Probing the ‘bipolar’ nature of the carbonic anhydrase active site: Aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms

标题
Probing the ‘bipolar’ nature of the carbonic anhydrase active site: Aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms
作者
关键词
Drug discovery, Carbonic anhydrase inhibitors, Isoform selectivity, Anti-glaucoma drugs, 1,3-oxadiazol-5-yl aromatics, Chemoselective sulfochlorination
出版物
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 101, Issue -, Pages 334-347
出版商
Elsevier BV
发表日期
2015-06-25
DOI
10.1016/j.ejmech.2015.06.022

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