Deciphering GRINA/Lifeguard1: Nuclear Location, Ca2+ Homeostasis and Vesicle Transport

A homozygous pathogenic missense variant broadens the phenotypic and mutational spectrum of CREB3L1-related osteogenesis imperfecta

(2019) Brecht Guillemyn et al.   HUMAN MOLECULAR GENETICS

Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated Protein Isoform Variation in the Mouse Brain

(2019) Darshan Sapkota et al.   Cell Reports

Gut permeability and mimicry of the Glutamate Ionotropic Receptor NMDA type Subunit Associated with protein 1 (GRINA) as potential mechanisms related to a subgroup of people with schizophrenia with elevated antigliadin antibodies (AGA IgG)

(2019) Daniela Čiháková et al.   SCHIZOPHRENIA RESEARCH

PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis

(2019) Yi Qin et al.   Cell Communication and Signaling

Grina/TMBIM3 modulates voltage-gated CaV2.2 Ca2+ channels in a G-protein-like manner

(2019) Robert Theodor Mallmann et al.   CELL CALCIUM

The MYC oncogene is a global regulator of the immune response

(2018) Stephanie C. Casey et al.   BLOOD

Myosin 1b promotes axon formation by regulating actin wave propagation and growth cone dynamics

(2018) Olga Iuliano et al.   JOURNAL OF CELL BIOLOGY

Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm

(2018) K. Tsafou et al.   JOURNAL OF MOLECULAR BIOLOGY

Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling

(2018) Serena Ricci et al.   MOLECULAR NEUROBIOLOGY

New insights into the phylogeny of the TMBIM superfamily across the tree of life: Comparative genomics and synteny networks reveal independent evolution of the BI and LFG families in plants

(2018) Samuel D. Gamboa-Tuz et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Germ cell-intrinsic requirement for the homeodomain transcription factor PKnox1/Prep1 in adult spermatogenesis

(2018) Yasuhiro Kawai et al.   PLoS One

Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq

(2018) Fabienne Lescroart et al.   SCIENCE

Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly

(2018) David S.W. Protter et al.   Cell Reports

The Immediate Early Gene Egr3 Is Required for Hippocampal Induction of Bdnf by Electroconvulsive Stimulation

(2018) Kimberly T. Meyers et al.   Frontiers in Behavioral Neuroscience

EGR3 Immediate Early Gene and the Brain-Derived Neurotrophic Factor in Bipolar Disorder

(2018) Bianca Pfaffenseller et al.   Frontiers in Behavioral Neuroscience

Adropin: An endocrine link between the biological clock and cholesterol homeostasis

(2018) Sarbani Ghoshal et al.   Molecular Metabolism

Genome wide association study identifies novel potential candidate genes for bovine milk cholesterol content

(2018) Duy N. Do et al.   Scientific Reports

Transmembrane protein GRINA modulates aerobic glycolysis and promotes tumor progression in gastric cancer

(2018) Dan-Hua Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport

(2018) Friederike Kosyna et al.   Cells

Presynaptic increase in IP3 receptor type 1 concentration in the early phase of hippocampal synaptic plasticity

(2018) Håvard Ringsevjen et al.   BRAIN RESEARCH

The retinoic acid receptor-related orphan receptor α positively regulates tight junction protein claudin domain-containing 1 mRNA expression in human brain endothelial cells

(2017) Hiroshi Matsuoka et al.   JOURNAL OF BIOCHEMISTRY

Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress

(2017) Yin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells

(2017) Iris A. García et al.   JOURNAL OF CELL SCIENCE

Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+channels

(2017) Jessica R. Thomas et al.   JOURNAL OF GENERAL PHYSIOLOGY

Hot Genes in Schizophrenia: How Clinical Datasets Could Help to Refine their Role

(2017) Stefano Porcelli et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Estrogen receptor-related receptor γ regulates testicular steroidogenesis through direct and indirect regulation of steroidogenic gene expression

(2017) Eunsook Park et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

FunCoup 4: new species, data, and visualization

(2017) Christoph Ogris et al.   NUCLEIC ACIDS RESEARCH

The eukaryotic linear motif resource – 2018 update

(2017) Marc Gouw et al.   NUCLEIC ACIDS RESEARCH

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer

(2017) Guia Carrara et al.   Open Biology

Functional interaction between nonreceptor tyrosine kinase c-Abl and SR-Rich protein RBM39

(2016) Sanyue Mai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extraintestinal manifestations of celiac disease: 33-mer gliadin binding to glutamate receptor GRINA as a new explanation

(2016) Albert Garcia-Quintanilla et al.   BIOESSAYS

Recognizing metal and acid radical ion-binding sites by integratingab initiomodeling with template-based transferals

