Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport

Importin-β and exportin-5 are indicators of acute viral infection: Correlation of their detection with commercially available detection kits

(2018) Gerard J. Nuovo et al.   Annals of Diagnostic Pathology

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models

(2018) Cristina Corno et al.   BIOCHEMICAL PHARMACOLOGY

Clinical Implications of Targeting XPO1-mediated Nuclear Export in Multiple Myeloma

(2018) Ujjawal H. Gandhi et al.   Clinical Lymphoma Myeloma & Leukemia

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

(2018) Rosa Puertollano et al.   EMBO JOURNAL

Xpo7 is a broad-spectrum exportin and a nuclear import receptor

(2018) Metin Aksu et al.   JOURNAL OF CELL BIOLOGY

Selective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma

(2018) Dan T. Vogl et al.   JOURNAL OF CLINICAL ONCOLOGY

A Phase II Trial of Selinexor, an Oral Selective Inhibitor of Nuclear Export Compound, in Abiraterone‐ and/or Enzalutamide‐Refractory Metastatic Castration‐Resistant Prostate Cancer

(2018) Xiao X. Wei et al.   ONCOLOGIST

Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3

(2018) Anna Sergeevna Sowa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses

(2018) et al.   Viruses-Basel

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V

(2018) Sarah C. Atkinson et al.   Scientific Reports

Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma

(2018) Abbey R. Sadowski et al.   BMC Veterinary Research

The Tau of Nuclear-Cytoplasmic Transport

(2018) Evan Lester et al.   NEURON

In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals

(2018) Douglas G. Widman et al.   PLoS One

Selinexor plus low-dose bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma

(2018) Nizar J. Bahlis et al.   BLOOD

Current and developing synthetic pharmacotherapy for treating relapsed/refractory multiple myeloma

(2017) Klaus Podar et al.   EXPERT OPINION ON PHARMACOTHERAPY

Mutant Huntingtin Disrupts the Nuclear Pore Complex

(2017) Jonathan C. Grima et al.   NEURON

Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles

(2017) Ruth Ann Veach et al.   PLoS One

Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer

(2017) Giovanni Luca Gravina et al.   Oncotarget

CRM1 Inhibitors for Antiviral Therapy

(2017) Cynthia Mathew et al.   Frontiers in Microbiology

Dual mechanisms regulate the nucleocytoplasmic localization of human DDX6

(2017) Jo-Hsi Huang et al.   Scientific Reports

Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin

(2017) Manoj Garg et al.   Scientific Reports

Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone

(2016) Irfana Muqbil et al.   CANCER LETTERS

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia

(2016) Thomas Vercruysse et al.   CLINICAL CANCER RESEARCH

Importin α: a key molecule in nuclear transport and non-transport functions

(2016) Yoichi Miyamoto et al.   JOURNAL OF BIOCHEMISTRY

KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells

(2016) J Etchin et al.   LEUKEMIA

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies

(2016) Z A Hing et al.   LEUKEMIA

Nuclear import of the thyroid hormone receptor α1 is mediated by importin 7, importin β1, and adaptor importin α1

(2016) Vincent R. Roggero et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Targeting the Nuclear Import Receptor Kpn 1 as an Anticancer Therapeutic

(2016) P. J. van der Watt et al.   MOLECULAR CANCER THERAPEUTICS

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma

(2016) Joel G. Turner et al.   Oncotarget

Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1

(2015) Henna V. Kuusisto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways

(2015) Friederike K. Kosyna et al.   BIOLOGICAL CHEMISTRY

Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis

(2015) Wenqing Yan et al.   CELLULAR SIGNALLING

Nuclear transport factors: global regulation of mitosis

(2015) Douglass J Forbes et al.   CURRENT OPINION IN CELL BIOLOGY

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

(2015) Jeffery D Haines et al.   NATURE NEUROSCIENCE

Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein

(2015) Jo Ishizawa et al.   PHARMACOLOGY & THERAPEUTICS

Upregulation of KPNβ1 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis

(2015) Jia Zhu et al.   TUMOR BIOLOGY

Role of a nuclear localization signal on the minor capsid Proteins VP2 and VP3 in BKPyV nuclear entry

(2015) Shauna M. Bennett et al.   VIROLOGY

Drosophila TIM Binds Importin α1, and Acts as an Adapter to Transport PER to the Nucleus

(2015) A. Reum Jang et al.   PLoS Genetics

Structural Basis of Targeting the Exportin CRM1 in Cancer

(2015) Achim Dickmanns et al.   Cells

Nucleocytoplasmic shuttling of the Duchenne muscular dystrophy gene product dystrophin Dp71d is dependent on the importin α/β and CRM1 nuclear transporters and microtubule motor dynein

(2014) R. Suárez-Sánchez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells

(2014) Liselotte Angus et al.   CARCINOGENESIS

KPNA2 predicts long term survival in patients with anaplastic oligoastrocytomas

(2014) Konstantinos Gousias et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Nucleo-cytoplasmic transport as a therapeutic target of cancer

(2014) Giovanni Luca Gravina et al.   Journal of Hematology & Oncology

Selective inhibitors of nuclear export (SINE)– a novel class of anti-cancer agents

(2014) Kaushal Parikh et al.   Journal of Hematology & Oncology

Verdinexor, a Novel Selective Inhibitor of Nuclear Export, Reduces Influenza A Virus Replication In Vitro and In Vivo

(2014) O. Perwitasari et al.   JOURNAL OF VIROLOGY

The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway

(2014) Eric Fleta-Soriano et al.   Microbial Cell Factories

CBS9106-Induced CRM1 Degradation Is Mediated by Cullin Ring Ligase Activity and the Neddylation Pathway

(2014) N. Saito et al.   MOLECULAR CANCER THERAPEUTICS

Preclinical Evaluation of the Novel, Orally Bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in Spontaneous Canine Cancer: Results of a Phase I Study

(2014) Cheryl A. London et al.   PLoS One

Clinical translation of nuclear export inhibitors in cancer

(2014) William T. Senapedis et al.   SEMINARS IN CANCER BIOLOGY

Biological Significance of the Importin-β Family-Dependent Nucleocytoplasmic Transport Pathways

(2014) Makoto Kimura et al.   TRAFFIC

Plasmodium falciparum signal recognition particle components and anti-parasitic effect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP

(2014) M Panchal et al.   Cell Death & Disease

Peptide Inhibitor of NF-κB Translocation Ameliorates Experimental Atherosclerosis

(2013) Beñat Mallavia et al.   AMERICAN JOURNAL OF PATHOLOGY

Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin

(2013) M.Y.F. Tay et al.   ANTIVIRAL RESEARCH

Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication

(2013) Lindsay Lundberg et al.   ANTIVIRAL RESEARCH

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

(2013) K. Kojima et al.   BLOOD

Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias

(2013) C. J. Walker et al.   BLOOD

Nuclear karyopherin-α2 expression in primary lesions and metastatic lymph nodes was associated with poor prognosis and progression in gastric cancer

(2013) Bolag Altan et al.   CARCINOGENESIS

CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas

(2013) Fang Zhou et al.   MEDICAL ONCOLOGY

CRM1 Is a Cellular Target of Curcumin: New Insights for the Myriad of Biological Effects of an Ancient Spice

(2013) Mingshan Niu et al.   TRAFFIC

The prognostic significance of nuclear CSE1L in urinary bladder urothelial carcinomas

(2012) Chun-Chao Chang et al.   Annals of Diagnostic Pathology

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

(2012) Kylie M. Wagstaff et al.   BIOCHEMICAL JOURNAL

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

(2012) R. Lapalombella et al.   BLOOD

Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia

(2012) P. Ranganathan et al.   BLOOD

Nuclear Transport of Wilms′ Tumour Protein Wt1 Involves Importins α and β

(2012) Reinhard Depping et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma

(2012) Kejie Zhang et al.   EXPERIMENTAL HEMATOLOGY

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

(2011) Jonathan F. Soderholm et al.   ACS Chemical Biology

Nuclear retention of importin α coordinates cell fate through changes in gene expression

(2011) Yoshinari Yasuda et al.   EMBO JOURNAL

Nuclear Exportin Receptor CAS Regulates the NPI-1–Mediated Nuclear Import of HIV-1 Vpr

(2011) Eri Takeda et al.   PLoS One

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries

(2010) Martin Hintersteiner et al.   ACS Chemical Biology

Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport

(2010) Géza Ambrus et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bioisostere of valtrate, anti-HIV principle by inhibition for nuclear export of Rev

(2010) Satoru Tamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Halogenated analogs of 1′-acetoxychavicol acetate, Rev-export inhibitor from Alpinia galanga, designed from mechanism of action

(2010) Satoru Tamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport

(2010) Jean-Yves Wach et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Notch1 signaling is mediated by importins alpha 3, 4, and 7

(2010) Kerstin Huenniger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport

(2010) Simone Bonazzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Importin  3 Interacts with HIV-1 Integrase and Contributes to HIV-1 Nuclear Import and Replication

(2010) Z. Ao et al.   JOURNAL OF VIROLOGY

The Nuclear Pore Complex and Nuclear Transport

(2010) S. R. Wente et al.   Cold Spring Harbor Perspectives in Biology

New Rev-export inhibitor from Alpinia galanga and structure–activity relationship

(2009) Satoru Tamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo

(2009) S. C. Mutka et al.   CANCER RESEARCH

Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer

(2008) Aurelia Noske et al.   CANCER

Design of Peptide Inhibitors for the Importin α/β Nuclear Import Pathway by Activity-Based Profiling

(2008) Shunichi Kosugi et al.   CHEMISTRY & BIOLOGY

Evolutionary and Transcriptional Analysis of Karyopherin β Superfamily Proteins

(2008) Yu Quan et al.   MOLECULAR & CELLULAR PROTEOMICS

Nuclear translocation of hypoxia-inducible factors (HIFs): Involvement of the classical importin α/β pathway

(2007) Reinhard Depping et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH