The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance

Erythropoietin inhibits chemotherapy-induced cell death and promotes a senescence-like state in leukemia cells

(2019) Thuc-Nghi Duc Pham et al.   Cell Death & Disease

Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

(2019) Alexander Schulz et al.   Cancers

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide

(2018) Lu Lu et al.   ONCOGENE

Recent Advances in Lgr5 + Stem Cell Research

(2018) Carly Leung et al.   TRENDS IN CELL BIOLOGY

Tescalcin/c-Src/IGF1Rβ-mediated STAT3 activation enhances cancer stemness and radioresistant properties through ALDH1

(2018) Jei Ha Lee et al.   Scientific Reports

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibition of LEF1-Mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness

(2018) So-Yeon Park et al.   CLINICAL CANCER RESEARCH

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

(2017) Gwenola Manic et al.   GUT

The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model

(2017) Katharine Victoria Jensen et al.   PLoS One

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks inex vivoculture

(2016) Fanny Grillet et al.   GUT

Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

(2016) Li Du et al.   Nature Communications

Fractionated radiation exposure amplifies the radioresistant nature of prostate cancer cells

(2016) N. McDermott et al.   Scientific Reports

Aldehyde Dehydrogenase Is Regulated by  -Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells

(2015) M. Cojoc et al.   CANCER RESEARCH

STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma

(2015) J. Lau et al.   CANCER RESEARCH

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

Targeting JAK kinase in solid tumors: emerging opportunities and challenges

(2015) M Buchert et al.   ONCOGENE

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma

(2015) E Singer et al.   Cell Death & Disease

Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

(2014) Khalid Abubaker et al.   BMC CANCER

PAK1 Tyrosine Phosphorylation Is Required to Induce Epithelial-Mesenchymal Transition and Radioresistance in Lung Cancer Cells

(2014) E. Kim et al.   CANCER RESEARCH

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Radiation-induced signaling pathways that promote cancer cell survival (Review)

(2014) ASHLEY L. HEIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy

(2014) Melanie Spitzner et al.   Cancers

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells

(2013) P. Kroon et al.   CANCER RESEARCH

Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance

(2013) A. Quintas-Cardama et al.   CLINICAL CANCER RESEARCH

Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma

(2013) TADASHI ASHIZAWA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells

(2013) Xiuting Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer

(2013) S. You et al.   MOLECULAR CANCER THERAPEUTICS

PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility

(2013) C Zhou et al.   ONCOGENE

Discovery of the cancer stem cell related determinants of radioresistance

(2013) Claudia Peitzsch et al.   RADIOTHERAPY AND ONCOLOGY

Clinical perspectives of cancer stem cell research in radiation oncology

(2013) Rebecca Bütof et al.   RADIOTHERAPY AND ONCOLOGY

Cancer Stem Cell Niche: The Place to Be

(2011) T. Borovski et al.   CANCER RESEARCH

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of JAK2 Signaling by TG101209 Enhances Radiotherapy in Lung Cancer Models

(2011) Yunguang Sun et al.   Journal of Thoracic Oncology

Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays

(2010) Yi Qing et al.   BMC CANCER

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Overexpression of STAT3 Potentiates Growth, Survival, and Radioresistance of Non-Small-Cell Lung Cancer (NSCLC) cells

(2010) Zhen-Jie Yin et al.   JOURNAL OF SURGICAL RESEARCH

Expression of cyclin D2 is an independent predictor of the development of hepatic metastasis in colorectal cancer

(2009) R. Sarkar et al.   Colorectal Disease

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

(2009) Maureen M. Sherry et al.   STEM CELLS