Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations

(2017) Giuseppina De Simone et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Treatment of Rheumatoid Arthritis

(2017) Silvia Bua et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment

(2017) Chandra Bhushan Mishra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides

(2017) Elvira Bruno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Comparative Evaluation of the Anticonvulsant Profile, Carbonic-Anhydrate Inhibition and Teratogenicity of Novel Carbamate Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide

(2017) David Bibi et al.   NEUROCHEMICAL RESEARCH

Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine–benzenesulfonamides acting as carbonic anhydrase inhibitors

(2016) Daniela Vullo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

(2016) Claudiu T. Supuran   Expert Opinion on Drug Metabolism & Toxicology

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

(2015) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors

(2015) Anna Di Fiore et al.   CHEMICAL COMMUNICATIONS

Out of the active site binding pocket for carbonic anhydrase inhibitors

(2015) Katia D'Ambrosio et al.   CHEMICAL COMMUNICATIONS

A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases

(2015) Emma Langella et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment

(2015) Francesca Perut et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Bacterial, fungal and protozoan carbonic anhydrases as drug targets

(2015) Clemente Capasso et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Acetazolamide for the treatment of idiopathic intracranial hypertension

(2015) Claudiu T Supuran   Expert Review of Neurotherapeutics

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors

(2015) Lorenzo Di Cesare Mannelli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

How many carbonic anhydrase inhibition mechanisms exist?

(2015) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of 1,1′-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors

(2015) Giuseppe La Regina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acetazolamide for the treatment of idiopathic intracranial hypertension

(2015) Claudiu T Supuran   Expert Review of Neurotherapeutics

6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII

(2014) Aiga Grandane et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sulfonamides and their isosters as carbonic anhydrase inhibitors

(2014) Fabrizio Carta et al.   Future Medicinal Chemistry

Antiglaucoma carbonic anhydrase inhibitors: a patent review

(2013) Emanuela Masini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013)

(2013) Simona Maria Monti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antiobesity carbonic anhydrase inhibitors: a literature and patent review

(2013) Andrea Scozzafava et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

(2013) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates

(2013) Marouan Rami et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Carbonic Anhydrase IX as a Target for Designing Novel Anticancer Drugs

(2012) S. M. Monti et al.   CURRENT MEDICINAL CHEMISTRY

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

(2012) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

(2012) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

(2011) Fabrizio Carta et al.   CHEMICAL COMMUNICATIONS

Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drug Design Studies of the Novel Antitumor Targets Carbonic Anhydrase IX and XII

(2010) O. Guler et al.   CURRENT MEDICINAL CHEMISTRY

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

(2010) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates?

(2009) Giuseppina De Simone et al.   Chemical Biology & Drug Design

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors

(2008) Anna Di Fiore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Are Carbonic Anhydrase Inhibitors Suitable for Obtaining Antiobesity Drugs ?

(2008) Anna Fiore et al.   CURRENT PHARMACEUTICAL DESIGN

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity

(2008) Claudiu T Supuran et al.   EXPERT OPINION ON EMERGING DRUGS

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY