7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII

Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII

(2015) Alessio Nocentini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

6-Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells

(2015) Aiga Grandane et al.   JOURNAL OF MEDICINAL CHEMISTRY

6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA

(2015) Muhammet Tanc et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and antifungal activity of 1,2,3-triazole phenylhydrazone derivatives

(2015) Zhi-Cheng Dai et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII

(2014) Aiga Grandane et al.   BIOORGANIC & MEDICINAL CHEMISTRY

6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII

(2014) Aiga Grandane et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sulfonamides and their isosters as carbonic anhydrase inhibitors

(2014) Fabrizio Carta et al.   Future Medicinal Chemistry

Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry

(2014) Nicolino Pala et al.   ACS Medicinal Chemistry Letters

7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors

(2013) Muhammet Tanc et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO2 capture

(2013) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo

(2013) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII

(2012) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insights towards sulfonamide drug specificity in α-carbonic anhydrases

(2012) Mayank Aggarwal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural product coumarins that inhibit human carbonic anhydrases

(2012) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II

(2012) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Update on carbonic anhydrase inhibitors: a patent review (2008 – 2011)

(2012) Mayank Aggarwal et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Click Chemistry on a Ruthenium Polypyridine Complex. An Efficient and Versatile Synthetic Route for the Synthesis of Photoactive Modular Assemblies

(2012) Aurélie Baron et al.   INORGANIC CHEMISTRY

Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors

(2012) Adeline Bonneau et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Three new aromatic sulfonamide inhibitors of carbonic anhydrases I, II, IV and XII

(2012) C. T. Supuran et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Structure-based drug discovery of carbonic anhydrase inhibitors

(2012) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Structural annotation of human carbonic anhydrases

(2012) Mayank Aggarwal et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

(2012) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

(2012) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Facile synthesis of coumarin bioisosteres—1,2-benzoxathiine 2,2-dioxides

(2012) Aiga Grandane et al.   TETRAHEDRON

5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors

(2011) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata

(2011) Simona Maria Monti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

(2011) Fabrizio Carta et al.   CHEMICAL COMMUNICATIONS

Carbonic anhydrase inhibitors and activators for novel therapeutic applications

(2011) Claudiu T Supuran   Future Medicinal Chemistry

Carbonic Anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry

(2011) Fei Liu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds

(2011) Deniz Ekinci et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dithiocarbamates strongly inhibit the β-class carbonic anhydrases fromMycobacterium tuberculosis

(2011) Alfonso Maresca et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

(2011) Nadia Touisni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Product-Based Phenols as Novel Probes for Mycobacterial and Fungal Carbonic Anhydrases

(2011) Rohan A. Davis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation

(2011) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

Phosphorylation-Dependent Kinase-Substrate Cross-Linking

(2010) Sujit Suwal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors

(2010) Claudiu T. Supuran   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and dual PPARα/δ agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516

(2010) Calin C. Ciocoiu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

(2010) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transition-Metal-Free Catalytic Synthesis of 1,5-Diaryl-1,2,3-triazoles

(2010) Sen W. Kwok et al.   ORGANIC LETTERS

In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives

(2009) Julia K.J. Ahlskog et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

(2009) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I–XIV with a series of substituted phenols including paracetamol and salicylic acid

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I–XIV)

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes

(2008) Mika Hilvo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY