Article
Biochemistry & Molecular Biology
Aneta Bednarova, Viera Habalova, Ivan Tkac
Summary: This study investigated the association between BDNF polymorphisms and depression and schizophrenia. The results showed that BDNF rs962369 was significantly associated with an increased risk of single-episode major depression disorder (MDD) and recurrent MDD, but not with schizophrenia. The frequency of the minor allele C of BDNF rs962369 varied across different subgroups, with the highest frequency in patients with recurrent MDD and the lowest in schizophrenia patients.
Article
Biochemistry & Molecular Biology
Qingxia Yang, Qiaowen Xing, Qingfang Yang, Yaguo Gong
Summary: Schizophrenia, bipolar disorder, and major depressive disorder are the most common psychiatric disorders. Diagnosing these disorders is difficult due to overlaps in genetic epidemiology and molecular genetics. This study used transcriptomic data to identify key genes and construct a classification model for differentiating these disorders. The model showed potential for improving the diagnoses of these psychiatric disorders.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Clinical Neurology
Kody G. Kennedy, Megan Mio, Benjamin I. Goldstein, Paolo Brambilla, Giuseppe Delvecchio
Summary: This review and meta-analysis found that individuals with severe mental illness, especially schizophrenia, have wider retinal venules compared to controls, indicating a potential connection between cerebrovascular health and mental illness.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Majid Alhomrani, Abdulhakeem S. Alamri, Imed Mabrouk, Ayman Al-hazmi, Mohamed M. Hassan, Fethi Ben Abdallah, Rihab Lagha, Walaa F. Alsanie, Anas Alomery, Ahmed Gaber, Syed Mohammed Basheeruddin Asdaq
Summary: This study explores the association between polymorphisms in the 5-MTHFR and ITGB3 genes and the development of major depressive disorder (MDD). The findings suggest that the C667T and T1565C polymorphisms are linked to MDD.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Clinical Neurology
Zongchang Li, David Li, Xiaogang Chen
Summary: This study shows differences in genetic association between bipolar I disorder (BD-I) and bipolar II disorder (BD-II) with schizophrenia (SCZ) and major depressive disorder (MDD). The study finds that BD-II is more polygenic compared to BD-I, SCZ, and MDD, and there is substantial polygenic overlap between BD-I and SCZ, as well as between BD-I and MDD. The study also identifies specific shared genetic loci between BD subtypes and SCZ or MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Po-Han Chou, Wen-Chun Liu, Wei-Hao Lin, Chih-Wei Hsu, Shao-Cheng Wang, Kuan-Pin Su
Summary: Near-infrared spectroscopy (NIRS) can be used to differentiate major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SZ) at the individual level by analyzing the spatiotemporal characteristics of hemodynamic responses. This can provide diagnostic support in clinical settings.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cell Biology
Shiwan Tao, Yamin Zhang, Qiang Wang, Chunxia Qiao, Wei Deng, Sugai Liang, Jinxue Wei, Wei Wei, Hua Yu, Xiaojing Li, Mingli Li, Wanjun Guo, Xiaohong Ma, Liansheng Zhao, Tao Li
Summary: This study identified transdiagnostic subtypes of schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics abnormalities. The two subtypes differed in clinical diagnosis, functional impairment, and brain white matter abnormalities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Jiaqi Zhou, Miao Li, Xueying Wang, Yuwen He, Yan Xia, John A. Sweeney, Richard F. Kopp, Chunyu Liu, Chao Chen
Summary: Pharmacotherapy is the most common treatment for SCZ, BD, and MDD, but pharmacogenetic studies have limited clinical utility. DNAm, an epigenetic modification, has been proposed to be involved in the pathogenesis and drug treatment of these disorders. BDNF DNAm shows promise as a predictor of antidepressant treatment response for MDD, while more pharmacoepigenetic studies are needed for a variety of diseases. Future research should utilize system-wide analysis and strict analytical procedures.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Agnieszka Jelen, Rafal Swiechowski, Marta Zebrowska-Nawrocka, Aleksandra Salagacka-Kubiak, Dagmara Szmajda-Krygier, Piotr Ga Lecki, Ewa Balcerczak
Summary: This study evaluated the association between ABCB1 gene polymorphism and depression, as well as the effectiveness of its treatment. The results showed that T-129C does not play an important role in rDD development, but other studied SNPs do have an additive impact on the course of depression and its treatment effectiveness.
Review
Biochemistry & Molecular Biology
Bruna Rodrigues Gontijo, Isabella Possatti, Caroline Ferreira Fratelli, Alexandre Sampaio Rodrigues Pereira, Larissa Sousa Silva Bonasser, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da Silva
Summary: This systematic review aims to investigate the role of the SLC6A3 gene variant on the modulation of pharmacotherapy in Major Depressive Disorder (MDD). The presence of the SS (9R/9R) genotype and S (9R) allele has been associated with an increased risk of developing MDD and a decreased response to antidepressant therapy. However, conflicting findings among studies indicate the need for further research to understand the role of this polymorphism in the onset of MDD.
Article
Medicine, General & Internal
Chenghao Yang, Shen Li, Yanyan Ma, Bing Chen, Meijuan Li, Fokko J. Bosker, Jie Li, Ilja M. Nolte
Summary: The study investigated the associations between variants of the FKBP5 gene and antidepressant treatment resistance and susceptibility to MDD in the Han Chinese population. However, no significant SNP or haplotype associations were found in the whole patient group. Larger and better-phenotyped samples may be needed for a definitive conclusion on the involvement of this gene in MDD.
Article
Psychiatry
Kuk-In Jang, Sungkean Kim, Soo Young Kim, Chany Lee, Jeong-Ho Chae
Summary: The study investigated brain phenotyping in patients with schizophrenia and major depressive disorder using EEG. Patients showed deficiencies in N1 and P3 components in the sum of amplitudes and cortical sources, indicating attentional dysfunction. LDA and SVM classifiers in the AP300 are useful for distinguishing patients with SZ and HCs and/or MDD and HCs.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Yanzhuo Song, Jingyu Yang, Miao Chang, Yange Wei, Zhiyang Yin, Yue Zhu, Yuning Zhou, Yifang Zhou, Xiaowei Jiang, Feng Wu, Lingtao Kong, Ke Xu, Fei Wang, Yanqing Tang
Summary: Schizophrenia, bipolar disorder, and major depressive disorder have common neuroimaging characteristics. This study found different alterations in hippocampal subregions among these disorders, providing evidence for the different functions of these subregions in psychiatric pathology.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Peiyu Cao, Congxin Chen, Qi Si, Yuting Li, Fangfang Ren, Chongyang Han, Jingjing Zhao, Xiying Wang, Guoxin Xu, Yuxiu Sui
Summary: This study aimed to verify the continuum of major psychiatric disorders by comparing the volume differences in hippocampal subfields in schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD). The results showed a gradual increase in hippocampal subfield volumes from SZ to MDD to BD. Combined with illness duration and drug intervention, hippocampal volume may better reflect shared pathophysiology and mechanisms across psychiatric disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Nan Lyu, Guoqiang Xing, Jian Yang, Xuequan Zhu, Xixi Zhao, Ling Zhang, Gang Wang
Summary: Psychiatric disorders are severe conditions with unknown etiology, commonly misdiagnosed due to overlapping symptoms. Valid biomarkers for diagnosis are lacking. Serum indicators of inflammation, nutrients, and neurohormones show different patterns in schizophrenia, bipolar disorder, and major depressive disorder patients, suggesting the need for more specific biomarkers in the future.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Letter
Clinical Neurology
Kazuhito Takahashi, Saeko Yokotsuka-Ishida, Toshinori Nakamura, Daimei Sasayama, Shinsuke Washizuka
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Daimei Sasayama, Miyuki Chijiiwa, Shun Nogawa, Kenji Saito, Hiroshi Kunugi
Summary: This study found that adults with biromantic and homoromantic orientations in Japan are more likely to experience psychological distress compared to heterosexual individuals, and these mental health disparities are unrelated to personality profiles.
Article
Immunology
Hiroaki Hori, Shuhei Izawa, Fuyuko Yoshida, Hiroshi Kunugi, Yoshiharu Kim, Shinya Mizukami, Yusuke Inoue, Hirokuni Tagaya, Yuko Hakamata
Summary: Childhood maltreatment is associated with increased inflammation and disruption of the circadian rhythm of interleukin-6 (IL-6), which may contribute to a range of trauma-related conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Endocrinology & Metabolism
Yuko Hakamata, Yuhki Suzuki, Hajime Kobashikawa, Hiroaki Hori
Summary: Adverse childhood experiences (ACEs) can have long-lasting neurobiological effects, increasing the risk of developing mental disorders later in life. This systematic review integrates existing evidence from multiple fields and shows that individuals with ACEs exhibit blunted cortisol response to stress, low-grade inflammation indicated by increased C-reactive protein levels, exaggerated amygdalar response to negative emotions, and reduced hippocampal gray matter volume. These alterations are observed consistently in individuals with and without psychiatric diagnoses.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Psychology, Developmental
Mitsuaki Iwasa, Yasuo Shimizu, Daimei Sasayama, Miho Imai, Hiroko Ohzono, Miori Ueda, Ikuko Hara, Hideo Honda
Summary: This long-term follow-up study found that psychosocial outcomes for autistic adults are generally limited, but many individuals still engage in important areas of life such as work, education, and sports. The study also revealed that individuals with lower IQ at age five had worse outcomes, while outcomes were not significantly associated with IQ for those with IQ above 50.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Sumie Yui, Daimei Sasayama, Masaki Yamaguchi, Shinsuke Washizuka
Summary: This study found that patients with major depressive disorder had significantly higher levels of several cytokines in their saliva, which is consistent with previous studies showing elevated levels of cytokines in peripheral blood. These findings provide preliminary support for elucidating the pathophysiology underlying major depressive disorder by examining salivary cytokine levels.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Psychiatry
Zui Narita, Shoko Nozaki, Ryo Shikimoto, Hiroaki Hori, Yoshiharu Kim, Masaru Mimura, Shoichiro Tsugane, Norie Sawada
Summary: This study examined the relationship between vegetable and fruit consumption, particularly flavonoid-rich fruits, in mid-life and major depressive disorder (MDD) in later life. The results showed that consuming high amounts of total fruit, excluding juice, and flavonoid-rich fruits was associated with decreased odds of MDD.
TRANSLATIONAL PSYCHIATRY
(2022)
Letter
Medicine, General & Internal
Daimei Sasayama, Rie Kuge, Yuki Toibana, Hideo Honda
Article
Psychiatry
Toshinori Nakamura, Misaki Shimizu-Ichikawa, Kazuhito Takahashi, Sari Shimizu, Takashi Ichiyama, Keisuke Todoroki, Masataka Konno, Daisuke Amada, Daimei Sasayama, Shinsuke Washizuka
Summary: This article describes a case of sudden respiratory failure during the treatment of catatonia, which required intensive care. Electroconvulsive therapy (ECT) was successfully administered in the intensive care unit, relieving the catatonia symptoms and improving the respiratory failure. It highlights the importance of monitoring the patient's physical and psychological symptoms, as respiratory status may deteriorate rapidly in a catatonic state.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Yusuke Arai, Daimei Sasayama, Kazuaki Kuraishi, Shiho Murata, Nobuteru Usuda, Mika Tsuchida, Yuka Nakajima, Shinsuke Washizuka
Summary: This study aimed to investigate the effects of brexpiprazole on sleep architecture in patients with schizophrenia. The results showed that add-on brexpiprazole could alter the sleep architecture of patients with schizophrenia. Future studies are needed to replicate these findings and further explore the beneficial influence of brexpiprazole on sleep.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Neurosciences
Risa Yamada, Takeshi Fujii, Kotaro Hattori, Hiroaki Hori, Ryo Matsumura, Tomoko Kurashimo, Naoko Ishihara, Sumiko Yoshida, Tomiki Sumiyoshi, Hiroshi Kunugi
Summary: This study aimed to determine if the discrepancy between depression severity rated by clinicians and that reported by patients depends on key behavioral/psychological features in patients with mood disorders. The findings suggest that patients with adverse emotional experiences, autistic-like traits, and self-blame coping styles perceive greater distress than that evaluated objectively by clinicians. The results indicate the need for inclusion of subjective assessments to effectively evaluate depressive symptoms in patients deemed to have these psycho-behavioral concerns.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Psychology, Developmental
Hideo Honda, Daimei Sasayama, Taemi Niimi, Ayako Shimizu, Yuki Toibana, Rie Kuge, Hidetoshi Takagi, Aya Nakajima, Reiko Sakatsume, Michiko Takahashi, Takuma Heda, Yukari Nitto, Shota Tsukada, Akiko Nishigaki
Summary: This study investigates the awareness of developmental problems among preschool teachers and childcare workers, as well as their communication with parents regarding concerns about a child's development or diagnosis of NDDs. Data from 10,354 children in 206 preschools and childcare centers were collected, showing that a considerable number of children had concerns about their development but the teachers did not share this information with their parents. The findings highlight challenges in information-sharing between teachers/childcare workers and parents.
CHILD CARE HEALTH AND DEVELOPMENT
(2023)
Article
Medicine, General & Internal
Yusuke Arai, Daimei Sasayama, Akira Kuraishi, Reiko Sahara, Shiho Murata, Akira Tanaka, Kotaro Amemiya, Nobuteru Usuda, Kazuaki Kuraishi, Shinsuke Washizuka
Summary: This study retrospectively examined the association between mood stabilizers, specifically sodium valproate, and the risk of pneumonia development in COVID-19 infected patients with schizophrenia. The study found that patients using sodium valproate were more likely to develop pneumonia, suggesting it as a risk factor for pneumonia in COVID-19 infected patients with chronic schizophrenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Hitomi Kawanishi, Hiroaki Hori, Fuyuko Yoshida, Mariko Itoh, Mingming Lin, Madoka Niwa, Megumi Narita, Takeshi Otsuka, Keiko Ino, Risa Imai, Shin Fukudo, Toshiko Kamo, Hiroshi Kunugi, Yoshiharu Kim
Summary: This study found that suicidal ideation and risk in PTSD patients were positively correlated with high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) levels. The risk alleles of CRP rs2794520 and IL6 rs1800796 were also associated with a higher risk of suicide. These findings suggest that genetic variations within inflammatory genes might be valuable in identifying PTSD patients at high risk of suicide.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Psychology, Clinical
Madoka Niwa, Tomoko Kato, Ryoko Narita-Ohtaki, Rieko Otomo, Yosuke Suga, Mayumi Sugawara, Zui Narita, Hiroaki Hori, Toshiko Kamo, Yoshiharu Kim
Summary: This pilot study aimed to evaluate the feasibility, safety, and outcomes of Skills Training in Affective and Interpersonal Regulation (STAIR) Narrative Therapy (SNT) for women with complex posttraumatic stress disorder (CPTSD) and a history of childhood abuse in a Japanese clinical setting. The results showed significant improvements in symptoms and preliminary evidence for the feasibility and safety of SNT for CPTSD in this population.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