(2016) Xiuzhen Hu et al.   BIOINFORMATICS

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor

(2016) Colleen A. McGourty et al.   CELL

DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer

(2016) H. Alqahtani et al.   CELLULAR SIGNALLING

Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway

(2016) Melanie Vanessa Halbach et al.   CEREBELLUM

The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development

(2016) T.F. Sumter et al.   CURRENT MOLECULAR MEDICINE

Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos

(2016) Prachi N. Ghule et al.   DEVELOPMENTAL BIOLOGY

Loss of Mbd2 Protects Mice Against High-Fat Diet–Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure

(2016) Jia Cheng et al.   DIABETES

Estrogen-related receptor gamma implicated in a phenotype including hearing loss and mild developmental delay

(2016) Samantha LP Schilit et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Molecular recognition features (MoRFs) in three domains of life

(2016) Jing Yan et al.   Molecular BioSystems

Mutations in spliceosomal proteins and retina degeneration

(2016) Šárka Růžičková et al.   RNA Biology

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ

(2016) Xiaoxiao Wang et al.   Oncotarget

Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1 , ire-1 , and xbp-1

(2016) Karla A. Mark et al.   Cell Reports

Estrogen-Related Receptor γ Plays a Key Role in Vascular Calcification Through the Upregulation of BMP2 ExpressionSignificance

(2015) Ji-Hyun Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA2+-filling state

(2015) Dmitrij A. Lisak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα

(2015) Akira Iizuka et al.   Brain Structure & Function

Early Growth Response 3 regulates genes of inflammation and directly activates IL6 and IL8 expression in prostate cancer

(2015) V T Baron et al.   BRITISH JOURNAL OF CANCER

Dependence of Hippocampal Function on ERRγ-Regulated Mitochondrial Metabolism

(2015) Liming Pei et al.   Cell Metabolism

Sexual Cell-Fate Reprogramming in the Ovary by DMRT1

(2015) Robin E. Lindeman et al.   CURRENT BIOLOGY

Vitamin D and alternative splicing of RNA

(2015) Rui Zhou et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Estrogen-Related Receptor α (ERRα) and ERRγ Are Essential Coordinators of Cardiac Metabolism and Function

(2015) Ting Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity

(2014) Matthew T. Weirauch et al.   CELL

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Calmodulation meta-analysis: Predicting calmodulin binding via canonical motif clustering

(2014) Karen Mruk et al.   JOURNAL OF GENERAL PHYSIOLOGY

Calmodulin regulation (calmodulation) of voltage-gated calcium channels

(2014) Manu Ben-Johny et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pseudogenization of testis-specific Lfg5 predates human/Neanderthal divergence

(2014) Marco Mariotti et al.   JOURNAL OF HUMAN GENETICS

Inhibitor of Differentiation 4 (ID4) Inactivation Promotes De Novo Steroidogenesis and Castration-Resistant Prostate Cancer

(2014) Divya Patel et al.   MOLECULAR ENDOCRINOLOGY

Prediction of DNA binding motifs from 3D models of transcription factors; identifying TLX3 regulated genes

(2014) Mario Pujato et al.   NUCLEIC ACIDS RESEARCH

Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells

(2014) Sara L. Fossum et al.   NUCLEIC ACIDS RESEARCH

CDD: NCBI's conserved domain database

(2014) Aron Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

TMBIM protein family: ancestral regulators of cell death

(2014) D Rojas-Rivera et al.   ONCOGENE

Regulatory effects of SKAR in interferon   signaling and its role in the generation of type I IFN responses

(2014) B. Kroczynska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo

(2014) N. S. Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for a pH-sensitive calcium leak across membranes

(2014) Y. Chang et al.   SCIENCE

RNA Helicases DDX5 and DDX17 Dynamically Orchestrate Transcription, miRNA, and Splicing Programs in Cell Differentiation

(2014) Etienne Dardenne et al.   Cell Reports

Genome-wide RNAi Screen Reveals a Role for Multipass Membrane Proteins in Endosome-to-Golgi Retrieval

(2014) Sophia Y. Breusegem et al.   Cell Reports

Physiological functions of endoplasmic reticulum stress transducer OASIS in central nervous system

(2013) Atsushi Saito   ANATOMICAL SCIENCE INTERNATIONAL

Protter: interactive protein feature visualization and integration with experimental proteomic data

(2013) Ulrich Omasits et al.   BIOINFORMATICS

DNA-Binding Specificities of Human Transcription Factors

(2013) Arttu Jolma et al.   CELL

Unfolded phosphopolypeptides enable soft and hard tissues to coexist in the same organism with relative ease

(2013) Carl Holt   CURRENT OPINION IN STRUCTURAL BIOLOGY

Transcriptional cross talk between orphan nuclear receptor ERR  and transmembrane transcription factor ATF6  coordinates endoplasmic reticulum stress response

(2013) J. Misra et al.   NUCLEIC ACIDS RESEARCH

The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways

(2013) Samaan Samaan et al.   NUCLEIC ACIDS RESEARCH

Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport

(2013) Hicham Mahboubi et al.   PLoS One

Evolutionary conservation of the polyproline II conformation surrounding intrinsically disordered phosphorylation sites

(2013) W. Austin Elam et al.   PROTEIN SCIENCE

FROM BINDING MOTIFS IN CHIP-SEQ DATA TO IMPROVED MODELS OF TRANSCRIPTION FACTOR BINDING SITES

(2013) IVAN KULAKOVSKIY et al.   Journal of Bioinformatics and Computational Biology

The novel function of HINFP as a co-activator in sterol-regulated transcription ofPCSK9in HepG2 cells

(2012) Hai Li et al.   BIOCHEMICAL JOURNAL

TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

(2012) D Rojas-Rivera et al.   CELL DEATH AND DIFFERENTIATION

Identification of novel splice variants in horn cancer by RNA-Seq analysis in Zebu cattle

(2012) Amrutlal K. Patel et al.   GENOMICS

The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine

(2012) Rie Asada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin D Suppression of Endoplasmic Reticulum Stress Promotes an Antiatherogenic Monocyte/Macrophage Phenotype in Type 2 Diabetic Patients

(2012) Amy E. Riek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kr-pok increasesFASNexpression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter

(2012) Bu-Nam Jeon et al.   JOURNAL OF LIPID RESEARCH

ID2: A negative transcription factor regulating oligodendroglia differentiation

(2012) Xing-Shu Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The C Terminus of the Large Tegument Protein pUL36 Contains Multiple Capsid Binding Sites That Function Differently during Assembly and Cell Entry of Herpes Simplex Virus

(2012) J. Schipke et al.   JOURNAL OF VIROLOGY

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor

(2012) S Germann et al.   ONCOGENE

Transcriptome Sequencing Revealed Significant Alteration of Cortical Promoter Usage and Splicing in Schizophrenia

(2012) Jing Qin Wu et al.   PLoS One

Alteration of POLDIP3 Splicing Associated with Loss of Function of TDP-43 in Tissues Affected with ALS

(2012) Atsushi Shiga et al.   PLoS One

The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export

(2012) Eric G. Folco et al.   PLoS One

Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation

(2012) Atsushi Saito et al.   Nature Communications

Mouse transmembrane BAX inhibitor Motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system

(2011) Joseph A. Nielsen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Deep Sequencing of MYC DNA-Binding Sites in Burkitt Lymphoma

(2011) Volkhard Seitz et al.   PLoS One

Landscape of the SOX2 protein-protein interactome

(2011) Xuefeng Fang et al.   PROTEOMICS

Structure and function of ALG-2, a penta-EF-hand calcium-dependent adaptor protein

(2011) Masatoshi Maki et al.   Science China-Life Sciences

Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7

(2010) Aleksandra Janowicz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intestinal lineage commitment of embryonic stem cells

(2010) Li Cao et al.   DIFFERENTIATION

Transmembrane BAX Inhibitor Motif Containing (TMBIM) Family Proteins Perturbs atrans-Golgi Network Enzyme, Gb3 Synthase, and Reduces Gb3 Biosynthesis

(2010) Toshiyuki Yamaji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen-related receptor γ modulates cell proliferation and estrogen signaling in breast cancer

(2010) Nobuhiro Ijichi et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Id4, a New Candidate Gene for Senile Osteoporosis, Acts as a Molecular Switch Promoting Osteoblast Differentiation

(2010) Yoshimi Tokuzawa et al.   PLoS Genetics

LFG: a candidate apoptosis regulatory gene family

(2009) Lan Hu et al.   APOPTOSIS

Expression of SNURF–SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis

(2009) Michaela Wawrzik et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Calmodulin-driven Nuclear Entry: Trigger for Sex Determination and Terminal Differentiation

(2009) John A. Hanover et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis

(2009) William A. Alaynick et al.   MOLECULAR ENDOCRINOLOGY

Identification, analysis, and prediction of protein ubiquitination sites

(2009) Predrag Radivojac et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Midkine translocated to nucleoli and involved in carcinogenesis

(2009) Li-Cheng Dai   WORLD JOURNAL OF GASTROENTEROLOGY

Modulation of adipogenesis-related gene expression by estrogen-related receptor γ during adipocytic differentiation

(2008) Mayumi Kubo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Altered gene expression in the superior temporal gyrus in schizophrenia

(2008) Nikola A Bowden et al.   BMC GENOMICS

A Rat Brain Bicistronic Gene with an Internal Ribosome Entry Site Codes for a Phencyclidine-binding Protein with Cytotoxic Activity

(2008) Dongwei Hui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network

(2008) Nicolas Simonis et al.   NATURE METHODS

Structural Basis for Ca2+-Dependent Formation of ALG-2/Alix Peptide Complex: Ca2+/EF3-Driven Arginine Switch Mechanism

(2008) Hironori Suzuki et al.   STRUCTURE

Midkine accumulated in nucleolus of HepG2 cells involved in rRNA transcription

(2008) Li-Cheng Dai et al.   WORLD JOURNAL OF GASTROENTEROLOGY