Article
Biochemistry & Molecular Biology
Brianna N. Kerr, Daniel Duffy, Caitriona E. McInerney, Ashton Hutchinson, Inaya Dabaja, Rana Bazzi, Stephane Roux, Kevin M. Prise, Karl T. Butterworth
Summary: This study aimed to evaluate the radiosensitizing and immunomodulatory properties of differentially PEGylated GNPs in GBM cells. The results showed that PEGylation improved the radiobiological efficacy, with double-strand break induction being identified as a mechanism. PEGylated GNPs also enhanced the immunogenicity of radiotherapy, correlating with upregulation of inflammatory cytokines. These findings suggest that ID11 and ID12 could be potential candidates for RT-drug combination in future GBM preclinical investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Sofia Cordoba, Abel Cordoba, Beatriz Gil, Raquel Benlloch, Silvia Rodriguez, Dina Najjari-Jamal, Sofia Santana, Lucie Bresson, Cristina de la Fuente, Jesus Romero, Michael Pinkawa
Summary: This article emphasizes the crucial role of radiotherapy in the treatment of vulvar cancer, particularly the advantages of brachytherapy. It provides recent data on the importance of radiotherapy in both primary and recurrent cases of vulvar cancer.
Review
Biology
Amelia Barcellini, Alexandra Charalampopoulou, Loris De Cecco, Andrei Fodor, Emanuela Rabaiotti, Giorgio Candotti, Simona Secondino, Angelica Facoetti, Laura Deborah Locati, Sandro Pignata, Ester Orlandi, Giorgia Mangili
Summary: Radiotherapy is increasingly being used in combination with surgery, chemotherapy, and novel drugs to treat ovarian cancer. This review aims to summarize the current understanding of the radiosensitivity and radioresistance of ovarian cancer, which is the deadliest gynecological cancer worldwide. Understanding the mechanisms of radiosensitivity and identifying potential biomarkers of radioresistance could be crucial in guiding clinical decision-making, considering the high rate of recurrence in and out of the radiotherapy fields, especially in the era of personalized oncology.
Review
Oncology
Liping Pan, Juan Han, Ming Lin
Summary: For patients with refractory breast cancer, integrative immunotherapies are becoming crucial in treatment. However, many patients do not respond to treatment or relapse. The tumor microenvironment and cancer stem cells play important roles in the progression of breast cancer. Modulating the immune system and targeting breast cancer stem cells directly are essential strategies for improving therapeutic efficacy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Environmental Sciences
Mark P. Little, Richard Wakeford, Simon D. Bouffler, Kossi Abalo, Michael Hauptmann, Nobuyuki Hamada, Gerald M. Kendall
Summary: Studies show that there is a significant increase in the risk of cancer and benign neoplasms in infants and children who receive low or moderate levels of radiation. The risks are particularly higher in those exposed to radiation in utero or as children, with brain/CNS tumors, thyroid cancer, and leukemia showing particularly large excess relative risks.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Oncology
Emily Russell, Victoria Dunne, Ben Russell, Hibaaq Mohamud, Mihaela Ghita, Stephen J. McMahon, Karl T. Butterworth, Giuseppe Schettino, Conor K. McGarry, Kevin M. Prise
Summary: This study found radiosensitizing effects of SPIONs in 5 out of 6 cancer cell lines, with no correlation between cell-specific uptake of SPIONs and DNA damage levels. The in vivo study demonstrated a significant decrease in tumor growth rate when SPIONs were combined with radiation therapy.
RADIATION ONCOLOGY
(2021)
Review
Oncology
Dana M. Omer, Hannah M. Thompson, Floris S. Verheij, Jonathan B. Yuval, Roni Rosen, Nathalie R. A. Beets, Anisha Luthra, Paul B. Romesser, Philip B. Paty, Julio Garcia-Aguilar, Francisco Sanchez-Vega
Summary: Radiation therapy for prostate cancer increases the risk of developing rectal cancer compared to surgery. Treating radiation-associated rectal cancer is challenging due to limited and contradictory evidence. This review discusses the unique considerations of treating rectal cancer patients after prostate radiotherapy.
Review
Oncology
Laura Vanderwaeren, Ruveyda Dok, Kevin Verstrepen, Sandra Nuyts
Summary: Proton radiation therapy is a modern radiotherapy method that offers more precision in treating tumors with lower toxicity to healthy tissue. Despite growing clinical experience, the radiobiological effects of proton radiation remain not fully understood.
Review
Biochemistry & Molecular Biology
Fabio Busato, Badr El Khouzai, Maddalena Mognato
Summary: Ionizing radiation is a well-established method for cancer treatment, but some tumors are resistant to radiotherapy. By considering tumor genetics/epigenetics, tumor microenvironment, tumor metabolism, and the presence of non-malignant cells, clinical strategies targeting radioresistant tumors can be improved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
L. Danielle Rodin, Anna J. Dare, Reanne Booker, Christopher Booth, Heather Bryant, Ophira Ginsburg, Meredith Giuliani, Mary Gospodarowicz, Sumit Gupta, Nazik Hammad, Zeev Rosberger, Simon Sutcliffe, Craig C. Earle
Summary: Cancer control is not a top priority in Canada's international health and development agenda, but it is crucial for achieving the country's Sustainable Development Goal commitments. Success in global cancer control will depend on Canadian leaders and institutions building consensus and working together. Collaboration should focus on framing core issues, building a broad coalition base, aligning with international partners, and establishing a governance structure based on principles of equity, diversity, and inclusion.
Article
Nutrition & Dietetics
Zalina Abu Zaid, May Kay Neoh, Zulfitri Azuan Mat Daud, Nor Baizura Md Yusop, Zuriati Ibrahim, Zuwariah Abdul Rahman, Norshariza Jamhuri, Aishah Zafirah Abdul Azim
Summary: This study aimed to evaluate the weight loss during and post-treatment among head and neck cancer patients. The study found that the average weight loss during treatment was 7.4%, and post-treatment weight loss was 2.1%. One month after treatment completion, patients showed significant improvements in nutrition status and muscle mass, but there was a decrease in oral nutritional supplement intake.
Article
Biology
Rusen Cosar, Alaattin Ozen, Ebru Tastekin, Necdet Sut, Suat Cakina, Selma Demir, Sule Parlar, Dilek Nurlu, Yusuf Kavuzlu, Zafer Kocak
Summary: This animal study aimed to investigate the association between radiation-induced lung toxicity and gene expression. The results showed that radiation-induced lung toxicity was more severe in male rats. Higher gene expression levels in females may contribute to lower toxicity. Additional data is needed to support these findings.
RADIATION RESEARCH
(2022)
Article
Medicine, General & Internal
Srinivasan Vijayakumar, Maurice King, Mary R. Nittala, Roy J. Duhe
Summary: Radiotherapy is essential for cancer care, with new advances in precision medicine integrating genomics, proteomics, and other fields into treatment. A broader understanding of cancer biology beyond traditional radiation biology is becoming increasingly necessary for future progress in radiotherapy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Multidisciplinary Sciences
Silvana Parisi, Sara Lillo, Alberto Cacciola, Gianluca Ferini, Vito Valenti, Anna Viola, Anna Santacaterina, Angelo Platania, Anna Brogna, Consuelo Tamburella, Stefano Pergolizzi
Summary: Older cancer patients with comorbidities are frail, but radiotherapy can be a beneficial and effective treatment approach for them, ensuring patient compliance and minimal local toxicity.
Review
Oncology
Anne Sophie V. M. van den Heerik, Nanda Horeweg, Stephanie M. de Boer, Tjalling Bosse, Carien L. Creutzberg
Summary: Endometrial cancer is primarily treated with surgery, with adjuvant treatments such as radiotherapy and chemotherapy being considered based on clinico-pathological risk factors. Recent studies have shown the effectiveness of different treatment strategies for different risk levels of endometrial cancer, highlighting the importance of personalized treatment approaches. Molecular classification and targeted treatments are emerging as potential advancements in the field, with ongoing trials exploring their impact on patient outcomes.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Editorial Material
Oncology
Melanie Schneider, Annett Linge, Mechthild Krause, Michael Baumann
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Markus Donix, Annekatrin Seidlitz, Maria Buthut, Steffen Loeck, Gisa Meissner, Claudia Matthes, Esther G. C. Troost, Michael Baumann, Felix Raschke, Jennifer Linn, Mechthild Krause
Summary: This study investigated the relationship between hippocampal structure and memory deficits in patients with WHO grade 3 and grade 4 gliomas after radiotherapy. The results showed no changes in hippocampal thickness or cognitive abilities three months after completing radiotherapy. However, subjective memory impairment was associated with symptoms of depression, highlighting the importance of intervention to improve the quality of life for these patients.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Volker Arndt, Daniela Doege, Stefan Froehling, Peter Albers, Hana Alguel, Ralf Bargou, Carsten Bokemeyer, Martin Bornhaeuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Bruemmendorf, Hartmut Doehner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann
Summary: The capacities of German Comprehensive Cancer Centers (CCCs) in various aspects of oncology care were significantly affected during the first 2 years of the COVID-19 pandemic. Follow-up, psycho-oncologic care, and tumor surgery were particularly impacted, along with other areas of multidisciplinary oncological care. This study highlights the importance of developing strategies to prevent similar limitations in the future.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Daria Klusa, Fabian Lohaus, Andre Franken, Marian Baumbach, Monica Cojoc, Paul Dowling, Annett Linge, Anne Offermann, Steffen Loeck, Dejan Husman, Mahdi Rivandi, Bernhard Polzer, Vera Freytag, Tobias Lange, Hans Neubauer, Michael Kuecken, Sven Perner, Tobias Hoelscher, Anna Dubrovska, Mechthild Krause, Ina Kurth, Michael Baumann, Claudia Peitzsch
Summary: We investigated the circulating tumor cells (CTCs) of patients with metastatic prostate cancer, and found that the number of CTCs is associated with the time of biochemical progression after radiotherapy. Specifically, the expression of CXCR4 and CCL2 is related to cellular radiosensitivity, tumorigenicity, and stem-like potential.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Dinah Linke, Lukas Donix, Claudia Peitzsch, Holger H. H. Erb, Anna Dubrovska, Manuel Pfeifer, Christian Thomas, Susanne Fuessel, Kati Erdmann
Summary: This study investigated various approaches targeting ABCB1 to resensitize DTX-resistant prostate cancer cells. It was found that ABCB1 was the only transporter highly upregulated in the resistant cells, and its inhibition and knockdown completely reversed the resistance to DTX. In addition, partial reversal was achieved by inhibiting glycosylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Oncology
Birgitte Vrou Offersen, Marianne C. Aznar, Carol Bacchus, Rob P. Coppes, Eric Deutsch, Dieter Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Anne W. M. Lee, Steffen Loeck, David I. Thwaites, Albert J. van der Kogel, Uulke van der Heide, Vincenzo Valentini, Jens Overgaard, Michael Baumann
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Sebastian Starke, Alexander Zwanenburg, Karoline Leger, Klaus Zoephel, Joerg Kotzerke, Mechthild Krause, Michael Baumann, Esther G. C. Troost, Steffen Loeck
Summary: This study investigates the predictive ability of machine learning-based radiomics models using imaging data obtained during the course of treatment. Features were extracted from pre-treatment CT and FDG-PET images, as well as images obtained two and three weeks after the start of radiochemotherapy. Models comprised of combined features from both modalities and multiple timepoints were evaluated. The results show that predictive model performance is improved when features from in-treatment imaging are used.
