Article
Immunology
Chen Xi Yang, Emma Schon, Ma'en Obeidat, Michael S. Kobor, Lisa McEwen, Julie MacIsaac, David Lin, Richard M. Novak, Fleur Hudson, Hartwig Klinker, Nila Dharan, Steve Horvath, Jean Bourbeau, Wan Tan, Don D. Sin, S. F. Paul Man, Ken Kunisaki, Janice M. Leung
Summary: This study found evidence of advanced methylation aging in persons living with HIV (PLWH) before the initiation of antiretroviral therapy (ART) and with preserved immune status. Compared to HIV-negative controls, PLWH had significantly higher methylation age, with black race, low CD4 and high CD8 T-cell counts, and duration of HIV being risk factors for age acceleration.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Virginia Veronica Visconti, Ida Cariati, Simona Fittipaldi, Riccardo Iundusi, Elena Gasbarra, Umberto Tarantino, Annalisa Botta
Summary: DNA methylation is a crucial epigenetic mechanism in regulating gene expression, and plays an important role in aging-bone diseases such as osteoporosis and osteoarthritis. Recent studies have shown new discoveries on the involvement of DNA methylation in the pathogenesis of these diseases, highlighting the significance of investigating the specific tissues associated with them.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Oluwagbenga Dada, Christopher Adanty, Nasia Dai, Richie Jeremian, Sauliha Alli, Philip Gerretsen, Ariel Graff, John Strauss, Vincenzo De Luca
Summary: The study found evidence of epigenetic age acceleration associated with psychosis severity in individuals with schizophrenia, using two different algorithms for DNAm age analysis.
PSYCHIATRY RESEARCH
(2021)
Review
Medicine, General & Internal
Adam Li, Zane Koch, Trey Ideker
Summary: Numerous studies have shown that epigenetic age is associated with various factors and can be computed based on DNA methylation patterns. The focus of research needs to shift from accurate age prediction to understanding the links between the epigenome and aging mechanisms. Current research areas include epigenetic clocks and investigation of the epigenome to build a mechanistic theory of aging and inform clinical practice.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Sambit Roy, Niharika Sinha, Binbin Huang, Holly Cline-Fedewa, Norbert Gleicher, Jianrong Wang, Aritro Sen
Summary: In females, the expression of particular genes is regulated through epigenetic modifications, and one of these modifications, called H3K27me3, is involved in gene repression. The enzyme JMJD3 can remove the H3K27me3 modification and promote gene expression. This study shows that JMJD3 specifically expressed in ovarian granulosa cells (GCs) is necessary for maintaining normal fertility in females. The deletion of JMJD3 in GCs leads to decreased healthy follicles, disrupted estrous cycle, and subfertility. Furthermore, JMJD3 is important for mitochondrial function, and its reduction results in decreased mitochondrial DNA content in GCs. The expression of JMJD3 also decreases with age in mice and humans. Overall, this study highlights the critical role of JMJD3 in maintaining normal ovarian function and female fertility, and suggests a potential involvement of JMJD3 in female reproductive aging.
Article
Immunology
Krisann K. Oursler, Vincent C. Marconi, Zeyuan Wang, Ke Xu, Monty Montano, Kaku So-Armah, Amy C. Justice, Yan Sun
Summary: The associations between epigenetic age acceleration markers and physiologic frailty and mortality in people with HIV provide insight into accelerated aging and support the development of interventions for preventing and treating age-related diseases in this population.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Ziyu Zhang, Baoyu Chen, Yuwen Zhu, Tianyi Zhang, Yibiao Yuan, Xiaoling Zhang, Yong Xu
Summary: TGF-beta regulates the transcription of the prometastatic small GTPase RHOJ by activating MKL1 and recruiting the H3K9/H3K27 dual demethylase KDM7A. KDM7A can be used to predict prognosis in breast cancer patients and its knockdown attenuates migration, invasion, growth, and metastasis of breast cancer cells. KDM7A is a direct transcriptional target of TGF-beta signaling, and small-molecule inhibitors of KDM7A may provide therapeutic solutions for malignant breast cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Geriatrics & Gerontology
Fedor Galkin, Polina Mamoshina, Kirill Kochetov, Denis Sidorenko, Alex Zhavoronkov
Summary: DNA methylation aging clocks have become an invaluable tool in biogerontology research, with deep learning showing promise as an accurate method for predicting age. The newly presented DeepMAge clock demonstrates biological relevance by assigning higher predicted age to individuals with certain health-related conditions.
Article
Psychology, Clinical
Anthony S. Zannas, Sarah D. Linnstaedt, Xinming An, Jennifer S. Stevens, Nathaniel G. Harnett, Alyssa R. Roeckner, Katelyn I. Oliver, David R. Rubinow, Elisabeth B. Binder, Karestan C. Koenen, Kerry J. Ressler, Samuel A. McLean
Summary: Psychological trauma exposure and PTSD are associated with advanced epigenetic age. This study found that epigenetic age measured at the time of trauma may predict the subsequent development of PTSD. The neural substrates underlying posttraumatic outcomes associated with epigenetic aging are unclear.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biology
Daniel W. Belsky, Avshalom Caspi, David L. Corcoran, Karen Sugden, Richie Poulton, Louise Arseneault, Andrea Baccarelli, Kartik Chamarti, Xu Gao, Eilis Hannon, Hona Lee Harrington, Renate Houts, Meeraj Kothari, Dayoon Kwon, Jonathan Mill, Joel Schwartz, Pantel Vokonas, Cuicui Wang, Benjamin S. Williams, Terrie E. Moffitt
Summary: This study reports a novel blood biomarker of aging called DunedinPACE, which was validated in five datasets. Results showed that DunedinPACE is associated with morbidity, disability, and mortality, and provides incremental prediction beyond the GrimAge clock. This finding is significant for gerontology and geroscience research.
Review
Cell Biology
Annamaria la Torre, Filomena Lo Vecchio, Antonio Greco
Summary: Aging is characterized by a progressive decline in tissue and organ function, marked by molecular changes at the DNA and protein level. These changes contribute to the development of various human pathologies and increase mortality risk. Understanding the hallmarks of aging, particularly epigenetic modifications, can potentially lead to therapeutic approaches for age-related decline and disease.
Article
Cell Biology
Quentin Alle, Enora Le Borgne, Paul Bensadoun, Camille Lemey, Nelly Bechir, Melissa Gabanou, Fanny Estermann, Christelle Bertrand-Gaday, Laurence Pessemesse, Karine Toupet, Romain Desprat, Jerome Vialaret, Christophe Hirtz, Daniele Noel, Christian Jorgensen, Francois Casas, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Recent studies on cell reprogramming have shown that a short induction of OSKM can improve cell physiology and prevent musculoskeletal deterioration in mice. This treatment also improves tissue structures in various organs and increases lifespan by 15% through rejuvenation of age-related DNA methylation signatures.
Article
Genetics & Heredity
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
Summary: This study investigated the impact of metformin on the epigenetic age in subjects with type 2 diabetes mellitus (DM). The results showed an association between metformin intake and slower epigenetic aging.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Qi Gao, Fang Chen, Lijun Zhang, Ai Wei, Yongxiang Wang, Zhiwei Wu, Wangsen Cao
Summary: In this study, it was found that DNA methylation alterations in renal aging play significant roles, with suppression of NRF2 and KLOTHO leading to elevated DNMT expression and gene promoter hypermethylation. Treatment with DNMT inhibitor or natural polyphenol oleuropein reversed the epigenetic suppression of antiaging factors and mitigated structural and functional changes in aging kidneys.
Review
Genetics & Heredity
Jin Sun, Bokai Cheng, Yongkang Su, Man Li, Shouyuan Ma, Yan Zhang, Anhang Zhang, Shuang Cai, Qiligeer Bao, Shuxia Wang, Ping Zhu
Summary: N6-methyladenosine (m(6)A) is the most common and conserved internal eukaryotic mRNA modification. Recent studies have shown that altered m(6)A levels and abnormal regulator expression play a crucial role in the ageing process and the occurrence of age-related diseases.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Maria Szatmari-Toth, Tanja Ilmarinen, Alexandra Mikhailova, Heli Skottman, Anu Kauppinen, Kai Kaarniranta, Endre Kristof, Lyubomyr Lytvynchuk, Zoltan Vereb, Laszlo Fesus, Goran Petrovski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Kai Kaarniranta, Elzbieta Pawlowska, Joanna Szczepanska, Aleksandra Jablkowska, Janusz Blasiak
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Janusz Blasiak, Elzbieta Pawlowska, Jan Chojnacki, Joanna Szczepanska, Cezary Chojnacki, Kai Kaarniranta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Janusz Blasiak, Elzbieta Pawlowska, Anna Sobczuk, Joanna Szczepanska, Kai Kaarniranta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Sofia Ranta-aho, Niina Piippo, Eveliina Korhonen, Kai Kaarniranta, Maria Hytti, Anu Kauppinen
Summary: The study found that TAS-116 could prevent the activation of caspase-1, subsequently reducing the release of mature IL-1 beta. TAS-116 has a better in vitro therapeutic index than geldanamycin. In summary, TAS-116 appears to be a well-tolerated Hsp90 inhibitor, with the capability to prevent the activation of the NLRP3 inflammasome in human RPE cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Janusz Blasiak, Juha M. T. Hyttinen, Joanna Szczepanska, Elzbieta Pawlowska, Kai Kaarniranta
Summary: AMD is the leading cause of visual impairment in the aging population, with age and family history as the strongest risk factors. Long non-coding RNAs play a significant role in the pathogenesis of AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Vanessa Derenji de Mello, Tuomas Selander, Jaana Lindstroem, Jaakko Tuomilehto, Matti Uusitupa, Kai Kaarniranta
Summary: Elevated serum plasmalogen dm16:0, saturated odd-chain FA 15.0, and omega-3 very long-chain FAs were found to be associated with a decreased occurrence of retinal microaneurysms (MA). The correlation of high serum triglycerides with MA occurrence was attenuated when considering these MA-associated serum lipid markers.
Review
Pharmacology & Pharmacy
Charis Rousou, Carl C. L. Schuurmans, Arto Urtti, Enrico Mastrobattista, Gert Storm, Chrit Moonen, Kai Kaarniranta, Roel Deckers
Summary: This review discusses the use of ultrasound and microbubbles for ocular drug delivery, focusing on enhancing efficacy by disrupting the blood-retina barrier, inducing cellular uptake, and achieving targeted delivery of genes. Safety and tolerability aspects of USMB are also highlighted as crucial for clinical translation.
Article
Cell Biology
Mooud Amirkavei, Flavia Plastino, Anders Kvanta, Kai Kaarniranta, Helder Andre, Ari Koskelainen
Summary: Cells have stress-response pathways to cope with stress factors for homeostasis maintenance; low doses of stress may be beneficial; HHS was found to enhance autophagy gene expression and activation through HSF1.
Article
Biochemistry & Molecular Biology
Ali Koskela, Federico Manai, Filippo Basagni, Mikko Liukkonen, Michela Rosini, Stefano Govoni, Massimo Dal Monte, Adrian Smedowski, Kai Kaarniranta, Marialaura Amadio
Summary: Antioxidant systems play key roles in elderly diseases, including age-related macular degeneration (AMD). This study investigated the protective effects of nature-inspired hybrids on retinal pigment epithelial (RPE) cells. The hybrids increased the expression of Nrf2-target genes and improved intracellular redox balance without affecting autophagy flux. Furthermore, the hybrids enhanced cell survival and reduced inflammation when exposed to proteasome and autophagy inhibitors. The study suggests that Nrf2 is a valuable target for treating AMD.
Review
Nutrition & Dietetics
Susanne Csader, Sonja Korhonen, Kai Kaarniranta, Ursula Schwab
Summary: The purpose of this study was to evaluate the effect of dietary supplementation on the progression of age-related macular degeneration (AMD). The systematic review and meta-analysis showed that the combination of lutein, zeaxanthin, and n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) supplementation may be beneficial in preventing AMD progression and deterioration of visual function. These results encourage further research on the combination of lutein, zeaxanthin, and n-3 LC-PUFA in early AMD patients.
Review
Cell Biology
Hanna Helotera, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. It is classified into dry and neovascular forms, with neovascular AMD being associated with angiogenesis and inflammatory regulators.
Review
Biochemistry & Molecular Biology
Juha M. T. Hyttinen, Janusz Blasiak, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is a complex disease characterized by damage to the retina and is a major cause of vision loss in elderly people. This review explores the role of non-coding RNAs in regulating mitochondrial function and antioxidant stress response in AMD. These molecules have the potential to be used as diagnostic markers and therapeutic targets for AMD and other oxidative stress-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Maeve Boyce, Ying Xin, Olivia Chowdhury, Peng Shang, Haitao Liu, Victoria Koontz, Anastasia Strizhakova, Mihir Nemani, Stacey Hose, J. Samuel Zigler, Matthew Campbell, Debasish Sinha, James T. Handa, Kai Kaarniranta, Jiang Qian, Sayan Ghosh
Summary: This study reveals the interaction between microglia and neutrophils in the pathogenesis of AMD, demonstrating that microglia trigger early RPE changes by regulating neutrophil function and inducing their activation. The study also identifies the Akt2 pathway in microglia as a potential therapeutic target for early AMD.
Article
Biochemistry & Molecular Biology
Maija Toppila, Maria Hytti, Eveliina Korhonen, Sofia Ranta-aho, Niina Harju, Markus M. Forsberg, Kai Kaarniranta, Aaro Jalkanen, Anu Kauppinen
Summary: Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Inhibition of PROLY-OLIGOPEPTIDASE (PREP) by KYP-2047 has been shown to reduce oxidative stress and inflammation, and clear cellular protein aggregates.
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
