HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

SIRT1 negatively regulates the protein stability of HIPK2

(2013) Joohyun Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization

(2013) Timan Polonio-Vallon et al.   CELL CYCLE

Active regulator of SIRT1 is required for ribosome biogenesis and function

(2013) John R. P. Knight et al.   NUCLEIC ACIDS RESEARCH

Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

(2013) N. Bitomsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis

(2012) Thomas G. Hofmann et al.   BIOESSAYS

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

Regulation of SIRT1 activity by genotoxic stress

(2012) J. Yuan et al.   GENES & DEVELOPMENT

DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

(2012) Laura Zannini et al.   Journal of Molecular Cell Biology

Peptide Switch Is Essential for Sirt1 Deacetylase Activity

(2011) Hyeog Kang et al.   MOLECULAR CELL

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

(2011) J-H Mao et al.   ONCOGENE

The Loss of the p53 Activator HIPK2 Is Responsible for Galectin-3 Overexpression in Well Differentiated Thyroid Carcinomas

(2011) Luca Lavra et al.   PLoS One

Cutaneous HPV23 E6 Prevents p53 Phosphorylation through Interaction with HIPK2

(2011) Dorothea Muschik et al.   PLoS One

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1

(2009) Se-Yong Kim et al.   CANCER LETTERS

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

A c-Myc–SIRT1 feedback loop regulates cell growth and transformation

(2009) Jian Yuan et al.   JOURNAL OF CELL BIOLOGY

HIPK2 modulates p53 activity towards pro-apoptotic transcription

(2009) Rosa Puca et al.   Molecular Cancer

JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

(2009) Nargis Nasrin et al.   PLoS One

Role of nuclear bodies in apoptosis signalling

(2008) Eva Krieghoff-Henning et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

How cells switch HIPK2 on and off

(2008) D Sombroek et al.   CELL DEATH AND DIFFERENTIATION

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

(2008) Melanie Winter et al.   NATURE CELL BIOLOGY

Regulation of apoptosis by PML and the PML-NBs

(2008) R Bernardi et al.   ONCOGENE