Article
Biochemistry & Molecular Biology
Aakanksha Jha, Joseph Larkin III, Erika Moore
Summary: This study introduces a PEGDA hydrogel platform to investigate the utilization of SOCS1-KIR as a macrophage phenotype manipulating peptide. Results from immunocytochemistry, cytokine secretion assays, and gene expression analysis demonstrate a reduction in M1 activation due to SOCS1-KIR treatment. The retention of SOCS1-KIR in the hydrogel and the unaffected swelling ratio of the hydrogel are also demonstrated.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Plant Sciences
Isadora de Fatima Braga Magalhaes, Ana Leticia Marinho Figueiredo, Elizeu Mendes da Silva, Adryan Adam Batalha de Miranda, Claudia Quintino da Rocha, Katia da Silva Calabrese, Fernando Almeida-Souza, Ana Lucia Abreu-Silva
Summary: A study focuses on the anti-inflammatory potential of Passovia ovata extract, which contains high levels of flavonoids. The results demonstrate significant reduction in inflammatory markers both in cell experiments and animal models. This study indicates the potential of Passovia ovata extract as a new agent for suppressing inflammatory responses.
Article
Pharmacology & Pharmacy
Xiaoxia Wang, Xiao-Min Ren, Huan He, Fan Li, Kunqian Liu, Fenqing Zhao, Huixiang Hu, Pingping Zhang, Bin Huang, Xuejun Pan
Summary: Multiple studies have shown that exposure to micro- or nano-plastics can damage the viability and function of macrophages in intestinal tissue, possibly due to cell apoptosis and inflammation. In this study, the cytotoxicity and pro-inflammatory effects of 80 nm polystyrene nano-plastics (PS-NP) and 3 μm polystyrene micro-plastics (PS-MP) on mouse macrophages were investigated. The results demonstrated that both PS-NP and PS-MP induced cell apoptosis, and PS-NP had a more potent inflammatory effect by enhancing the secretion of inflammatory cytokines. Mechanistically, PS-NP and PS-MP were found to cause cytotoxicity and inflammation by producing reactive oxygen species and nitric oxide in the cells. Overall, this study highlighted the cytotoxicity and pro-inflammatory effects of PS-NP and PS-MP on macrophages, which could lead to intestinal inflammation, with PS-NP showing greater impacts.
Article
Cell Biology
Yinghua Zhao, Fei Peng, Jiayi He, Yilun Qu, Huiming Ni, Lingling Wu, Xiangmei Chen
Summary: The SOCS1 peptidomimetic can protect against pathologic glomerular changes in MsPGN by reducing macrophage infiltration and inhibiting macrophage polarization through the inhibition of the JAK2/STAT1 pathway.
Article
Microbiology
Matsayapan Pudla, Sucharat Sanongkiet, Peeraya Ekchariyawat, Chularat Luangjindarat, Marisa Ponpuak, Pongsak Utaisincharoen
Summary: TLR9 plays a crucial role in suppressing macrophage killing of Burkholderia pseudomallei by regulating pyroptosis. This finding provides a novel mechanism of TLR9 in the regulation of intracellular bacterial killing by macrophages, which could potentially be leveraged for therapeutic intervention.
MICROBIOLOGY SPECTRUM
(2022)
Article
Cardiac & Cardiovascular Systems
Yan Zhang, Shengbao Cai, Xiaoxue Ding, Can Lu, Ruodan Wu, Haiyan Wu, Yiyi Shang, Mingjie Pang
Summary: In this study, it was discovered that inhibition of miR-30a-5p may improve cardiac injury following viral myocarditis by promoting M2 polarization of macrophages via SOCS1 upregulation. The anti-inflammatory mechanisms of miR-30a-5p inhibition could potentially lead to the development of new therapeutic strategies for viral myocarditis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Chemistry, Physical
Liza L. Ramenzoni, Laura B. Flueckiger, Thomas Attin, Patrick R. Schmidlin
Summary: This study found that exposure to higher concentrations of titanium and zirconia particles under sterile lipopolysaccharide (LPS) inflammation significantly increased cytotoxicity. Macrophages exposed to TiO2 particles showed up to approximately 3.5-fold higher upregulation than ZrO2 from 12 to 48 hours, but pro-inflammatory gene expression induced by both TiO2 and ZrO2 particles was further enhanced when exposed to LPS.
Article
Immunology
Rajani Kandhi, Mehdi Yeganeh, Akihiko Yoshimura, Alfredo Menendez, Sheela Ramanathan, Subburaj Ilangumaran
Summary: The study found that SOCS1 plays a critical role in controlling liver fibrosis and the development of hepatocellular carcinoma, and regulates the recruitment and differentiation of pro-inflammatory macrophages by attenuating HSC activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Dorsaf Bouzazi, Wael Mami, Amor Mosbah, Naziha Marrakchi, Melika Ben Ahmed, Erij Messadi
Summary: Snake natriuretic peptide (NP) Lebetin 2 (L2) has anti-inflammatory effects by regulating the release of inflammatory cytokines and promoting M2 macrophage polarization through activation of IL-10 signaling. L2 increases IL-10 release in a sustained manner and promotes downstream M2 macrophage polarization, while reducing TNF-alpha and IL-6 release in lipopolysaccharide (LPS)-activated cells. The effect of L2 is mediated by stimulating NP receptors.
Article
Cell Biology
Rui Zhou, Keran Niu, Chaoying Wang, Jianghui He, Wenjun Huang, Tao Li, Huan Lan, Yanmin Zhang, Xitong Dang, Liang Mao
Summary: CHRFAM7A may increase leukocyte mobilization and activate macrophages, leading to enhanced immune response at the early stage of inflammation.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Oncology
Anna Sicuranza, Ilaria Ferrigno, Elisabetta Abruzzese, Alessandra Iurlo, Sara Galimberti, Antonella Gozzini, Luigiana Luciano, Fabio Stagno, Antonella Russo Rossi, Nicola Sgherza, Daniele Cattaneo, Corrado Zuanelli Brambilla, Cristina Marzano, Carmen Fava, Olga Mulas, Emanuele Cencini, Adele Santoni, Vincenzo Sammartano, Alessandro Gozzetti, Luca Puccetti, Monica Bocchia
Summary: This study investigates the role of inflammatory status in the increased incidence of arterial occlusive events (AOEs) during nilotinib treatment in chronic myeloid leukemia (CML) patients. The study finds that nilotinib treatment results in a pro-inflammatory and pro-oxidative environment, as evidenced by elevated levels of inflammatory markers. The study also suggests that longer follow-up is needed to confirm the active role of nilotinib in the pathogenesis of AOEs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Sudarshan Singh Rathore, Lalitha Cheepurupalli, Jaya Gangwar, Thiagarajan Raman, Jayapradha Ramakrishnan
Summary: This study aimed to unravel the interaction between Klebsiella biofilm and macrophages. The results showed that the phagocytic rate against heat inactivated and live biofilms significantly increased when macrophages were activated by LPS + IFN-gamma. Heat-inactivated and live biofilms induced similar phagocytic responses and up-regulation of pro-inflammatory genes in macrophages.
Article
Immunology
Valeria Longo, Alessandra Longo, Giorgia Adamo, Antonino Fiannaca, Sabrina Picciotto, Laura La Paglia, Daniele Romancino, Massimo La Rosa, Alfonso Urso, Fabio Cibella, Antonella Bongiovanni, Paolo Colombo
Summary: PBDE-47 can affect the expression of intracellular miRNAs and interfere with the biogenesis of sEVs, leading to an overload of specific immune-related miRNAs. Studies have shown that sEVs derived from PBDE-47 can modulate macrophage immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Padhmavathi Selvam, Chih-Mei Cheng, Hans-Uwe Dahms, Vinoth Kumar Ponnusamy, Yu-Yo Sun
Summary: Pulmonary fibrosis, a chronic lung disease, is caused by genetic and environmental factors. Research shows that AhR-activated macrophages can trigger inflammation and fibrotic progression in pulmonary epithelial cells.
Article
Cell Biology
Qiushi Qin, Rui Li, Lan Li, Yue Zhang, Shuwei Deng, Liuluan Zhu
Summary: This study reveals that Blimp-1 regulates the production of multiple pro-inflammatory cytokines by controlling nuclear translocation and transcriptional activity. This finding may offer potential therapeutic strategies for cytokine storm-related diseases.
INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Ruixue Ren, Yong He, Dong Ding, Aoyuan Cui, Huarui Bao, Jing Ma, Xin Hou, Yu Li, Dechun Feng, Xiaoling Li, Suthat Liangpunsakul, Bin Gao, Hua Wang
Summary: Aging exacerbates alcohol-induced liver injury through down-regulation of the neutrophilic SIRT1-C/EBP alpha-miR-223 axis, which is also observed in chronic alcohol users with acute intoxication. This axis could be a therapeutic target for the prevention and treatment of ALD.
Article
Gastroenterology & Hepatology
Robim M. Rodrigues, Yong He, Seonghwan Hwang, Adeline Bertola, Bryan Mackowiak, Yeni Ait Ahmed, Wonhyo Seo, Jing Ma, Xiaolin Wang, Seol Hee Park, Yukun Guan, Yaojie Fu, Tamara Vanhaecke, Dechun Feng, Bin Gao
Summary: This study found that E-selectin induces neutrophil recruitment in adipose tissue, promoting inflammation and lipolysis, thereby exacerbating the progression from steatosis to NASH.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qian Li, Jia-Xin Tan, Yong He, Fang Bai, Shi-Wei Li, Yi-Wen Hou, Long-Shan Ji, Ya-Ting Gao, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, Miao Fang, Yue-Qiu Gao, Man Li
Summary: This study suggests that Atractylenolide III (ATL III) is a potential therapeutic drug for the treatment of NAFLD. ATL III can inhibit liver injury and lipid accumulation, and reduce oxidative stress, inflammation, and fibrosis. Its mechanism may be achieved by activating the hepatic AdipoR1-mediated AMPK/SIRT1 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Longshan Ji, Qian Li, Yong He, Xin Zhang, Zhenhua Zhou, Yating Gao, Miao Fang, Zhuo Yu, Robim M. Rodrigues, Yueqiu Gao, Man Li
Summary: Nonalcoholic fatty liver disease (NAFLD) is a liver disease characterized by excessive accumulation of liver fat and metabolic stress-induced liver injury. Traditional Chinese medicine (TCM) has unique advantages in the treatment of NAFLD. Various TCM formulas, including Potentilla discolor Bunge (PDB), have been reported to improve NAFLD by exhibiting anti-oxidative, anti-inflammatory, and lipid metabolism-improving effects.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Gastroenterology & Hepatology
Seol Hee Park, Wonhyo Seo, Ming-Jiang Xu, Bryan Mackowiak, Yuhong Lin, Yong He, Yaojie Fu, Seonghwan Hwang, Seung-Jin Kim, Yukun Guan, Dechun Feng, Liqing Yu, Richard Lehner, Suthat Liangpunsakul, Bin Gao
Summary: The study investigated the influence of oxidative and nonoxidative alcohol metabolism pathways, diet-induced obesity, and adipose tissues on the development of acute liver injury in a single ethanol binge model. The results showed that alcohol, not acetaldehyde, promoted acute alcohol-induced liver injury by inducing ER stress, adipocyte death, and lipolysis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yaojie Fu, Bryan Mackowiak, Dechun Feng, Hongkun Lu, Yukun Guan, Taylor Lehner, Hongna Pan, Xin Wei Wang, Yong He, Bin Gao
Summary: miR-223 plays a critical role in regulating hypoxia-induced tumor immunosuppression and angiogenesis in hepatocellular carcinoma, and may serve as a novel therapeutic target.
Review
Pharmacology & Pharmacy
Liu Yang, Yawen Hao, Joost Boeckmans, Robim M. Rodrigues, Yong He
Summary: Nonalcoholic fatty liver disease (NAFLD) is a major global cause of chronic liver disease. Despite extensive research and clinical trials, there are no FDA-approved treatments for severe forms of NAFLD due to its complex etiology and pathogenesis. Inflammation and the role of immune cells and extracellular vesicles (EVs) derived from inflammatory cells and hepatocytes are key factors in NAFLD progression. This review focuses on the involvement of immune cells, microRNA-enriched EVs, and potential drug targets in the treatment of NAFLD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Jialin Zhou, Han Xie, Jun Liu, Ruixiang Huang, Yufei Xiang, Dasheng Tian, Erbao Bian
Summary: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a class of small regulatory RNAs that regulate transposons in germ cells and are associated with various malignant tumors. The functions and mechanisms of piRNAs in cancer are still unclear. This review summarizes the current findings on the biogenesis, function, and mechanisms of piRNAs and PIWI proteins in cancer, discusses their clinical significance as biomarkers and therapeutic tools, and presents critical questions for future research.
Review
Oncology
MengTing Wang, QingYang Chen, ShuJie Wang, Han Xie, Jun Liu, RuiXiang Huang, YuFei Xiang, YanYi Jiang, DaSheng Tian, ErBao Bian
Summary: Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with transcription factors, histone-modifying enzymes and cofactors. They play central roles in the treatment of cancer by altering protein-coding gene expression and noncoding regulatory element function, promoting tumorigenesis and malignancy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Zhigang Chen, Dasheng Tian, Xueran Chen, Meng Cheng, Han Xie, JiaJia Zhao, Jun Liu, Zhiyou Fang, Bing Zhao, Erbao Bian
Summary: In this study, a glioma-specific long non-coding RNA (lncRNA), named LIMD1-AS1, was found to be significantly overexpressed in glioma compared to normal brain tissue. High levels of LIMD1-AS1 were associated with shorter survival time in glioma patients. Functional experiments demonstrated that LIMD1-AS1 overexpression promoted glioma cell proliferation, migration, and invasion, while LIMD1-AS1 knockdown inhibited these processes. Mechanistically, inhibition of CDK7 attenuated MED1 recruitment to the super-enhancer of LIMD1-AS1, leading to decreased expression of LIMD1-AS1. Furthermore, LIMD1-AS1 directly bound to HSPA5, activating interferon signaling.
CELL DEATH & DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Csaba Matyas, Eszter Trojnar, Suxian Zhao, Muhammad Arif, Partha Mukhopadhyay, Attila Kovacs, Alexandra Fabian, Marton Tokodi, Zsolt Bagyura, Bela Merkely, Laszlo Kohidai, Eszter Lajko, Angela Takacs, Yong He, Bin Gao, Janos Paloczi, Falk W. Lohoff, Gyorgy Hasko, Wen-Xing Ding, Pal Pacher
Summary: This study found a positive correlation between PCSK9 and age-related CVD, and demonstrated that PCSK9 inhibition can effectively slow down the progression of CVD in aging rats.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Dechun Feng, Xiaogang Xiang, Yukun Guan, Adrien Guillot, Hongkun Lu, Chingwen Chang, Yong He, Hua Wang, Hongna Pan, Cynthia Ju, Sean P. Colgan, Frank Tacke, Xin Wei Wang, George Kunos, Bin Gao
Summary: Monocyte-derived macrophages (MoMFs) are rapidly recruited to and encapsulated necrotic areas during liver injury, playing a key role in repairing necrotic lesions. They induce cell death-resistant hepatocytes to form a protective capsule and participate in necrotic tissue removal and liver repair. MoMFs also activate hepatic stellate cells to eliminate necrotic lesions through α-smooth muscle actin expression.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Jing Ma, Adrien Guillot, Zhihong Yang, Bryan Mackowiak, Seonghwan Hwang, Ogyi Park, Brandon J. Peiffer, Ali Reza Ahmadi, Luma Melo, Praveen Kusumanchi, Nazmul Huda, Romil Saxena, Yong He, Yukun Guan, Dechun Feng, Pau Sancho-Bru, Mengwei Zang, Andrew MacGregor Cameron, Ramon Bataller, Frank Tacke, Zhaoli Sun, Suthat Liangpunsakul, Bin Gao
Summary: Two distinct patterns of intrahepatic neutrophil infiltration are observed in severe alcoholic hepatitis (SAH) patients, suggesting separate mechanisms driving liver injury.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Yaojie Fu, Shanshan Liu, Robim M. Rodrigues, Ying Han, Cao Guo, Zhanwei Zhu, Yong He, Bryan Mackowiak, Dechun Feng, Bin Gao, Shan Zeng, Hong Shen
Summary: This study explored the role of VIP/VIPR1 signaling in controlling hepatocellular carcinoma (HCC). VIPR1 expression was found to be downregulated in HCC tissues and correlated with advanced clinical stages, tumor growth, recurrence, and poor outcomes. Activation of VIPR1 by VIP inhibited HCC growth and metastasis by regulating arginine biosynthesis. Mechanistically, VIP treatment restored ASS1 expression and suppressed CAD phosphorylation in an mTOR/p70S6K signaling dependent manner. Restoring VIPR1 and using VIPR1 agonists may be a promising approach in HCC treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Gang Zong, Xiuhao Huo, Tian Huai, Erbao Bian, Bing Zhao
Summary: miR-129 can inhibit the proliferation of glioma cells, increase the apoptosis rate of glioma cells, and promote autophagy by regulating the expression of autophagy-related proteins. The mechanism may be related to miR-129 regulating Notch-1.
ACTA MEDICA MEDITERRANEA
(2022)