Article
Biochemistry & Molecular Biology
Sha Liu, Jiazhong Shi, Liwei Wang, Yaqin Huang, Baixiong Zhao, Hua Ding, Yuting Liu, Wuxing Wang, Zhiwen Chen, Jin Yang
Summary: This study reveals for the first time that EMP1 deficiency promotes bladder cancer cell migration and confers resistance to ferroptosis/oxidative stress, thus promoting bladder cancer metastasis via PPARG.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Oncology
Tiange Chi, Mina Wang, Xu Wang, Ke Yang, Feiyu Xie, Zehuan Liao, Peng Wei
Summary: PPARs are lipid sensors and metabolic regulators, with PPAR-γ showing potential in inhibiting cell proliferation, inducing apoptosis, and disrupting inflammation. However, safety concerns including drug interactions need to be addressed for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Seungchan An, Seok Young Hwang, Junpyo Gong, Sungjin Ahn, In Guk Park, Soyeon Oh, Young-Won Chin, Minsoo Noh
Summary: In this study, a machine-learning model was developed to predict the adiponectin-secretion-promoting activity of flavonoid-associated phytochemicals (FAPs). By establishing a structure-activity relationship model and a multiple linear regression model, the adiponectin activity of FAPs was successfully predicted and validated through experimental validation, providing a computational reconstruction method for phenotype-based screening systems.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Biochemistry & Molecular Biology
Johannes Werner, Kim E. Boonekamp, Tianzuo Zhan, Michael Boutros
Summary: Wnt ligands are secreted signaling proteins with a wide range of biological effects. Dysregulation of Wnt signaling is associated with cancer, and genetic alterations result in pathway hyperactivation. Recent research focuses on the interaction of Wnt signaling with tumor micro-environment. The review outlines the function of Wnt ligands in different tumors and their impact on key phenotypes, as well as approaches to target them in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiaohui Ji, Wenqian Zhang, Liqin Yin, Zunhan Shi, Jinwen Luan, Linshan Chen, Longhua Liu
Summary: The number of patients with type 2 diabetes is increasing, posing challenges to public health and economic development. Peroxisome proliferator-activated receptor gamma (PPAR gamma) has been identified as a potential drug target for the treatment of type 2 diabetes. Post-translational modifications (PTMs) of PPAR gamma offer a promising approach to develop safer compounds for diabetes treatment.
Review
Oncology
Xinyang Zhong, Xuefeng He, Yaxian Wang, Zijuan Hu, Huixia Huang, Senlin Zhao, Ping Wei, Dawei Li
Summary: Colorectal cancer is a common and deadly cancer, and the Warburg effect plays a significant role in promoting cancer metastasis and altering the tumor microenvironment. Understanding the mechanisms of the Warburg effect in colorectal cancer and identifying new therapeutic targets is a promising approach.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giuseppina Augimeri, Daniela Bonofiglio
Summary: The breast tumor microenvironment (TME) is recognized as a key player in tumor development and progression for breast cancer patients, with peroxisome proliferator-activated receptor (PPAR) gamma emerging as a potential therapeutic target. Activation of PPAR gamma inhibits breast cancer cell growth and may educate altered stromal cells to counteract inflammation, offering a more efficient way to treat breast cancer.
Article
Oncology
Tomoka Takatani-Nakase, Chihiro Matsui, Maiko Hosotani, Mika Omura, Koichi Takahashi, Ikuhiko Nakase
Summary: Breast cancer cells show increased migration activity under hypoxic conditions, which is correlated with elevated expression of Na+/H+ exchanger isoform 1 (NHE1) and its role in epithelial-mesenchymal transition (EMT). Inhibition of NHE1 by using PPAR gamma agonists can modulate cell migration activity.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Liuqian Xu, Suning Che, Huiqing Chen, Qian Liu, Juanjuan Shi, Jianhua Jin, Yongzhong Hou
Summary: As a master transcription factor, c-Myc promotes tumor immune escape. The role of PPARγ in c-Myc-mediated tumor immune escape is unclear. This study found that the PPARγ agonist pioglitazone reduced c-Myc protein expression by inducing its ubiquitination and degradation. Additionally, pioglitazone inhibited the expression of immune checkpoint proteins PD-L1 and CD47, thus inhibiting tumor immune escape mediated by c-Myc.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Review
Oncology
Chen Liang, Jing-Bo Yang, Xin-Yi Lin, Bi-Lan Xie, Yun-Xian Xu, Shu Lin, Tian-Wen Xu
Summary: Colorectal cancer is the third most common malignancy in the world and is a leading cause of cancer death. MicroRNAs play a significant role in tumor progression, immune system activity, anticancer drug resistance, and the tumor microenvironment. By studying the function of microRNAs in colorectal cancer, new ideas for diagnosis and treatment can be developed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Physical
Suresha N. N. Deveshegowda, Ji-Rui Yang, Zhang Xi, Omantheswara Nagaraja, Kashifa Fazl-Ur-Rahman, Bhanuprakash C. C. Narasimhachar, Gautam Sethi, Ganga Periyasamy, Mahendra Madegowda, Shobith Rangappa, Vijay Pandey, Peter E. E. Lobie, Basappa Basappa
Summary: Bioactive dihydropyrimidinones (DHPs) were synthesized via a multicomponent Biginelli reaction catalyzed by nano-zirconium dioxide. The DHPs exhibited a good correlation between the computed and experimental parameters. The ligands 4d and 4e showed inhibition of cell proliferation with IC50 values of 11.8 and 15.8 muM, respectively, and bioinformatic analysis revealed their similarity to rosiglitazone, suggesting their potential as synthetic PPAR-gamma ligands.
Review
Endocrinology & Metabolism
Elien Alderweireldt, Charlotte Grootaert, Olivier De Wever, John Van Camp
Summary: This review discusses how the two-front environment affects the bioenergetic status of colonocytes throughout the development of colorectal cancer (CRC) and explores dietary strategies that target the specific metabolic preferences of CRC cells, potentially influencing their bioenergetics and outcome.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Oncology
Naoshad Muhammad, Fiona Ruiz, Jennifer Stanley, Ramachandran Rashmi, Kevin Cho, Kay Jayachandran, Michael C. Zahner, Yi Huang, Jin Zhang, Stephanie Markovina, Gary J. Patti, Julie K. Schwarz
Summary: Obesity can impact cancer risk and patient response to therapy. It has been observed that obese patients with cervical cancer have better outcomes after chemoradiotherapy. Using preclinical models, it was found that certain free fatty acids sensitize cervical cancer to radiotherapy through a p53-dependent mechanism. These findings suggest that supplementation with specific fatty acids may improve tumor responses to radiotherapy.
Review
Oncology
Shirin Azizidoost, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Riyadh Ahmad Ali, Maryam Cheraghzadeh, Maryam Farzaneh
Summary: Colorectal cancer is the third leading cause of cancer death in the world. Recent studies have shown that long non-coding RNAs play important roles in colorectal cancer cells, and NEAT1 is a key factor involved in the development and progression of colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Review
Immunology
Daniel Toobian, Pradipta Ghosh, Gajanan D. Katkar
Summary: This review article focuses on the potential roles of peroxisome proliferator-activated receptors (PPARs) in macrophage biology, as well as the modulation of immune cell function, microbial infection, and inflammatory diseases by dual and pan PPAR agonists.
FRONTIERS IN IMMUNOLOGY
(2021)
