New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides

Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII

(2012) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: New selective tumor-associated carbonic anhydrase inhibitors

(2012) Guillaume Compain et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Stereoselective hydrofluorination of ynamides: a straightforward synthesis of novel α-fluoroenamides

(2012) Guillaume Compain et al.   CHEMICAL COMMUNICATIONS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Carbonic anhydrase III: A neglected isozyme is stepping into the limelight

(2012) Anna-Kaisa Harju et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II

(2012) Cemalettin Alp et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

(2012) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II

(2011) Anna Di Fiore et al.   CHEMICAL COMMUNICATIONS

Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABAC receptors

(2011) Izumi Yamamoto et al.   CHEMICAL COMMUNICATIONS

The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABACreceptor

(2011) Izumi Yamamoto et al.   CHEMICAL COMMUNICATIONS

Novel therapies for glaucoma: a patent review 2007 – 2011

(2011) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Carbonic Anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry

(2011) Fei Liu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Synthesis ofgem-Chlorofluorinated Nitrogen-Containing Derivatives after Superelectrophilic Activation in Superacid HF/SbF5

(2011) Fei Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

(2010) Anna Di Fiore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors

(2010) Claudiu T. Supuran   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Superelectrophilic Activation in Superacid HF/SbF5and Synthesis of Benzofused Sultams

(2010) Fei Liu et al.   ORGANIC LETTERS

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein−Ligand Binding

(2008) Vijay M. Krishnamurthy et al.   CHEMICAL REVIEWS

The Alpha-Carbonic Anhydrase from the Malaria Parasite and its Inhibition

(2008) Jerapan Krungkrai et al.   CURRENT PHARMACEUTICAL DESIGN

Diuretics: From Classical Carbonic Anhydrase Inhibitors to Novel Applications of the Sulfonamides

(2008) Claudiu Supuran   CURRENT PHARMACEUTICAL DESIGN

Are Carbonic Anhydrase Inhibitors Suitable for Obtaining Antiobesity Drugs ?

(2008) Anna Fiore et al.   CURRENT PHARMACEUTICAL DESIGN

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity

(2008) Claudiu T Supuran et al.   EXPERT OPINION ON EMERGING DRUGS

Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II

(2008) John F. Domsic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited—old leads for new applications?

(2008) Claudia Temperini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide

(2008) Anna Di Fiore et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS