Epigenetic regulation of macrophages: from homeostasis maintenance to host defense

Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis

(2019) Yong-Bae Kim et al.   Cellular & Molecular Immunology

Primed macrophages directly and specifically reject allografts

(2019) Zhulang Chu et al.   Cellular & Molecular Immunology

Macrophages are the primary effector cells in IL-7-induced arthritis

(2019) Seung-jae Kim et al.   Cellular & Molecular Immunology

LncRNA NEAT1 promotes inflammatory response in sepsis-induced liver injury via the Let-7a/TLR4 axis

(2019) Cui-Cui Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα

(2018) Anant Jaiswal et al.   Cellular & Molecular Immunology

The biology of serous cavity macrophages

(2018) Calum C. Bain et al.   CELLULAR IMMUNOLOGY

Role of epigenetics in the development of childhood asthma

(2018) Elizabeth J. Davidson et al.   Current Opinion in Allergy and Clinical Immunology

The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

(2018) Zsolt Czimmerer et al.   IMMUNITY

Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

(2018) Moumita Datta et al.   IMMUNITY

Long non-coding RNA NEAT1 plays an important role in sepsis-induced acute kidney injury by targeting miR-204 and modulating the NF-κB pathway

(2018) Yi Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MEG3-4 is a miRNA decoy that regulates IL-1β abundance to initiate and then limit inflammation to prevent sepsis during lung infection

(2018) Rongpeng Li et al.   Science Signaling

MEG3-4 is a miRNA decoy that regulates IL-1β abundance to initiate and then limit inflammation to prevent sepsis during lung infection

(2018) Rongpeng Li et al.   Science Signaling

Histone deacetylase 2 is essential for LPS-induced inflammatory responses in macrophages

(2018) Chenming Wu et al.   IMMUNOLOGY AND CELL BIOLOGY

Induction of innate immune memory via microRNA targeting of chromatin remodelling factors

(2018) John J. Seeley et al.   NATURE

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

EP300-HDAC1-SWI/SNF functional unit defines transcription of some DNA repair enzymes during differentiation of human macrophages

(2018) Julita Pietrzak et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-β production by mediating H3K79me2/3 methylation in macrophages

(2018) Xiang Chen et al.   Cellular & Molecular Immunology

The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory

(2018) Bence Daniel et al.   IMMUNITY

Therapeutic Epigenetic Reprogramming of Trained Immunity in Myeloid Cells

(2018) R.M. Rodriguez et al.   TRENDS IN IMMUNOLOGY

Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF

(2017) Kyuho Kang et al.   IMMUNITY

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Microglial Priming as Trained Immunity in the Brain

(2017) Michael J. Haley et al.   NEUROSCIENCE

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

(2017) Burak H. Alver et al.   Nature Communications

Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses

(2016) Jeremy M. Simon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

IRF8 is the target of SIRT1 for the inflammation response in macrophages

(2016) Yanhui Jia et al.   Innate Immunity

The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis

(2016) Risa Ebina-Shibuya et al.   JOURNAL OF BIOCHEMISTRY

TLR4, TLR7/8 agonist-induced miR-146a promotes macrophage tolerance to MyD88-dependent TLR agonists

(2016) M. Abu Nahid et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

(2016) Xia Li et al.   NATURE IMMUNOLOGY

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

Sall1 is a transcriptional regulator defining microglia identity and function

(2016) Anne Buttgereit et al.   NATURE IMMUNOLOGY

Bromodomain and Extra Terminal (BET) Inhibitor Suppresses Macrophage-Driven Steroid-Resistant Exacerbations of Airway Hyper-Responsiveness and Inflammation

(2016) Thi Hiep Nguyen et al.   PLoS One

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks

(2016) Dinshaw J. Patel   Cold Spring Harbor Perspectives in Biology

Epigenetic dynamics of monocyte-to-macrophage differentiation

(2016) Stefan Wallner et al.   Epigenetics & Chromatin

IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages

(2016) Yu Qiao et al.   Cell Reports

Chromatin remodelers: We are the drivers!!

(2016) Monica Tyagi et al.   Nucleus

Chromatin remodelers: We are the drivers!!

(2016) Monica Tyagi et al.   Nucleus

Probing the phenomenon of trained immunity in invertebrates during a transgenerational study, using brine shrimp Artemia as a model system

(2016) Parisa Norouzitallab et al.   Scientific Reports

The effects of cytosine methylation on general transcription factors

(2016) Jianshi Jin et al.   Scientific Reports

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic MiceNovelty and Significance

(2015) Mohan Babu et al.   CIRCULATION RESEARCH

Epigenetics and Metabolism

(2015) S. T. Keating et al.   CIRCULATION RESEARCH

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model

(2015) Yongqing Li et al.   Journal of Trauma and Acute Care Surgery

PC222. Altered Histone Methylation at the IL-1B Promoter in Diabetic Macrophages Enhances Inflammation and Impairs Wound Healing

(2015) Andrew Kimball et al.   JOURNAL OF VASCULAR SURGERY

Oxidized low-density lipoprotein upregulates microRNA-146a via JNK and NF-κB signaling

(2015) ZHENWEI LI et al.   Molecular Medicine Reports

Long non-coding RNA and chromatin remodeling

(2015) Pei Han et al.   RNA Biology

Expression Profile of MicroRNAs in Gram-Negative Bacterial Sepsis

(2015) Chorng-Kuang How et al.   SHOCK

Exploiting genomics and natural genetic variation to decode macrophage enhancers

(2015) Casey E. Romanoski et al.   TRENDS IN IMMUNOLOGY

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program

(2015) Shicheng Su et al.   Nature Communications

Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model

(2015) Yongqing Li et al.   Journal of Trauma and Acute Care Surgery

Histone Deacetylase 9 Represses Cholesterol Efflux and Alternatively Activated Macrophages in Atherosclerosis Development

(2014) Qiang Cao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibiting epigenetic enzymes to improve atherogenic macrophage functions

(2014) Jan Van den Bossche et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

(2014) Nina Cabezas-Wallscheid et al.   Cell Stem Cell

Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages

(2014) Qian Yan et al.   CELLULAR SIGNALLING

Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA

(2014) M. A. Reddy et al.   DIABETES

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Macrophages in intestinal homeostasis and inflammation

(2014) Calum C. Bain et al.   IMMUNOLOGICAL REVIEWS

MicroRNA profiling reveals opposing expression patterns for miR-511 in alternatively and classically activated macrophages

(2014) Danielle Karo-Atar et al.   JOURNAL OF ASTHMA

Histone Acetylation and Flagellin Are Essential for Legionella pneumophila-Induced Cytokine Expression

(2014) B. Schmeck et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

(2014) Xiaosong Yang et al.   MOLECULAR ENDOCRINOLOGY

lncRNAs: Insights into their function and mechanics in underlying disorders

(2014) Xiaolei Li et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

(2014) Giuseppe Lo Sasso et al.   PLoS One

HDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages

(2014) Bing Yan et al.   PLoS One

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

SOCS1 hypermethylation mediated by DNMT1 is associated with lipopolysaccharide-induced inflammatory cytokines in macrophages

(2014) Chang Cheng et al.   TOXICOLOGY LETTERS

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Histone Deacetylase 7 Promotes Toll-like Receptor 4-dependent Proinflammatory Gene Expression in Macrophages

(2013) Melanie R. Shakespear et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription

(2013) Minna U. Kaikkonen et al.   MOLECULAR CELL

Effect of natural genetic variation on enhancer selection and function

(2013) S. Heinz et al.   NATURE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

(2013) Noelia A-Gonzalez et al.   NATURE IMMUNOLOGY

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes

(2013) Nicolai A. Kittan et al.   PLoS One

Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis

(2013) Hugh S. Markus et al.   STROKE

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

(2012) S. Willenborg et al.   BLOOD

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

The Role of MicroRNA-146a in the Pathogenesis of the Diabetic Wound-Healing Impairment: Correction With Mesenchymal Stem Cell Treatment

(2012) J. Xu et al.   DIABETES

The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation

(2012) S. Chen et al.   GENES & DEVELOPMENT

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

(2012) Daniel J. Gough et al.   IMMUNITY

Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

(2012) Stephanie C. Ganal et al.   IMMUNITY

MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages

(2012) Maliheh Nazari-Jahantigh et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20

(2012) Joshua D. Stender et al.   MOLECULAR CELL

Cell-Type-Specific Control of Enhancer Activity by H3K9 Trimethylation

(2012) Yina Zhu et al.   MOLECULAR CELL

Suppression of the antiviral response by an influenza histone mimic

(2012) Ivan Marazzi et al.   NATURE

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear factor- B binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome

(2012) Q. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Epigenetic regulation of macrophage polarization and function

(2012) Lionel B. Ivashkiv   TRENDS IN IMMUNOLOGY

Signals and Combinatorial Functions of Histone Modifications

(2011) Tamaki Suganuma et al.   Annual Review of Biochemistry

Inflammatory signaling in macrophages: Transitions from acute to tolerant and alternative activation states

(2011) Lionel B. Ivashkiv   EUROPEAN JOURNAL OF IMMUNOLOGY

Pioneer transcription factors: establishing competence for gene expression

(2011) K. S. Zaret et al.   GENES & DEVELOPMENT

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b

(2011) M. V. S. Rajaram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Bcl-6 and NF- B cistromes mediate opposing regulation of the innate immune response

(2010) G. D. Barish et al.   GENES & DEVELOPMENT

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

(2009) Vladimir R. Ramirez-Carrozzi et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

(2009) Francesca De Santa et al.   EMBO JOURNAL

The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance

(2009) Xiaoping Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice

(2008) Anna J. Bowes et al.   AMERICAN JOURNAL OF PATHOLOGY

Differentiation and heterogeneity in the mononuclear phagocyte system

(2008) D A Hume   Mucosal Immunology

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

(2008) Masako Kohyama et al.   NATURE

Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clock

(2008) Y. Kumaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA