A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases

Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors

(2015) Anna Di Fiore et al.   CHEMICAL COMMUNICATIONS

Out of the active site binding pocket for carbonic anhydrase inhibitors

(2015) Katia D'Ambrosio et al.   CHEMICAL COMMUNICATIONS

Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII

(2014) Melissa D’Ascenzio et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors

(2013) Giuseppina De Simone et al.   Expert Opinion on Drug Discovery

Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors

(2012) David P. Martin et al.   CHEMICAL COMMUNICATIONS

Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors

(2012) Anna Di Fiore et al.   CHEMICAL COMMUNICATIONS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Carbonic Anhydrase IX as a Target for Designing Novel Anticancer Drugs

(2012) S. M. Monti et al.   CURRENT MEDICINAL CHEMISTRY

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

(2012) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II

(2011) Anna Di Fiore et al.   CHEMICAL COMMUNICATIONS

DSX: A Knowledge-Based Scoring Function for the Assessment of Protein–Ligand Complexes

(2011) Gerd Neudert et al.   Journal of Chemical Information and Modeling

Drug Design Studies of the Novel Antitumor Targets Carbonic Anhydrase IX and XII

(2010) O. Guler et al.   CURRENT MEDICINAL CHEMISTRY

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel acetate-bound complex of human carbonic anhydrase II

(2008) Pooja Anjali Mazumdar et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Are Carbonic Anhydrase Inhibitors Suitable for Obtaining Antiobesity Drugs ?

(2008) Anna Fiore et al.   CURRENT PHARMACEUTICAL DESIGN

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY