Article
Biochemistry & Molecular Biology
Zhiling Kuang, Jiyuan Ke, Jiong Hong, Zhongliang Zhu, Liwen Niu
Summary: PCI domain proteins play important roles in post-transcriptional gene regulation. In this study, the structure of yeast Thp3-Csn12-Sem1 ternary complex was determined, revealing significant structural differences compared to the Sac3-Thp1-Sem1 complex. This structure provides a foundation for further exploring its specific recruitment to the spliceosome.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Hyun-Sun Park, Jongbok Lee, Hyun-Shik Lee, Seong Hoon Ahn, Hong-Yeoul Ryu
Summary: The relationship between transcription and aging has been extensively studied. The nuclear mRNA export plays a crucial role in cellular aging and age-related neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Belen Pacheco-Fiallos, Matthias K. Vorlaender, Daria Riabov-Bassat, Laura Fin, Francis J. O'Reilly, Farja I. Ayala, Ulla Schellhaas, Juri Rappsilber, Clemens Plaschka
Summary: Newly made mRNAs are recognized and organized by the essential TREX complex for nuclear export. Cryo-electron microscopy and tomography structures reveal that mRNAs are recognized through multivalent interactions between TREX subunit ALYREF and mRNP-bound exon junction complexes. Endogenous mRNPs form compact globules that are coated by multiple TREX complexes, providing a framework to understand mRNA biogenesis and export.
Article
Cell Biology
Suji Lim, Yan Liu, Byung-Ho Rhie, Chun Kim, Hong-Yeoul Ryu, Seong Hoon Ahn
Summary: The study finds that Sus1 is a key factor in linking transcription and mRNA nuclear export. SAGA DUB module and TREX-2 have distinct roles in yeast replicative lifespan. Loss of Sus1 affects growth and lifespan, which depends on TREX-2. Increasing mRNA export factors can rescue the effects.
Article
Medicine, Research & Experimental
Benjamin J. Murdock, Joshua P. Famie, Caroline E. Piecuch, Kristen D. Raue, Faye E. Mendelson, Cole H. Pieroni, Sebastian D. Iniguez, Lili Zhao, Stephen A. Goutman, Eva L. Feldman
Summary: These findings suggest that NK cells contribute to ALS progression in a sex- and age-specific manner, and that age and sex are critical variables in designing and assessing ALS immunotherapy.
Article
Cell Biology
Yihu Xie, Shengyan Gao, Ke Zhang, Prasanna Bhat, Bradley P. Clarke, Kimberly Batten, Menghan Mei, Matthew Gazzara, Jerry W. Shay, Kristen W. Lynch, Alexia E. Angelos, Pate S. Hill, Austin L. Ivey, Beatriz M. A. Fontoura, Yi Ren
Summary: This study reveals the importance of the high-order SARNP/Tho1 complex interacting with DDX39B/RNA in mRNP assembly and export.
Article
Plant Sciences
Wei Kong, Shutang Tan, Qing Zhao, De-Li Lin, Zhi-Hong Xu, Jiri Friml, Hong-Wei Xue
Summary: The study revealed the important regulatory role of the PELOTA-HBS1 complex in plants, confirming its functionality in degrading T-DNA disrupted PDK1 transcripts to rescue growth and developmental defects.
Article
Multidisciplinary Sciences
Karolina Piekarska, Zuzanna Urban-Wojciuk, Malgorzta Kurkowiak, Iwona Pelikant-Malecka, Adriana Schumacher, Justyna Sakowska, Jan Henryk Spodnik, Lukasz Arcimowicz, Hanna Zielinska, Boguslaw Tymoniuk, Alicja Renkielska, Janusz Siebert, Ewa Slominska, Piotr Trzonkowski, Ted Hupp, Natalia Maria Marek-Trzonkowska
Summary: Transfer of mitochondria from mesenchymal stem cells to allogeneic Treg cells enhances the immunosuppressive functions of Treg cells, providing potential for the development of cell-based immunotherapies.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Simeon R. Mihaylov, Lydia M. Castelli, Ya-Hui Lin, Aytac Gul, Nikita Soni, Christopher Hastings, Helen R. Flynn, Oana Paun, Mark J. Dickman, Ambrosius P. Snijders, Robert Goldstone, Oliver Bandmann, Tatyana A. Shelkovnikova, Heather Mortiboys, Sila K. Ultanir, Guillaume M. Hautbergue
Summary: The RS domain of PGC-1α directly interacts with RNA and the nuclear RNA export receptor NXF1, and this RNA-binding activity is required for the nuclear export of mitochondrial-related mRNAs and mitochondrial homeostasis.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Merce Gomar-Alba, Vasilisa Pozharskaia, Bogdan Cichocki, Celia Schaal, Arun Kumar, Basile Jacquel, Gilles Charvin, J. Carlos Igual, Manuel Mendoza
Summary: Nuclear pore complexes (NPCs) mediate communication between the nucleus and the cytoplasm and regulate gene expression. Lysine acetyltransferase Esa1 acetylates the nuclear pore basket component Nup60, which recruits the mRNA export factor Sac3, to promote mRNA export. This mechanism also regulates cell entry into S phase and prevents premature commitment to a new cell division cycle in G1 daughter cells.
Article
Medicine, Research & Experimental
Lin Zhang, Yicong Wan, Zihan Zhang, Yi Jiang, Zhiyue Gu, Xiaoling Ma, Sipei Nie, Jing Yang, Jinghe Lang, Wenjun Cheng, Lan Zhu
Summary: This study reveals a crucial role of IGF2BP1 in the m(6)A-dependent regulatory mechanism in endometrial cancer, shedding light on disease progression and potential biological functions.
Review
Oncology
Katherine L. B. Borden
Summary: This review highlights the importance of RNA export in cellular trafficking and the aberrant phenomena observed in cancer. Studies on RNA export machinery and relevant NPC components offer potential therapeutic strategies for targeting cancer.
Review
Parasitology
Susanne Kramer
Summary: The passage of mRNAs through nuclear pores into the cytoplasm is essential for all eukaryotes, with mRNA export tightly connected to nuclear mRNA processing. Trypanosoma brucei exhibits unusual features in nuclear mRNA processing, lacking key complexes and proteins found in opisthokonts. Further investigation is needed to determine the extent of mRNA export regulation in trypanosomes and the evolutionary implications of mRNA export across eukaryotes.
Article
Biochemistry & Molecular Biology
Inga Loedige, Artem Baranovskii, Samantha Mendonsa, Sayaka Dantsuji, Niko Popitsch, Laura Breimann, Nadja Zerna, Vsevolod Cherepanov, Miha Milek, Stefan Ameres, Marina Chekulaeva
Summary: Cells require specific shapes and subcellular compartments to perform biological functions, which is achieved through the asymmetric distribution of mRNAs. The current model of mRNA localization involves specific sequences called zipcodes, but additional mechanisms are likely involved. This study investigates the role of mRNA stability in localization and reveals that mRNA destabilization elements mediate the localization of mRNAs associated with housekeeping functions to neurites in various types of neurons.
Article
Medicine, Research & Experimental
Stephanie Kim, Rami Khoriaty, Lu Li, Madison McClune, Theodosia A. Kalfa, Julia Wu, Daniel Peltier, Hideaki Fujiwara, Yaping Sun, Katherine Oravecz-Wilson, Richard A. King, David Ginsburg, Pavan Reddy
Summary: The activation of T cells leads to increased trafficking via the ER-to-Golgi pathway, which is crucial for the regulation of T cell secretome. Deficiency of SEC23B may impair T cell functions, while increased levels of SEC23A in CDAII patients' T cells contribute to maintaining their functions.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Hematology
Donna Oksenberg, Kobina Dufu, Mira P. Patel, Chihyuan Chuang, Zhe Li, Qing Xu, Abel Silva-Garcia, Chengjing Zhou, Athiwat Hutchaleelaha, Larysa Patskovska, Yury Patskovsky, Steven C. Almo, Uma Sinha, Brian W. Metcalf, David R. Archer
BRITISH JOURNAL OF HAEMATOLOGY
(2016)
Article
Chemistry, Medicinal
Brian Metcalf, Chihyuan Chuang, Kobina Dufu, Mira P. Patel, Abel Silva-Garcia, Carl Johnson, Qing Lu, James R. Partridge, Larysa Patskovska, Yury Patskovsky, Steven C. Almo, Matthew P. Jacobson, Lan Hua, Qing Xu, Stephen L. Gwaltney, Calvin Yee, Jason Harris, Bradley P. Morgan, Joyce James, Donghong Xu, Athiwat Hutchaleelaha, Kumar Paulvannan, Donna Oksenberg, Zhe Li
ACS MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Hematology
Kobina Dufu, Mira Patel, Donna Oksenberg, Pedro Cabrales
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2018)
Article
Physiology
Nathan D. Putz, Ciara M. Shaver, Kobina Dufu, Chien-Ming Li, Qing Xu, Athiwat Hutchaleelaha, Josh Lehrer-Graiwer, Susan M. Majka, Lorraine B. Ware, Julie A. Bastarache
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Cell Biology
Kobina Dufu, Michaela J. Livingstone, Jan Seebacher, Steven P. Gygi, Stuart A. Wilson, Robin Reed
GENES & DEVELOPMENT
(2010)
Article
Hematology
Jo Howard, Claire Jane Hemmaway, Paul Telfer, D. Mark Layton, John Porter, Moji Awogbade, Timothy Mant, Daniel D. Gretler, Kobina Dufu, Athiwat Hutchaleelaha, Mira Patel, Vincent Siu, Sandra Dixon, Noel Landsman, Margaret Tonda, Joshua Lehrer-Graiwer
Article
Physiology
Glenn M. Stewart, Steven Chase, Troy J. Cross, Courtney M. Wheatley-Guy, Michael Joyner, Timothy Curry, Josh Lehrer-Graiwer, Kobina Dufu, Nicholas E. Vlahakis, Bruce D. Johnson
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Kobina Dufu, Alexander T. Williams, Cynthia R. Muller, Cynthia M. Walser, Alfredo Lucas, Allyn M. Eaker, Carsten Alt, Brian E. Cathers, Donna Oksenberg, Pedro Cabrales
Summary: The study suggests that increasing hemoglobin affinity for oxygen can improve the survival rate and brain tissue oxygenation of SCD mice under hypoxic conditions.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biophysics
Glenn M. Stewart, Troy J. Cross, Michael J. Joyner, Steven C. Chase, Timothy Curry, Josh Lehrer-Graiwer, Kobina Dufu, Nicholas E. Vlahakis, Bruce D. Johnson
Summary: This study investigated the impact of pharmacologically left shifting the oxygen-hemoglobin dissociation curve on arterial blood gases and pulmonary gas exchange during maximal exercise in hypoxia. It was found that left shifting the ODC can improve arterial oxygen saturation during hypoxia without affecting exercise capacity, but may reduce exercise capacity in normoxia. Further research is needed to explore the effects of left shifting the ODC under different conditions and levels of hypoxia.
HIGH ALTITUDE MEDICINE & BIOLOGY
(2021)
Article
Physiology
Halima Al Balushi, Kobina Dufu, David C. Rees, John N. Brewin, Anke Hannemann, Donna Oksenberg, David C-Y Lu, John S. Gibson
PHYSIOLOGICAL REPORTS
(2019)
Article
Cardiac & Cardiovascular Systems
Kobina Dufu, Ozlem Yalcin, Eilleen S. Y. Ao-ieong, Athiwat Hutchaleelala, Qing Xu, Zhe Li, Nicholas Vlahakis, Donna Oksenberg, Josh Lehrer-Graiwer, Pedro Cabrales
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2017)
Article
Hematology
Kobina Dufu, Josh Lehrer-Graiwer, Eleanor Ramos, Donna Oksenberg
HEMATOLOGY REPORTS
(2016)
Article
Physiology
Xin Geng, Kobina Dufu, Athiwat Hutchaleelaha, Qing Xu, Zhe Li, Chien-Ming Li, Mira P. Patel, Nicholas Vlahakis, Josh Lehrer-Graiwer, Donna Oksenberg
PHYSIOLOGICAL REPORTS
(2016)
Article
Hematology
Kobina Dufu, Donna Oksenberg
HEMATOLOGY REPORTS
(2018)