elisabeth Johanna Leehr, Lena Waltemate, Hannah Lemke, Alexandrea Winter, Katharina Thiel, Katharina Brosch, Tina Meller, Frederike Stein, Per Hoffmann, Axel Krug, Tilo Kircher, Till Andlauer, Eva Beins, Markus M. Noethen, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
