Bromodomain and Extra Terminal (BET) Inhibitor Suppresses Macrophage-Driven Steroid-Resistant Exacerbations of Airway Hyper-Responsiveness and Inflammation

TNF-α and Macrophages Are Critical for Respiratory Syncytial Virus–Induced Exacerbations in a Mouse Model of Allergic Airways Disease

(2016) Thi Hiep Nguyen et al.   JOURNAL OF IMMUNOLOGY

BET Inhibition AttenuatesHelicobacter pylori–Induced Inflammatory Response by Suppressing Inflammatory Gene Transcription and Enhancer Activation

(2016) Jinjing Chen et al.   JOURNAL OF IMMUNOLOGY

CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET

(2015) Rachel L. Clifford et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The impact of asthma exacerbations and preventive strategies

(2015) LeRoy M. Graham et al.   CURRENT MEDICAL RESEARCH AND OPINION

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

(2015) Jing Jing Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BET Bromodomains Regulate Transforming Growth Factor-β-induced Proliferation and Cytokine Release in Asthmatic Airway Smooth Muscle

(2015) Mark M. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High IFN-γ and low SLPI mark severe asthma in mice and humans

(2015) Mahesh Raundhal et al.   JOURNAL OF CLINICAL INVESTIGATION

Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice

(2015) Josefa M. Sullivan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BET inhibitor resistance emerges from leukaemia stem cells

(2015) Chun Yew Fong et al.   NATURE

The Importance of Bacterial and Viral Infections Associated with Adult Asthma Exacerbations in Clinical Practice

(2015) Motoyasu Iikura et al.   PLoS One

Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations

(2014) E. A. Schwantes et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations

(2014) D. M. Manthei et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Impaired lung function is associated with systemic inflammation and macrophage activation: TABLE 1

(2014) Katherine J. Baines et al.   EUROPEAN RESPIRATORY JOURNAL

Impaired macrophage phagocytosis of bacteria in severe asthma

(2014) Zhike Liang et al.   RESPIRATORY RESEARCH

Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle

(2014) François Lamoureux et al.   Nature Communications

Increased cytokine/chemokines in serum from asthmatic and non-asthmatic patients with viral respiratory infection

(2013) María J Giuffrida et al.   Influenza and Other Respiratory Viruses

BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

(2013) A. C. Belkina et al.   JOURNAL OF IMMUNOLOGY

Macrophage/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease

(2012) Dina Schneider et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Impaired macrophage phagocytosis in non-eosinophilic asthma

(2012) J. L. Simpson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Emerging roles of pulmonary macrophages in driving the development of severe asthma

(2012) M. Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

(2012) H. S. Bandukwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK Cell Deficiency Predisposes to Viral-Induced Th2-Type Allergic Inflammation via Epithelial-Derived IL-25

(2010) G. E. Kaiko et al.   JOURNAL OF IMMUNOLOGY

IL-27/IFN-  Induce MyD88-Dependent Steroid-Resistant Airway Hyperresponsiveness by Inhibiting Glucocorticoid Signaling in Macrophages

(2010) J. J. Li et al.   JOURNAL OF IMMUNOLOGY

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

(2009) Diana C. Hargreaves et al.   CELL

Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype

(2009) R. H. Dougherty et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Interferon-γ and pulmonary macrophages contribute to the mechanisms underlying prolonged airway hyperresponsiveness

(2009) M. Yang et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Pathogenesis of Steroid-Resistant Airway Hyperresponsiveness: Interaction between IFN-  and TLR4/MyD88 Pathways

(2009) M. Yang et al.   JOURNAL OF IMMUNOLOGY

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

(2008) P Bhavsar et al.   THORAX