Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

(2016) Stephanos Pavlides et al.   Aging-US

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation 

(2011) Vivian Chen et al.   CELL CYCLE

A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells

(2011) M. J. Birket et al.   JOURNAL OF CELL SCIENCE

The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

(2010) Alejandro Vazquez-Martin et al.   BREAST CANCER RESEARCH AND TREATMENT

Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype

(2010) G Kristiansen et al.   BRITISH JOURNAL OF CANCER

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis

(2010) R. M. Memmott et al.   Cancer Prevention Research

Metformin and Other Biguanides in Oncology: Advancing the Research Agenda

(2010) M. Pollak   Cancer Prevention Research

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

RB-pathway disruption in breast cancer

(2010) Adam Ertel et al.   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

(2010) Stephanos Pavlides et al.   CELL CYCLE

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status

(2010) Alejandro Vazquez-Martin et al.   CELL CYCLE

Metformin and Energy Metabolism in Breast Cancer: From Insulin Physiology to Tumour-initiating Stem Cells

(2010) A. Vazquez-Martin et al.   CURRENT MOLECULAR MEDICINE

Quantitative mitochondrial redox imaging of breast cancer metastatic potential

(2010) He N. Xu et al.   JOURNAL OF BIOMEDICAL OPTICS

Neurons and Neuronal Stem Cells Survive in Glucose-Free Lactate and in High Glucose Cell Culture Medium During Normoxia and Anoxia

(2010) Sascha Wohnsland et al.   NEUROCHEMICAL RESEARCH

Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-Depleted Murine Embryonic Stem Cells

(2010) Florian Markowetz et al.   PLoS Computational Biology

Role of glutamate in neuron-glia metabolic coupling

(2009) Pierre J Magistretti   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

[11C] Acetoacetate Utilization by Breast and Prostate Tumors: a PET and Biodistribution Study in Mice

(2008) Simon Authier et al.   MOLECULAR IMAGING AND BIOLOGY

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

(2008) James A. Dykens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY