Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders
出版年份 2019 全文链接
标题
Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders
作者
关键词
-
出版物
MOLECULAR PSYCHIATRY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-05-29
DOI
10.1038/s41380-019-0438-9
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways
- (2019) Xiaoting Wu et al. NEURON
- Phenotypic spectrum of NRXN1 mono‐ and bi‐allelic deficiency: a systematic review
- (2019) P. Castronovo et al. CLINICAL GENETICS
- Can Animal Models of Copy Number Variants that Predispose to Schizophrenia Elucidate Underlying Biology?
- (2018) Annika Forsingdal et al. BIOLOGICAL PSYCHIATRY
- NRXN1 deletion syndrome; phenotypic and penetrance data from 34 families
- (2018) Maryam Al Shehhi et al. European Journal of Medical Genetics
- An integrative analysis of non-coding regulatory DNA variations associated with autism spectrum disorder
- (2018) Sarah M. Williams et al. MOLECULAR PSYCHIATRY
- Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures
- (2018) Emanuele Felice Osimo et al. MOLECULAR PSYCHIATRY
- Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
- (2018) Andrew E. Jaffe et al. NATURE NEUROSCIENCE
- Dendritic structural plasticity and neuropsychiatric disease
- (2018) Marc P. Forrest et al. NATURE REVIEWS NEUROSCIENCE
- Neurexin–Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction
- (2018) Guanglin Xing et al. eLife
- Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships
- (2018) Peng Zhang et al. CELL
- α-Neurexins Together with α2δ-1 Auxiliary Subunits Regulate Ca2+ Influx through Cav2.1 Channels
- (2018) Johannes Brockhaus et al. JOURNAL OF NEUROSCIENCE
- γ-Neurexin and Frizzled Mediate Parallel Synapse Assembly Pathways Antagonized by Receptor Endocytosis
- (2018) Peri T. Kurshan et al. NEURON
- Predicting polygenic risk of psychiatric disorders
- (2018) Alicia R. Martin et al. BIOLOGICAL PSYCHIATRY
- Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
- (2018) Michael J. Gandal et al. SCIENCE
- The neuronal protein Neurexin directly interacts with the Scribble–Pix complex to stimulate F-actin assembly for synaptic vesicle clustering
- (2017) Menglong Rui et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An intra-amygdala circuit specifically regulates social fear learning
- (2017) Robert C Twining et al. NATURE NEUROSCIENCE
- Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation
- (2017) Xinlu Ding et al. NATURE NEUROSCIENCE
- Genetic insights into the neurodevelopmental origins of schizophrenia
- (2017) Rebecca Birnbaum et al. NATURE REVIEWS NEUROSCIENCE
- Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome
- (2017) Alden Y. Huang et al. NEURON
- Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calcium Channels
- (2017) Xia-Jing Tong et al. NEURON
- Genome-wide Analysis of the Role of Copy Number Variation in Schizophrenia Risk in Chinese
- (2016) Zhiqiang Li et al. BIOLOGICAL PSYCHIATRY
- Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin
- (2016) Sandeep K. Singh et al. CELL
- Molecular characterization of NRXN1 deletions from 19,263 clinical microarray cases identifies exons important for neurodevelopmental disease expression
- (2016) Chelsea Lowther et al. GENETICS IN MEDICINE
- Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held
- (2016) B Zhang et al. MOLECULAR PSYCHIATRY
- Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
- (2016) Christian R Marshall et al. NATURE GENETICS
- Neurexin regulates nighttime sleep by modulating synaptic transmission
- (2016) Huawei Tong et al. Scientific Reports
- Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.
- (2015) James Dachtler et al. BEHAVIORAL NEUROSCIENCE
- Phenotypic characterization of nonsocial behavioral impairment in neurexin 1α knockout rats.
- (2015) Frederic Esclassan et al. BEHAVIORAL NEUROSCIENCE
- Investigation of the Prenatal Expression Patterns of 108 Schizophrenia-Associated Genetic Loci
- (2015) Rebecca Birnbaum et al. BIOLOGICAL PSYCHIATRY
- β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling
- (2015) Garret R. Anderson et al. CELL
- Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1
- (2015) ChangHui Pak et al. Cell Stem Cell
- Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogaster
- (2015) Aoife Larkin et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression
- (2015) Tao Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging
- (2015) A K Jenkins et al. MOLECULAR PSYCHIATRY
- Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database
- (2015) Jinchen Li et al. MOLECULAR PSYCHIATRY
- Inhibitory Synapses Get Madd for Neuroligin
- (2015) Peng Zhang et al. NEURON
- Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms
- (2015) Marc V. Fuccillo et al. NEURON
- Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators
- (2015) Qinghong Yan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function
- (2015) Karzan Muhammad et al. Nature Communications
- A network of autism linked genes stabilizes two pools of synaptic GABAA receptors
- (2015) Xia-Jing Tong et al. eLife
- A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model
- (2014) Danielle S. Rudd et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis
- (2014) D. W. Morris et al. HUMAN MOLECULAR GENETICS
- Dystroglycan Binding to α-Neurexin Competes with Neurexophilin-1 and Neuroligin in the Brain
- (2014) Carsten Reissner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Calsyntenin-3 Molecular Architecture and Interaction with Neurexin 1α
- (2014) Zhuoyang Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Copy number variation in schizophrenia in Sweden
- (2014) J P Szatkiewicz et al. MOLECULAR PSYCHIATRY
- Synaptic, transcriptional and chromatin genes disrupted in autism
- (2014) Silvia De Rubeis et al. NATURE
- De novo mutations in schizophrenia implicate synaptic networks
- (2014) Menachem Fromer et al. NATURE
- A polygenic burden of rare disruptive mutations in schizophrenia
- (2014) Shaun M. Purcell et al. NATURE
- Identification of Candidate Single-Nucleotide Polymorphisms in NRXN1 Related to Antipsychotic Treatment Response in Patients with Schizophrenia
- (2014) Aaron Jenkins et al. NEUROPSYCHOPHARMACOLOGY
- Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing
- (2014) Barbara Treutlein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Incomplete penetrance of NRXN1 deletions in families with schizophrenia
- (2014) Giovanna Todarello et al. SCHIZOPHRENIA RESEARCH
- Fraternal Twins With Autism, Severe Cognitive Deficit, and Epilepsy: Diagnostic Role of Chromosomal Microarray Analysis
- (2014) Jaime Imitola et al. Seminars in Pediatric Neurology
- Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior in Mice
- (2014) Luis G. Rabaneda et al. Cell Reports
- Deletion of α-neurexin II results in autism-related behaviors in mice
- (2014) J Dachtler et al. Translational Psychiatry
- A common cognitive, psychiatric, and dysmorphic phenotype in carriers ofNRXN1deletion
- (2014) Marina Viñas-Jornet et al. Molecular Genetics & Genomic Medicine
- Detection of Clinically Relevant Genetic Variants in Autism Spectrum Disorder by Whole-Genome Sequencing
- (2013) Yong-hui Jiang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Refinement and Discovery of New Hotspots of Copy-Number Variation Associated with Autism Spectrum Disorder
- (2013) Santhosh Girirajan et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Investigation ofNRXN1deletions: Clinical and molecular characterization
- (2013) Mindy Preston Dabell et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Molecular and clinical characterization of 25 individuals with exonic deletions ofNRXN1and comprehensive review of the literature
- (2013) Frédérique Béna et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Identification of candidate intergenic risk loci in autism spectrum disorder
- (2013) Susan Walker et al. BMC GENOMICS
- Exon-disrupting deletions ofNRXN1in idiopathic generalized epilepsy
- (2013) Rikke S. Møller et al. EPILEPSIA
- CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1
- (2013) E. Rees et al. HUMAN MOLECULAR GENETICS
- Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays
- (2013) G. Costain et al. HUMAN MOLECULAR GENETICS
- Specific Trans-Synaptic Interaction with Inhibitory Interneuronal Neurexin Underlies Differential Ability of Neuroligins to Induce Functional Inhibitory Synapses
- (2013) K. Futai et al. JOURNAL OF NEUROSCIENCE
- High rate of disease-related copy number variations in childhood onset schizophrenia
- (2013) K Ahn et al. MOLECULAR PSYCHIATRY
- The Specific α-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development
- (2013) Katherine L. Pettem et al. NEURON
- Altered Social Behaviours in Neurexin 1α Knockout Mice Resemble Core Symptoms in Neurodevelopmental Disorders
- (2013) Hannah Mary Grayton et al. PLoS One
- Copy Number Variants in German Patients with Schizophrenia
- (2013) Lutz Priebe et al. PLoS One
- Performance Comparison of Bench-Top Next Generation Sequencers Using Microdroplet PCR-Based Enrichment for Targeted Sequencing in Patients with Autism Spectrum Disorder
- (2013) Eriko Koshimizu et al. PLoS One
- Differential regulation of neurexin at glutamatergic and GABAergic synapses
- (2013) Giulia Pregno et al. Frontiers in Cellular Neuroscience
- Neurexin-1β Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1
- (2013) Grégory Giannone et al. Cell Reports
- Neurexins
- (2013) Carsten Reissner et al. GENOME BIOLOGY
- Implication of a Rare Deletion at Distal 16p11.2 in Schizophrenia
- (2013) Saurav Guha JAMA Psychiatry
- Mutations in NRXN1 in a family multiply affected with brain disorders: NRXN1 mutations and brain disorders
- (2012) Linh Duong et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Rare copy number variants in neuropsychiatric disorders: Specific phenotype or not?
- (2012) Maarten J. Van Den Bossche et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Analysis of Copy Number Variation in Alzheimer’s Disease: The NIALOAD/ NCRAD Family Study
- (2012) Shanker Swaminathan et al. Current Alzheimer Research
- Phenotypic spectrum and genotype–phenotype correlations of NRXN1 exon deletions
- (2012) Christian P Schaaf et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- GluR 2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
- (2012) S.-J. Lee et al. JOURNAL OF NEUROSCIENCE
- Mutation analysis of the NRXN1 gene in a Chinese autism cohort
- (2012) Yalan Liu et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Rate of de novo mutations and the importance of father’s age to disease risk
- (2012) Augustine Kong et al. NATURE
- Mutations affecting synaptic levels of neurexin-1β in autism and mental retardation
- (2012) Rafael J. Camacho-Garcia et al. NEUROBIOLOGY OF DISEASE
- Presynaptically Released Cbln1 Induces Dynamic Axonal Structural Changes by Interacting with GluD2 during Cerebellar Synapse Formation
- (2012) Aya Ito-Ishida et al. NEURON
- De Novo Gene Disruptions in Children on the Autistic Spectrum
- (2012) Ivan Iossifov et al. NEURON
- A Discovery Resource of Rare Copy Number Variations in Individuals with Autism Spectrum Disorder
- (2012) Aparna Prasad et al. G3-Genes Genomes Genetics
- Rare Deletions at the Neurexin 3 Locus in Autism Spectrum Disorder
- (2011) Andrea K. Vaags et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications
- (2011) Douglas F. Levinson et al. AMERICAN JOURNAL OF PSYCHIATRY
- A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population
- (2011) Weihua Yue et al. Behavioral and Brain Functions
- Genome-Wide Analysis Shows Increased Frequency of Copy Number Variation Deletions in Dutch Schizophrenia Patients
- (2011) Jacobine E. Buizer-Voskamp et al. BIOLOGICAL PSYCHIATRY
- SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1
- (2011) Takatoshi Iijima et al. CELL
- Neurexin-Neuroligin Adhesions Capture Surface-Diffusing AMPA Receptors through PSD-95 Scaffolds
- (2011) M. Mondin et al. JOURNAL OF NEUROSCIENCE
- Rare structural variation of synapse and neurotransmission genes in autism
- (2011) X Gai et al. MOLECULAR PSYCHIATRY
- Dendritic spine pathology in neuropsychiatric disorders
- (2011) Peter Penzes et al. NATURE NEUROSCIENCE
- Neurexin-Neuroligin Transsynaptic Interaction Mediates Learning-Related Synaptic Remodeling and Long-Term Facilitation in Aplysia
- (2011) Yun-Beom Choi et al. NEURON
- The role of neurexins in schizophrenia and autistic spectrum disorder
- (2011) A.C. Reichelt et al. NEUROPHARMACOLOGY
- Dynamic Changes in Neurexins' Alternative Splicing: Role of Rho-Associated Protein Kinases and Relevance to Memory Formation
- (2011) Gabriela Rozic et al. PLoS One
- Neurexin-1 and Frontal Lobe White Matter: An Overlapping Intermediate Phenotype for Schizophrenia and Autism Spectrum Disorders
- (2011) Aristotle N. Voineskos et al. PLoS One
- The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
- (2011) G. J. Soler-Llavina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response
- (2011) Tristram A.P. Lett et al. SCHIZOPHRENIA RESEARCH
- The Crystal Structure of the α-Neurexin-1 Extracellular Region Reveals a Hinge Point for Mediating Synaptic Adhesion and Function
- (2011) Meghan T. Miller et al. STRUCTURE
- Suggestion of Roles for Both Common and Rare Risk Variants in Genome-wide Studies of Schizophrenia
- (2010) Michael J. Owen et al. ARCHIVES OF GENERAL PSYCHIATRY
- A Syd-1 homologue regulates pre- and postsynaptic maturation inDrosophila
- (2010) David Owald et al. JOURNAL OF CELL BIOLOGY
- LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development
- (2010) T. J. Siddiqui et al. JOURNAL OF NEUROSCIENCE
- Functional impact of global rare copy number variation in autism spectrum disorders
- (2010) Dalila Pinto et al. NATURE
- Neurexins Physically and Functionally Interact with GABAA Receptors
- (2010) Chen Zhang et al. NEURON
- New Copy Number Variations in Schizophrenia
- (2010) Chiara Magri et al. PLoS One
- Copy Number Variation in Schizophrenia in the Japanese Population
- (2009) Masashi Ikeda et al. BIOLOGICAL PSYCHIATRY
- Presynaptic Targeting of α4β2 Nicotinic Acetylcholine Receptors Is Regulated by Neurexin-1β
- (2009) Shi-Bin Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Common genetic variants on 5p14.1 associate with autism spectrum disorders
- (2009) Kai Wang et al. NATURE
- Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
- (2009) Joseph T. Glessner et al. NATURE
- Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis
- (2009) Stephanie L Barrow et al. Neural Development
- LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation
- (2009) Joris de Wit et al. NEURON
- LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation
- (2009) Jaewon Ko et al. NEURON
- Normal Development of Brain Circuits
- (2009) Gregory Z Tau et al. NEUROPSYCHOPHARMACOLOGY
- Mouse neurexin-1 deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
- (2009) M. R. Etherton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neurexin 1 (NRXN1) Deletions in Schizophrenia
- (2009) G. Kirov et al. SCHIZOPHRENIA BULLETIN
- A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia
- (2009) Anna C. Need et al. PLoS Genetics
- Structural Variation of Chromosomes in Autism Spectrum Disorder
- (2008) Christian R. Marshall et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
- (2008) Hyung-Goo Kim et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Disruption of the neurexin 1 gene is associated with schizophrenia
- (2008) Dan Rujescu et al. HUMAN MOLECULAR GENETICS
- Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers
- (2008) J. Nussbaum et al. HUMAN MOLECULAR GENETICS
- Neuroligins and neurexins link synaptic function to cognitive disease
- (2008) Thomas C. Südhof NATURE
- Rare chromosomal deletions and duplications increase risk of schizophrenia
- (2008) Jennifer L. Stone et al. NATURE
- Large recurrent microdeletions associated with schizophrenia
- (2008) Hreinn Stefansson et al. NATURE
- Neurexin 1α structural variants associated with autism
- (2008) Jin Yan et al. NEUROSCIENCE LETTERS
- Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components
- (2008) C. Reissner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
- (2008) T. Walsh et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started