Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery

Carbonic anhydrases are involved in mitochondrial biogenesis and control the production of lactate by human Sertoli cells

(2019) Raquel L. Bernardino et al.   FEBS Journal

Novel approaches for designing drugs that interfere with pH regulation

(2019) Emanuela Berrino et al.   Expert Opinion on Drug Discovery

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

(2019) Paul C. McDonald et al.   GASTROENTEROLOGY

A new widespread subclass of carbonic anhydrase in marine phytoplankton

(2019) Erik L. Jensen et al.   ISME Journal

Targeting hypoxia-induced carbonic anhydrase IX enhances immune checkpoint blockade locally and systemically

(2019) Shawn C Chafe et al.   Cancer Immunology Research

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

(2019) Hedlund et al.   Cancers

Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies

(2018) Alessio Nocentini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

(2018) Samuele Cazzamalli et al.   CLINICAL CANCER RESEARCH

Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform

(2018) Hany S. Ibrahim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018)

(2018) Alessio Nocentini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Carbonic anhydrase activators

(2018) Claudiu T Supuran   Future Medicinal Chemistry

Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition

(2018) Benoit Métayer et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Evaluation of 99m Tc-sulfonamide and sulfocoumarin derivatives for imaging carbonic anhydrase IX expression

(2018) Misaki Nakai et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Management of Rheumatoid Arthritis

(2018) Ozlem Akgul et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of β-Adrenergic Receptors Blocker–Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy

(2018) Alessio Nocentini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX

(2018) Murat Bozdag et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemically Defined Antibody– and Small Molecule–Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis

(2018) Samuele Cazzamalli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one

(2018) Claudiu T. Supuran et al.   MEDICINAL RESEARCH REVIEWS

Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function

(2018) Avni Bhatt et al.   MOLECULAR NEUROBIOLOGY

Development of a Small Molecule Tubulysin B Conjugate for Treatment of Carbonic Anhydrase IX Receptor Expressing Cancers

(2018) Isaac S. Marks et al.   MOLECULAR PHARMACEUTICS

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding

(2018) Giuseppina De Simone et al.   CHEMICAL COMMUNICATIONS

Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008–2018)

(2018) Alessio Nocentini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases

(2018) Claudiu T. Supuran   EXPERT OPINION ON THERAPEUTIC PATENTS

Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas

(2018) Claudiu T. Supuran   EXPERT OPINION ON THERAPEUTIC PATENTS

Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

(2018) Alessio Nocentini et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors

(2018) Özlen Güzel-Akdemir et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases

(2018) Andrea Angeli et al.   ACS Medicinal Chemistry Letters

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

(2018) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors

(2018) Claudiu T. Supuran   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides

(2017) Mam Y. Mboge et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Primary mono- and bis-sulfonamides obtained via regiospecific sulfochlorination of N-arylpyrazoles: inhibition profile against a panel of human carbonic anhydrases

(2017) Mikhail Krasavin et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

(2017) Aleksandrs Pustenko et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, synthesis and evaluation of 18F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging

(2017) Zhengxing Zhang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

(2017) Vincenzo Alterio et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Treatment of Rheumatoid Arthritis

(2017) Silvia Bua et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus

(2017) Lucas Canto de Souza et al.   NEUROPHARMACOLOGY

Structure and function of carbonic anhydrases

(2016) C. T. Supuran   BIOCHEMICAL JOURNAL

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

(2016) Vincenzo Alterio et al.   CHEMICAL COMMUNICATIONS

Advances in structure-based drug discovery of carbonic anhydrase inhibitors

(2016) Claudiu T. Supuran   Expert Opinion on Drug Discovery

Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

(2016) Claudiu T. Supuran   Expert Opinion on Drug Metabolism & Toxicology

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

(2016) Francesca Margheri et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma

(2016) Daniela Vullo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in Vivo Biological Evaluation of 68Ga-Labeled Carbonic Anhydrase IX Targeting Small Molecules for Positron Emission Tomography

(2016) Deborah Sneddon et al.   JOURNAL OF MEDICINAL CHEMISTRY

PET Imaging of Carbonic Anhydrase IX Expression of HT-29 Tumor Xenograft Mice with 68Ga-Labeled Benzenesulfonamides

(2016) Joseph Lau et al.   MOLECULAR PHARMACEUTICS

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

(2016) Anastasia Karioti et al.   MOLECULES

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII

(2015) Alessio Nocentini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

(2015) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Out of the active site binding pocket for carbonic anhydrase inhibitors

(2015) Katia D'Ambrosio et al.   CHEMICAL COMMUNICATIONS

A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases

(2015) Emma Langella et al.   CHEMISTRY-A EUROPEAN JOURNAL

Probing the ‘bipolar’ nature of the carbonic anhydrase active site: Aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms

(2015) Mikhail Krasavin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acetazolamide for the treatment of idiopathic intracranial hypertension

(2015) Claudiu T Supuran   Expert Review of Neurotherapeutics

7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibitsα-carbonic anhydrases without hydrolysis of the lactam ring

(2015) Daniela Vullo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII

(2015) Alessio Nocentini et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors

(2015) Lorenzo Di Cesare Mannelli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and carbonic anhydrase inhibitory properties of amino acid – coumarin/quinolinone conjugates incorporating glycine, alanine and phenylalanine moieties

(2015) F. Zehra Küçükbay et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

How many carbonic anhydrase inhibition mechanisms exist?

