Article
Endocrinology & Metabolism
Fei Luo, Chao Xing, Sumeet K. Asrani, Shili Li, Guosheng Liang, Helen H. Hobbs, Jonathan C. Cohen
Summary: This study identified a missense variant in the insulin receptor associated with fatty liver disease in a four generation family, but experiments in mice failed to show a causal relationship between this variant and the disease or any impact on hepatic triglyceride metabolism.
MOLECULAR METABOLISM
(2021)
Article
Nutrition & Dietetics
Jui-Ting Yang, Yu-Jen Chen, Chao-Wei Huang, Ya-Chin Wang, Harry J. Mersmann, Pei-Hwa Wang, Shih-Torng Ding
Summary: The study demonstrates that DHA negatively regulates the adipogenic TN in both pigs in vivo and in humans/pigs in vitro, potentially through SREBP-1c or FoxO. This down-regulation of TN associated with fibrinolysis and adipogenesis could contribute to the beneficial effects of DHA on alleviating obesity-induced metabolic syndromes.
Article
Agriculture, Dairy & Animal Science
Yiwei Zhu, Lin Lei, Xinghui Wang, Qianming Jiang, Juan J. Loor, Fanrong Kong, Linfang Chen, Jinxia Li, Chenchen Zhao, Menglin Liu, Guowen Liu, Xinwei Li
Summary: This study aims to investigate the potential role of the INSIG1-SCAP-SREBP-1c axis in the progression of fatty liver in dairy cows. It was found that cows with severe fatty liver had higher levels of β-hydroxybutyrate and free fatty acids and lower level of glucose in their blood. The liver of these cows also exhibited lower abundance of INSIG1 protein and higher abundance of SCAP and SREBP-1c proteins. Furthermore, in vitro experiments showed that decreased INSIG1 abundance contributed to enhanced SREBP-1c processing and triglyceride synthesis in hepatocytes. Therefore, the INSIG1-SCAP-SREBP-1c axis may serve as a potential target for the treatment of fatty liver in dairy cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Food Science & Technology
Eliana Alves, Abigail Simoes, M. Rosario Domingues
Summary: Thousands of tons of fruit seeds are discarded annually worldwide as agro-industrial byproducts, which have high oil content and rich in fatty acids, yet remain poorly studied in terms of their lipid profile. Current analytical methods allow accurate identification and structural characterization of compounds in small quantities, while lipidomic analysis will provide a new perspective on these value-added byproducts.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Food Science & Technology
Tiago Jardim Costa, M. Rosario M. Domingues, Eliana Alves
Summary: Tree nuts and oily fruits are highly consumed worldwide due to their nutritional value and health benefits. However, the lipidomic analysis of these foods is still in its early stages.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Neurosciences
Wenwen Zhu, Lan Xu, Haoqiang Zhang, Sai Tian, Ke An, Wuyou Cao, Jijing Shi, Wei Tang, Shaohua Wang
Summary: The study revealed that elevated plasma FFA levels and lower apolipoprotein A1 levels in type 2 diabetes mellitus patients are associated with early cognitive impairment, especially in terms of attention and executive deficits. Additionally, the G allele of SREBP-1c rs11868035 may play a protective role in memory function.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
E. Peltomaa, H. Asikainen, J. Blomster, H. Pakkanen, C. Rigaud, P. Salmi, S. Taipale
Summary: Chemotaxonomic biomarkers, such as fatty acids, sterols, and carotenoids, can be used to monitor and evaluate the nutritional quality of phytoplankton communities. These biomolecules can help classify phytoplankton groups, although some limitations exist in accurately distinguishing certain groups. The combination of fatty acids, sterols, and carotenoids yields the most accurate phylogenetic information.
Review
Biotechnology & Applied Microbiology
Yingjie Song, Xuewei Yang, Shuangfei Li, Yanqing Luo, Jo-Shu Chang, Zhangli Hu
Summary: Thraustochytrids are eukaryotes and obligate marine protists that are considered as a promising feed additive due to their production of health-benefiting bioactive compounds. This review comprehensively evaluates the bioactive compounds in Thraustochytrids and summarizes their metabolic networks and biosynthetic pathways. The stress-based strategies used in Thraustochytrids are also examined to explore methodologies for enhancing specific product yields. Overall, this critical review provides comprehensive information to boost the commercial productivity of specific bioactive substances by Thraustochytrids.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Po-Fan Hsieh, Wen-Ping Jiang, Praveenkumar Basavaraj, Shih-Yin Huang, Phakkhathorn Ruangsai, Jin-Bin Wu, Guan-Jhong Huang, Wen-Chin Huang
Summary: The study demonstrates that the cell suspension culture extract from Eriobotrya japonica (EJCE) shows significant anticancer efficacy in prostate cancer cells, including castration-resistant prostate cancer. EJCE inhibits lipogenesis-related factors, reduces intracellular fatty acid levels, induces apoptosis, and suppresses tumor growth in a xenograft mouse model, suggesting its potential as a novel therapeutic approach for aggressive prostate cancer.
Article
Engineering, Biomedical
Xiaoqing Sun, Yichun Gao, Zhiyu Li, Jing He, Yao Wu
Summary: By introducing magnetic nanoparticles into hydroxyapatite scaffolds, a transition from proinflammatory (M1) to anti-inflammatory (M2) macrophages during bone healing is achieved, contributing to the upregulation of peroxisome proliferator-activated receptor (PPAR) signals and enhancement of fatty acid metabolism. Magnetic cues also play a critical role in M2 polarization by coupling protein corona, intracellular PPAR signals, and metabolism. The magnetic scaffolds may exhibit further inhibition of M1 polarization when combined with an exterior magnetic field.
Article
Nutrition & Dietetics
Jacob Sellers, Abigail Brooks, Savanie Fernando, Gabrielle Westenberger, Sadie Junkins, Shauri Smith, Kisuk Min, Ahmed Lawan
Summary: The liver plays a crucial role in regulating glucose and lipid homeostasis in response to nutritional signals. Activation of MKP-1 in overnutrition helps control lipid metabolism in the liver, while the impact of MKP-1 in response to fasting is still unclear. Fasting induces upregulation of MKP-1, leading to resistance to hepatic steatosis and changes in key transcription factors involved in fatty acid and cholesterol metabolism, suggesting a beneficial role of MKP-1 in hepatic lipid utilization during fasting.
Article
Biochemistry & Molecular Biology
Yu-Chi Chen, Rong-Jane Chen, Szu-Yuan Peng, Winston C. Y. Yu, Vincent Hung-Shu Chang
Summary: KLF10 is a phospho-regulated transcriptional factor involved in lipogenesis, with AMPK phosphorylating KLF10 at Thr189 to activate and stabilize it, thereby repressing SREBP-1C expression and affecting the development of NAFLD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Bowen Lou, Haoyu Wu, Hannes Ott, Katrin Bennewitz, Chen Wang, Gernot Poschet, Hui Liu, Zuyi Yuan, Jens Kroll, Jianqing She
Summary: It is postulated that hyperuremia induces SREBP1 activation, leading to hepatic fatty acid biosynthesis and subsequent cardiac dysfunction. The study also found a correlation between high uric acid levels and cardiac function as well as lipid profile.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Siyuan Luan, Rou Xie, Yushang Yang, Xin Xiao, Jianfeng Zhou, Xiaokun Li, Pinhao Fang, Xiaoxi Zeng, Xiangrong Yu, Meiwan Chen, Huile Gao, Yong Yuan
Summary: This study proposes an acid-responsive aggregated nanosystem that enhances the therapeutic efficacy of radiotherapy and chemotherapy in esophageal cancer by accumulating and retaining in tumor tissues and improving radiosensitization and targeted drug delivery.
Article
Chemistry, Multidisciplinary
Han-yu Yang, Ming Liu, Yun Sheng, Liang Zhu, Meng-meng Jin, Tian-xin Jiang, Lu Yang, Pei-hua Liu, Xiao-dong Liu, Li Liu
Summary: The study found that all-trans retinoic acid (ATRA) worsened diabetes symptoms by impairing glucose-stimulated insulin secretion (GSIS) partly through activating the RXR/SREBP-1c/UCP2 pathway. This highlights the possible role of ATRA in diabetic progression and suggests new strategies for diabetes treatment.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Won-Il Choi, Jae-Hyeon Yoon, Ji-Yang Song, Bu-Nam Jeon, Joo-Man Park, Dong-In Koh, Yong-Ho Ahn, Kyung-Sup Kim, In-Kyu Lee, Man-Wook Hur
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2019)
Article
Biochemistry & Molecular Biology
Bu-Nam Jeon, Ji-Yang Song, Jin Won Huh, Woo-Ick Yang, Man-Wook Hur
Article
Microbiology
Chang Kyung Kang, Kyoung-Ho Song, Seong Eun Kim, Eu Suk Kim, Wan Beom Park, Kyung-Hwa Park, Shin Hye Chun, Shinwon Lee, Chong Rae Cho, Seung Ji Kang, Myoung-don Oh, Yeon-Sook Kim, Sun Hee Lee, Yee Gyung Kwak, Hee-Chang Jang, Chung-Jong Kim, Young Keun Kim, Ji-Hwan Bang, Sungmin Kiem, Ki Tae Kwon, Younghee Jung, Yu Min Kang, Sook-In Jung, Hong Bin Kim, Nam-Joong Kim, Pyoeng Gyun Choe, Taek Soo Kim, Su Jin Choi, Kyoung Un Park, Yun Jung Choi, Kyoung Mi Kwon, Jung In Park, Su-Mi Choi, Seon Jin Yun, Jongyoun Yi, Sohee Park, Hyeon-jeong Hwang, Youngsoon Lee, Hee Kyoung Choi, Myung Sook Han, Sang Won Park, Dong-Kie Kim, Sae-Am Song, Min Ji Kang, Jae Gyun Shin, Hye-In Kim, Seung Min Shin
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Medicine, General & Internal
Susan Swindells, Jaime-Federico Andrade-Villanueva, Gary J. Richmond, Giuliano Rizzardini, Axel Baumgarten, Mar Masia, Gulam Latiff, Vadim Pokrovsky, Fritz Bredeek, Graham Smith, Pedro Cahn, Yeon-Sook Kim, Susan L. Ford, Christine L. Talarico, Parul Patel, Vasiliki Chounta, Herta Crauwels, Wim Parys, Simon Vanveggel, Joseph Mrus, Jenny Huang, Conn M. Harrington, Krischan J. Hudson, David A. Margolis, Kimberly Y. Smith, Peter E. Williams, William R. Spreen
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Infectious Diseases
Yeon-Sook Kim, Jeoungyeon Kim, Yeon-Joo Choi, Hye-Jin Park, Won-Jong Jang
TRANSBOUNDARY AND EMERGING DISEASES
(2020)
Article
Infectious Diseases
Brandon Trent, Yuejin Liang, Yan Xing, Marisol Esqueda, Yang Wei, Nam-Hyuk Cho, Hong-Il Kim, Yeon-Sook Kim, Thomas R. Shelite, Jiyang Cai, Jiaren Sun, Donald H. Bouyer, Jinjun Liu, Lynn Soong
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Seyoung Yu, Won-Il Choi, Yo Jun Choi, Hye-Youn Kim, Friedhelm Hildebrandt, Heon Yung Gee
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Article
Urology & Nephrology
Eugen Widmeier, Seyoung Yu, Anish Nag, Youn Wook Chung, Makiko Nakayama, Lucia Fernandez-del-Rio, Hannah Hugo, David Schapiro, Florian Buerger, Won-Il Choi, Martin Helmstaedter, Jae-woo Kim, Ji-Hwan Ryu, Min Goo Lee, Catherine F. Clarke, Friedhelm Hildebrandt, Heon Yung Gee
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Seo-Hyun Choi, Su-Yeon Cho, Jiyang Song, Man-Wook Hur
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Seo-Hyun Choi, Dong-In Koh, Haemin Ahn, Jin Young Kim, Youngsoo Kim, Man-Wook Hur
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Chemistry, Medicinal
Eun Jung Bae, Won Gun Choi, Haushabhau S. Pagire, Suvarna H. Pagire, Saravanan Parameswaran, Jun-Ho Choi, Jihyeon Yoon, Won-il Choi, Ji Hun Lee, Jin Sook Song, Myung Ae Bae, Mijin Kim, Jae-Han Jeon, In-Kyu Lee, Hail Kim, Jin Hee Ahn
Summary: A new series of 1,2,4-oxadiazolylphenyl alanine derivatives have been identified as potential TPH1 inhibitors, showing promise for the treatment of obesity and fatty liver diseases. Compound 23a, the most active in vitro, demonstrated significant improvements in body weight, body fat, hepatic lipid accumulation, glucose intolerance, and energy expenditure in high-fat diet-fed mice.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hyeon-Ji Kang, Byong-Keol Min, Won-Il Choi, Jae-Han Jeon, Dong Wook Kim, Sungmi Park, Yun-Kyung Lee, Hwa-jin Kim, Ju-Eun Byeon, Younghoon Go, Hye Jin Ham, Yong Hyun Jeon, Mi-Jin Kim, Jung Yi Lee, Adam R. Wende, Sung Hee Choi, Robert A. Harris, In-Kyu Lee
Summary: The study revealed that PDK1 and PDK2 are novel regulators of adipogenesis and play critical roles in obesity, with deficiencies offering protection against diet-induced obesity in mice. The enzymes play important roles in the development and growth of fat cells, suggesting that targeting PDK enzymes could be a potential approach to combat obesity.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Minhee Kim, Wonil Choi, Jihyeon Yoon, Byung-kwan Jeong, Suvarna H. Pagire, Haushabhau S. Pagire, Jungsun Park, Jung Eun Nam, Chang Joo Oh, Jae-Han Jeon, Seong Soon Kim, Byung Hoi Lee, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jin Hee Ahn
Summary: Non-alcoholic fatty liver disease (NAFLD) is a prevalent disease worldwide, characterized by excessive fat accumulation in the liver. This study discovered the role of the serotonin receptor subtype 5HT(2A) in regulating hepatic lipid metabolism. Newly synthesized peripheral 5HT(2A) receptor antagonists showed potential for treating NAFLD.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Won-Il Choi, Jae-Hyun Yoon, Seo-Hyun Choi, Bu-Nam Jeon, Hail Kim, Man-Wook Hur
Summary: The study revealed that Zbtb7c protein represses the expression of the SIRT1 gene by interacting with the p53 protein. Overexpression of Zbtb7c affects the expression of genes involved in lipid metabolism, potentially providing a molecular target for the treatment of diabetes, obesity, and longevity.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
