Article
Multidisciplinary Sciences
Katrin Rabold, Martijn Zoodsma, Inge Grondman, Yunus Kuijpers, Manita Bremmers, Martin Jaeger, Bowen Zhang, Willemijn Hobo, Han J. Bonenkamp, Johannes H. W. de Wilt, Marcel J. R. Janssen, Lenneke A. M. Cornelissen, Ilse C. H. Van Engen-van Grunsven, Willem J. M. Mulder, Jan W. A. Smit, Gosse J. Adema, Mihai G. Netea, Yang Li, Cheng-Jian Xu, Romana T. Netea-Maier
Summary: This study conducted single-cell transcriptomics and functional analyses of myeloid cells in patients with non-medullary thyroid carcinoma and multinodular goiter, revealing distinct transcriptional and functional changes occurring in these cells before their tumor infiltration, which are already initiated in the bone marrow.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Joseph R. Podojil, Andrew C. Cogswell, Ming-Yi Chiang, Valerie Eaton, Igal Ifergan, Tobias Neef, Dan Xu, Khyati A. Meghani, Yanni Yu, Sophia M. Orbach, Tushar Murthy, Michael T. Boyne, Adam Elhofy, Lonnie D. Shea, Joshua J. Meeks, Stephen D. Miller
Summary: This study found that the use of ONP-302 can control tumors by reprogramming myeloid cells through the activation of the STING/IL-15/NK cell mechanism, and enhance the efficacy of anti-PD-1.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Arailym Aronova, Federica Tosato, Nawraa Naser, Yaw Asare
Summary: Innate immune pathways play a crucial role in the development of atherosclerosis and targeting these pathways may effectively reduce the risk of cardiovascular disease. Understanding the interplay between these pathways and the long-term reprogramming of immune cells is essential for the development of targeted therapeutic interventions.
Review
Oncology
Simon T. Barry, Dmitry I. Gabrilovich, Owen J. Sansom, Andrew D. Campbell, Jennifer P. Morton
Summary: Myeloid cells in the tumour microenvironment have a significant impact on tumour progression, making them a key target for clinical therapies. However, large-scale clinical trials targeting these cells have had limited success. Understanding the specific functions and roles of different myeloid cell subpopulations within the tumour microenvironment could improve the design of successful clinical trials for myeloid-targeting therapies.
NATURE REVIEWS CANCER
(2023)
Review
Immunology
Siroon Bekkering, Jorge Dominguez-Andres, Leo A. B. Joosten, Niels P. Riksen, Mihai G. Netea
Summary: Trained immunity is a newly recognized phenomenon where cells of the innate immune system exhibit memory characteristics and enhanced responses upon secondary challenge. It explains the heterologous effects of vaccines, but can also lead to maladaptive effects in chronic inflammatory conditions.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Review
Immunology
Marianna Rowlands, Florencia Segal, Dominik Hartl
Summary: The clinical presentations of COVID-19 are highly variable, and the pathophysiological mechanisms that govern different disease courses are still poorly understood. Severity of COVID-19 may be associated with dysregulation of myeloid-derived suppressor cells (MDSCs). MDSCs play a crucial role in COVID-19 infection by modulating T-cell responses and promoting an inflammatory state through secretion of mediators.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Mohamed-Ali Hakimi
Summary: Like many intracellular pathogens, Toxoplasma gondii uses effector proteins to manipulate host cells and promote transmission and persistence. This review summarizes how T. gondii effectors control the fate of infected cells and the outcome of infection through specific mechanisms.
ANNUAL REVIEW OF MICROBIOLOGY
(2022)
Review
Immunology
Jingli Lu, Yan Liang, Haiyang Meng, Ailing Zhang, Junjie Zhao, Chengliang Zhang
Summary: The article discusses the metabolic and epigenetic features of Treg cells, as well as the impact of metabolites on epigenetic changes in Treg cells, which in turn affect the activation, differentiation, and function of Treg cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Neurosciences
Stefan H. Stricker, Magdalena Goetz
Summary: The vulnerability of the mammalian brain lies in its limited ability to generate new neurons after maturation, but the direct conversion of non-neuronal cells to neurons offers a promising avenue for brain repair. Understanding the identity and chromatin hallmarks of induced neurons is crucial to avoid adverse effects and novel tools for manipulating specific epigenetic marks hold potential for erasing aberrant epigenetic memory and advancing therapeutic approaches for brain repair.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Oncology
Jordi Alcaraz, Rafael Ikemori, Alejandro Llorente, Natalia Diaz-Valdivia, Noemi Reguart, Miguel Vizoso
Summary: Lung cancer is the leading cause of cancer-related death worldwide, with the stroma of lung cancer and other solid tumors being rich in tumor-associated fibroblasts (TAFs) exhibiting an activated/myofibroblast-like phenotype. Growing evidence suggests that TAFs support key steps of tumor progression and are epigenetically reprogrammed compared to healthy fibroblasts. The mechanisms underlying this reprogramming involve interactions with cancer cells, pro-fibrotic cytokines, extracellular matrix stiffness, smoking particles, and other environmental cues, leading to DNA hypomethylation and selective transcriptional repression in lung TAFs.
Article
Immunology
Minhong Huang, Emir Malovic, Alyssa Ealy, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
Summary: Epigenetic reprogramming allows innate immune cells to form memories of environmental stimuli, enhancing their response to subsequent stressors. In this study, microglial cells were primed with LPS and showed augmented inflammatory responses to the secondary stressor Mn. The deposition of H3K27ac was found to be involved in the immune memory formation, and inhibition of H3K27ac deposition attenuated the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Elisa Jentho, Cristian Ruiz-Moreno, Boris Novakovic, Ioannis Kourtzelis, Wout L. Megchelenbrink, Rui Martins, Triantafyllos Chavakis, Miguel P. Soares, Lydia Kalafati, Joel Guerra, Franziska Roestel, Peter Bohm, Maren Godmann, Tatyana Grinenko, Anne Eugster, Martina Beretta, Leo A. B. Joosten, Mihai G. Netea, Michael Bauer, Hendrik G. Stunnenberg, Sebastian Weis
Summary: Trained immunity refers to long-lasting adaptations of innate immunity, and labile heme has been identified as a previously unrecognized inducer of trained immunity. Unlike other inducers that rely on pathogen-associated molecular patterns, heme training activates a unique signaling pathway and is associated with the expansion of self-renewing hematopoetic stem cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Linchong Sun, Huafeng Zhang, Ping Gao
Summary: Metabolic rewiring and epigenetic remodeling, which are closely linked in cancer development, play important roles in tumor progression and immune escape. Metabolites can affect the function of chromatin-modifying enzymes, influencing processes such as tumor progression and immunosurveillance.
Article
Chemistry, Multidisciplinary
Guotao Peng, Sandeep Keshavan, Lucia Delogu, Yuyoung Shin, Cinzia Casiraghi, Bengt Fadeel
Summary: This study demonstrates that two-dimensional transition metal dichalcogenides (TMDs), specifically MoS2, can trigger trained immunity in human macrophages. This induction of trained immunity involves epigenetic pathway and metabolic rewiring, leading to changes in immune gene expression and cellular metabolism.
Article
Pharmacology & Pharmacy
Chunying Peng, Katrin Rabold, Mihai G. G. Netea, Martin Jaeger, Romana T. T. Netea-Maier
Summary: Lenvatinib is a multitarget tyrosine kinase inhibitor approved for the treatment of various cancers. Recent data suggest that TKIs like Lenvatinib may have additional immunological effects, but the specific impact on human immune cells in thyroid cancer is unknown.
Article
Cell Biology
Beatriz Suarez-Alvarez, Ramon M. Rodriguez, Karin Schlangen, Aroa Baragano Raneros, Leonardo Marquez-Kisinousky, Agustin F. Fernandez, Carmen Diaz-Corte, Ana M. Aransay, Carlos Lopez-Larrea
Article
Immunology
Ramon M. Rodriguez, Beatriz Suarez-Alvarez, Jose L. Lavin, David Mosen-Ansorena, Aroa Baragano Raneros, Leonardo Marquez-Kisinousky, Ana M. Aransay, Carlos Lopez-Larrea
JOURNAL OF IMMUNOLOGY
(2017)
Article
Urology & Nephrology
Beatriz Suarez-Alvarez, Jose Luis Morgado-Pascual, Sandra Rayego-Mateos, Ramon M. Rodriguez, Raul Rodrigues-Diez, Pablo Cannata-Ortiz, Ana B. Sanz, Jesus Egido, Pierre-Louis Tharaux, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2017)
Article
Oncology
Aroa Baragano Raneros, Alfredo Minguela Puras, Ramon M. Rodriguez, Enrique Colado, Teresa Bernal, Eduardo Anguita, Adela Vasco Mogorron, Alberto Chaparro Gil, J. R. Vidal-Castineira, Leonardo Marquez-Kisinousky, Paula Diaz Bulnes, Amelia Martinez Marin, Maria Carmen Garcia Garay, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea
Article
Immunology
Beatriz Diaz-Molina, Paula Diaz-Bulnes, Reyes Carvajal Palao, Maria Jose Bernardo, Ramon M. Rodriguez, Viviana Corte-Iglesias, Cesar Moris de la Tassa, Jose Luis Lambert, Beatriz Suarez-Alvarez
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Rocio G. Urdinguio, Virginia Lopez, Gustavo F. Bayon, Rafael Diaz de la Guardia, Marta I. Sierra, Estela Garcia-Torano, Raul F. Perez, Maria G. Garcia, Antonella Carella, Patricia C. Pruneda, Cristina Prieto, Marija Dmitrijeva, Pablo Santamarina, Thalia Belmonte, Cristina Mangas, Elena Diaconu, Cecilia Ferrero, Juan Ramon Tejedor, Juan Luis Fernandez-Morera, Cristina Bravo, Clara Bueno, Alejandra Sanjuan-Pla, Ramon M. Rodriguez, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Teresa Bernal, Enrique Colado, Milagros Balbin, Olivia Garcia-Suarez, Maria Dolores Chiara, Ines Saenz-de-Santa-Maria, Francisco Rodriguez, Ana Pando-Sandoval, Luis Rodrigo, Laura Santos, Ana Salas, Jesus Vallejo-Diaz, Ana C. Carrera, Daniel Rico, Inmaculada Hernandez-Lopez, Amparo Vaya, Jose M. Ricart, Edward Seto, Nuria Sima-Teruel, Alejandro Vaquero, Luis Valledor, Maria Jesus Canal, David Pisano, Osvaldo Grana-Castro, Tim Thomas, Anne K. Voss, Pablo Menendez, Ana Villar-Garea, Rainer Deutzmann, Agustin F. Fernandez, Mario F. Fraga
NUCLEIC ACIDS RESEARCH
(2019)
Article
Cell Biology
Ramon M. Rodriguez, Beatriz Suarez-Alvarez, Jose L. Lavin, Alex M. Ascension, Monika Gonzalez, Juan J. Lozano, Aroa B. Raneros, Paula D. Bulnes, Jose R. Vidal-Castineira, Covadonga Huidobro, Cristina Martin-Martin, Ana B. Sanz, Marta Ruiz-Ortega, Amaya Puig-Kroger, Angel L. Corbi, Marcos J. Arauzo-Bravo, Ana M. Aransay, Carlos Lopez-Larrea
Review
Immunology
Paula Diaz-Bulnes, Maria Laura Saiz, Carlos Lopez-Larrea, Ramon M. Rodriguez
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Karim Perez-Romero, Ramon M. Rodriguez, Amedeo Amedei, Gwendolyn Barcelo-Coblijn, Daniel H. Lopez
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Genetics & Heredity
Ramon Maria Rodriguez, Maria Laura Saiz, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea
Summary: The aging process is linked to epigenetic changes in immune cells, but the source of these alterations is not clear. Understanding this epigenetic drift in the immune system can offer crucial insights into the aging process and each individual's immune history.
TRENDS IN GENETICS
(2022)
Article
Immunology
Ramon M. Rodriguez, Maria P. Hernandez-Fuentes, Viviana Corte-Iglesias, Maria Laura Saiz, Juan Jose Lozano, Ana R. Cortazar, Isabel Mendizabal, Maria Luisa Suarez-Fernandez, Eliecer Coto, Antonio Lopez-Vazquez, Carmen Diaz-Corte, Ana M. Aransay, Carlos Lopez-Larrea, Beatriz Suarez-Alvarez
Summary: Genome-wide DNA methylation analysis in kidney transplant recipients revealed distinct methylation signatures associated with operational tolerance and chronic rejection. Tolerance was linked to demethylation in immune function genes, while rejection was associated with intracellular signaling and ubiquitination pathways. Analysis of methylation patterns in tolerant patients showed similarities with those receiving low doses of steroids, suggesting a potential epigenetic mechanism for tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alice Chaplin, Ramon Maria Rodriguez, Juan Jose Segura-Sampedro, Aina Ochogavia-Segui, Dora Romaguera, Gwendolyn Barcelo-Coblijn
Summary: Obesity is a major risk factor for colorectal cancer, and visceral adipose tissue may play a key role in tumor development and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Aroa Baragano Raneros, Ramon M. Rodriguez, Aida Bernardo Florez, Pilar Palomo, Enrique Colado, Alfredo Minguela, Beatriz Suarez Alvarez, Carlos Lopez-Larrea
Summary: B7-H6, a ligand for NKp30 activating receptor, is a poor prognosis biomarker in solid cancers. BRD4, overexpressed in AML cells, positively regulates B7-H6 expression through acetylation and recruitment of transcription factors. High B7-H6 levels in AML patients are associated with increased BRD4 levels, myelodysplastic-derived AML, and del5q, indicating poor prognosis.
Review
Surgery
B. Suarez-Alvarez, R. M. Rodriguez, M. Ruiz-Ortega, C. Lopez-Larrea
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)