标题
An environment-dependent transcriptional network specifies human microglia identity
作者
关键词
-
出版物
SCIENCE
Volume 356, Issue 6344, Pages eaal3222
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2017-05-26
DOI
10.1126/science.aal3222
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Sall1 is a transcriptional regulator defining microglia identity and function
- (2016) Anne Buttgereit et al. NATURE IMMUNOLOGY
- Efficient derivation of microglia-like cells from human pluripotent stem cells
- (2016) Julien Muffat et al. NATURE MEDICINE
- Microglia development follows a stepwise program to regulate brain homeostasis
- (2016) O. Matcovitch-Natan et al. SCIENCE
- Specification of tissue-resident macrophages during organogenesis
- (2016) E. Mass et al. SCIENCE
- Microglia function during brain development: New insights from animal models
- (2015) Parizad M. Bilimoria et al. BRAIN RESEARCH
- Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
- (2015) Shashank Tripathi et al. Cell Host & Microbe
- Microglia: Multitasking Specialists of the Brain
- (2015) Alessandra Maria Casano et al. DEVELOPMENTAL CELL
- Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models
- (2015) Terry C. Burns et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Roadmap for regulation
- (2015) Casey E. Romanoski et al. NATURE
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- The selection and function of cell type-specific enhancers
- (2015) Sven Heinz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Microglia Plasticity During Health and Disease: An Immunological Perspective
- (2015) Anat Shemer et al. TRENDS IN IMMUNOLOGY
- Microglia Function in Central Nervous System Development and Plasticity
- (2015) Dorothy P. Schafer et al. Cold Spring Harbor Perspectives in Biology
- Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis
- (2015) Alberto Capurro et al. Frontiers in Neuroscience
- Microglia as a critical player in both developmental and late-life CNS pathologies
- (2014) Noël C. Derecki et al. ACTA NEUROPATHOLOGICA
- Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression
- (2014) Jeanette N. McClintick et al. ALCOHOL
- Microglial dysfunction in brain aging and Alzheimer's disease
- (2014) Kira Irving Mosher et al. BIOCHEMICAL PHARMACOLOGY
- Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
- (2014) Yonit Lavin et al. CELL
- Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities
- (2014) David Gosselin et al. CELL
- RNA-Seq Data Mining: Downregulation of NeuroD6 Serves as a Possible Biomarker for Alzheimer’s Disease Brains
- (2014) Jun-ichi Satoh et al. DISEASE MARKERS
- Ontogeny and Functions of Central Nervous System Macrophages
- (2014) Atsuko Katsumoto et al. JOURNAL OF IMMUNOLOGY
- Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
- (2014) Andrea Crotti et al. NATURE NEUROSCIENCE
- Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
- (2014) Monica R.P. Elmore et al. NEURON
- The Evolving Biology of Microglia in Alzheimer’s Disease
- (2014) Tarja M. Malm et al. Neurotherapeutics
- Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms
- (2014) Brigit E. Riley et al. PLoS One
- Advanced Heat Map and Clustering Analysis Using Heatmap3
- (2014) Shilin Zhao et al. Biomed Research International
- voom: precision weights unlock linear model analysis tools for RNA-seq read counts
- (2014) Charity W Law et al. GENOME BIOLOGY
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
- (2013) Warren A. Whyte et al. CELL
- Super-Enhancers in the Control of Cell Identity and Disease
- (2013) Denes Hnisz et al. CELL
- Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
- (2013) Christopher N. Parkhurst et al. CELL
- Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
- (2013) Bin Zhang et al. CELL
- Microglial Dysregulation in Psychiatric Disease
- (2013) Luciana Romina Frick et al. Clinical & Developmental Immunology
- The transcription factor PU.1 is critical for viability and function of human brain microglia
- (2013) Amy M. Smith et al. GLIA
- Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription
- (2013) Minna U. Kaikkonen et al. MOLECULAR CELL
- Effect of natural genetic variation on enhancer selection and function
- (2013) S. Heinz et al. NATURE
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
- (2013) Katrin Kierdorf et al. NATURE NEUROSCIENCE
- Identification of a unique TGF-β–dependent molecular and functional signature in microglia
- (2013) Oleg Butovsky et al. NATURE NEUROSCIENCE
- The microglial sensome revealed by direct RNA sequencing
- (2013) Suzanne E Hickman et al. NATURE NEUROSCIENCE
- The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
- (2013) Danielle Welter et al. NUCLEIC ACIDS RESEARCH
- Extensive Variation in Chromatin States Across Humans
- (2013) M. Kasowski et al. SCIENCE
- Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription
- (2013) H. Kilpinen et al. SCIENCE
- Identification of Genetic Variants That Affect Histone Modifications in Human Cells
- (2013) G. McVicker et al. SCIENCE
- A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
- (2013) Isaac M. Chiu et al. Cell Reports
- Genes and pathways underlying regional and cell type changes in Alzheimer's disease
- (2013) Jeremy A Miller et al. Genome Medicine
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
- (2012) Emmanuel L Gautier et al. NATURE IMMUNOLOGY
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
- (2012) Dorothy P. Schafer et al. NEURON
- Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease
- (2012) Louise M. Collins et al. NEUROPHARMACOLOGY
- A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
- (2012) C. Schulz et al. SCIENCE
- An optimized protocol for the acute isolation of human microglia from autopsy brain samples
- (2011) Marta Olah et al. GLIA
- Neuroinflammation in Parkinson's disease
- (2011) Etienne C. Hirsch et al. PARKINSONISM & RELATED DISORDERS
- Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive Disorders
- (2011) Alejandra Borjabad et al. PLoS Pathogens
- Mechanisms Underlying Inflammation in Neurodegeneration
- (2010) Christopher K. Glass et al. CELL
- Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: A multimodal imaging study
- (2010) Marios Politis et al. HUMAN BRAIN MAPPING
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Gene expression reveals overlap between normal aging and Alzheimer's disease genes
- (2010) Dimitrios Avramopoulos et al. NEUROBIOLOGY OF AGING
- The Sequence Read Archive
- (2010) R. Leinonen et al. NUCLEIC ACIDS RESEARCH
- Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
- (2010) F. Ginhoux et al. SCIENCE
- Genetic Control of Human Brain Transcript Expression in Alzheimer Disease
- (2009) Jennifer A. Webster et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death
- (2009) Kaoru Saijo et al. CELL
- Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function
- (2009) P R Maycox et al. MOLECULAR PSYCHIATRY
- Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration
- (2008) Alice S. Chen-Plotkin et al. HUMAN MOLECULAR GENETICS
- Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set
- (2008) Winnie S. Liang et al. PHYSIOLOGICAL GENOMICS
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