Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

Foxm1 controls a pro-stemness microRNA network in neural stem cells

(2018) Zein Mersini Besharat et al.   Scientific Reports

The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells

(2017) Evelina Miele et al.   Oncotarget

The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity

(2017) Pietro Laneve et al.   Oncotarget

Numb is involved in the non-random segregation of subcellular vesicles in colorectal cancer stem cells

(2016) Wei-Lun Hwang et al.   CELL CYCLE

Hepatitis B e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 activity

(2016) Dan Liu et al.   HEPATOLOGY

Regulation of Numb isoform expression by activated ERK signaling

(2016) D Rajendran et al.   ONCOGENE

Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma

(2015) Yinying Lu et al.   HEPATOLOGY

Numb downregulation suppresses cell growth and is associated with a poor prognosis of human hepatocellular carcinoma

(2015) CHENGZHI XIE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genetic and molecular alterations across medulloblastoma subgroups

(2015) Patryk Skowron et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Proteomic analysis of human sonic hedgehog (SHH) medulloblastoma stem-like cells

(2015) Maurizio Ronci et al.   Molecular BioSystems

Role of Numb expression and nuclear translocation in endometrial cancer

(2015) CHAO WANG et al.   Oncology Letters

The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma

(2015) Junmou Hong et al.   Oncotarget

microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1

(2013) Neha Garg et al.   EMBO JOURNAL

Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development

(2013) Kee K. Kim et al.   JOURNAL OF CELL BIOLOGY

Overexpression of Numb suppresses tumor cell growth and enhances sensitivity to cisplatin in epithelioid malignant pleural mesothelioma

(2013) YANMENG KANG et al.   ONCOLOGY REPORTS

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

(2012) Marcel Kool et al.   ACTA NEUROPATHOLOGICA

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

(2012) Paul A. Northcott et al.   NATURE

Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase Activity

(2012) Xiuli Jiang et al.   STEM CELLS

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

Global Profiling and Molecular Characterization of Alternative Splicing Events Misregulated in Lung Cancer

(2010) C. M. Misquitta-Ali et al.   MOLECULAR AND CELLULAR BIOLOGY

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

(2010) L Di Marcotullio et al.   ONCOGENE

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

(2009) Angelo Cicalese et al.   CELL

Hedgehog signalling in colon cancer and stem cells

(2009) Alberto Gulino et al.   EMBO Molecular Medicine

The multiple functions of Numb

(2009) Alberto Gulino et al.   EXPERIMENTAL CELL RESEARCH

Cerebellum of the Premature Infant: Rapidly Developing, Vulnerable, Clinically Important

(2009) Joseph J. Volpe   JOURNAL OF CHILD NEUROLOGY

Symmetric Division and Expression of Its Regulatory Gene Numb in Human Cervical Squamous Carcinoma Cells

(2009) Huaizeng Chen et al.   PATHOBIOLOGY

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

(2009) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: Analysis in mouse embryonic fibroblasts

(2008) Polloneal Jymmiel R. Ocbina et al.   DEVELOPMENTAL DYNAMICS

Cytotoxic effects of a novel pyrazolopyrimidine derivative entrapped in liposomes in anaplastic thyroid cancer cells in vitro and in xenograft tumors in vivo

(2008) M Celano et al.   ENDOCRINE-RELATED CANCER

Medulloblastoma Stem Cells

(2008) Xing Fan et al.   JOURNAL OF CLINICAL ONCOLOGY

Characterization of Numb expression in astrocytomas

(2008) Benedict Yan et al.   NEUROPATHOLOGY