(2015) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins

(2015) Marta Ferraroni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic Anhydrase Inhibitors with Dual-Tail Moieties To Match the Hydrophobic and Hydrophilic Halves of the Carbonic Anhydrase Active Site

(2015) Rajendra P. Tanpure et al.   JOURNAL OF MEDICINAL CHEMISTRY

6-Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells

(2015) Aiga Grandane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acetazolamide for the treatment of idiopathic intracranial hypertension

(2015) Claudiu T Supuran   Expert Review of Neurotherapeutics

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

(2015) Paul C. McDonald et al.   Oncotarget

A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

(2014) Nikolaus Krall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators

(2014) Mohamed-Chiheb Saada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII

(2014) Aiga Grandane et al.   BIOORGANIC & MEDICINAL CHEMISTRY

6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII

(2014) Aiga Grandane et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

(2014) Bogdan Draghici et al.   CHEMICAL COMMUNICATIONS

Fluorinated pyrrolidines and piperidines incorporating tertiary benzenesulfonamide moieties are selective carbonic anhydrase II inhibitors

(2014) Alexandre Le Darz et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors

(2014) Giuseppina De Simone et al.   Biomed Research International

Structural elucidation of the hormonal inhibition mechanism of the bile acid cholate on human carbonic anhydrase II

(2014) Christopher D. Boone et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors

(2013) Muhammet Tanc et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors

(2013) Vincenzo Alterio et al.   BIOPOLYMERS

Modulation of the Initial Mineralization Process of SaOS-2 Cells by Carbonic Anhydrase Activators and Polyphosphate

(2013) Xiaohong Wang et al.   CALCIFIED TISSUE INTERNATIONAL

New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides

(2013) Benoît Métayer et al.   CHEMICAL COMMUNICATIONS

Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors

(2013) Giuseppina De Simone et al.   Expert Opinion on Drug Discovery

Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review

(2013) Mayank Aggarwal et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antiglaucoma carbonic anhydrase inhibitors: a patent review

(2013) Emanuela Masini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013)

(2013) Simona Maria Monti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antiobesity carbonic anhydrase inhibitors: a literature and patent review

(2013) Andrea Scozzafava et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

(2013) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX

(2013) Aditi Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo

(2013) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: Implications for biological assembly and inhibitor development

(2012) Ewa S. Pilka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Natural product coumarins that inhibit human carbonic anhydrases

(2012) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

(2012) Daniel D. Long et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition

(2012) Isao Nishimori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases

(2012) Jean-Yves Winum et al.   CHEMICAL COMMUNICATIONS

Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors

(2012) Anna Di Fiore et al.   CHEMICAL COMMUNICATIONS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Secondary and tertiary sulfonamides: a patent review (2008 – 2012)

(2012) Andrea Scozzafava et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Sulfonamides: a patent review (2008 – 2012)

(2012) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors

(2012) Adeline Bonneau et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Structural annotation of human carbonic anhydrases

(2012) Mayank Aggarwal et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

(2012) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

(2012) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action

(2011) Francesco Mincione et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives

(2011) Mohamed-Chiheb Saada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors

(2011) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

(2011) Fabrizio Carta et al.   CHEMICAL COMMUNICATIONS

Novel therapies for glaucoma: a patent review 2007 – 2011

(2011) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters

(2011) Hüseyin Çavdar et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology

(2011) Francesca Fabrizi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

(In)organic anions as carbonic anhydrase inhibitors

(2011) Giuseppina De Simone et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

(2011) Nadia Touisni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

(2010) Fabian Buller et al.   ACS Chemical Biology

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

(2010) Anna Di Fiore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

(2010) Fabio Pacchiano et al.   CHEMICAL COMMUNICATIONS

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

(2010) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma

(2009) Rebecca M. Steele et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic Anhydrase Inhibitors. Comparison of Chlorthalidone and Indapamide X-ray Crystal Structures in Adducts with Isozyme II: When Three Water Molecules and the Keto−Enol Tautomerism Make the Difference†

(2009) Claudia Temperini et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Coumarin-Binding Site in Carbonic Anhydrase Accommodates Structurally Diverse Inhibitors: The Antiepileptic Lacosamide As an Example and Lead Molecule for Novel Classes of Carbonic Anhydrase Inhibitors

(2009) Claudia Temperini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing

(2009) Sarah S. Picaud et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study†

(2008) Albert A. Barrese et al.   BIOCHEMISTRY

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II

(2008) Esra Bayram et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I–XIV

(2008) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I–XIV with a series of substituted phenols including paracetamol and salicylic acid

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference

(2008) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I–XIV)

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic Anhydrase Activation and the Drug Design

(2008) Claudia Temperini et al.   CURRENT PHARMACEUTICAL DESIGN

Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II

(2008) John F. Domsic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide

(2008) Anna Di Fiore et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS