Design, synthesis and evaluation of 18F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging

Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma

(2017) Samuele Cazzamalli et al.   JOURNAL OF CONTROLLED RELEASE

Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

(2016) Francesca Margheri et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1,3,4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors

(2016) Chandra Bhushan Mishra et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Isoform-selective inhibitory profile of 2-imidazoline-substituted benzene sulfonamides against a panel of human carbonic anhydrases

(2016) Claudiu T. Supuran et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars

(2016) Adriano Mollica et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases

(2016) Cem Yamali et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells

(2016) Cristina Federici et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents

(2016) Jorge R. A. Diaz et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

One-step synthesis of 4-[18F]fluorobenzyltriphenylphosphonium cation for imaging with positron emission tomography

(2016) Zhengxing Zhang et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis and in Vivo Biological Evaluation of 68Ga-Labeled Carbonic Anhydrase IX Targeting Small Molecules for Positron Emission Tomography

(2016) Deborah Sneddon et al.   JOURNAL OF MEDICINAL CHEMISTRY

A 99mTc-Labeled Ligand of Carbonic Anhydrase IX Selectively Targets Renal Cell Carcinoma In Vivo

(2016) N. Krall et al.   JOURNAL OF NUCLEAR MEDICINE

PET Imaging of Carbonic Anhydrase IX Expression of HT-29 Tumor Xenograft Mice with 68Ga-Labeled Benzenesulfonamides

(2016) Joseph Lau et al.   MOLECULAR PHARMACEUTICS

[64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma

(2016) Il Minn et al.   Oncotarget

Targeting carbonic anhydrase IX with small organic ligands

(2015) Moreno Wichert et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Trimeric Radiofluorinated Sulfonamide Derivatives to Achieve In Vivo Selectivity for Carbonic Anhydrase IX-Targeted PET Imaging

(2015) J. Lau et al.   JOURNAL OF NUCLEAR MEDICINE

18F-Trifluoroborate Derivatives of [Des-Arg10]Kallidin for Imaging Bradykinin B1 Receptor Expression with Positron Emission Tomography

(2015) Zhibo Liu et al.   MOLECULAR PHARMACEUTICS

Imaging Bradykinin B1 Receptor with 68Ga-Labeled [des-Arg10]Kallidin Derivatives: Effect of the Linker on Biodistribution and Tumor Uptake

(2015) Guillaume Amouroux et al.   MOLECULAR PHARMACEUTICS

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

(2015) Madduri Srinivasarao et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids

(2015) Andrew V. Mossine et al.   ORGANIC LETTERS

Imaging of carbonic anhydrase IX with an 111In-labeled dual-motif inhibitor

(2015) Xing Yang et al.   Oncotarget

PET/CT imaging of renal cell carcinoma with 18F-VM4-037: a phase II pilot study

(2015) Baris Turkbey et al.   Abdominal Radiology

A General Copper-Mediated Nucleophilic18F Fluorination of Arenes

(2014) Matthew Tredwell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

(2014) Nikolaus Krall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

(2014) Joseph C. Walsh et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum —The η-carbonic anhydrases

(2014) Sonia Del Prete et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of 18F-labeled tertiary benzenesulfonamides for imaging carbonic anhydrase IX expression in tumours with positron emission tomography

(2014) Joseph Lau et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In Vivo Radioimaging of Bradykinin Receptor B1, a Widely Overexpressed Molecule in Human Cancer

(2014) K.-S. Lin et al.   CANCER RESEARCH

Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges

(2014) S Basavaraj et al.   Acta Pharmaceutica Sinica B

Development and biological evaluation of 99mTc-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers

(2013) Vamsidhar Akurathi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography

(2013) Jinhe Pan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Synthesis and SAR of Novel Re/99mTc-Labeled Benzenesulfonamide Carbonic Anhydrase IX Inhibitors for Molecular Imaging of Tumor Hypoxia

(2012) Genliang Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

(2011) Nadia Touisni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic Anhydrase IX in Renal Cell Carcinoma: Implications for Prognosis, Diagnosis, and Therapy

(2010) Alexander B. Stillebroer et al.   EUROPEAN UROLOGY

Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia

(2010) Vamsidhar Akurathi et al.   NUCLEAR MEDICINE AND BIOLOGY

Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2diffusion

(2008) Pawel Swietach et al.   BJU INTERNATIONAL

Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths

(2008) Pawel Swietach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes

(2008) Mika Hilvo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY