Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

Role of Protein Kinases in Hedgehog Pathway Control and Implications for Cancer Therapy

(2019) Valentina Montagnani et al.   Cancers

Phase Ib Study of Glasdegib, a Hedgehog Pathway Inhibitor, in Combination with Standard Chemotherapy in Patients with AML or High-Risk MDS

(2018) Michael R. Savona et al.   CLINICAL CANCER RESEARCH

Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

(2018) Ramon J Whitson et al.   NATURE MEDICINE

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function

(2018) Jinqiu Lu et al.   ONCOGENE

Non-canonical activation of hedgehog in prostate cancer cells mediated by the interaction of transcriptionally active androgen receptor proteins with Gli3

(2018) Na Li et al.   ONCOGENE

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

(2018) Yen-An Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe

(2018) Silvia Pietrobono et al.   Cell Death & Disease

Trichostatin A promotes GLI1 degradation and P21 expression in multiple myeloma cells

(2018) Yan Geng et al.   Cancer Management and Research

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation

(2018) Laura Antonucci et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA‑361‑3p regulates retinoblastoma cell proliferation and stemness by targeting hedgehog signaling

(2018) Dan Zhao et al.   Experimental and Therapeutic Medicine

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

(2018) Luana Abballe et al.   Frontiers in Pediatrics

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

(2018) Silvia Pietrobono et al.   Cells

Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance

(2017) Wolfgang Gruber et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I trial of the oral smoothened inhibitor sonidegib in combination with paclitaxel in patients with advanced solid tumors

(2017) A. Stathis et al.   INVESTIGATIONAL NEW DRUGS

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

(2017) A Po et al.   ONCOGENE

Inhibition of Gli1‑mediated prostate cancer cell proliferation by inhibiting the mTOR/S6K1 signaling pathway

(2017) Hong Yang et al.   Oncology Letters

Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation

(2017) Rui Zhang et al.   Oncotarget

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma

(2017) Sonia Coni et al.   Scientific Reports

Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system

(2017) Yuhong Han et al.   PLOS BIOLOGY

GLI2 cell-specific activity is controlled at the level of transcription and RNA processing: Consequences to cancer metastasis

(2016) Helle Sadam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target

(2016) Jiancheng Zhou et al.   CANCER LETTERS

Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation

(2016) Yan Wang et al.   CANCER RESEARCH

Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment

(2016) Yinshi Huang et al.   CLINICAL CANCER RESEARCH

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma

(2016) Reinhard Dummer et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

A phase I trial of the Hedgehog inhibitor, sonidegib (LDE225), in combination with etoposide and cisplatin for the initial treatment of extensive stage small cell lung cancer

(2016) M. Catherine Pietanza et al.   LUNG CANCER

Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment

(2016) Ann Hanna et al.   Molecular Cancer

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

(2016) Yumi Miyazaki et al.   Molecular Cancer

WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma

(2016) J Wen et al.   ONCOGENE

A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma

(2016) Daniel W. Bowles et al.   ORAL ONCOLOGY

Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways

(2016) Yi Cheng et al.   PLoS One

DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway

(2016) Rajeev Singh et al.   Oncotarget

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint

(2016) Laura Di Magno et al.   Oncotarget

DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance

(2016) Wolfgang Gruber et al.   Oncotarget

Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer

(2016) Keisuke Yamamoto et al.   Oncotarget

Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors

(2015) Zhaohui Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Active IKK  promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma

(2015) N. K. Agarwal et al.   BLOOD

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

(2015) Hayley J. Sharpe et al.   CANCER CELL

ErbB2 signaling activates the Hedgehog pathway via PI3K–Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts

(2015) Maxim Kebenko et al.   CELLULAR SIGNALLING

Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth

(2015) Davide D’Amico et al.   DEVELOPMENTAL CELL

p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9

(2015) Joon Won Yoon et al.   DNA REPAIR

MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor

(2015) Lucile Hoch et al.   FASEB JOURNAL

SOX9 inhibits  -TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties

(2015) W. Deng et al.   JOURNAL OF CELL SCIENCE

Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction

(2015) Yuhong Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitogen-activated protein kinases and Hedgehog-GLI signaling in cancer: A crosstalk providing therapeutic opportunities?

(2015) Elisabetta Rovida et al.   SEMINARS IN CANCER BIOLOGY

Mechanisms Regulating Protein Localization

(2015) Nicholas C. Bauer et al.   TRAFFIC

Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002

(2015) Weiya Wang et al.   OncoTargets and Therapy

Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

(2015) Philipp Schneider et al.   Nature Communications

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

(2015) Narinder Sharma et al.   Oncotarget

AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma

(2015) Yen-Hsing Li et al.   Cell Reports

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer

(2015) Bingchen Han et al.   Cell Reports

Treatment with PF-04449913, an oral smoothened antagonist, in patients with myeloid malignancies: a phase 1 safety and pharmacokinetics study

(2015) Giovanni Martinelli et al.   Lancet Haematology

Hedgehog Signaling in the Maintenance of Cancer Stem Cells

(2015) Catherine Cochrane et al.   Cancers

Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance

(2015) Komaraiah Palle et al.   Cancers

Histone Deacetylase 6 Represents a Novel Drug Target in the Oncogenic Hedgehog Signaling Pathway

(2015) P. K. Dhanyamraju et al.   MOLECULAR CANCER THERAPEUTICS

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer

(2015) Tapati Mazumdar et al.   Oncotarget

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma

(2015) Pritha Paul et al.   Oncotarget

miR-326 Is Downstream of Sonic Hedgehog Signaling and Regulates the Expression of Gli2 and Smoothened

(2014) Zhihua Jiang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling

(2014) Yumei Diao et al.   BMC CANCER

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

(2014) Verline Justilien et al.   CANCER CELL

Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer

(2014) Jillian Brechbiel et al.   CANCER TREATMENT REVIEWS

A Phase I Study of PF-04449913, an Oral Hedgehog Inhibitor, in Patients with Advanced Solid Tumors

(2014) A. J. Wagner et al.   CLINICAL CANCER RESEARCH

A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors

(2014) J. Rodon et al.   CLINICAL CANCER RESEARCH

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

(2014) P. Infante et al.   EMBO JOURNAL

The BET Bromodomain Inhibitor I-BET151 Acts Downstream of Smoothened Protein to Abrogate the Growth of Hedgehog Protein-driven Cancers

(2014) Jun Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner

(2014) Monica D. Nye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma

(2014) Sabrina Pricl et al.   Molecular Oncology

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

(2014) Yujie Tang et al.   NATURE MEDICINE

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis

(2014) E Pantazi et al.   Cell Death & Disease

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

(2014) Pawel Niewiadomski et al.   Cell Reports

Histone Acetyltransferase PCAF Is Required for Hedgehog-Gli-Dependent Transcription and Cancer Cell Proliferation

(2013) M. Malatesta et al.   CANCER RESEARCH

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

(2013) D Mazzà et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs

(2013) Aamir Ahmad et al.   Journal of Hematology & Oncology

Menin Directly Represses Gli1 Expression Independent of Canonical Hedgehog Signaling

(2013) Buddha Gurung et al.   MOLECULAR CANCER RESEARCH

Noncanonical Regulation of the Hedgehog Mediator GLI1 by c-MYC in Burkitt Lymphoma

(2013) Joon Won Yoon et al.   MOLECULAR CANCER RESEARCH

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

(2013) Scott X. Atwood et al.   NATURE

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

(2013) Mariella Gruber Filbin et al.   NATURE MEDICINE

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells

(2013) GUODONG ZHU et al.   ONCOLOGY REPORTS

Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy

(2013) Sonia Coni et al.   PLoS One

Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1

(2013) Frank Götschel et al.   PLoS One

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes

(2012) Hironori Iwasaki et al.   CANCER SCIENCE

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

(2012) Markus Eberl et al.   EMBO Molecular Medicine

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning

(2012) K. A. Peterson et al.   GENES & DEVELOPMENT

Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures

(2012) Sandrine Eimer et al.   NEURO-ONCOLOGY

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function

(2012) S Pandolfi et al.   ONCOGENE

MEK1–RSK2 contributes to hedgehog signaling by stabilizing GLI2 transcription factor and inhibiting ubiquitination

(2012) Z Liu et al.   ONCOGENE

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer

(2011) A. D. Steg et al.   CLINICAL CANCER RESEARCH

GLI2 Transcription Factor Mediates Cytokine Cross-talk in the Tumor Microenvironment

(2011) Sherine F. Elsawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

(2011) Marina Grachtchouk et al.   JOURNAL OF CLINICAL INVESTIGATION

Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer

(2011) D. Gioeli et al.   MOLECULAR CANCER THERAPEUTICS

WIP1 Enhances Tumor Formation in a Sonic Hedgehog–Dependent Model of Medulloblastoma

(2011) Tiffany A. Doucette et al.   NEUROSURGERY

Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells

(2011) X Cao et al.   ONCOGENE

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

(2011) Yongbin Chen et al.   PLOS BIOLOGY

Hedgehog beyond medulloblastoma and basal cell carcinoma

(2010) Stephan Teglund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Non-consensus GLI binding sites in Hedgehog target gene regulation

(2010) Martina Winklmayr et al.   BMC MOLECULAR BIOLOGY

TGF-  Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

(2010) R. W. Johnson et al.   CANCER RESEARCH

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

(2010) Gerrit J. P. Dijkgraaf et al.   CANCER RESEARCH

Requirement of TGFβ Signaling for SMO-mediated Carcinogenesis

(2010) Qipeng Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

(2010) Elspeth M. Beauchamp et al.   JOURNAL OF CLINICAL INVESTIGATION

GLI2-Mediated Melanoma Invasion and Metastasis

(2010) Vasileia-Ismini Alexaki et al.   JNCI-Journal of the National Cancer Institute

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

(2010) Zainab Jagani et al.   NATURE MEDICINE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS

(2010) Matthias Lauth et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

(2010) L Di Marcotullio et al.   ONCOGENE

Heterozygosity for Pten Promotes Tumorigenesis in a Mouse Model of Medulloblastoma

(2010) Robert C. Castellino et al.   PLoS One

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

(2010) Monique T. Barakat et al.   TRENDS IN MOLECULAR MEDICINE

Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors

(2010) Thomas C. Whisenant et al.   PLoS Computational Biology

Review: Targeting the Hedgehog pathway in cancer

(2010) Sachin Gupta et al.   Therapeutic Advances in Medical Oncology

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway

(2009) Harald Schnidar et al.   CANCER RESEARCH

Sonic Hedgehog Signaling Pathway Is Activated in ALK-Positive Anaplastic Large Cell Lymphoma

(2009) R. R. Singh et al.   CANCER RESEARCH

A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion

(2009) H.-W. Lo et al.   CANCER RESEARCH

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

The multiple functions of Numb

(2009) Alberto Gulino et al.   EXPERIMENTAL CELL RESEARCH

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Identification of a Suppressive Mechanism for Hedgehog Signaling through a Novel Interaction of Gli with 14-3-3

(2009) Yoshinari Asaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cloning of the HumanGLI2Promoter

(2009) Sylviane Dennler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein

(2009) Elspeth Beauchamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines

(2009) Shinji Mizuarai et al.   Molecular Cancer

Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer

(2009) Motoko Seto et al.   MOLECULAR CARCINOGENESIS

GLI1 Is a Central Mediator of EWS/FLI1 Signaling in Ewing Tumors

(2009) Jay Joo et al.   PLoS One

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

(2009) J. M. Hyman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling

(2008) Markku Varjosalo et al.   CELL

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

(2008) Elisabetta Ferretti et al.   EMBO JOURNAL

Identification of the gene transcription repressor domain of Gli3

(2008) Robert Tsanev et al.   FEBS LETTERS

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Protein Kinase Cδ Negatively Regulates Hedgehog Signaling by Inhibition of Gli1 Activity

(2008) Qingsong Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Human Glioma-associated Oncogene 1 (GLI1) Splice Variants Reveal Distinct Mechanisms in the Terminal Transduction of the Hedgehog Signal

(2008) Takashi Shimokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Arrestin-Mediated Localization of Smoothened to the Primary Cilium

(2008) J. J. Kovacs et al.   SCIENCE