标题
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
作者
关键词
-
出版物
NATURE MEDICINE
Volume 19, Issue 11, Pages 1410-1422
出版商
Springer Nature
发表日期
2013-11-08
DOI
10.1038/nm.3389
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
- (2013) James Kim et al. CANCER CELL
- Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
- (2013) A. Jimeno et al. CLINICAL CANCER RESEARCH
- Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation
- (2013) Lisa D. Mills et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
- (2013) Scott X. Atwood et al. NATURE
- Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling
- (2013) Elissaveta Petrova et al. Nature Chemical Biology
- Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations
- (2013) Priscilla K Brastianos et al. NATURE GENETICS
- Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer
- (2013) E. S. Antonarakis et al. ONCOLOGIST
- Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO
- (2013) V. E. Clark et al. SCIENCE
- Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation
- (2012) Yu Wang et al. ACS Chemical Biology
- Loss of SUFU Function in Familial Multiple Meningioma
- (2012) Mervi Aavikko et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Initial Assessment of Tumor Regrowth After Vismodegib in Advanced Basal Cell Carcinoma
- (2012) Anne Lynn S. Chang et al. ARCHIVES OF DERMATOLOGY
- Developmental signaling pathways in cancer stem cells of solid tumors
- (2012) Christina Karamboulas et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma
- (2012) S. Blotta et al. BLOOD
- Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells
- (2012) Josep Domingo-Domenech et al. CANCER CELL
- The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
- (2012) Yan Wang et al. CANCER CELL
- Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
- (2012) Jeffrey A. Magee et al. CANCER CELL
- Abstract 4818: The predictive value of a 5-gene signature as a patient pre-selection tool in medulloblastoma for Hedgehog pathway inhibitor therapy
- (2012) Dereck Amakye et al. CANCER RESEARCH
- Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
- (2012) B. Ramaswamy et al. CANCER RESEARCH
- Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity
- (2012) Yu Wang et al. CHEMISTRY & BIOLOGY
- Vismodegib
- (2012) C. M. Rudin CLINICAL CANCER RESEARCH
- A Phase II, Randomized, Placebo-Controlled Study of Vismodegib as Maintenance Therapy in Patients with Ovarian Cancer in Second or Third Complete Remission
- (2012) S. B. Kaye et al. CLINICAL CANCER RESEARCH
- A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer
- (2012) J. Berlin et al. CLINICAL CANCER RESEARCH
- Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling
- (2012) N. B. Hassounah et al. CLINICAL CANCER RESEARCH
- Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition
- (2012) Qing Chang et al. INTERNATIONAL JOURNAL OF CANCER
- Hedgehog pathway inhibition and the race against tumor evolution
- (2012) Scott X. Atwood et al. JOURNAL OF CELL BIOLOGY
- High Frequency of Germline SUFU Mutations in Children With Desmoplastic/Nodular Medulloblastoma Younger Than 3 Years of Age
- (2012) Laurence Brugières et al. JOURNAL OF CLINICAL ONCOLOGY
- Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
- (2012) Trevor J. Pugh et al. NATURE
- Dissecting the genomic complexity underlying medulloblastoma
- (2012) David T. W. Jones et al. NATURE
- Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures
- (2012) Sandrine Eimer et al. NEURO-ONCOLOGY
- Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome
- (2012) Jean Y. Tang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
- (2012) Aleksandar Sekulic et al. NEW ENGLAND JOURNAL OF MEDICINE
- Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis
- (2012) V. M. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
- (2012) M. Rajurkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small Molecule Antagonists in Distinct Binding Modes Inhibit Drug-Resistant Mutant of Smoothened
- (2011) Haiyan Tao et al. CHEMISTRY & BIOLOGY
- Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Cooperative Hedgehog-EGFR signaling
- (2011) Doris Mangelberger Frontiers in Bioscience-Landmark
- In vitro and in vivo characterization of a novel hedgehog signaling antagonist in human glioblastoma cell lines
- (2011) Pietro Ferruzzi et al. INTERNATIONAL JOURNAL OF CANCER
- Should All Women With Breast Cancer Be Tested forBRCAMutations at the Time of Diagnosis?
- (2011) Steven A. Narod JOURNAL OF CLINICAL ONCOLOGY
- A crucial requirement for Hedgehog signaling in small cell lung cancer
- (2011) Kwon-Sik Park et al. NATURE MEDICINE
- The cancer stem cell: premises, promises and challenges
- (2011) Hans Clevers NATURE MEDICINE
- Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
- (2010) James Kim et al. CANCER CELL
- Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
- (2010) Gerrit J. P. Dijkgraaf et al. CANCER RESEARCH
- Hedgehog pathway activation in chronic myeloid leukemia: A promise for a novel combination therapeutic approach?
- (2010) Zainab Jagani et al. CELL CYCLE
- Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
- (2010) Stefan Peukert et al. ChemMedChem
- Targeting Hedgehog -- a Cancer Stem Cell Pathway
- (2010) A. A. Merchant et al. CLINICAL CANCER RESEARCH
- Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma
- (2010) Ingrid Slade et al. Familial Cancer
- Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site
- (2010) Henry R. Maun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
- (2010) Elspeth M. Beauchamp et al. JOURNAL OF CLINICAL INVESTIGATION
- Small Tumors, Intermediate Models, Big Hopes
- (2010) Lillian L. Siu JOURNAL OF CLINICAL ONCOLOGY
- Unusual Case of Extrapulmonary Metastatic Recurrence in a Patient With Osteosarcoma
- (2010) Vivek S. Radhakrishnan et al. JOURNAL OF CLINICAL ONCOLOGY
- Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway
- (2010) Zainab Jagani et al. NATURE MEDICINE
- Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
- (2010) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Genetic Landscape of the Childhood Cancer Medulloblastoma
- (2010) D. W. Parsons et al. SCIENCE
- Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
- (2010) S. Buonamici et al. Science Translational Medicine
- Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway
- (2009) Harald Schnidar et al. CANCER RESEARCH
- Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
- (2009) Frédéric Varnat et al. EMBO Molecular Medicine
- GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
- (2009) O. Nolan-Stevaux et al. GENES & DEVELOPMENT
- PTCH1 and SMO Gene Alterations in Keratocystic Odontogenic Tumors
- (2009) L.-S. Sun et al. JOURNAL OF DENTAL RESEARCH
- Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
- (2009) Chen Zhao et al. NATURE
- A small molecule that binds Hedgehog and blocks its signaling in human cells
- (2009) Benjamin Z Stanton et al. Nature Chemical Biology
- Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
- (2009) Charles M. Rudin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium
- (2009) Christopher W. Wilson et al. PLoS One
- Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
- (2009) J. M. Hyman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
- (2009) H. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
- (2009) Yu Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
- (2009) R. L. Yauch et al. SCIENCE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure
- (2008) Hiromichi Kimura et al. CANCER CELL
- Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation
- (2008) Christine Dierks et al. CANCER CELL
- Hedgehog: functions and mechanisms
- (2008) M. Varjosalo et al. GENES & DEVELOPMENT
- An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
- (2008) G. Feldmann et al. MOLECULAR CANCER THERAPEUTICS
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
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