Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways

Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

(2012) C. S. F. Wong et al.   CANCER RESEARCH

The Ubiquitin Ligase Siah2 Regulates PPARγ Activity in Adipocytes

(2012) Gail Kilroy et al.   ENDOCRINOLOGY

DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells

(2012) Naoe Taira et al.   JOURNAL OF CLINICAL INVESTIGATION

A Redox-Regulated SUMO/Acetylation Switch of HIPK2 Controls the Survival Threshold to Oxidative Stress

(2012) Laureano de la Vega et al.   MOLECULAR CELL

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

Identification of a Src Tyrosine Kinase/SIAH2 E3 Ubiquitin Ligase Pathway That Regulates C/EBP  Expression and Contributes to Transformation of Breast Tumor Cells

(2011) T. R. Sarkar et al.   MOLECULAR AND CELLULAR BIOLOGY

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

(2011) Hyungsoo Kim et al.   MOLECULAR CELL

Oxygen-Dependent Cleavage of the p75 Neurotrophin Receptor Triggers Stabilization of HIF-1α

(2011) Natacha Le Moan et al.   MOLECULAR CELL

Role of p53 Serine 46 in p53 Target Gene Regulation

(2011) Leonie Smeenk et al.   PLoS One

The Ski protein negatively regulates Siah2-mediated HDAC3 degradation

(2010) Hong-Ling Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors

(2010) Jianfei Qi et al.   CANCER CELL

The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions

(2010) Stefanie Ritterhoff et al.   EMBO JOURNAL

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

(2010) Sergi Aranda et al.   FASEB JOURNAL

Siah Proteins: Novel Drug Targets in the Ras and Hypoxia Pathways

(2009) C. M. House et al.   CANCER RESEARCH

ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage

(2009) Naoe Taira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin Ligase Siah2 and the Hypoxia Response

(2009) K. Nakayama et al.   MOLECULAR CANCER RESEARCH

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

(2009) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer

(2008) Maurice P. H. M. Jansen et al.   BREAST CANCER RESEARCH AND TREATMENT

Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling

(2008) Markku Varjosalo et al.   CELL

Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth

(2008) Atique U. Ahmed et al.   JNCI-Journal of the National Cancer Institute

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

(2008) Melanie Winter et al.   NATURE CELL BIOLOGY

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response

(2008) Marco A. Calzado et al.   NATURE CELL BIOLOGY

Inhibition of Siah ubiquitin ligase function

(2008) A Möller et al.   ONCOGENE

The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

(2008) J. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA