Article
Psychology, Multidisciplinary
Stefanie H. Meeuwis, Henriet van Middendorp, Dieuwke S. Veldhuijzen, Andrea W. M. Evers
Summary: Placebo and nocebo effects are mediated by expectation in an open-label context, but not in a closed-label context. Ignorance of bodily signals may moderate the direct effects of nocebo suggestions, and behavioral activation system may modulate the effects of suggestions on itch through expectation. Other interindividual differences showed limited impact on placebo and nocebo responding in itch.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Caroline Schlueter, Christoph Fraenz, Patrick Friedrich, Onur Guentuerkuen, Erhan Genc
Summary: This study utilized NODDI to investigate the association between the microstructural architecture of the amygdala and neuroticism. The findings revealed that lower neurite density in the lateral amygdala nucleus was significantly associated with higher scores in depression, one facet of neuroticism. This suggests that changes in the microstructure of the amygdala could impair its filtering function and potentially lead to neuroticism-related disorders.
HUMAN BRAIN MAPPING
(2022)
Article
Biology
Celia Soussi, Sylvie Berthoz, Valentine Chirokoff, Sandra Chanraud
Summary: To adapt to a new environment, individuals must choose between previously successful strategies and new strategies, and this trade-off is related to intrinsic brain connectivity and psychological factors.
Article
Psychology, Social
Emorie D. Beck, David Condon, Josh Jackson
Summary: Most investigations on the structure of personality traits neglect the age factor and assume a consistent structure across the lifespan. This study examined age differences in divergence and convergence, the similarity between the Big Five and network structures, and the consistency of network structure across age groups. The results suggest that older adults have a different structure of personality than younger adults.
EUROPEAN JOURNAL OF PERSONALITY
(2023)
Article
Multidisciplinary Sciences
Sepehr Saeedpour, Mostafa Minadari Hossein, Ophelia Deroy, Bahador Bahrami
Summary: This study successfully replicated previous laboratory-based results using an open-source web model, demonstrating the interindividual consistency of Pavlovian influence over a two-week period. However, the correlations observed were slightly lower than the standards employed in psychometrics and self-reported measures.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Food Science & Technology
Ivonne M. C. M. Rietjens, Takayuki Tanaka, Yoko Masuzawa, Hidehiro Nakamura, Yuko Ishizaka, Keng Ngee Teoh
Summary: The study investigates human variability in glutamate plasma and brain levels to define a chemical-specific adjustment factor, resulting in a more accurate health-based guidance value for glutamates.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jia-Chen Liu, Sheng-Hua Liu, Guang Fu, Xiao-Rui Qiu, Run-Dong Jiang, Sheng-Yuan Huang, Yong-Li Zhu, Wei-Zheng Li
Summary: This research identified that CD8 + T cells and NK cells were significantly lower in obese individuals, and 11 drugs/compounds were considered to possess obesity-control potential. Furthermore, the expression of drug targets in obese patients were higher than those in controls, suggesting immune cells as potential therapeutic targets for obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Alex M. Mawla, Talitha van der Meulen, Mark O. Huising
Summary: Using ATAC-Seq, the chromatin landscape of mouse alpha, beta, and delta cells were compared, revealing that alpha and delta cells are poised, but repressed, from becoming beta cells. Differential chromatin accessibility also showed preferentially enriched distal-intergenic regions in beta cells compared to alpha or delta cells.
Article
Sport Sciences
Richard S. Metcalfe, Brendon J. Gurd, Niels B. J. Vollaard
Summary: Previous studies have shown wide variance in changes in insulin sensitivity following exercise training, but they often neglect to account for measurement errors. This study used individual response standard deviation (SDIR) to investigate interindividual variability in insulin sensitivity outcomes after low-volume sprint interval training (SID). The results indicate meaningful individual responses to SIT, but there is uncertainty about the true interindividual differences.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Adela Madrid-Paredes, Javier Martin, Ana Marquez
Summary: This review provides an updated overview of the potential role of -omic approaches in predicting the clinical efficacy of therapies used in Rheumatoid Arthritis (RA). Although significant efforts have been made, there are currently no validated biomarkers of drug response in RA. -Omic studies have shown significant differences in molecular profiles associated with treatment response for different drugs and cell types. Further research analyzing the response to the complete therapeutical arsenal used in RA, including less studied therapies like sarilumab and JAK inhibitors, is greatly needed.
Article
Oncology
John Gallon, Erick Loomis, Edward Curry, Nicholas Martin, Leigh Brody, Ian Garner, Robert Brown, James M. Flanagan
Summary: The genomic distribution of accessible chromatin sites is altered in cisplatin-resistant ovarian cell lines from high grade serous ovarian cancer patients, with changes at intergenic regions associated with gene expression and resistance mechanisms. The distribution of platinum adducts correlates with chromatin changes and distinguishes between sensitive and resistant cell lines, with fewer adducts around gene promoters and more at intergenic regions in resistant cells. These findings highlight the role of chromatin changes in gene regulation in the development of drug resistance in ovarian cancer.
CLINICAL EPIGENETICS
(2021)
Article
Clinical Neurology
Olga Galli, Christopher W. Jones, Olivia Larson, Mathias Basner, David F. Dinges
Summary: The neurobehavioral response to sleep loss varies between individuals and is not well understood. This study examined the impact of various factors on the response to chronic partial sleep restriction and found that personality, intelligence, chronotype, sleepiness, and demographic factors did not significantly affect neurobehavioral vulnerability. Only superior baseline performance and ability to sustain wakefulness were associated with resilience to decrements in vigilant attention. Differences in vulnerability to sleep loss were not explained by prior sleep history or homeostatic sleep response. Further research is needed to explore the influence of internal and external demands on sleep-wake modulation.
Article
Oncology
Norikazu Masuda, Kenji Tamura, Hiroyuki Yasojima, Akihiko Shimomura, Masataka Sawaki, Min-Jung Lee, Akira Yuno, Jane Trepel, Ryoko Kimura, Yozo Nishimura, Shigehira Saji, Hiroji Iwata
Summary: This study examined the safety, efficacy, and pharmacokinetics of Entinostat monotherapy and combined Entinostat/exemestane in Japanese patients with endocrine therapy-resistant breast cancer. The results showed that both treatments were well tolerated, with some patients achieving stable disease for more than 6 months. Further investigation on the correlation between pharmacokinetics and Ac-K in peripheral blood CD19+ B cells, as well as T-cell activation markers, is warranted.
Article
Endocrinology & Metabolism
Zuzana Jackova, Jan J. Stepan, Stepan Coufal, Martin Kostovcik, Natalie Galanova, Zuzana Reiss, Karel Pavelka, Laszlo Wenchich, Hana Hruskova, Miloslav Kverka
Summary: Ovarian hormone deficiency increases the risk of osteoporosis and bone fractures in women, but this study found no specific gut microbiota signature associated with hormone levels. Hormonal therapy after oophorectomy prevented bone loss but had only marginal effects on gut microbiota composition.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Caoileann H. Murphy, Claire Connolly, Ellen M. Flanagan, Kathleen A. J. Mitchelson, Elena de Marco Castro, Brendan Egan, Lorraine Brennan, Helen M. Roche
Summary: The study found minimal interindividual variability in changes in appendicular lean mass, muscle function, and triglycerides in response to LEU-PRO and LEU-PRO+n-3 supplementation in older adults at risk of sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Psychiatry
Filip Milosavljevic, Nikola Bukvic, Zorana Pavlovic, Cedo Miljevic, Vesna Pesic, Espen Molden, Magnus Ingelman-Sundberg, Stefan Leucht, Marin M. Jukic
Summary: This study quantified the differences in exposure to various psychiatric drugs among patients with genetically associated CYP2C19 and CYP2D6 poor, intermediate, and normal metabolism, providing a scientific foundation for genotype-based dosing recommendations that could improve clinical outcomes for patients with psychiatric disorders.
Review
Pharmacology & Pharmacy
Magnus Ingelman-Sundberg, Volker M. Lauschke
Summary: Drug development is a challenging and failure-prone process, with liver toxicity being a major cause of safety failures. The current preclinical systems for compound selection are inadequate, necessitating the development of new strategies to increase clinical success rates. Human liver spheroids are becoming increasingly utilized for various analyses and drug development, showing promise as a new standard in translational pharmacology and toxicology.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hasan Cagin Lenk, Katharina Kloditz, Inger Johansson, Robert Lovsletten Smith, Marin Jukic, Espen Molden, Magnus Ingelman-Sundberg
Summary: This translational study evaluated the role of NFIB genetic polymorphism in the interindividual variability of the polymorphic CYP2D6 enzyme activity. The results showed that NFIB regulates CYP2D6 gene expression and its polymorphism can predict the rate of CYP2D6 dependent drug metabolism in vivo.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Editorial Material
Pharmacology & Pharmacy
Magnus Ingelman-Sundberg
Summary: Genetic variation in polymorphic genes plays a crucial role in influencing the pharmacokinetics and pharmacodynamics of different drugs through various mechanisms, contributing to the observed phenotypic variability.
Article
Cell Biology
Chris S. Pridgeon, Dian P. Bolhuis, Filip Milosavljevic, Marina Manojlovic, Akos Vegvari, Massimiliano Gaetani, Marin M. Jukic, Magnus Ingelman-Sundberg
Summary: 3D liver spheroids provide a suitable model for studying chronic drug-induced liver toxicity and have revealed a novel drug-induced stress response. The formation of long slender filaments, known as thorns, may indicate hepatocyte metaplasia in response to toxicity, and alterations in ECM-derived protein expression could serve as biomarkers for liver disease and chronic drug-induced hepatotoxicity.
Article
Pharmacology & Pharmacy
Chris S. Pridgeon, Inger Johansson, Magnus Ingelman-Sundberg
Summary: This study validated the use of liquid biopsy-based quantification of cfRNA in plasma exosomes as a proxy measurement for predicting hepatic CYP gene expression and drug metabolism rate, but the correlations were too weak to be a reliable substitute for therapeutic drug monitoring (TDM).
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Genetics & Heredity
Sigrid Haeggstrom, Magnus Ingelman-Sundberg, Svante Paabo, Hugo Zeberg
Summary: Genetic variation in genes encoding cytochrome P450 enzymes affects the metabolism of drugs and endogenous compounds. The locus on chromosome 10 containing the cytochrome genes CYP2C8 and CYP2C9 shows linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, resulting in a haplotype associated with altered drug metabolism. We demonstrate that this haplotype is inherited from Neanderthals and plays a significant role in the metabolism of warfarin and phenytoin.
PHARMACOGENOMICS JOURNAL
(2022)
Letter
Pharmacology & Pharmacy
Chris S. Pridgeon, Inger Johansson, Magnus Ingelman-Sundberg
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Hasan Cagin Lenk, Robert Lovsletten Smith, Kevin S. O'Connell, Marin M. Jukic, Marianne Kristiansen Kringen, Ole A. Andreassen, Magnus Ingelman-Sundberg, Espen Molden
Summary: This study found that genetic variants in CYP1A and NFIB have a significant impact on the dose requirements and clinical response of clozapine, especially in smokers. Smokers carrying these genetic variants may require higher doses to achieve therapeutic effects.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Marin Jukic, Filip Milosavljevi, Espen Molden, Magnus Ingelman-Sundberg
Summary: Pharmacogenomic psychiatry, a well-developed research field in oncology, is expanding in psychiatry. Recent large studies have shown that preemptive genotyping can bring true benefits and cost-effectiveness to psychotherapy. However, there is still a lack of knowledge on many other heritable genetic factors that play a crucial role in explaining interindividual differences in response to psychiatric drugs. Therefore, more effort should be put into further developing pharmacogenomic psychiatry for broader clinical implementation.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Sara Redensek Trampuz, Sander van Riet, Asa Nordling, Magnus Ingelman-Sundberg
Summary: Connective tissue growth factor (CTGF) plays a role in regulating extracellular matrix (ECM) production and is elevated in liver fibrosis patients. In a 3D liver co-culture spheroid model, treatment with TGF-beta 1 or free fatty acids (FFA) increased the deposition of COL1A1 and expression of CTGF. Recombinant CTGF and angiotensin II also induced the expression of CTGF, TGF-beta 1, COL1A1, LOX, and IL-6. Silencing CTGF reduced COL1A1 deposition induced by both TGF-beta 1 and FFA. IL-6 was found to induce CTGF, COL1A1, and TGF-beta 1 production, suggesting its involvement in the CTGF-induced fibrosis pathway.
Article
Pharmacology & Pharmacy
Birgit M. Wollmann, Robert L. Smith, Marianne Kristiansen Kringen, Magnus Ingelman-Sundberg, Espen Molden, Elisabet Storset
Summary: This study aimed to investigate the correlation between solanidine metabolism and CYP2D6-mediated metabolism of risperidone in patients with known CYP2D6 genotypes. The results showed strong positive correlations between solanidine metabolism and CYP2D6-mediated risperidone metabolism.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Katharina Kloditz, Eida Tewolde, Asa Nordling, Magnus Ingelman-Sundberg
Summary: During systemic inflammation, pro-inflammatory cytokines have significant effects on the expression of genes encoding drug metabolizing enzymes. A 3D liver spheroid model was used to study these effects and found that certain cytokines decrease the expression of CYP3A4 and UGT2B10, while increasing the expression of CYP2E1 and UGT1A3. Inhibitors of JAK1/2 were able to inhibit these cytokine-induced changes. These findings suggest that the 3D spheroid system is a versatile tool for studying drug metabolism under inflammatory conditions.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Erkka Jarvinen, Helen S. Hammer, Oliver Poetz, Magnus Ingelman-Sundberg, Tore Bjerregaard Stage
Summary: The study assessed the usage of 3D spheroid primary human hepatocytes (PHHs) for studying the induction of important cytochrome P450 enzymes and drug transporters. The results showed that the 3D spheroid PHHs model can effectively investigate the mRNA and protein induction of hepatic drug-metabolizing enzymes and transporters, providing a solid basis for clinically relevant research.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Pharmacology & Pharmacy
Magnus Ingelman-Sundberg, Marin Jukic, Line Skute Braten, Marianne Kristiansen Kringen, Espen Molden
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