Article
Oncology
Bouchra Tawk, Katrin Rein, Christian Schwager, Maximilian Knoll, Ute Wirkner, Juliane Hoerner-Rieber, Jakob Liermann, Ina Kurth, Panagiotis Balermpas, Claus Roedel, Annett Linge, Steffen Loeck, Fabian Lohaus, Ingeborg Tinhofer, Mechtild Krause, Martin Stuschke, Anca Ligia Grosu, Daniel Zips, Stephanie E. Combs, Claus Belka, Albrecht Stenzinger, Christel Herold-Mende, Michael Baumann, Peter Schirmacher, Jurgen Debus, Amir Abdollahi
Summary: This study suggests that the DNA methylation landscape of tumor cells may indicate epigenetic changes caused by chronic tumor hypoxia. The researchers developed a tumor hypoxia classifier (Hypoxia-M) based on DNA methylation profiles, which showed independent prognostic effects in patients with head and neck squamous cell carcinoma (HNSCC). These findings underscore the importance of DNA methylation-based classifiers as biomarkers of tumor hypoxia.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Michael Baumann, Julio Celis, Ulrik Ringborg, Manuel Heitor, Anton Berns, Tit Albreht, Jeliazko Arabadjiev, Michael Boutros, Mario Brandenburg, Helena Canhao, Fatima Carneiro, Christine Chomienne, Francesco De Lorenzo, Alexander M. M. Eggermont, Angel Font, Elena Garralda, Margarida Goulart, Rui Henrique, Mark Lawler, Lena Maier-Hein, Francoise Meunier, Simon Oberst, Pedro Oliveira, Maria Papatriantafyllou, Joachim Schuez, Eric Solary, Alfonso Valencia, Rosalia Vargas, Elisabete Weiderpass, Nils Wilking
Summary: European cancer research stakeholders gathered in Heidelberg, Germany, for the 5(th) Gago conference on European Cancer Policy in October 2022. The meeting focused on the current state of cancer research and care policy in Europe, identifying gaps in existing programs and proposing priorities for the future through the Heidelberg Manifesto for cancer research. The discussions in the meeting covered various aspects of cancer research, including infrastructure, digitalization, and collaboration, with an emphasis on implementation and sustainability.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Chiara Valentini, Nadja Ebert, Lydia Koi, Manuel Pfeifer, Steffen Loeck, Christoph Erdmann, Mechthild Krause, Michael Baumann
Summary: This study aimed to compare the efficacy of fractionated radiotherapy versus radiochemotherapy with cisplatin in HPV-positive and negative human head and neck squamous cell carcinoma xenografts. The results showed that RCT significantly increased local tumor control in two out of three HPV-positive tumor models and one HPV-negative tumor model. In the pooled group of all HPV-positive tumors, RCT substantially enhanced local tumor control, while this effect was not observed in HPV-negative tumors.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Ayse Sedef Koeseer, Simona Di Gaetano, Claudia Arndt, Michael Bachmann, Anna Dubrovska
Summary: Tumor cells exhibit functional heterogeneity, and cancer stem cells (CSCs) are a population of tumor cells with self-renewal and differentiation properties. CSCs are found in most solid and hematological tumors and are characterized by various markers. These markers can be used to develop tumor-specific antibodies, immune cells, vaccines, and immune responses to tumor cells, including CSCs. This review discusses CSC-directed immunotherapies, their clinical development, safety and efficacy improvements, and future strategies for enhancing anti-CSC immunotherapy.
Article
Medicine, Research & Experimental
Lydia Koi, Verena Bitto, Corina Weise, Lisa Moebius, Annett Linge, Steffen Loeck, Ala Yaromina, Maria Jose Besso, Chiara Valentini, Manuel Pfeifer, Jens Overgaard, Daniel Zips, Ina Kurth, Mechthild Krause, Michael Baumann
Summary: Combining nimorazole with radiochemotherapy can improve local tumor control in some patients with head and neck squamous cell carcinoma, especially those with hypoxic tumors. In addition, molecular biomarkers have been identified for targeted therapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Biographical-Item
Multidisciplinary Sciences
Michael Baumann, Magnus von Knebel Doeberitz
Article
Oncology
Daniel Martin Klotz, Franziska Maria Schwarz, Anna Dubrovska, Kati Schuster, Mirko Theis, Alexander Krueger, Oliver Kutz, Theresa Link, Pauline Wimberger, Stephan Drukewitz, Frank Buchholz, Juergen Thomale, Jan Dominik Kuhlmann
Summary: We established an in vitro model for PARPi-resistant ovarian cancer and found that PARPi-resistant cells exhibit broad cross-resistance to other PARPis and chemotherapeutic drugs regardless of the BRCA1 status. Co-culture experiments showed that PARPi-resistant cells have a disadvantage in proliferation under drug-free conditions but quickly gain dominance under olaparib selection pressure, which can be blocked by ABC-transporter protein inhibitors. Overall, our well-characterized in vitro model is useful for dissecting mechanisms of PARPi resistance and studying the clonal dynamics of PARPi-resistant cells.
Review
Oncology
David A. Jaffray, Felicia Knaul, Michael Baumann, Mary Gospodarowicz
Summary: The pace of technological innovation has made radiotherapy one of the most technologically intense disciplines in medicine. However, global barriers hinder access to this effective treatment. Efforts are being made in the radiation oncology community to align individualized therapy with global access needs.
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
