Article
Agriculture, Multidisciplinary
Qian Wan, Jie Xu, Chengjing Zhu, Xingxing Liu, Yijun Tu, Jiachuan Lei, Jianqing Yu
Summary: In this study, 16 compounds, including 9 new amide alkaloids, were isolated from the roots of Piper longum L. These compounds exhibited better anti-inflammatory activities compared to indomethacin. Among them, five dimeric amide alkaloids showed synergistic effects with chemotherapeutic drugs against cervical cancer cells and enhanced the efficacy of paclitaxel in paclitaxel-resistant cervical cancer cells. Additionally, these dimeric amide alkaloids could promote cancer cell apoptosis through the Src/ERK/STAT3 signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yang Xia, Hongwei Jiang, Jinwen Chen, Fang Xu, Guoxiu Zhang, Dongshan Zhang
Summary: Low-dose Taxol can attenuate the progression of diabetic kidney disease (DKD) by modulating the Smad3-HIPK2/p53 axis, making it a promising therapeutic drug for DKD.
Article
Chemistry, Physical
Aritra Kumar Dan, Bari Aamna, Soumik De, Miguel Pereira-Silva, Raghaba Sahu, Ana Claudia Paiva-Santos, Sagarika Parida
Summary: Sericin nanoparticles have emerged as a promising drug delivery vector in cancer treatment, offering enhanced efficacy, stability, and targeted delivery of chemotherapeutic drugs. This review provides a comprehensive summary of the current research status and synthesis techniques of sericin nanoparticles, highlighting their potential in cancer mitigation.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Nanoscience & Nanotechnology
Mahaveer P. Purohit, Aditya K. Kar, Manisha Kumari, Debabrata Ghosh, Satyakam Patnaik
Summary: Combining antiangiogenic and chemotherapeutic drugs within multimodal nanocarriers has shown promising clinical benefits in inhibiting tumor growth and progression. The study reports the combinatorial efficacy of heparin, selenium NPs, and doxorubicin in inhibiting cancer cell viability and inducing apoptosis. The nanocarriers demonstrated excellent water dispersity and strong anticancer potential in in vitro assays, while in vivo imaging highlighted their tumor targeting ability. Overall, these results qualify the nanocarriers as a potential clinical therapeutic candidate.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Cell Biology
Md Ataur Rahman, Moon Nyeo Park, Md Hasanur Rahman, Md Mamunur Rashid, Rokibul Islam, Md Jamal Uddin, Md Abdul Hannan, Bonglee Kim
Summary: p53, the key tumor suppressor protein, plays a significant role in regulating various biological processes, including energy metabolism, cell cycle, apoptosis, and more. Autophagy, a crucial cellular process, is involved in maintaining cellular homeostasis. The relationship between p53 and autophagy is complex and not completely understood, as p53 can both inhibit and activate autophagy depending on its cellular localization and mode of action. Understanding the interaction between p53 and autophagy is important for cancer treatment and management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Qiulian Zhou, Jiali Deng, Jianhua Yao, Jiaxin Song, Danni Meng, Yujiao Zhu, Minjun Xu, Yajun Liang, Jiahong Xu, Joost P. G. Sluijter, Junjie Xiao
Summary: Exercise-induced HIPK2 suppression attenuates cardiomyocyte apoptosis and protects against myocardial infarction by decreasing P-P53 levels. Inhibition of HIPK2 represents a potential novel therapeutic intervention for myocardial infarction.
Review
Chemistry, Medicinal
Nirmala Tilija Pun, Chul-Ho Jeong
Summary: Cancer is incurable due to the progressive changes in cancer cells leading to resistance and recurrence, necessitating the development of new drugs or alternative therapeutic strategies. Drug repurposing, such as using statins, has emerged as an economical, safe, and efficacious approach to cancer therapy, capitalizing on existing drugs for new indications. Studies have shown statins can inhibit cancer cell proliferation and induce apoptosis as monotherapy, or be used in combination therapy to overcome drug resistance. Ongoing explorations in in vitro, in vivo, and clinical trials are aiming to further improve chemotherapy outcomes for cancer patients.
Article
Biochemistry & Molecular Biology
Nipin Sp, Dong Young Kang, Jin-Moo Lee, Se Won Bae, Kyoung-Jin Jang
Summary: 6-Gingerol, an active polyphenol in ginger, has been found to induce DNA damage response, cell cycle arrest, mitochondrial apoptosis, and suppression of tumorsphere formation in breast cancer cells by increasing ROS levels and activating p53-dependent intrinsic apoptosis signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Lirong Liang, Ze Fan, Danyi He, Youyi Zhao, Tian Zeng, Bing Liu, Tianyuan Ma, Junjun Kang, Hui Zhang
Summary: This study investigated the role of HIPK2/AKT/mTOR signaling in sevoflurane-induced neurotoxicity and found that the up-regulation of this signaling pathway played a crucial role in neuronal apoptosis caused by sevoflurane exposure. The results suggest that HIPK2/AKT/mTOR signaling could be a potential therapeutic target for protecting against anesthesia-induced cytotoxicity.
NEUROTOXICITY RESEARCH
(2022)
Article
Cell Biology
Dong Ha Kim, Hyojeong Park, Yun Jung Choi, Myoung-Hee Kang, Tae-Keun Kim, Chan-Gi Pack, Chang-Min Choi, Jae Cheol Lee, Jin Kyung Rho
Summary: Exosomal miR-1260b promotes angiogenesis in HUVECs and metastasis in NSCLC by targeting HIPK2, and may serve as a potential prognostic marker for lung cancer.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae-Ho Lee, Byoung Kuk Jang, Mi Kyung Kim
Summary: The study found that kahweol induces apoptosis in hepatocellular carcinoma cells by inhibiting the phosphorylation of specific signaling pathways, suggesting it as a potential inhibitor of HCC cell growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ling-Yen Chiu, I-Lun Hsin, Jen-Ning Tsai, Chih-Jung Chen, Chu-Chyn Ou, Wen-Jun Wu, Gwo-Tarng Sheu, Jiunn-Liang Ko
Summary: The combination treatment of Saracatinib and GMI showed synergistic and additive cytotoxic effects on A549 and A400 cells, inducing caspase-7 activation in A549 cells. The study suggests a novel strategy for treating lung cancer, with or without drug resistance, using a combination of GMI and Saracatinib.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Anjali Phour, Vidit Gaur, Ahana Banerjee, Jayanta Bhattacharyya
Summary: This review discusses the development of advanced recombinant protein polymers designed for the delivery of chemotherapeutics, and highlights their importance in overcoming the limitations of conventional chemotherapy and improving the therapeutic index.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Multidisciplinary Sciences
Kenichi Hirabayashi, Masaki Miyazawa, Yumi Takanashi, Masashi Morimachi, Aya Kawanishi, Tsubasa Saika, Toshio Nakagohri, Naoya Nakamura
Summary: miR-4653-3p is associated with invasiveness, tumorigenesis, and prognosis of PDAC. High expression of miR-4653-3p is correlated with advanced clinical and pathological features and worse prognosis. HIPK2 has been identified as a target of miR-4653-3p, and miR-4653-3p participates in PDAC development and worse prognosis by reducing HIPK2 expression.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Physical
Jianfeng Guo, Yifang Zou, Leaf Huang
Summary: Immunogenic cell death (ICD) activates the immune system to eliminate tumors. However, using chemotherapeutic drugs as ICD inducers in tumor immunotherapy faces challenges such as poor solubility, short circulation, non-specific distribution, and toxicity. Recent advances in nanotechnology and pharmaceutical formulation offer solutions to overcome these challenges.
Article
Biochemical Research Methods
Jana Sieber, Christian Hauer, Madhuri Bhuvanagiri, Stefan Leicht, Jeroen Krijgsveld, Gabriele Neu-Yilik, Matthias W. Hentze, Andreas E. Kulozik
MOLECULAR & CELLULAR PROTEOMICS
(2016)
Article
Biochemical Research Methods
Irma Virant-Klun, Stefan Leicht, Christopher Hughes, Jeroen Krijgsveld
MOLECULAR & CELLULAR PROTEOMICS
(2016)
Article
Biochemical Research Methods
Anke Liepelt, Isabel S. Naarmann-de Vries, Nadine Simons, Katrin Eichelbaum, Sophia Foehr, Stuart K. Archer, Alfredo Castello, Bjoern Usadel, Jeroen Krijgsveld, Thomas Preiss, Gernot Marx, Matthias W. Hentze, Dirk H. Ostareck, Antje Ostareck-Lederer
MOLECULAR & CELLULAR PROTEOMICS
(2016)
Article
Biochemistry & Molecular Biology
Mahmoud-Reza Rafiee, Charles Girardot, Gianluca Sigismondo, Jeroen Krijgsveld
Article
Biochemistry & Molecular Biology
Alfredo Castello, Bernd Fischer, Christian K. Frese, Rastislav Horos, Anne-Marie Alleaume, Sophia Foehr, Tomaz Curk, Jeroen Krijgsveld, Matthias W. Hentze
Article
Cell & Tissue Engineering
Satoshi Okawa, Sladjana Gagrica, Carla Blin, Christine Ender, Steven M. Pollard, Jeroen Krijgsveld
Article
Multidisciplinary Sciences
Vasiliy O. Sysoev, Bernd Fischer, Christian K. Frese, Ishaan Gupta, Jeroen Krijgsveld, Matthias W. Hentze, Alfredo Castello, Anne Ephrussi
NATURE COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
Birgit Rogell, Bernd Fischer, Mandy Rettel, Jeroen Krijgsveld, Alfredo Castello, Matthias W. Hentze
Article
Multidisciplinary Sciences
Linda Noetzold, Lukas Frank, Minakshi Gandhi, Maria Polycarpou-Schwarz, Matthias Gross, Manuel Gunkel, Nina Beil, Holger Erfle, Nathalie Harder, Karl Rohr, Jakob Trendel, Jeroen Krijgsveld, Thomas Longerich, Peter Schirmacher, Michael Boutros, Sylvia Erhardt, Sven Diederichs
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Torsten Mueller, Mathias Kalxdorf, Remi Longuespee, Daniel N. Kazdal, Albrecht Stenzinger, Jeroen Krijgsveld
MOLECULAR SYSTEMS BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Mahmoud-Reza Rafiee, Gianluca Sigismondo, Mathias Kalxdorf, Laura Foerster, Britta Bruegger, Julien Bethune, Jeroen Krijgsveld
MOLECULAR SYSTEMS BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Mathias Kalxdorf, Torsten Mueller, Oliver Stegle, Jeroen Krijgsveld
Summary: IceR is a quantitative workflow for proteomics that combines high identification rates of data-dependent acquisition with low missing value rates, improving quantification precision, accuracy, reliability, and data completeness. Applied to plasma and single-cell proteomics data, IceR enhances the number of reliably quantified proteins, improves discriminability between single-cell populations, and allows reconstruction of a developmental trajectory.
NATURE COMMUNICATIONS
(2021)
Review
Biochemical Research Methods
Gianluca Sigismondo, Dimitris N. Papageorgiou, Jeroen Krijgsveld
Summary: Chromatin is composed of genomic DNA and proteins in the nucleus of eukaryotic cells, playing a crucial role in regulating cellular processes. Histones, the best known protein constituents in chromatin, undergo post-translational modifications to recruit accessory proteins for specific functions. Proteomic approaches have been instrumental in understanding the complex interplay within chromatin, enabling the identification and quantification of proteins and modifications in an unbiased manner.
Article
Biochemistry & Molecular Biology
Edoardo Fatti, Alexander Hirth, Andrea Svorinic, Matthias Guenther, Gunter Stier, Cristina-Maria Cruciat, Sergio P. Acebron, Dimitris Papageorgiou, Irmgard Sinning, Jeroen Krijgsveld, Thomas Hoefer, Christof Niehrs
Summary: DDX RNA helicases not only promote RNA processing, but also activate multiple protein kinases, including CK1ε and CK2. It has been found that different DDX proteins can stimulate the kinase activity of CK2, and DDX1, DDX24, DDX41, and DDX54 are required for full kinase activity in vitro and in Xenopus embryos. Mathematical modeling and experimental evidence suggest that DDX proteins function as nucleotide exchange factors, reducing unproductive reaction intermediates and substrate inhibition in CK2-mediated protein kinase stimulation.
Review
Cell Biology
Nade Abazova, Jeroen Krijgsveld
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2017)